Journal of Preventive Medicine and Public Health

Duk-Hee Lee

5 Articles

Excess Deaths in Korea During the COVID-19 Pandemic: 2020-2022: So-Jin Im, Ji-Yeon Shin, Duk-Hee Lee; J Prev Med Public Health. 2024;57(5):480-489. Published online August 20, 2024; DOI: https://doi.org/10.3961/jpmph.24.254

4,096 View
114 Download

Abstract Summary PDF Supplementary Material: Objectives
Excess deaths, an indicator that compares total mortality rates before and during a pandemic, offer a comprehensive view of the pandemic’s impact. However, discrepancies may arise from variations in estimating expected deaths. This study aims to compare excess deaths in Korea during the coronavirus disease 2019 pandemic using 3 methods and to analyze patterns using the most appropriate method.
Methods
Expected deaths from 2020 to 2022 were estimated using mortality data from 2015-2019 as reference years. This estimation employed 3 approaches: (1) simple average, (2) age-adjusted average, and (3) age-adjusted linear regression. Excess deaths by age, gender, and cause of death were also presented.
Results
The number of excess deaths varied depending on the estimation method used, reaching its highest point with the simple average and its lowest with the age-adjusted average. Age-adjusted linear regression, which accounts for both the aging population and declining mortality rates, was considered most appropriate. Using this model, excess deaths were estimated at 0.3% for 2020, 4.0% for 2021, and 20.7% for 2022. Excess deaths surged among individuals in their 20s throughout the pandemic, largely attributed to a rise in self-harm and suicide. Additionally, the results indicated sharp increases in deaths associated with “endocrine, nutritional, and metabolic diseases” and “symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified.”
Conclusions
Substantial variations in excess deaths were evident based on estimation method, with a notable increase in 2022. The heightened excess deaths among young adults and specific causes underscore key considerations for future pandemic responses.; Summary

Korean summary
초과 사망은 팬데믹 영향을 종합적으로 평가하는 핵심 지표로 잘 알려져 있으나, 추정 방법에 따라 결과가 다양한 것으로 보고되고 있다. 코로나19 팬데믹동안 흔하게 사용된 3가지 방법 – 단순 평균, 연령보정 평균, 연령 보정 선형 회귀식-을 이용하여 초과사망을 추정하였을 때, 추정 방법에 따라서 초과사망에 큰 차이가 있었다. 3가지 방법 중 인구 고령화와 사망률 감소 추이를 고려한 연령 보정 선형 회귀식이 가장 적절한 것으로 판단되었으며, 이 방법을 이용한 한국의 초과 사망은 2020년 0.3%, 2021년 4.0%, 2022년 20.7%로 추정되었다. 또한 팬데믹 전 기간 동안 20대 초과 사망이 급증했는데 이는 주로 자해와 자살의 증가로 인한 것이었으며, '내분비, 영양 및 대사 질환' 및 ' 달리 분류되지 않은 증상, 징후와 임상 및 검사의 이상소견”으로 인한 초과사망도 급증하였다.

Key Message
● Excess deaths, a comprehensive indicator of the pandemic’s impact, varied by estimation method.
● Using an age-adjusted linear regression approach, which considers an aging population and declining mortality rates, excess deaths in Korea during the COVID-19 pandemic were estimated at 0.3% for 2020, 4.0% for 2021, and 20.7% for 2022.
● Excess deaths surged among individuals in their 20s throughout the pandemic, mainly due to increased self-harm and suicide, alongside a sharp rise in deaths related to ‘endocrine, nutritional, and metabolic diseases’, and ‘symptoms, signs, and abnormal clinical and laboratory findings, not elsewhere classified’.

