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Keun Young Yoo 24 Articles
Cigarette Smoking and Mortality in the Korean Multi-center Cancer Cohort (KMCC) Study.
Eun Ha Lee, Sue K Park, Kwang Pil Ko, In Seong Cho, Soung Hoon Chang, Hai Rim Shin, Daehee Kang, Keun Young Yoo
J Prev Med Public Health. 2010;43(2):151-158.
DOI: https://doi.org/10.3961/jpmph.2010.43.2.151
  • 6,589 View
  • 184 Download
  • 30 Crossref
AbstractAbstract PDF
OBJECTIVES
The aim of this study was to evaluate the association between cigarette smoking and total mortality, cancer mortality and other disease mortalities in Korean adults. METHODS: A total of 14 161 subjects of the Korean Multi-center Cancer Cohort who were over 40 years of age and who were cancer-free at baseline enrollment reported their lifestyle factors, including the smoking status. The median follow-up time was 6.6 years. During the follow-up period from 1993 to 2005, we identified 1159 cases of mortality, including 260 cancer mortality cases with a total of 91 987 person-years, by the national death certificate. Cox proportional hazard regression model was used to estimate the hazard ratio (HR) of cigarette smoking for total mortality, cancer mortality and disease-specific mortality, as adjusted for age, gender, the geographic area and year of enrollment, the alcohol consumption status, the education level and the body mass index (BMI). RESULTS: Cigarette smoking was significantly associated with an increased risk of total mortality, all-cancer mortality and lung cancer mortality (p-trend, <0.01, <0.01, <0.01, respectively). Compared to non-smoking, current smokers were at a higher risk for mortality [HR (95% CI)=1.3 (1.1-1.5) for total mortality; HR (95% CI)=1.6 (1.1-2.2) for all-cancer mortality; HR (95% CI)=3.9 (1.9-7.7) for lung cancer mortality]. CONCLUSIONS: This study's results suggest that cigarette smoking might be associated with total mortality, all-cancer mortality and especially lung cancer mortality among Korean adults.
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    Woojin Kim, A Ram Kim, Minsu Ock, Young-Jee Jeon, Heun Lee, Daehwan Kim, Minjun Kim, Cheolin Yoo
    Annals of Occupational and Environmental Medicine.2023;[Epub]     CrossRef
  • Burden of Cancer Due to Cigarette Smoking and Alcohol Consumption in Korea
    Yoon-Sun Jung, Seok-Jun Yoon
    International Journal of Environmental Research and Public Health.2022; 19(6): 3493.     CrossRef
  • Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium
    Sangjun Lee, Jieun Jang, Sarah Krull Abe, Shafiur Rahman, Eiko Saito, Rashedul Islam, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Jeongseon Kim, Isao Oze, Chisato Nagata, San-Lin You, Myung-He
    International Journal of Epidemiology.2022; 51(4): 1190.     CrossRef
  • Smoking May Affect Pulmonary Function through DNA Methylation: an Epigenome-Wide Association Study in Korean Men
    So-Young Kwak, Clara Yongjoo Park, Min-Jeong Shin
    Clinical Nutrition Research.2020; 9(2): 134.     CrossRef
  • Analysis of multidimensional factors in attempts to quit using tobacco by Korean adolescents
    Mi-Jung Kang, Hyunjin Lee, Mirae Jo
    Environmental Health and Preventive Medicine.2020;[Epub]     CrossRef
  • The impact of basic livelihoods condition on the current smoking: Applying the counterfactual model
    Minhyeok Choi
    Korean Journal of Health Education and Promotion.2019; 36(1): 53.     CrossRef
  • Levels of Health and Subjective Life Expectancy among Community-dwelling Elders in Korea
    Ji Yeon An
    Journal of Korean Gerontological Nursing.2018; 20(1): 22.     CrossRef
  • Association and affecting factor between smoking and suicide idea: Focusing on comparison between district
    Seonhwa Yu, So Young Kim, Bo Ram Park, Mi-na Jo, Siekeyong Kim, Jong Hyock Park
    Korean Journal of Health Education and Promotion.2018; 35(3): 1.     CrossRef
  • The relationship between smoking and stroke by general characteristics: using the 6th Korea national health and nutrition examination survey
    Younghee Nam, Hyunjung Jung, Yesoon Kim
    Journal of Digital Contents Society.2018; 19(7): 1323.     CrossRef
  • Gender-related difference in the relationship between smoking status and periodontal diseases: the propensity score matching approach
    Eun-Sil Choi, Hae-Young Kim
    Journal of Korean Academy of Oral Health.2017; 41(2): 122.     CrossRef
  • The association between smoking or passive smoking and cardiovascular diseases using a Bayesian hierarchical model: based on the 2008-2013 Korea Community Health Survey
    Whanhee Lee, Sung-Hee Hwang, Hayoung Choi, Ho Kim
    Epidemiology and Health.2017; 39: e2017026.     CrossRef
  • Psychosocial Factors Associated With Smoking Intention in Korean Male Middle School Students
    Jin Suk Ra, Yoon Hee Cho
    The Journal of School Nursing.2017; 33(5): 355.     CrossRef
  • Physiological and clinical relevance of anomalous right coronary artery originating from left sinus of Valsalva in adults
    Sang Eun Lee, Cheol Woong Yu, Kyungil Park, Kyung Woo Park, Jung-Won Suh, Young-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Ho-Jun Jang, Jin-Shik Park, Sang-Hoon Na, Hyo-Soo Kim, Ki-Bong Kim, Bon-Kwon Koo
    Heart.2016; 102(2): 114.     CrossRef
  • Association Between Smoking and Physician-Diagnosed Stroke and Myocardial Infarction in Male Adults in Korea
    Sounghoon Chang, Hyeongsu Kim, Vitna Kim, Kunsei Lee, Hyoseon Jeong, Jung-Hyun Lee, Soon-Ae Shin, Eunyoung Shin, Minsu Park, Eunjung Ko
    International Journal of Environmental Research and Public Health.2016; 13(2): 158.     CrossRef
  • The relationship between smoking and depressive symptoms among Korean adults
    Han Na Sung, Jong Sung Kim
    Korean Journal of Health Education and Promotion.2016; 33(2): 57.     CrossRef
  • C-reactive Protein Concentration Is Associated With a Higher Risk of Mortality in a Rural Korean Population
