Table 1.Distribution of selected variables between non-small cell lung cancer patient and control subjects
Variables |
n (%)
|
p- value |
Patients n = 406 |
Controls n = 428 |
Age (y) (mean±SD) |
67.3 ± 10.2 |
63.2 ± 10.2 |
0.38 |
Age (y) |
|
|
|
≥ 60 |
317 (78.1) |
278 (64.9) |
0.07 |
< 60 |
89 (21.9) |
150 (35.1) |
|
Gender |
|
|
|
Male |
323 (79.6) |
336 (78.5) |
0.71 |
Female |
83 (20.4) |
92 (21.5) |
|
Smoking status |
|
|
|
Smokers |
346 (85.2) |
284 (66.4) |
<0.01 |
Non-smokers |
60 (14.8) |
144 (33.6) |
|
Family history of cancer |
|
|
|
No |
323 (79.6) |
313 (73.1) |
0.08 |
Yes |
83 (20.4) |
115 (26.9) |
|
Table 2.miR-196a allelic and genotype frequencies between non-small cell lung cancer patient and control subjects and their association with non-small cell lung cancer risks
Variables |
n (%)
|
p- value |
Genotypes |
Patients (n=406) |
Controls (n=428) |
OR (95% CI) |
Total1
|
T allele |
416 (51.2) |
466 (54.4) |
1.00 |
<0.36 |
|
C allele |
396 (48.8) |
390 (45.6) |
1.10 (0.90 - 1.35) |
|
|
TT |
96 (23.7) |
134 (31.3) |
1.00 |
<0.05 |
|
TC |
224 (55.2) |
198 (46.3) |
1.54 (1.10 - 2.17) |
|
|
CC |
86 (21.1) |
96 (22.4) |
1.17 (0.77 - 1.76) |
|
|
TC/CC |
310 (76.4) |
294 (68.7) |
1.42 (1.03 - 1.96) |
0.05 |
|
CC vs TC+TT |
86 (21.2) |
96 (22.4) |
0.08 (0.62 - 1.25) |
0.48 |
Age (y) |
|
|
|
|
|
≥60 |
T allele |
336 (51.7) |
311 (53.8) |
1.00 |
0.46 |
|
C allele |
314 (48.3) |
267 (46.2) |
1.09 (0.87 - 1.36) |
|
|
TT |
81 (24.9) |
93 (32.2) |
1.00 |
<0.05 |
|
TC |
174 (53.5) |
125 (43.3) |
1.60 (1.10 - 2.33) |
|
|
CC |
70 (21.5) |
71 (24.6) |
1.13 (0.73 - 1.77) |
|
|
TC/CC |
224 (75.1) |
196 (67.8) |
1.43 (1.01 - 2.03) |
<0.05 |
|
CC vs TC+TT |
70 (21.5) |
71 (24.6) |
0.84 (0.58 - 1.23) |
0.37 |
<60 |
T allele |
80 (49.4) |
155 (55.8) |
1.00 |
0.2 |
|
C allele |
82 (50.6) |
123 (44.2) |
1.29 (0.88 - 1.90) |
|
|
TT |
15 (18.5) |
41 (29.5) |
1.00 |
0.2 |
|
TC |
50 (61.7) |
73 (52.5) |
1.87 (0.94 - 3.74) |
|
|
CC |
16 (19.8) |
25 (18.0) |
1.75 (0.74 - 4.14) |
|
|
TC/CC |
66 (81.5) |
98 (70.5) |
1.84 (0.94 - 3.59) |
0.07 |
|
CC vs TC+TT |
16 (19.8) |
25 (18.0) |
1.12 (0.56 - 2.25) |
0.75 |
Sex |
|
|
|
|
|
Male |
T allele |
330 (51.1) |
368 (54.8) |
1.00 |
0.18 |
|
C allele |
316 (48.9) |
304 (45.2) |
1.16 (0.93 - 1.44) |
|
|
TT |
77 (23.9) |
109 (32.4) |
1.00 |
0.02 |
|
TC |