Comparison of Trends in Blood Pressure and the Prevalence of Obesity Among Korean and American Adolescents: A 12-Years Cross-sectional Study: Somi Heo, Seyoung Kwon, Yu-Mi Lee, Ji-Yeon Shin, Duk-Hee Lee; J Prev Med Public Health. 2020;53(1):45-55. Published online November 20, 2019; DOI: https://doi.org/10.3961/jpmph.19.198

5,056 View
202 Download
7 Crossref

Abstract Summary PDF Supplementary Material

Objectives
This study was conducted to explore recent trends in the prevalence of pediatric elevated blood pressure and hypertension (HTN) in Korea and the United States, applying the new HTN reference values for adolescents.
Methods
This study analyzed 17 339 (8755 Korean and 8584 American) adolescents aged 10 to 17 who participated in the Korea National Health and Nutrition Examination Survey and the National Health and Nutrition Examination Survey, respectively, between 2005 and 2016. HTN was defined using percentile-based reference values for non-overweight adolescents from 7 nations, and obesity was defined by body mass index (BMI) based on country-specific growth charts. All analyses were stratified by sex and year-over-year changes were evaluated by calculating the p for trend.
Results
Systolic blood pressure showed a statistically meaningful upward trend in Korean boys and girls, while diastolic blood pressure did not show any significant changes. Both systolic and diastolic blood pressure levels declined among United States boys and girls. The prevalence of elevated blood pressure and HTN remained similar in Korean adolescents, but declined in both sexes among United States adolescents. BMI increased in both sexes among Korean adolescents, although the overweight and obesity rates stayed the same. No significant trends were found in any obesity indices among United States adolescents. The prevalence of elevated blood pressure and HTN by obesity level was higher among Korean adolescents than among their United States peers in both sexes, and the gap became higher at more severe levels of obesity.
Conclusions
Despite the strong correlation between obesity and HTN, recent trends in the prevalence of HTN and obesity among Korean and United States adolescents were strikingly different. Follow-up studies are necessary to determine why the prevalence of HTN was more than twice as high among Korean adolescents than among their United States counterparts.

Summary

Korean summary
본 연구에서는 새로운 소아청소년 고혈압 기준을 이용하여, 최근 한국과 미국 소아청소년들의 혈압 및 고혈압 유병률의 변화 추이를 비교하였다. 비만과 고혈압간의 높은 관련성에도 불구하고 한국과 미국 소아청소년의 고혈압 유병률과 비만율은 서로 다른 변화 추이를 나타내었으며, 고혈압 발생에 있어서 한국 소아청소년들이 미국 소아청소년들보다 비만에 더 취약할 가능성을 나타내고 있어 이에 관한 후속연구가 필요하다.

Citations

Citations to this article as recorded by

Association Between Obesity and Blood Pressure Among Iranian Children and Adolescents: A Sub-analysis from the SHED LIGHT Study
Avisa Tabib, Akbar Nikpajouh, Maryam Aryafar, Niloufar Samiei, Yousef Rezaei, Hassan Ziaodini, Azam Goodarzi, Bahareh Kazemborji, Nasim Naderi, Sepideh Taghavi, Hooman Bakhshandeh, Saeid Hosseini
Pediatric Cardiology.2024; 45(6): 1192. CrossRef
Body Mass Index, Waist Circumference, Hip Circumference, Waist-To-Height Ratio: Which Affects Adolescent Hypertension More?
Melike TELLİOĞLU, Muammer YILMAZ, İnci ARIKAN, Yaşar ÇAKMAKÇI
Phoenix Medical Journal.2023; 5(1): 17. CrossRef
Combined associations of general obesity and central obesity with hypertension stages and phenotypes among children and adolescents in Zhejiang, China
Dong Zhao, Jiali Zhou, Danting Su, Yun Li, Weidi Sun, Boren Tan, Shuting Li, Ronghua Zhang, Peige Song
The Journal of Clinical Hypertension.2023; 25(11): 983. CrossRef
Дискордантные тренды повышенного артериального давления и избыточной массы тела у подростков 14–18 лет Новосибирска (по данным популяционных исследований в Новосибирске – 1989–2019 гг.)
Д. В. Денисова, Е. А. Беляевская
Ateroscleroz.2023; 19(3): 210. CrossRef
Association between body mass index and oesophageal cancer mortality: a pooled analysis of prospective cohort studies with >800 000 individuals in the Asia Cohort Consortium
Sangjun Lee, Jieun Jang, Sarah Krull Abe, Shafiur Rahman, Eiko Saito, Rashedul Islam, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Jeongseon Kim, Isao Oze, Chisato Nagata, San-Lin You, Myung-He
International Journal of Epidemiology.2022; 51(4): 1190. CrossRef
Correlates of Undiagnosed Hypertension Among Chinese and Korean American Immigrants
Brittany N. Morey, Connie Valencia, Sunmin Lee
Journal of Community Health.2022; 47(3): 425. CrossRef
Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants
Jieun Jang, Sangjun Lee, Kwang-Pil Ko, Sarah K. Abe, Md. Shafiur Rahman, Eiko Saito, Md. Rashedul Islam, Norie Sawada, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Jeongseon Kim, Isao Oze, Chisato Nagata, Shoichiro Tsugane, Hui Cai, Jian-Min
Cancer Epidemiology, Biomarkers & Prevention.2022; 31(9): 1727. CrossRef