    Jung Hyun Lee, Hyungseon Yeom, Hyeon Chang Kim, Il Suh, Mi Kyung Kim, Min-Ho Shin, Dong Hoon Shin, Sang-Baek Koh, Song Vogue Ahn, Tae-Yong Lee, So Yeon Ryu, Jae-Sok Song, Hong-Soon Choe, Young-Hoon Lee, Bo Youl Choi
    Journal of Preventive Medicine and Public Health.2016; 49(5): 275.     CrossRef
  • A Study on the Factors Related to Smoking and Smoking Conditions among College Students in Some Area
    Kyeong-Ah Kim
    Journal of the Korea Academia-Industrial cooperation Society.2016; 17(8): 465.     CrossRef
  • Comparison of the Health Status Between Korean Seniors and Overseas Korean Seniors in China and Japan
    Mi-Kyoung Cho, Ogcheol Lee, Gisoo Shin
    Journal of the Korea Academia-Industrial cooperation Society.2015; 16(3): 2079.     CrossRef
  • Combined Influence of Smoking Frequency and Intensity on Suicidal Ideation and Attempts in Korean High School Students
    Jin Suk Ra, Yoon Hee Cho, Hye Sun Kim
    Journal of the Korean Society of School Health.2015; 28(3): 168.     CrossRef
  • Factor Analysis of Effect on Cardiovascular Disease of Korean Police Officers
    Jingu Lee, Woojin Jeon, Jaehwan Cho
    Journal of the Korean Society of Radiology.2014; 8(1): 11.     CrossRef
  • How Computed Tomography Contrast Media and Magnetic Resonance Imaging Contrast Media Affect the Changes of Uptake Counts of201Tl
    Jin-Hyeok Lee, Hae-Kag Lee, Jae-Hwan Cho, Miju Cheon
    Journal of Magnetics.2014; 19(4): 372.     CrossRef
  • Influence of Physical Activity on Smoking Experience and Smoking Intensity in Korean High School Students
    Jin Suk Ra, Yoon Hee Cho
    Journal of the Korean Society of School Health.2014; 27(3): 181.     CrossRef
  • Attributable fraction of tobacco smoking on cancer using population-based nationwide cancer incidence and mortality data in Korea
    Sohee Park, Sun Ha Jee, Hai-Rim Shin, Eun Hye Park, Aesun Shin, Kyu-Won Jung, Seung-Sik Hwang, Eun Shil Cha, Young Ho Yun, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta
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  • Risk Factors for Smoking Behaviors Among Adolescents
    Sung Suk Chung, Kyoung Hwa Joung
    The Journal of School Nursing.2014; 30(4): 262.     CrossRef
  • Smoking in elderly Koreans: Prevalence and factors associated with smoking cessation
    Shin Kyum Kim, Joon Hyuck Park, Jung Jae Lee, Seok Bum Lee, Tae Hui Kim, Ji Won Han, Jong Chul Youn, Jin Hyeong Jhoo, Dong Young Lee, Ki Woong Kim
    Archives of Gerontology and Geriatrics.2013; 56(1): 214.     CrossRef
  • Less Healthy Dietary Pattern is Associated with Smoking in Korean Men According to Nationally Representative Data
    Sang-Yeon Suh, Ju Hyun Lee, Sang Shin Park, Ah-Ram Seo, Hong-Yup Ahn, Woo Kyung Bae, Yong Joo Lee, Eunji Yim
    Journal of Korean Medical Science.2013; 28(6): 869.     CrossRef
  • The Association between Smoking, Alcohol Intake, and Low-Salt Diet: Results from the 2008 Community Health Survey
    In-Ae Chun, Jong Park, Mi-Ah Han, Seong-Woo Choi, So-Yeon Ryu
    Journal of the Korean Dietetic Association.2013; 19(3): 223.     CrossRef
  • Impact of Individual and Combined Health Behaviors on All Causes of Premature Mortality Among Middle Aged Men in Korea: The Seoul Male Cohort Study
    Chul Woo Rhee, Ji Young Kim, Byung Joo Park, Zhong Min Li, Yoon-Ok Ahn
    Journal of Preventive Medicine and Public Health.2012; 45(1): 14.     CrossRef
  • Mortality and Potential Years of Life Lost of lung cancer between Korea and OECD countries before and after the year 2000
    Dong-Seok Kim, Ji-Won Park, Soo-Won Kang
    Journal of the Korea Academia-Industrial cooperation Society.2011; 12(7): 3138.     CrossRef
  • Evaluation and Development of Tobacco Control Policies Using Delphi Technique
    Jeong-Min Kim, Young-Su Ju, Yeol Kim, Hong-Gwan Seo
    Journal of the Korean Society for Research on Nicotine and Tobacco.2011; 2(1): 30.     CrossRef
Reliability of a Questionnaire for Women's Reproductive History.
Kwang Pil Ko, Sue Kyung Park, Yeonju Kim, Jisuk Bae, Jae kwan Jun, Jin Gwack, Keun Young Yoo
J Prev Med Public Health. 2008;41(3):181-185.
DOI: https://doi.org/10.3961/jpmph.2008.41.3.181
  • 5,324 View
  • 59 Download
  • 9 Crossref
AbstractAbstract PDF
OBJECTIVES
This study was performed to evaluate the reproducibility of a questionnaire concerned with reproductive history and to ascertain which characteristics of the subjects (age, the visit-revisit intervals, education and chronic disease) are associated with good reliability in the Korean Multi-Center Cancer Cohort (KMCC) study. MATERIALS AND METHODS: A total of 19,688 participants were enrolled between 1993 and 2004. Among them, we selected 386 participants who were aged 40 or more and who re-visited within 8 years after the first visit. Reliability was measured by the percent agreement according to error range for the continuous variables and the percent agreement and kappa statistics for the categorical variables. RESULTS: The pregnancy histories were reliable (kappa=0.67) and the reasons for being menopausal among the postmenopausal women were also reliable (kappa=0.92). The percent agreement of the breast-feeding history was high (96.1%), although the kappa statistic was low. For the continuous variables, when the error range of one variable was considered to be reliable, the percent agreement of the age at menarche and the age at the first full term pregnancy was good (69.4% and 83.6%), whereas that of the age at menopause was low (51.5%). The factors associated with high reliability were a younger age, the presence of chronic disease and a short visit-revisit time interval. CONCLUSIONS: The agreements for parity, the reasons for menopause, and the breastfeeding history in the reproductive history questionnaire used in the KMCC were relatively good. The questionnaire for the menarche age and the menopausal age might have lower reliability due to the difference between Korean age and American age. To obtain reliable information, more attention should be given to the items in questionnaire-based surveys, and especially for surveying old-aged women.
