Abstract
OBJECTIVES
Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort. METHODS: Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity. RESULTS: The RRs of serum glucose for liver caner were 1.20 (95% CI=0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI=1.24-6.18) for the >126 mg/dL serum glucose category (both compared to the <100 mg/dL category). In a subgroup analysis, the RR of serum glucose among those who were both HBsAg seronegative and non-drinkers was 4.46 (95% CI=1.09-18.28) for those with glucose levels >100 mg/dL. CONCLUSIONS: The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer.
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Citations to this article as recorded by
- Association Between Prediabetes and Risk, Mortality of Hepatocellular Carcinoma: A Meta-Analysis
Xin Ding, Li Deng, Chuan Cen, Yuyu Yang
Endocrine Research.2024; 49(4): 186. CrossRef - Associations between serum glucose, insulin, insulin resistance and the risk of incident primary liver cancer or chronic liver disease mortality: a nested case–control study
Jian Yin, Neal D. Freedman, Yiwei Liu, Sanford M. Dawsey, Huan Yang, Philip R. Taylor, Liangyu Yin, Bin Liu, Jianfeng Cui, Jinhu Fan, Wen Chen, Youlin Qiao, Christian C. Abnet
British Journal of Cancer.2023; 128(2): 275. CrossRef - Environmental contributions to gastrointestinal and liver cancer in the Asia–Pacific region
Kwang‐Pil Ko, Aesun Shin, Sooyoung Cho, Sue K Park, Keun‐Young Yoo
Journal of Gastroenterology and Hepatology.2018; 33(1): 111. CrossRef - Recognition criteria for occupational cancers in relation to hepatitis B virus and hepatitis C virus in Korea
Hogil Kim, Yun Kyung Chung, Inah Kim
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef - The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study
Xiaoshuang Feng, Gang Wang, Ni Li, Zhangyan Lyu, Shuohua Chen, Luopei Wei, Yuheng Chen, Shuanghua Xie, Wenjing Yang, Jian Yin, Hong Cui, Hongda Chen, Jiansong Ren, Jufang Shi, Shouling Wu, Min Dai, Jie He
British Journal of Cancer.2017; 117(9): 1405. CrossRef - Fasting glucose and risk of colorectal cancer in the Korean Multi-center Cancer Cohort
Hyeree Park, Sooyoung Cho, Hyeongtaek Woo, Sue K. Park, Hai-Rim Shin, Soung-Hoon Chang, Keun-Young Yoo, Aesun Shin, Cheng Hu
PLOS ONE.2017; 12(11): e0188465. CrossRef - Blood glucose concentration and risk of liver cancer: systematic review and meta-analysis of prospective studies
Hedong Han, Tianyi Zhang, Zhichao Jin, Honglei Guo, Xin Wei, Yuzhou Liu, Qi Chen, Jia He
Oncotarget.2017; 8(30): 50164. CrossRef - European Code against Cancer 4th Edition: Alcohol drinking and cancer
Chiara Scoccianti, Michele Cecchini, Annie S. Anderson, Franco Berrino, Marie-Christine Boutron-Ruault, Carolina Espina, Timothy J. Key, Michael Leitzmann, Teresa Norat, Hilary Powers, Martin Wiseman, Isabelle Romieu
Cancer Epidemiology.2016; 45: 181. CrossRef - European Code against Cancer 4th Edition: Alcohol drinking and cancer
Chiara Scoccianti, Michele Cecchini, Annie S. Anderson, Franco Berrino, Marie-Christine Boutron-Ruault, Carolina Espina, Timothy J. Key, Michael Leitzmann, Teresa Norat, Hilary Powers, Martin Wiseman, Isabelle Romieu
Cancer Epidemiology.2015; 39: S67. CrossRef - Cohort Profile: Community-based prospective cohort from the National Cancer Center, Korea
Jin-Kyoung Oh, Min Kyung Lim, E Hwa Yun, Min-Ho Choi, Sung-Tae Hong, Soung-Hoon Chang, Sue Kyung Park, Sung-Il Cho, Dong-Hyun Kim, Keun-Young Yoo, Hai-Rim Shin
International Journal of Epidemiology.2015; : dyv302. CrossRef - Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea
Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass
BMC Cancer.2014;[Epub] CrossRef - Prediabetes and the risk of cancer: a meta-analysis
Yi Huang, Xiaoyan Cai, Miaozhen Qiu, Peisong Chen, Hongfeng Tang, Yunzhao Hu, Yuli Huang
Diabetologia.2014; 57(11): 2261. CrossRef - Serum glucose and risk of cancer: a meta-analysis
Danielle J Crawley, Lars Holmberg, Jennifer C Melvin, Massimo Loda, Simon Chowdhury, Sarah M Rudman, Mieke Van Hemelrijck
BMC Cancer.2014;[Epub] CrossRef - Recent Evidence on Alcohol and Cancer Epidemiology
Chiara Scoccianti, Kurt Straif, Isabelle Romieu
Future Oncology.2013; 9(9): 1315. CrossRef - Multiplicative synergistic risk of hepatocellular carcinoma development among hepatitis B and C co-infected subjects in HBV endemic area: a community-based cohort study
Jin-Kyoung Oh, Hai-Rim Shin, Min Kyung Lim, Heeyoun Cho, Dong-Il Kim, Youngmee Jee, Haesun Yun, Keun-Young Yoo
BMC Cancer.2012;[Epub] CrossRef - Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma: Systematic review and meta‐analysis
Lisa Y. Cho, Jae Jeong Yang, Kwang‐Pil Ko, Boyoung Park, Aesun Shin, Min Kyung Lim, Jin‐Kyoung Oh, Sohee Park, Yoon Jun Kim, Hai‐Rim Shin, Keun‐Young Yoo, Sue K. Park
International Journal of Cancer.2011; 128(1): 176. CrossRef