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- A Survival Analysis of Gastric or Colorectal Cancer Patients Treated With Surgery: Comparison of Capital and a Non-capital City
- Nam-Soo Hong, Kyeong Soo Lee, Sin Kam, Gyu Seog Choi, Oh Kyoung Kwon, Dong Hee Ryu, Sang Won Kim
- J Prev Med Public Health. 2017;50(5):283-293. Published online July 3, 2017
- DOI: https://doi.org/10.3961/jpmph.17.043
- 6,161 View
- 223 Download
- 3 Crossref
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Supplementary Material - Objectives
The objective of the present study was to compare prognosis of patients with gastric or colorectal cancer according to places where they received surgeries. Methods: The cancer patients underwent surgeries in sampled hospitals located in Daegu were matched 1:1 to the patients who visited sampled hospitals in Seoul using propensity score method. After the occurrences of death were examined, Kaplan-Meier method was used for survival analysis and the log-rank test was performed to compare the survival curves. Results: A total of six out of 291 gastric cancer patients who had surgeries in Daegu died (2.1%) and ten deaths (3.4%) occurred from patients went Seoul hospitals. Out of 84 gastric cancer patients who had chemotherapy after surgeries in Daegu, 13 (15.5%) patients died while 18 (21.4%) deaths occurred among patients underwent surgeries in Seoul. Six deaths (6.9%) out of 87 colorectal cancer patients who had surgeries in Daegu were reported. Five patients (5.7%) died among the patients underwent surgeries in Seoul. Among the colorectal cancer patients with chemotherapy after surgeries, 13 patients (12.4%) who visited hospitals in Daegu and 14 (13.3%) patients who used medical centers in Seoul died. There were no significant differences according to places where patients used medical services. Conclusions: The result of this study is expected to be used as basic data for policy making to resolve centralization problem of cancer patients and to help patients to make rational choices in selection of medical centers. -
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Citations to this article as recorded by
- Domestic medical travel from non-Seoul regions to Seoul for initial breast cancer treatment: a nationwide cohort study
Jae Ho Jeong, Jinhong Jung, Hee Jeong Kim, Jong Won Lee, Beom-Seok Ko, Byung Ho Son, Kyung Hae Jung, Il Yong Chung
Annals of Surgical Treatment and Research.2023; 104(2): 71. CrossRef - MCR1 and KPC2 Co-producing Klebsiella pneumoniae Bacteremia: First Case in Korea
Ji Young Park, Sang Taek Heo, Ki Tae Kwon, Do Young Song, Kwang Jun Lee, Ji Ae Choi
Infection & Chemotherapy.2019; 51(4): 399. CrossRef - The Effect of Residential Area and Hospital Bed Size on the Use of Hospital in Other Regions for Cancer Inpatients
Sung-Soo Kim
Journal of Health Informatics and Statistics.2018; 43(1): 18. CrossRef
- Associations of Serum Ferritin and Transferrin % Saturation With All-cause, Cancer, and Cardiovascular Disease Mortality: Third National Health and Nutrition Examination Survey Follow-up Study
- Ki-Su Kim, Hye-Gyeong Son, Nam-Soo Hong, Duk-Hee Lee
- J Prev Med Public Health. 2012;45(3):196-203. Published online May 31, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.3.196
- 12,250 View
- 93 Download
- 31 Crossref
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Abstract
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Objectives Even though experimental studies have suggested that iron can be involved in generating oxidative stress, epidemiologic studies on the association of markers of body iron stores with cardiovascular disease or cancer remain controversial. This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality.
Methods The study subjects were men aged 50 years or older and postmenopausal women of the Third National Health and Nutrition Examination Survey 1988-1994. Participants were followed-up for mortality through December 31, 2006.
Results Serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality for either men or postmenopausal women. However, all-cause, cancer, and cardiovascular mortality were inversely associated with %TS in men. Compared with men in the lowest quintile, adjusted hazard ratios for all-cause, cancer, and cardiovascular mortality were 0.85, 0.86, 0.76, and 0.74 (
p for trend < 0.01), 0.82, 0.73, 0.75, and 0.63 (p for trend < 0.01), and 0.86, 0.81, 0.72, and 0.76 (p for trend < 0.01), respectively. For postmenopausal women, inverse associations were also observed for all-cause and cardiovascular mortality, but cancer mortality showed the significantly lower mortality only in the 2nd quintile of %TS compared with that of the 1st quintile.Conclusions Unlike speculation on the role of iron from experimental studies, %TS was inversely associated with all-cause, cancer and cardiovascular mortality in men and postmenopausal women. On the other hand, serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality.