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    Mario Romandini, Hye‐Sun Shin, Pierluigi Romandini, Andreina Laforí, Massimo Cordaro
    Journal of Clinical Periodontology.2020; 47(4): 429.     CrossRef
  • Validity and Reliability of the Questionnaire for Assessing Women’s Reproductive History in Azar Cohort Study
    Mohammad Zakaria Pezeshki, Atefeh Shadman, Mahasti Alizadeh, Sevil Hakimi, Fariba Heidari
    Journal of Caring Sciences.2017; 6(2): 183.     CrossRef
  • Hormone-related factors and post-menopausal onset depression: Results from KNHANES (2010–2012)
    Sun Jae Jung, Aesun Shin, Daehee Kang
    Journal of Affective Disorders.2015; 175: 176.     CrossRef
  • Menarche age, menopause age and other reproductive factors in association with post-menopausal onset depression: Results from Health Examinees Study (HEXA)
    Sun Jae Jung, Aesun Shin, Daehee Kang
    Journal of Affective Disorders.2015; 187: 127.     CrossRef
  • Persistent effects of women’s parity and breastfeeding patterns on their body mass index: results from the Million Women Study
    K L Bobrow, M A Quigley, J Green, G K Reeves, V Beral
    International Journal of Obesity.2013; 37(5): 712.     CrossRef
  • Relationship Between Body Mass Index and Early Menarche of Adolescent Girls in Seoul
    Chang-Mo Oh, In-Hwan Oh, Kyung-Sik Choi, Bong-Keun Choe, Tai-Young Yoon, Joong-Myung Choi
    Journal of Preventive Medicine and Public Health.2012; 45(4): 227.     CrossRef
  • Childhood Hair Product Use and Earlier Age at Menarche in a Racially Diverse Study Population: A Pilot Study
    Tamarra James-Todd, Mary Beth Terry, Janet Rich-Edwards, Andrea Deierlein, Ruby Senie
    Annals of Epidemiology.2011; 21(6): 461.     CrossRef
  • Menstrual factors and cancer risk among Korean women
    A. Shin, Y.-M. Song, K.-Y. Yoo, J. Sung
    International Journal of Epidemiology.2011; 40(5): 1261.     CrossRef
  • The Impact of Socioeconomic Status across Early Life on Age at Menarche Among a Racially Diverse Population of Girls
    Tamarra James-Todd, Parisa Tehranifar, Janet Rich-Edwards, Lina Titievsky, Mary Beth Terry
    Annals of Epidemiology.2010; 20(11): 836.     CrossRef
Cigarette Smoking and Gastric Cancer Risk in a Community-based Cohort Study in Korea.
Yeonju Kim, Aesun Shin, Jin Gwack, Jae Kwan Jun, Sue Kyung Park, Daehee Kang, Hai Rim Shin, Soung Hoon Chang, Keun Young Yoo
J Prev Med Public Health. 2007;40(6):467-474.
DOI: https://doi.org/10.3961/jpmph.2007.40.6.467
  • 5,728 View
  • 96 Download
  • 12 Crossref
AbstractAbstract PDF
OBJECTIVES
Gastric cancer is the most common incident cancer in Korea. Although Helicobacter pylori infection is the most important risk factor for the development of gastric cancer, cigarette smoking has also been suggested to play an important role in the development of gastric cancer. The objective of this study is to evaluate the relationship between cigarette smoking and gastric cancer risk in a Korean population. METHODS: The study population consisted of 13,785 subjects who had been enrolled in the Korean Multi-Center Cancer Cohort between 1993 and 2002. As of December 2002, 139 incident gastric cancer cases were ascertained through the Korea Central Cancer Registry and the National Death Certificate Database. Relative risks (RR) and 95% confidence intervals (CI) for gastric cancer were estimated using CoxZs proportional hazard model adjusted for age, education, alcohol drinking status and history of gastritis or ulcer. RESULTS: Significant dose-response relationships were observed between the duration of smoking and the risk of gastric cancer among the male subjects in comparison to non-smokers: men who smoked for 20-39 years had a 2.09- fold (95% CI 1.00-4.38) increase, and those who smoked for more than 40 years had a 3.13-fold (95% CI 1.59-6.17) increase in the risk of gastric cancer (Ptrend<0.01). CONCLUSIONS: This study suggests that a longer duration of cigarette smoking may increase the risk of gastric cancer development in a dose-response manner in Korean men. The association between smoking and gastric cancer risk in women should be verified in future studies with a larger number of cases.
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    In-Seob Lee, Young-Soo Park, Jeong Hoon Lee, Ji Young Park, Hee-Sung Kim, Beom-Su Kim, Jeong-Hwan Yook, Sung-Tae Oh, Byung-Sik Kim
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    Aesun Shin, Jeongseon Kim, Sohee Park
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    Jae Jeong Yang, Kwang-Pil Ko, Lisa Y Cho, Aesun Shin, Jin Gwack, Soung-Hoon Chang, Hai-Rim Shin, Keun-Young Yoo, Daehee Kang, Sue K Park
    BMC Cancer.2009;[Epub]     CrossRef
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Cigarette Smoking, Alcohol Consumption, Tuberculosis and Risk of Lung Cancer: The Korean Multi-center Cancer Cohort Study.
Jisuk Bae, Jin Gwack, Sue Kyung Park, Hai Rim Shin, Soung Hoon Chang, Keun Young Yoo
J Prev Med Public Health. 2007;40(4):321-328.
DOI: https://doi.org/10.3961/jpmph.2007.40.4.321
  • 5,801 View
  • 118 Download
  • 10 Crossref
AbstractAbstract PDF
OBJECTIVES
The aim of this study was to evaluate the roles of cigarette smoking, alcohol consumption, tuberculosis, and their interactions in the risk of lung cancer in a Korean cohort. METHODS: The study subjects comprised 13,150 males and females aged above 20 years old. During the follow up period from 1993 to 2002, 79 lung cancer cases were identified by the central cancer registry and the national death certificate database. Information on cigarette smoking, alcohol consumption and the history of physiciandiagnosed tuberculosis was obtained by interview. Indirect chest X-ray findings were also evaluated to ascertain tuberculosis cases. Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI) after adjusting for age and gender. RESULTS: Cigarette smoking was statistically significantly associated with an increased risk of lung cancer [for current smokers, RR = 2.33 (95% CI = 1.23 - 4.42) compared to non-smokers]. After further adjustment for cigarette smoking, both alcohol consumption and tuberculosis showed no statistically significant association with the risk of lung cancer [for current drinkers, RR = 0.80 (95% CI = 0.48 - 1.33) compared to non-drinkers] [for tuberculosis cases, RR = 1.17 (95% CI = 0.58 - 2.36) compared to noncases]. There was no statistically significant interaction between cigarette smoking and alcohol consumption (pinteraction = 0.38), or cigarette smoking and tuberculosis (p-interaction = 0.74). CONCLUSIONS: Although cigarette smoking was confirmed as a risk factor of lung cancer in this cohort study, this study suggests that alcohol consumption and tuberculosis may not be associated with the risk of lung cancer.
