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Korean Journal of Preventive Medicine 1994;27(2): 217-225.
A Case-Control Study of Primary Liver Cancer and Liver Disease History.
Dong Hyun Kim, Byung Joo Park, Keun Young Yoo, Yoon Ok Ahn, Hyo Suk Lee, Chung Yong Kim, Sang Il Lee, Moo Song Lee, Hyung Sik Ahn, Heon Kim, Tae Soo Park
1Department of Preventive Medicine, Seoul National University College of Medicine, Korea.
2Department of Preventive Medicine, Ulsan University College of Medicine, Korea.
3Department of Preventive Medicine, Chung-Buk National University College of Medicine, Korea.
4Korea Medical Insurance Corporation, Korea.
The relationship between past liver disease history and the risk of primary liver cancer was analyzed in a hospital-based case-control study conducted in Seoul on 165 patients with histologically or serologically confirmed hepatocellular carcinoma and individually age-and sex-matched 165 controls in hospital for ophthalmologic, ontologic, or nasopharyngeal problems. Significant association were observed for liver diseases occurring 5 or more years before liver cancer diagnosis[OR, 4.9;97% confidence interval(CI), 1.6~14.0) and family history of liver disease(OR, 9.0;95% CI, 2.1~38.8). These associations were mot appreciably modified by allowance for major identified potential confounding factors, From these results, it is possible to speculate that liver cell injuries caused by Considering the significant effect of family history of liver diseases on PLCA risk after adjusting past liver disease history, there might be genetic susceptibility in the carcinogenic mechanism of liver cancer. Further investigations are needed to clarify the effect of family history of liver disease on PLCA risk.
Key words: liver cancer; liver disease history; case-control study; family history of liver disease
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