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Citations
Citations to this article as recorded by- Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population ― NIPPON DATA90 ―
Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura
Circulation Journal.2024; 88(5): 742. CrossRef - Iron Metabolic Biomarkers and the Mortality Risk in the General Population: A Nationwide Population-Based Cohort Study
Yuanyuan Sun, Wenyao Peng, Siqi Lin, Jingjing Cui, Jiapeng Lu
Journal of the Endocrine Society.2024;[Epub] CrossRef - Advancing Patient Blood Management: Evaluation of Ferric Derisomaltose in a Tertiary Hospital
Mohd Muhaimin Kambali, Engku Hamidah Engku Muhammad Azmi
Global Journal of Transfusion Medicine.2024; 9(1): 65. CrossRef - Iron metabolism and atherosclerosis
Qian Guo, Christopher Qian, Zhong-Ming Qian
Trends in Endocrinology & Metabolism.2023; 34(7): 404. CrossRef - Transferrin predicts trimethylamine-N-oxide levels and is a potential biomarker of cardiovascular disease
Lamuel D. Bean, Jeffrey J. Wing, Randall E. Harris, Suzanne M. Smart, Subha V. Raman, M. Wesley Milks
BMC Cardiovascular Disorders.2022;[Epub] CrossRef - Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models
Leonardo dos Santos, Sabrina Rodrigues Bertoli, Renata Andrade Ávila, Vinícius Bermond Marques
Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(9): 130172. CrossRef - Association of ferritin and transferrin saturation with all-cause mortality, and the effect of concurrent inflammation: a danish cohort study
Nikki H. Mitchell, Henrik L. Jørgensen, Fie J. Vojdeman, Henriette P. Sennels, Christen L. Andersen, Margit Kriegbaum, Mia K. Grand, Christine W. Bang, Bent S. Lind
Scandinavian Journal of Clinical and Laboratory Investigation.2022; 82(7-8): 525. CrossRef - Iron Restriction Alleviates Atherosclerosis in ApoE KO Mice: An iTRAQ Proteomic Analysis
Gang Luo, Lu Xiang, Lin Xiao
International Journal of Molecular Sciences.2022; 23(24): 15915. CrossRef - Nano‐sensing and nano‐therapy targeting central players in iron homeostasis
Linyuan Wu, Yan Li, Ning Gu
WIREs Nanomedicine and Nanobiotechnology.2021;[Epub] CrossRef - Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism
Lin Xiao, Gang Luo, Hongxia Li, Ping Yao, Yuhan Tang
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(10): 159004. CrossRef - The role of hepcidin and iron homeostasis in atherosclerosis
Florian Wunderer, Lisa Traeger, Haakon H. Sigurslid, Patrick Meybohm, Donald B. Bloch, Rajeev Malhotra
Pharmacological Research.2020; 153: 104664. CrossRef - Iron loading, alcohol and mortality: A prospective study
Rudolph Schutte, Hugo Huisman, Catharina M.C. Mels, Shani Botha, Ruan Kruger, Wayne Smith, Iolanthé M. Kruger, Michelle Hawkins, Lee Smith, Yolandi Breet, Aletta E. Schutte
Clinical Nutrition.2019; 38(3): 1262. CrossRef - Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
Marko Lucijanic, Zeljko Prka, Vlatko Pejsa, Tajana Stoos-Veic, Jelena Lucijanic, Rajko Kusec
Leukemia Research.2018; 66: 89. CrossRef - Iron status in relation to cancer risk and mortality: Findings from a population‐based prospective study
Daniel A. Quintana Pacheco, Disorn Sookthai, Mirja E. Graf, Ruth Schübel, Theron Johnson, Verena A. Katzke, Rudolf Kaaks, Tilman Kühn
International Journal of Cancer.2018; 143(3): 561. CrossRef - Targeting iron metabolism in drug discovery and delivery
Bart J. Crielaard, Twan Lammers, Stefano Rivella
Nature Reviews Drug Discovery.2017; 16(6): 400. CrossRef - The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing
Nikolaos P. E. Kadoglou, Jane P. Biddulph, Snorri B. Rafnsson, Marialena Trivella, Petros Nihoyannopoulos, Panayotes Demakakos, Abelardo I Aguilera
PLOS ONE.2017; 12(6): e0178994. CrossRef - Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?