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Fasting Serum Glucose and Subsequent Liver Cancer Risk in a Korean Prospective Cohort.
Jin Gwack, Seung Sik Hwang, Kwang Pil Ko, Jae Kwan Jun, Sue Kyung Park, Soung Hoon Chang, Hai Rim Shin, Keun Young Yoo
J Prev Med Public Health. 2007;40(1):23-28.
DOI: https://doi.org/10.3961/jpmph.2007.40.1.23
  • 5,437 View
  • 78 Download
  • 15 Crossref
AbstractAbstract PDF
OBJECTIVES
Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort. METHODS: Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity. RESULTS: The RRs of serum glucose for liver caner were 1.20 (95% CI=0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI=1.24-6.18) for the >126 mg/dL serum glucose category (both compared to the <100 mg/dL category). In a subgroup analysis, the RR of serum glucose among those who were both HBsAg seronegative and non-drinkers was 4.46 (95% CI=1.09-18.28) for those with glucose levels >100 mg/dL. CONCLUSIONS: The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer.
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Fasting Serum Glucose Level and Gastric Cancer Risk in a Nested Case-control Study.
Jae Kwan Jun, Jin Gwack, Sue Kyung Park, Yun Hee Choi, Yeonju Kim, Aesun Shin, Soung Hoon Chang, Hai Rim Shin, Keun Young Yoo
J Prev Med Public Health. 2006;39(6):493-498.
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OBJECTIVES
Diabetes has been reported as a risk factor for several cancers. However, the association between diabetes and gastric cancer has been inconsistent. The aim of this study was to evaluate the association between the fasting serum glucose level and gastric cancer risk in Korea. METHODS: Among the members of the Korean Multi-Center Cancer Cohort (KMCC) from 1993 to 2004, a total of 100 incident gastric cancer cases were ascertained until December 31, 2002 and 400 controls were matched according to age, sex, and year and area of enrollment. Of the eligible subjects, those without fasting serum glucose level information were excluded, with a total of 64 cases and 236 controls finally selected. On enrollment, all subjects completed a baseline demographic and lifestyle characteristics questionnaire, and had their fasting serum glucose level measured. The Helicobacter pylori infection status was determined by an immunoblot assay using longterm stored serum. The odds ratios (ORs) were estimated using conditional and unconditional logistic regression models adjusted for the H. pylori infection status, smoking, drinking, education, follow-up period and matching variables. RESULTS: The ORs for risk of gastric cancer according to the serum glucose level were 1.33 [95% CI=0.50-3.53] and 1.66 [95% CI=0.55-5.02] for the categories of 100-125 and 126 mg/dL or greater, respectively, compared to the category of less than 100 mg/dL. No increased risk of gastric cancer according to the serum glucose level was found (p-trend=0.337). CONCLUSIONS: This study provides no evidence for an association of the serum glucose level with gastric cancer.
Summary
Assessment of DNA Viability in Long Term-Stored Buffy Coat Species for the Korean Multicenter Cancer Cohort.
Mihi Yang, Jihyun Yoo, Cheong Sik Kim, Aesun Shin, Daehee Kang, Soung Hoon Chang, Sue Kyung Park, Hai Rim Shin, Keun Young Yoo
Korean J Prev Med. 2003;36(4):373-376.
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AbstractAbstract PDF
OBJECTIVES
Peripheral blood-buffy coat fractions (N = 14, 956) have been stored at -70degrees C in the headquarter of the Korean Multicenter Cancer Cohort (KMCC), since 1993. To study the future molecular etiology of cancers using specimens of the cohort, properly stored specimens are necessary. Therefore, the DNA-viability of the buffy coat samples was investigated. METHODS: Buffy coat fraction samples were randomly selected from various collection areas and years (N = 100). The DNA viability was evaluate from the UV-absorbent ratios at 260/280nm and the PCR for beta-globin was performed with genomic DNA isolated from the buffy coat. RESULTS: PCR products were obtained from 85 and 98% of the C and H area-samples, respectively, using 50 or 100mul of the buffy coat. There were significant differences in the yields of the PCR-amplifications from the C and H areas (p < 0.05), which was due to differences in the homogenization of the buffy coat fractions available as aliquots. The PCR-products were obtained from all of the samples (N = 7) stored at the C area-local center, but the other aliquots stored at the headquarter were not PCR-amplified. Therefore, the PCR products in almost all the samples, even including the DNA-degraded samples, were obtained. In addition, an improvement in the DNA isolation, i.e. approx. 1.6 fold, was found after using extra RBC lysis buffer. CONCLUSIONS: PCR products for beta-globin were obtained from nearly all of the samples. The regional differences in the PCR amplifications were thought to have originated from the different sample-preparation and homogenization performance. Therefore, the long term-stored buffy coat species at the KMCC can be used for future molecular studies.
Summary
Estimation of Joint Risks for Developing Uterine Cervix Cancer in Korea.
Hachung Yoon, Aesun Shin, Sue Kyung Park, Myung Jin Jang, Keun Young Yoo
Korean J Prev Med. 2002;35(3):263-268.