Association of Homocysteine Levels With Blood Lead Levels and Micronutrients in the US General Population: Yu-Mi Lee, Mi-Kyung Lee, Sang-Geun Bae, Seon-Hwa Lee, Sun-Young Kim, Duk-Hee Lee; J Prev Med Public Health. 2012;45(6):387-393. Published online November 29, 2012; DOI: https://doi.org/10.3961/jpmph.2012.45.6.387

9,699 View
79 Download
19 Crossref

Abstract PDF

Objectives

Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels.

Methods

This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004.

Results

There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 µmol/L) as the outcome, there were similar patterns of interaction, though p-values for each interaction failed to reach statistical significance.

Conclusions

In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.

Summary

Citations

Citations to this article as recorded by

Blood Homocysteine Levels Mediate the Association Between Blood Lead Levels and Cardiovascular Mortality
Sapha Shibeeb, Atiyeh Abdallah, Zumin Shi
Cardiovascular Toxicology.2024; 24(1): 62. CrossRef
First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort
Ixel Hernandez-Castro, Sheryl L. Rifas-Shiman, Pi-I D. Lin, Jorge E. Chavarro, Diane R. Gold, Mingyu Zhang, Noel T. Mueller, Tamarra James-Todd, Brent Coull, Marie-France Hivert, Emily Oken, Andres Cardenas
Environment International.2024; 190: 108909. CrossRef
Association of low-level blood lead with plasma homocysteine in US children and adolescents
Lingfei Shi, Jia Zhou, Jinjiang Dong, Faliang Gao, Wenyan Zhao
Environmental Geochemistry and Health.2023; 45(7): 5013. CrossRef
Prevalence of hyperhomocysteinemia (HHcy) and its major determinants among hypertensive patients over 35 years of age
Minna Cheng, Hong Xue, Xinjian Li, Qinghua Yan, Dingliang Zhu, Yan Wang, Yan Shi, Chen Fu
European Journal of Clinical Nutrition.2022; 76(4): 616. CrossRef
Maternal exposure to heavy metals and risk for severe congenital heart defects in offspring
Chengrong Wang, Xin Pi, Shengju Yin, Mengyuan Liu, Tian Tian, Lei Jin, Jufen Liu, Zhiwen Li, Linlin Wang, Zhengwei Yuan, Yu Wang, Aiguo Ren
Environmental Research.2022; 212: 113432. CrossRef
Lead (Pb) exposure and heart failure risk
Zihan Chen, Xia Huo, Guangcan Chen, Xiuli Luo, Xijin Xu
Environmental Science and Pollution Research.2021; 28(23): 28833. CrossRef
Plasma Vitamin B12 and Folate Alter the Association of Blood Lead and Cadmium and Total Urinary Arsenic Levels with Chronic Kidney Disease in a Taiwanese Population
Yu-Mei Hsueh, Ya-Li Huang, Yuh-Feng Lin, Horng-Sheng Shiue, Ying-Chin Lin, Hsi-Hsien Chen
Nutrients.2021; 13(11): 3841. CrossRef
Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults
Jia Wei, John S Ji
BMJ Nutrition, Prevention & Health.2020; 3(2): 180. CrossRef
Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States
Minghui Li, Lihua Hu, Wei Zhou, Tao Wang, Lingjuan Zhu, Zhenyu Zhai, Huihui Bao, Xiaoshu Cheng
Scientific Reports.2020;[Epub] CrossRef
