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Eunha Oh 3 Articles
Increased DNA Damage of Lymphocytes in Korean Male Smokers.
Joohyun Lee, Eunil Lee, Eunha Oh, Juneyoung Lee, Donggeun Sul, Jooja Kim
J Prev Med Public Health. 2007;40(1):16-22.
DOI: https://doi.org/10.3961/jpmph.2007.40.1.16
  • 4,169 View
  • 32 Download
  • 2 Crossref
AbstractAbstract PDF
OBJECTIVE
The purpose of this study was to evaluate the levels of DNA damage in human lymphocytes caused by smoking and other lifestyle factors. METHODS: The study population consisted of 173 normal healthy male adults from 21 to 59 years old. The demographic and lifestyle variables were obtained from administered questionnaires. The level of lymphocytic DNA damage in the peripheral blood was evaluated by the Comet assay. Statistical analyses were done by general linear model analysis and Dunnett's multiple comparison. RESULTS: The difference in DNA damage between smokers and non-smokers was statistically significant. The means for the Tail%DNA were found to be 10.48 in the current smokers and 9.60 in the non-smokers (p<0.05). The tail moment means were 1.58 and 1.45 (p<0.05) for the current smokers and non-smokers, respectively. The number of cigarettes smoked per day did not result in a significant difference in the level of DNA damage among the smokers. Other lifestyle factors such as age, and drinking and exercise habits were not related to DNA damage. CONCLUSIONS: The DNA damage in the lymphocytes of smokers was found to be significantly higher than that for non-smokers. However, the number of cigarettes smoked per day was not related to DNA damage. Further study is needed to evaluate the relationship between the amount of smoking and level of damage to DNA. In addition, the status of DNA repair activities should be assessed.
Summary

Citations

Citations to this article as recorded by  
  • DNA strand breaks in peripheral blood leucocytes of Polish blood donors
    Małgorzata M Dobrzyńska, Krzysztof A Pachocki, Katarzyna Owczarska
    Mutagenesis.2018; 33(1): 69.     CrossRef
  • The effect of carrot juice, β-carotene supplementation on lymphocyte DNA damage, erythrocyte antioxidant enzymes and plasma lipid profiles in Korean smoker
    Hye-Jin Lee, Yoo Kyoung Park, Myung-Hee Kang
    Nutrition Research and Practice.2011; 5(6): 540.     CrossRef
Human Multi-route Exposure Assessment of Lead and Cadmium for Korean Volunteers.
Eunha Oh, Eun Il Lee, Hosub Lim, Jae Yeon Jang
J Prev Med Public Health. 2006;39(1):53-58.
  • 2,083 View
  • 52 Download
AbstractAbstract PDF
OBJECTIVES
We wanted to evaluate the main route of exposure to lead and cadmium for the general population in Korea by using multi-route and multi-media exposure assessment METHODS: Samples of air at the homes, samples of the food and water and peripheral blood samples were collected from thirty volunteers living in Seoul (the metropolitan area), Yong-in (the suburban area) and Ansan (the industrial area) in 2001. Graphite furnace atomic absorption spectrometric methods were used for the determination of the Pb and Cd levels in the air, food, water and blood samples. RESULTS: The average intake of lead through the air, drinking water and food were 5.06 microgram/day (26.3%), 0.002 microgram/day (0.1%), and 16.4 microgram/day (73.6%), respectively. The average intake of cadmium through the air, drinking water and food were 0.082 microgram/day (0.9%), 0.001 microgram/day (0.007%), and 12.61 microgram/day (99.0%), respectively. The blood lead level was statistically higher in the male subjects than in the female subjects (3.39 and 2.22 microgram/dl, respectively), and only gender was a significant variable on the multiple regression analysis for blood lead. CONCLUSIONS: This study showed that the intake of lead and cadmium through food was the major route of exposure. A policy to reduce the pollutants according to the exposure routes should be established. However, more studies will be needed to support these data for the general population.
Summary
DNA Damage of Lymphocytes in Volunteers after 4 hours Use of Mobile Phone.
Seonmi Ji, Eunha Oh, Donggeun Sul, Jae Wook Choi, Heechan Park, Eunil Lee
J Prev Med Public Health. 2004;37(4):373-380.   Published online November 30, 2004
  • 2,452 View
  • 138 Download
AbstractAbstract PDF
OBJECTIVES
There has been gradually increasing concern about the adverse health effects of electromagnetic radiation originating from cell phones which are widely used in modern life. Cell phone radiation may affect human health by increasing free radicals of human blood cells. This study has been designed to identify DNA damage of blood cells by electromagnetic radiation caused by cell phone use. METHODS: This study investigated the health effect of acute exposure to commercially available cell phones on certain parameters such as an indicator of DNA damage for 14 healthy adult volunteers. Each volunteer during the experiment talked over the cell phone with the keypad facing the right side of the face for 4 hours. The single cell gel electrophoresis assay (Comet assay), which is very sensitive in detecting the presence of DNA strand-breaks and alkali-labile damage in individual cells, was used to assess peripheral blood cells (T-cells, B-cells, granulocytes) from volunteers before and after exposure to cell phone radiation. The parameters of Comet assay measured were Olive Tail Moment and Tail DNA %. RESULTS: The Olive Tail Moment of B-cells and granulocytes and Tail DNA % of B-cells and granulocytes were increased by a statistically significant extent after 4- hour use of a cell phone compared with controls. CONCLUSION: It is concluded that cell phone radiation caused the DNA damage during the 4 hours of experimental condition. Nonetheless, this study suggested that cell phone use may increase DNA damage by electromagnetic radiation and other contributing factors.
Summary

JPMPH : Journal of Preventive Medicine and Public Health