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AbstractAbstract PDF
OBJECTIVE
This study was aiming at estimating the joint effects of various risk factors associated with uterine cervix cancer in Korea. METHODS: Data obtained from a case-control study were analyzed with a multiplicative model. RESULTS: After adjustment for age and husband's educational attainments, the family history of cervical cancer (OR=2.1, 95% CI=1.2-3.9), unstable marital status due to separation, by death or divorce, etc. (OR=2.8, 95% CI=1.7-4.6), and a large number of deliveries (> or = 3 vs. nulliparous OR=6.5, 95% CI=1.4-29.9) increased the risk of uterine cervix cancer. Conversely, first sexual intercourse at an older age (> or = 25 years vs. <19 years OR=0.4, 95% CI=0.2-0.6) and husband's circumcision (OR=0.7, 95% CI=0.5-1.0) decreased the risk. In the multiplicative model, the highest joint risk (OR=39.2, 95% CI 5.9-258.9) was observed in women with a family history of uterine cervical cancer, an unstable marital status, where the ex-husband was not circumcised, with 3 or more delivery experiences, and having her first sexual intercourse when younger than 19 years of age. However, women without a family history of uterine cervix cancer, married to a circumcised husband, having had her first sexual intercourse at 25 years or older, and nulliparous, showed the lowest joint effect (OR=0.3, 95% CI=0.1-0.5). CONCLUSION: As carcinogenesis is a complex action involving various factors, we consider a joint effects approach to be appropriate in an epidemiological study on risk factors for uterine cervix neoplasms.cervix neoplasm.
Summary
A Case-Control Study on the Relationship between Obesity and Female Colorectal Cancer.
Aesun Shin, Hachung Yoon, Keun Young Yoo
Korean J Prev Med. 2002;35(2):147-152.
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AbstractAbstract PDF
OBJECTIVES
A hospital-based case-control study was conducted to evaluate the role of obesity in the development of colorectal cancer. METHODS: Three hundred and twenty four histologically confirmed female colorectal cancer cases and 26,998 non-cancer controls were selected from patients invited to the Aichi Cancer Center, Nagoya, Japan between 1989 and 1995. Information concerning demographic factors, medical history, family medical history, reproductive factors and dietary factors were obtained from self-administered questionnaires and medical records. The effects of weight and body mass index to colorectal cancer were examined using multiple logistic regression to control for other risk factors. RESULTS: There was no significant association between female colorectal cancer and obesity. Heavier weight adjusted for height or body mass index did not increase the risk of colorectal cancer. CONCLUSIONS: These results suggest that there is no associa-tion between colorectal cancer risk and obesity in women.
Summary
Analysis of the Abstracts of Cancer Related Articles Published from 1990 to 1996 in Korea.
Chang Yup Kim, Young Ho Khang, Young Sung Lee, Chul Whan Kang, Keun Young Yoo, Gilwon Kang, Beom Man Ha
Korean J Prev Med. 2001;34(3):200-210.
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AbstractAbstract PDF
OBJECTIVE
To explore the status of cancer research in the Republic of Korea. METHODS: Thirty-eight medical journals, published in Korea between 1990 and 1996, were reviewed for abstracts relating to cancer research. Of the 5,899 eligible abstracts related to cancer, 4,732 were collected and evaluated. RESULTS: Including first author and first two co-authors, a total of 7,427 authors were identified. Those who published an average of one or more article per one year were defined as cancer researchers for this study. This group, however, accounted for a small proportion of the total (3.1%). Analysis of the selected abstracts showed that the study goals in more than half focused on pathophysiologic mechanisms. Studies that were designed to use causal relationships such as cohort studies and randomized controlled trials were rare. A greater number of analytic and experimental studies were found in abstracts published by the cancer researcher group. More advanced study designs that explored causal relationships and analytic procedures were found in abstracts published later than those abstracts published from 1990 to 1992. CONCLUSION: Our findings show that researchers who published more articles adopted more advanced study designs. This study provides primary data that can be used to compare the status of cancer research in future studies.
Summary
Size of Prostatitis Symptoms Using Prostatitis Symptom Index(PSI): The Effect of Prostatitis Symptoms on Quality of Life.
Seok Soo Byun, Daehee Kang, Keun Young Yoo, Sue Kyung Park, Cheol Kwak, Moon Ki Jo, Hyeon Hoe Kim, Chongwook Lee
Korean J Prev Med. 2000;33(4):449-458.
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AbstractAbstract PDF
OBJECTIVES
To determine the prevalence of prostatitis symptoms in the general population by questionnaire survey and to measure the effect of prostatitis symptoms on quality of life(QOL). MATERIALS AND METHODS: A cross sectional community-based epidemiologic study was performed on 2,034 men, living in the Seoul metropolitan area using stepwise random sampling. Out of 2,034 interviewees, 1,356 men who were older than 40 and provided sufficient information were selected for this study. The questionnaires were completed by well trained interviewers. Contents of the questionnaires included demographic data, the Prostatitis Symptom Index(PSI), the International Prostate Symptom Score(IPSS), a general health questionnaire section and a sexual health questionnaire section. The PSI was composed of a sum of the scores from three questions about dysuria, penile pain and perineal pain and it ranged 0 to 12. Incidence of prostatitis symptoms was defined by a score of 4 or more and the reference group was defined as consisting of those with a score of 3 or less. The rate of incidence of prostatitis symptoms was assessed according to age and the difference of QOL between the prostatitis symptoms group and the reference group. RESULTS: The overall positive rate of prostatitis symptoms measured by the PSI, in men older than 40, living in the Seoul metropolitan area, was 4.5%(61/1,356), adjusted to 4.8% by the relative proportion of this age group in the general population of the Seoul metropolitan area as compared to Korea and the World. The proportion of the group with prostatitis symptoms assessed by the PSI did not increase with age although the proportion of participants with moderate to severe lower urinary tract symptoms (LUTS) did increase with age. The group with prostatitis symptoms suffered from a much greater incidence of LUTS compared to the reference group (p<0.05). The QOL scores of the IPSS, and the general health and sexual health status of the group with prostatitis symptoms, were worse than those of the reference group.(p<0.05). CONCLUSIONS: The positive rate of prostatitis symptoms in men older than 40, living in the Seoul metropolitan area, was 4.8% and it didn't increase with age. The general QOL of the group with prostatitis symptoms was much worse than that of the reference group.
Summary
Assessment of the Glycophorin A Mutant Assay as a Biologic Marker for Low Dose Radiation Exposure.
Mina Ha, Keun Young Yoo, Sung Whan Ha, Dong Hyun Kim, Soo Hun Cho
Korean J Prev Med. 2000;33(2):165-173.