Thomas D. Coates, Susan Carson, John C. Wood, Vasilios Berdoukas
Annals of the New York Academy of Sciences.2016; 1368(1): 95. CrossRef - Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status
Stephen T. McSorley, Iain Jones, Donald C. McMillan, Dinesh Talwar
Translational Research.2016; 176: 119. CrossRef - High serum levels of ferritin at baseline are not associated with an increased risk of mortality in oldest old community‐dwelling adults: The OCTABAIX study
Francesc Formiga, Assumpta Ferrer, Gloria Padros, Carme Gimenez‐Argente, Rosa López Pisa, Xavier Corbella
Geriatrics & Gerontology International.2016; 16(2): 284. CrossRef - Iron toxicity and its possible association with treatment of Cancer: Lessons from hemoglobinopathies and rare, transfusion-dependent anemias
Mammen Puliyel, Arch G Mainous, Vasilios Berdoukas, Thomas D Coates
Free Radical Biology and Medicine.2015; 79: 343. CrossRef - Parameters influencing in-hospital mortality in patients hospitalized in intensive cardiac care unit: is there an influence of anemia and iron deficiency?
Ewa Uscinska, Bozena Sobkowicz, Robert Sawicki, Izabela Kiluk, Malgorzata Baranicz, Tomasz Stepek, Milena Dabrowska, Maciej Szmitkowski, Wlodzimierz J. Musial, Agnieszka M. Tycinska
Internal and Emergency Medicine.2015; 10(3): 337. CrossRef - Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey
R. J. Park, J. D. Moon
Diabetic Medicine.2015; 32(5): 673. CrossRef - Helicobacter pylori Seropositivity’s Association with Markers of Iron, 1-Carbon Metabolism, and Antioxidant Status among US Adults: A Structural Equations Modeling Approach
May A. Beydoun, Greg A. Dore, Jose A. Canas, Hind A. Beydoun, Alan B. Zonderman, Bradford D. Gessner
PLOS ONE.2015; 10(3): e0121390. CrossRef - Transferrin Saturation Ratio: A Method to Estimate Risk of Cardiovascular Mortality in the General Population?
Austin G Stack, Waleed Mohamed, Mohamed Elsayed
Biomarkers in Medicine.2014; 8(7): 913. CrossRef - Prediabetes, elevated iron and all-cause mortality: a cohort study
Arch G Mainous, Rebecca J Tanner, Thomas D Coates, Richard Baker
BMJ Open.2014; 4(12): e006491. CrossRef - Dietary Iron Intake and Body Iron Stores Are Associated with Risk of Coronary Heart Disease in a Meta-Analysis of Prospective Cohort Studies
Jacob Hunnicutt, Ka He, Pengcheng Xun
The Journal of Nutrition.2014; 144(3): 359. CrossRef - Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial
Carlos Muñoz-Bravo, Mario Gutiérrez-Bedmar, Jorge Gómez-Aracena, Antonio García-Rodríguez, Joaquín Navajas
Nutrients.2013; 5(7): 2384. CrossRef - Non-Hfe Iron Overload: Is Phlebotomy the Answer?
Simon Hazeldine, Debbie Trinder, John K. Olynyk
Current Hepatitis Reports.2013; 12(1): 20. CrossRef - Iron Deficiency and Cardiovascular Disease: An Updated Review of the Evidence
Emanuela Lapice, Maria Masulli, Olga Vaccaro
Current Atherosclerosis Reports.2013;[Epub] CrossRef - Iron Status and Survival in Diabetic Patients With Coronary Artery Disease
Beata Ponikowska, Tomasz Suchocki, Bartłomiej Paleczny, Martyna Olesinska, Slawomir Powierza, Ludmila Borodulin-Nadzieja, Krzysztof Reczuch, Stephan von Haehling, Wolfram Doehner, Stefan D. Anker, John G.F. Cleland, Ewa A. Jankowska
Diabetes Care.2013; 36(12): 4147. CrossRef - Presence in the Pre-Surgical Fine-Needle Aspiration of Potential Thyroid Biomarkers Previously Identified in the Post-Surgical One
Federica Ciregia, Laura Giusti, Angelo Molinaro, Filippo Niccolai, Patrizia Agretti, Teresa Rago, Giancarlo Di Coscio, Paolo Vitti, Fulvio Basolo, Pietro Iacconi, Massimo Tonacchera, Antonio Lucacchini, Alfredo Fusco
PLoS ONE.2013; 8(9): e72911. CrossRef
- Interaction Between Persistent Organic Pollutants and C-reactive Protein in Estimating Insulin Resistance Among Non-diabetic Adults
- Ki-Su Kim, Nam-Soo Hong, David R Jacobs, Duk-Hee Lee
- J Prev Med Public Health. 2012;45(2):62-69. Published online March 31, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.2.62
- 10,447 View
- 82 Download
- 12 Crossref
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Abstract
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Objectives Chronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes. Based on our recent findings on persistent organic pollutants (POPs) including the lack of an association between obesity and either insulin resistance or diabetes prevalence among subjects with very low concentrations of POPs, we hypothesized that POP concentrations may be associated with inflammation and modify the associations between inflammation and insulin resistance in non-diabetic subjects.