176 (54.5) |
150 (44.6) |
1.66 (1.15 - 2.39) |
|
|
CC |
70 (21.7) |
77 (22.9) |
1.29 (0.83 - 1.99) |
|
|
TC/CC |
246 (76.2) |
227 (67.6) |
1.53 (1.09 - 2.16) |
<0.01 |
|
CC vs TC+TT |
70 (21.7) |
77 (22.9) |
0.93 (0.64 - 1.34) |
0.70 |
Female |
T allele |
86 (51.8) |
98 (53.3) |
1.00 |
0.79 |
|
C allele |
80 (48.2) |
86 (46.7) |
1.06 (0.70 - 1.61) |
|
|
TT |
19 (22.9) |
25 (27.2) |
1.00 |
0.73 |
|
TC |
48 (57.8) |
48 (52.2) |
1.32 (0.64 - 2.70) |
|
|
CC |
16 (19.3) |
19 (20.7) |
1.11 (0.45 - 2.71) |
|
|
TC/CC |
64 (77.1) |
67 (72.8) |
1.26 (0.63 - 2.50) |
0.51 |
|
CC vs TC+TT |
16 (19.3) |
19 (20.7) |
0.92 (0.44 - 1.93) |
0.82 |
Smoking status |
|
|
|
|
|
Smokers |
T allele |
351 (50.7) |
307 (54.1) |
1.00 |
0.24 |
|
C allele |
341 (49.3) |
261 (46.0) |
1.14 (0.91 - 1.43) |
|
|
TT |
80 (23.1) |
88 (31.0) |
1.00 |
<0.05 |
|
TC |
191 (55.2) |
131 (46.1) |
1.60 (1.10 - 2.33) |
|
|
CC |
75 (21.7) |
65 (22.9) |
1.27 (0.81 - 1.99) |
|
|
TC/CC |
266 (76.9) |
196 (69.0) |
1.49 (1.05 - 2.13) |
<0.05 |
|
CC vs TC+TT |
75 (21.7) |
65 (22.9) |
0.93 (0.64 - 1.36) |
0.72 |
Non-smokers |
T allele |
65 (54.2) |
159 (55.2) |
1.00 |
0.85 |
|
C allele |
55 (45.8) |
129 (44.8) |
1.04 (0.68 - 1.60) |
|
|
TT |
16 (26.7) |
46 (31.9) |
1.00 |
0.55 |
|
TC |
33 (55.0) |
67 (46.5) |
1.42 (0.70 - 2.87) |
|
|
CC |
11 (18.3) |
31 (21.5) |
1.02 (0.42 - 2.49) |
|
|
TC/CC |
44 (73.3) |
98 (68.6) |
1.29 (0.66 - 2.52) |
0.46 |
|
CC vs TC+TT |
11 (18.3) |
31 (21.5) |
0.82 (0.38 - 1.76) |
0.61 |
Family history of cancer |
|
|
|
|
|
No |
T allele |
327 (50.6) |
344 (55.0) |
1.00 |
0.12 |
|
C allele |
319 (49.4) |
282 (45.0) |
1.19 (0.95 - 1.48) |
|
|
TT |
75 (23.2) |
100 (32.0) |
1.00 |
0.03 |
|
TC |
177 (54.8) |
144 (46.0) |
1.64 (1.13 - 2.38) |
|
|
CC |
71 (22.0) |
69 (22.0) |
1.37 (0.88 - 2.14) |
|
|
TC/CC |
248 (76.8) |
213 (68.1) |
1.55 (1.09 - 2.21) |
<0.01 |
|
CC vs TC+TT |
71 (220.) |
69 (22.0) |
1.00 (0.68 - 1.45) |
0.98 |
Yes |
T allele |
89 (53.6) |
122 (53.0) |
1.00 |
0.91 |
|
C allele |
77 (46.4) |
108 (47.0) |
0.98 (0.66 - 1.46) |
|
|
TT |
21 (25.3) |
34 (29.6) |
1.00 |
0.4 |
|
TC |
47 (56.6) |
54 (47.0) |
1.41 (0.72 - 2.75) |
|
|
CC |
15 (18.1) |
27 (23.5) |
0.90 (0.39 - 2.07) |
|
|
TC/CC |
61 (74.7) |
81 (70.4) |
1.24 (0.66 - 2.34) |
0.51 |
|
CC vs TC+TT |
15 (180.) |
22 (23.5) |
0.72 (0.35 - 1.46) |
0.36 |