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AbstractAbstract PDF
OBJECTIVES
To assess the availability of the glycophorin A (GPA) assay to detect the biological effect of ionizing radiation in workers exposed to low-doses of radiation. METHODS: Information on confounding factors, such as age and cigarette smoking was obtained on 144 nuclear power plant workers and 32 hospital workers, by a self-administered questionnaire. Information on physical exposure levels was obtained from the registries of radiation exposure monitoring and control at each facility. The GPA mutant assay was performed using the BR6 method with modification by using a FACScan flow cytometer. RESULTS: As confounders, age and cigarette smoking habits showed increasing trends with GPA variants, but these were of no statistical significance. Hospital workers showed a higher frequency of the GPA variant than nuclear power plant workers in terms of the NO variant. Significant dose-response relationships were obtained from in simple and multiple linear regression models. The slope of the regression equation for nuclear power plant workers was much smaller than that of hospital workers. These findings suggest that there may be apparent dose-rate effects. CONCLUSION: In population exposed to chronic low-dose radiation, the GPA assay has a potential to be used as an effective biologic marker for assessing the bone marrow cumulative exposure dose.
Summary
Factors Associated with the Use of Pap Test in a Rural Area.
Kun Sei Lee, Hye Won Koo, Won Jin Lee, Soung Hoon Chang, Keun Young Yoo
Korean J Prev Med. 1999;32(2):147-154.
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AbstractAbstract PDF
OBJECTIVES
To construct basic data to develop strategies for achieving higher Pap test coverage rate by evaluating factors associated with the use of Pap test through population-based survey. METHODS: 16.4%(671) of the 4,090 women, who were eligible population for this study, in 3 Myens of Chung-ju City participated in this study voluntarily from July 21 to 26, 1997. After basic physical examination by trained doctors, they were interviewed with structured questionnaire by well-educated interviewers. RESULTS: It shows that only 54.3% of study participants experienced Pap test. The strongest factor which is related with the use of Pap test was the history of having breast screening tests(aOR=8.71, 95% CI=4.25-17.84). Probability of ever having Pap test was also higher in married women(aOR of single=0.46, 95% CI=0.29-0.72), younger(Ptrend<0.05), more educated (Ptrend<0.001), non-smoker (aOR of smoker=0.26, 95% CI=0.12-0.55), women of ever having hepatitis test(aOR=2.60, 95% CI=1.73-3.88) in multiple linear logistic analysis. CONCLUSIONS: This study suggests that several factors significantly associated with the use of Pap test, and especially, high-risk population for cervical cancer such as women of older ages, less educated, living alone are less likely to have the Pap test. We should concentrate on encouraging high-risk women in the use of Pap test to improve Pap test coverage rate.
Summary
An Application of Delphi Method to the Assessment of Current Status of Cancer Research.
Young Ho Khang, Seok Jun Yoon, Gil Won Kang, Chang Yup Kim, Keun Young Yoo, Young Soo Shin
Korean J Prev Med. 1998;31(4):844-856.
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AbstractAbstract PDF
Globally, cancer research has been considered one of the most important field of biomedical researches. Recently, in Korea, there are increasing concerns about cancer research and the development of national cancer control programme. For the efficient investment in cancer research at the national level, strategic approach is needed based on the nationwide information about current status of research. However even the basic data on cancer research have not been systematically collected, and are not available when necessary. The aim of this study is to assess current status of cancer research. For this purpose, this study applied two round Delphi method in which fifteen experts in cancer research fields participated. They rated each items on the initial list at the first round, and modified their responses at the second round. Panels responded that pathogenesis of cancer, research and development of cancer drug, and oncogene, etc. are the most urgent and important research fields. They assessed national level of cancer research as being 49.6% of the world highest level. Coefficient of variation tended to be lowered with the iteration. Predictive stability was evaluated to be lower in items of urgency than in items of importance and research level. Although this study shares the same limitations in the selection of the experts with many other Delphi studies, it provides a primary data that would be required to plan the national strategy of the cancer research.
Summary
Incidence of Female Breast Cancer in a Defined Area in Korea.
Keun Young Yoo, Sue Kyung Park, Joo Hon Sung, Dong Young Noh, Kuk Jin Choe
Korean J Prev Med. 1998;31(4):592-603.
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AbstractAbstract PDF
This study was conducted to estimate incidence rate of female breast cancer in a defined area of Chungchongbuk-do in Korea. The presumptive breast cancer cases were selected from two different sources, i.e., medical utilization database of the National Health Insurance Corporation and the database from the National Cancer Registry. Medical students visited each hospital where the presumptive cases had been treated as a breast cancer patient, and made a dictation of medical record of each patient based on the claims stored in the Insurance Corporation from January to December 1995. The diagnoses in the claims included one of the following diagnostic codes; ICD-9 174-175(malignant neoplasms of the breast), 233(carcinoma in situ of the breast and genito-urinary system)or ICD-10 C50(malignant neoplasms of the breast), D05(carcinoma in situ of the breast and genito-urinary system). Each case has been confirmed as having a breast cancer by a breast surgeon through a medical record review. Age-standardized incidence rate of female breast cancer to the Korean population was estimated to be 10.5(95%confidence interval : 8.1-12.9)per 100,000 persons in 1995. Age-standardized rate to the world population was 9.8 per 100,000 persons, and the truncated rate for ages 35-64 was 27.2 per 100,000 persons. Validity of these estimates is discussing in comparison with previous methods of incidence estimation in Korea.
Summary
Lung cancer, chronic obstructive pulmonary disease and air pollution.
Joo Hon Sung, Soo Hun Cho, Dae Hee Kang, Keun Young Yoo
Korean J Prev Med. 1997;30(3):585-598.