Methods Cross-sectional associations among serum POPs, C-reactive protein (CRP), and homeostasis model assessment of insulin resistance (HOMA-IR) were investigated in 748 non-diabetic participants aged ≥20 years. Nineteen types of POPs in 5 subclasses were selected because the POPs were detectable in ≥60% of the participants.
Results Among the five subclasses of POPs, only organochlorine (OC) pesticides showed positive associations with CRP concentrations, while polychlorinated biphenyls (PCBs) showed inverse associations with CRP concentrations. There were statistically significant interactions between CRP and OC pesticides and between CRP and PCBs, in estimating HOMA-IR (P for interaction <0.01 and <0.01, respectively). CRP was not associated with HOMA-IR among subjects with low concentrations of OC pesticides or PCBs, while CRP was strongly associated with HOMA-IR among subjects with high concentrations of these POPs.
Conclusions In the current study, OC pesticides were associated with increased levels of CRP, a marker of inflammation, and both OC pesticides and PCBs may also modify the associations between CRP and insulin resistance.
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Summary
Citations
Citations to this article as recorded by- Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review
Quentin A. Serrano, Sébastien Le Garf, Vincent Martin, Serge S. Colson, Nicolas Chevalier
International Journal of Molecular Sciences.2024; 25(2): 883. CrossRef - The associations between endocrine disrupting chemicals and markers of inflammation and immune responses: A systematic review and meta-analysis
Zhiqin Liu, Yao Lu, Kunxia Zhong, Chenchen Wang, Xi Xu
Ecotoxicology and Environmental Safety.2022; 234: 113382. CrossRef - Endocrine Disruptors and the Induction of Insulin Resistance
Rafael Vanni, Renata Maksoud Bussuan, Renato Luiz Rombaldi, Alberto K. Arbex
Current Diabetes Reviews.2021;[Epub] CrossRef - Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies
F.M. Peinado, F. Artacho-Cordón, R. Barrios-Rodríguez, J.P. Arrebola
Environmental Research.2020; 186: 109561. CrossRef - Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals
S. Dusanov, J. Ruzzin, H. Kiviranta, T.O. Klemsdal, L. Retterstøl, P. Rantakokko, R. Airaksinen, S. Djurovic, S. Tonstad
Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(7): 735. CrossRef - Health and environmental effects of persistent organic pollutants
Omar M.L. Alharbi, Al Arsh Basheer, Rafat A. Khattab, Imran Ali
Journal of Molecular Liquids.2018; 263: 442. CrossRef - The influence of persistent organic pollutants in the traditional Inuit diet on markers of inflammation
L. K. Schæbel, E. C. Bonefeld-Jørgensen, H. Vestergaard, S. Andersen, Jaymie Meliker
PLOS ONE.2017; 12(5): e0177781. CrossRef - Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study
Martha P. Montgomery, Eric Postel, David M. Umbach, Marie Richards, Mary Watson, Aaron Blair, Honglei Chen, Dale P. Sandler, Silke Schmidt, Freya Kamel
Environmental Health Perspectives.2017;[Epub] CrossRef - Hemostatic, inflammatory, and oxidative markers in pesticide user farmers
Fatima Zohra Madani, Merzouk Hafida, Sid Ahmed Merzouk, Bouchra Loukidi, Katia Taouli, Michel Narce
Biomarkers.2016; 21(2): 138. CrossRef - Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers
Mary Turyk, Giamila Fantuzzi, Victoria Persky, Sally Freels, Anissa Lambertino, Maria Pini, Davina H. Rhodes, Henry A. Anderson
Environmental Research.2015; 140: 335. CrossRef - Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland
L. K. Schæbel, E. C. Bonefeld-Jørgensen, P. Laurberg, H. Vestergaard, S. Andersen
Journal of Nutritional Science.2015;[Epub] CrossRef - Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort
Jitender Kumar, P. Monica Lind, Samira Salihovic, Bert van Bavel, Erik Ingelsson, Lars Lind
Environmental Health Perspectives.2014; 122(9): 977. CrossRef
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