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AbstractAbstract PDF
BACKGROUND
Although there are growing concerns about the adverse health effect of air pollution, not much evidence on health effect of current air pollution level had been accumulated yet in Korea. This study was designed to evaluate the chronic health effect of air pollution using Korean Medical Insurance Corporation (KMIC) data and air quality data. Medical insurance data in Korea have some drawback in accuracy, but they do have some strength especially in their national coverage, in having unified ID system and individual information which enables various data linkage and chronic health effect study. METHOD: This study utilized the data of Korean Environmental Surveillance System Study (Surveillance Study), which consist of asthma, acute bronchitis, chronic obstructive pulmonary diseases (COPD), cardiovascular diseases (congestive heart failure and ischemic heart disease), all cancers, accidents and congenital anomaly, i.e., mainly potential environmental diseases. We reconstructed a nested case-control study with Surveillance Study data and air pollution data in Korea. Among 1,037,210 insured who completed questionnaire and physical examination in 1992, disease free (for chronic respiratory disease and cancer) persons, between the age of 35-64 with smoking status information were selected to reconstruct cohort of 564,991 persons. The cohort was followed-up to 1995 (1992-5) and the subjects who had the diseases in Surveillance Study were selected. Finally, the patients, with address information and available air pollution data, left to be 'final subjects'. Cases were defined to all lung cancer cases (424) and COPD admission cases (89), while control groups are determined to all other patients than two case groups among 'final subjects'. That is, cases are probable chronic environmental diseases, while controls are mainly acute environmental diseases. For exposure, Air quality data in 73 monitoring sites between 1991 - 1993 were analyzed to surrogate air pollution exposure level of located areas (58 areas). Five major air pollutants data, TSP, O3, SO2, CO, NOx was available and the area means were applied to the residents of the local area. 3-year arithmetic mean value, the counts of days violating both long-term and shot-term standards during the period were used as indices of exposure. Multiple logistic regression model was applied. All analyses were performed adjusting for current and past smoking history, age, gender. Results: Plain arithmetic means of pollutants level did not succeed in revealing any relation to the risk of lung cancer or COPD, while the cumulative counts of non-attainment days did. All pollutants indices failed to show significant positive findings with COPD excess. Lung cancer risks were significantly and consistently associated with the increase of O3and CO exceedance counts(to corrected error level - 0.017) and less strongly and consistently with SO2 and TSP. SO2and TSP showed weaker and less consistent relationship. O3and CO were estimated to increase the risks of lung cancer by 2.04 and 1.46 respectively, the maximal probable risks, derived from comparing more polluted area (95%) with cleaner area (5%). CONCLUSIONS: Although not decisive due to potential misclassication of exposure, these results were drawn by relatively conservative interpretation, and could be used as an evidence of chronic health effect especially for lung cancer. O3might be a candidate for promoter of lung cancer, while CO should be considered as surrogated measure of motor vehicle emissions. The control selection in this study could have been less appropriate for COPD, and further evaluation with another setting might be necessary.
Summary
Seroepidemiologic Study of Hepatitis B Virus(HBV) and Hepatitis C Virus(HCV) Infection among Koreans in Rural Area, Korea.
Hai Rim Shin, Joon Youn Kim, Jue Bok Song, Byung Seong Suh, Jung Man Kim, Bu Ok Lee, Su Ryang Kim, Mu Guan Yang, Chae Un Lee, Jin Ho Chun, Keun Young Yoo, Yoon Ok Ahn
Korean J Prev Med. 1997;30(1):17-30.
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AbstractAbstract PDF
To estimate the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and to determine associated risk factors, a population-based seroepidemiologic study was carried out. In 1993, a health examination survey of the population was carried out in rural area known to have a high incidence of liver cancer. The study population were those who volunteered to participate in a health survey over 10 years of age. Examinees were interviewed by specially trained staffs. Sera from 1,033 study subjects were tested for hepatitis B surface antigen (HBsAg) by reverse passive hemagglutinin (RPHA) estimation and for hepatitis C virus antibody (anti-HCV) by 2nd generation passive hemagglutinin (PHA) estimation, The age and sex standardized prevalence of HBsAg was 6.3% which was similar to national average, but that of anti-HCV was 5.1% which was 4 to 5 times higher than that of blood or other health examinees in Korea. In a multivariate analysis, transfusion history, surgical operative history, and acupuncture history were not associated with HBsAg positivity. In contrast, acupuncture history (adjusted odds ratio[OR]=2.2 : 95% Confidence interval[CI] 1.0-4.7) and surgical operative history(adjusted OR=2.0 : 95% CI 1.0-4.1) were associated with anti-HCV positivity. The present study suggest that there is an highly endemic area of HCV infection in Korea and probably this endemicity is associated with a parenteral source of HCV infection other than blood transfusion.
Summary
Nationwide Incidence Estimation of Uterine Cervix Cancer among Korean Women.
Byung Joo Park, Moo Song Lee, Yoon Ok Ahn, Young Min Choi, Yeong Su Ju, Keun Young Yoo, Hun Kim, Ha Seung Yew, Tae Soo Park
Korean J Prev Med. 1996;29(4):843-852.
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AbstractAbstract PDF
To estimate the incidence of uterine cervix cancer among Korean women, we have conducted a study using the claim data on the beneficiaries of Korea Medical Insurance Corporation(KMIC). All medical records of the potential cases with diagnosis of ICD-9 180, 181, 182, 199, 219, 233 in the claims sent by medical care institutions in the whole country to the KMIC from January 1988 to December 1989, were abstracted and Gynecology specialist reviewed the records to identify the new cases of uterine cervix cancer among the potential cases during the corresponding period. Using these data, the incidence of uterine cervix cancer among Korean women was estimated as of July 1, 1988 to June 30, 1989. The crude rate was estimated to be 17.34(95% CI: 16.76~17.92) per 100,000 and the cumulative rates for the ages 0~64 and 0~74 were 1.7% and 2.2%, respectively. The age-adjusted rate for the world population was 19.93 per 100,000 which was higher than those of other Asian countries including China and Japan in 1983~1987. The truncated rate for ages 35~64 was 52.05 per 100,000 which was one of the highest in the world. With increasing age, the incidence rate increased to 78.11 per 100,000 in women aged 55~59 years, then it decreased in the older groups. This finding suggests that detecting rate of uterine cervix cancer may decrease in women aged 60 years or older due to detecting rate of uterine cervix cancer may decrease in women aged 60 years or older due to inadequate medical care seeking behavior. In the geographical area, the SIR of Jeju province was significantly low but it might be due to statistical unstability by small case numbers.
Summary
A Case-Control Study on Risk Factors of Uterine Cervix Cancer in Korea.
Hye Won Koo, Keun Young Yoo, Dong Hyun Kim, Yong Sang Song, No Hyun Park, Soon Beom Kang, Hyo Pyo Lee, Yoon Ok Ahn, Chae Un Lee
Korean J Prev Med. 1996;29(2):159-172.
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AbstractAbstract PDF
A hospital-based case-control study was carried out to investigate the risk factors of uterine cervical cancer in korea. Information on a wide-range of life-styles, which might be related with uterine cervix cancer, has been routinely collected through a dual application of the self-administered questionnaire and the direct interview by a well-trained nurse at the Department of Gynecology, Seoul National University Hospitals since 1992. The number of cervical cancer cases, histologically confirmed at the hospital, were 284. Included were 939 women as controls, who were free of past history of any malignancies. Adjusted odds ratio and 95% confidence limits were based on the unconditional logistic regression model. The multivariate logistic model was constructed under the consideration of biologic characteristics on the natural history of the malignancy. In the multivariate results, the uterine cervical cancer risk was higher in women of shorter height(P(trend) <0.05), less educated spouse (P(trend) < 0.001), multiple marriages(adjusted OR=2,70,95% C.I. 1.64~4.47), ever had a family history (adjusted OR=2.14., 95 % C.I. l.18~3.89), multiparity (P(trend) < 0.001), and early age at first delivery (P(trend) < 0.001). These results strongly suggest that the uterine cervix cancer might be related to the reproductive factors, and probably with sexual behaviour of both women and men in Korea.
Summary
Survey Methods on Cancer Epidemic.
Byung Joo Park, Jong Myon Bae, Yoon Ok Ahn, Keun Young Yoo
Korean J Prev Med. 1994;27(3):411-424.
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AbstractAbstract PDF
The survey methods for confirming the epidemicity and identifying the possible causes of the cancer epidemic can be different from those for infectious diseases. The procedure for confirming whether the outbreak is epidemic or not is quite different. Household survey for identifying cancer cases and residents actually living at the area should be done. Hospital survey for medical record review should be performed to identify all cancer cases among the residents of the outbreak area and confirming the final diagnoses of the cancer cases. Comparing the level of cancer incidence or mortality with other areas can be done by using poison distribution, or calculating SIR (standard Incidence Ratio) from cumulative incidence rates. Case-control study can be conducted to identify the etiologic factors of the cancer epidemic and to establish strategy for preventing further recurrence of the outbreak.
Summary
A Case-Control Study of Primary Liver Cancer and Liver Disease History.
Dong Hyun Kim, Byung Joo Park, Keun Young Yoo, Yoon Ok Ahn, Hyo Suk Lee, Chung Yong Kim, Sang Il Lee, Moo Song Lee, Hyung Sik Ahn, Heon Kim, Tae Soo Park
Korean J Prev Med. 1994;27(2):217-225.
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AbstractAbstract PDF
The relationship between past liver disease history and the risk of primary liver cancer was analyzed in a hospital-based case-control study conducted in Seoul on 165 patients with histologically or serologically confirmed hepatocellular carcinoma and individually age-and sex-matched 165 controls in hospital for ophthalmologic, ontologic, or nasopharyngeal problems. Significant association were observed for liver diseases occurring 5 or more years before liver cancer diagnosis[OR, 4.9;97% confidence interval(CI), 1.6~14.0) and family history of liver disease(OR, 9.0;95% CI, 2.1~38.8). These associations were mot appreciably modified by allowance for major identified potential confounding factors, From these results, it is possible to speculate that liver cell injuries caused by Considering the significant effect of family history of liver diseases on PLCA risk after adjusting past liver disease history, there might be genetic susceptibility in the carcinogenic mechanism of liver cancer. Further investigations are needed to clarify the effect of family history of liver disease on PLCA risk.
Summary
Comparison of Control Methods for Estimation Bias in Unmatched Analysis of Matched Data.
Keun Young Yoo
Korean J Prev Med. 1990;23(3):247-254.
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AbstractAbstract PDF
No abstract available.
Summary
Seroepidemiology of Hepatitis B virus Infection in Healthy Korean Adults in Seoul.
Keun Young Yoo, Byung Joo Park, Yoon Ok Ahn
Korean J Prev Med. 1988;21(1):89-98.
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AbstractAbstract PDF
While there have been not a few reports on the seroepidemiological characteristics of hepatitis B virus (HBV) infection in Korea, most of them, however, have had several limitations; operational definition of HBV infection, validity of detection methods of HBV serologic markers, size of the study population, and confirmation of the vaccination history against HBV, etc. In order to avoid such limitations, authors randomly selected 1,495 healthy adults among the 217,511 insured (target population) of Korean Medical Insurance Corporation, living in seoul, and tested HBV(HBsAg, anti-HBs and anti-HBc) of all the subjects were tested, 392(26.2%) of interview failure cases 742 nonvaccinee were excluded from the actual population. Finally, the serologic markers tested of 742 nonvaccinee (study population) only were analyzed for the seroepidemiologic observation of the natural infection of HBV. The seroepidemiological characteristics of HBV infection in Korea were as follows ; 1 Point prevalence of HBs antigenemia was 11.7(9.1-14.3)% in male, which was slightly higher than that of female, 9.5(3.7-15.3)%. This level was one of the highest among those of Asian-Pacific countries. Decreasing tendency of HBsAg prevalence after the age of 50 was observed, which seems to be due to selective attrition of HBV chronic carriers among the healthy adults and/or to the limited-lasting duration of the HBs antigenemia, in part. 2. Point prevalence of anti-HBc(78.8% in male, 50.9% in female) was higher than that of anti-HBs(65.2% in male, 46.6% in female), respectively. And both of them were higher in male than in female. Increasing tendency of the prevalence of both antibodies was observed by age, which seems to be largely due to recurrent infection in adults and to some cumulative effect, in part, of their relatively longer-lasting duration. 3. The level of HBV infection defined by positive for at least one of the 3 serologic markers of HBV by RIA method was 84.7(81.8-87.6)% in male and 61.2(51.9-70.5)% in female, which was also one of the highest among those of Asian-Pacific countries. The proportion of susceptible population to HBV infection among healthy adults was 15.3% in male and 38.8% in female. 4. The relative frequency of current or past infection and chronic carrier among HBV infected person was estimated. The currently or past infected was estimated 75.7% in male and 71.8% in female, and chronic carrier state, 13.8% in male and 14.1% in female. The analysis of the geometric mean of the antibody titer in anti-HBs positive sera indicated also to be compatible with the above findings, suggesting that active, even though inapparent, infection of HBV occur so frequently among healthy adults in Korea.
Summary
Effect of Oxygen on the Antidotal Action of Thiosulfate in Cyanide Poisoning.
Keun Young Yoo
Korean J Prev Med. 1982;15(1):161-166.
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Cyanide poisoning is expected to be antagonized by the administration of oxygen, when it is administered in combination with the conventional cyanide antidote, sodium,thiosulfate. However, the antidotal efficacy and its exact mechanism of oxygen in cyanide poisoning is still a controversial one. To test the effect of oxygen on the antidotal action of thiosulfate ,in cyanide poisoning, author designed this study on the dose-mortality patterns for potassium cyanide in mice. Potency ratios derived from LDso values were compared in groups of mice treated with sodium thiosulfate alone and sodium thiosulfate with oxygen. These results indicated that oxygen enhances the anti-dotal effect of sodium thiosulfate, effectively. This fact demonstrates that oxygen is of importance in the treatment of cyanide poisoning.
Summary

JPMPH : Journal of Preventive Medicine and Public Health