Biomonitoring findings for occupational lead exposure in battery and ceramic tile workers using biochemical markers, alkaline comet assay, and micronucleus test coupled with fluorescence in situ hybridisation
Vilena Kašuba, Mirta Milić, Davor Želježić, Marin Mladinić, Alica Pizent, Zorana Kljaković-Gašpić, Melita Balija, Irena Jukić
Archives of Industrial Hygiene and Toxicology.2020; 71(4): 339. CrossRef
Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?
Caterina Ledda, Emanuele Cannizzaro, Piero Lovreglio, Ermanno Vitale, Angela Stufano, Angelo Montana, Giovanni Li Volti, Venerando Rapisarda
Antioxidants.2019; 9(1): 30. CrossRef
Single Nucleotide Polymorphisms in Key One-Carbon Metabolism Genes and Their Association with Blood Folate and Homocysteine Levels in a Chinese Population in Yunnan
Juan Ni, Yaoxian Liu, Tao Zhou, Xiayu Wu, Xu Wang
Genetic Testing and Molecular Biomarkers.2018; 22(3): 193. CrossRef
α-Tocopherol supplementation and the oxidative stress, homocysteine, and antioxidants in lead exposure
Sławomir Kasperczyk, Michał Dobrakowski, Aleksandra Kasperczyk, Ewa Nogaj, Marta Boroń, Zbigniew Szlacheta, Ewa Birkner
Archives of Environmental & Occupational Health.2017; 72(3): 153. CrossRef
Determinants of hyperhomocysteinemia in healthy and hypertensive subjects: A population-based study and systematic review
Liyuan Han, Yanfen Liu, Changyi Wang, Linlin Tang, Xiaoqi Feng, Thomas Astell-Burt, Qi wen, Donghui Duan, Nanjia Lu, Guodong Xu, Kaiyue Wang, Lu Zhang, Kaibo Gu, Sihan Chen, Jianping Ma, Tao Zhang, Dingyun You, Shiwei Duan
Clinical Nutrition.2017; 36(5): 1215. CrossRef
Effect of occupational exposure to lead on new risk factors for cardiovascular diseases
Adam Prokopowicz, Andrzej Sobczak, Magdalena Szuła-Chraplewska, Marzena Zaciera, Jolanta Kurek, Izabela Szołtysek-Bołdys
Occupational and Environmental Medicine.2017; 74(5): 366. CrossRef
Blood lead, cadmium and mercury in relation to homocysteine and C-reactive protein in women of reproductive age: a panel study
Anna Z. Pollack, Sunni L. Mumford, Lindsey Sjaarda, Neil J. Perkins, Farah Malik, Jean Wactawski-Wende, Enrique F. Schisterman
Environmental Health.2017;[Epub] CrossRef
Blood lead levels, iron metabolism gene polymorphisms and homocysteine: a gene-environment interaction study
Kyoung-Nam Kim, Mee-Ri Lee, Youn-Hee Lim, Yun-Chul Hong
Occupational and Environmental Medicine.2017; 74(12): 899. CrossRef
Evaluation and management of lead exposure
Hwan-Cheol Kim, Tae-Won Jang, Hong-Jae Chae, Won-Jun Choi, Mi-Na Ha, Byeong-Jin Ye, Byoung-Gwon Kim, Man-Joong Jeon, Se-Yeong Kim, Young-Seoub Hong
Annals of Occupational and Environmental Medicine.2015;[Epub] CrossRef
Lead Exposure, B Vitamins, and Plasma Homocysteine in Men 55 Years of Age and Older: The VA Normative Aging Study
Kelly M. Bakulski, Sung Kyun Park, Marc G. Weisskopf, Katherine L. Tucker, David Sparrow, Avron Spiro, Pantel S. Vokonas, Linda Huiling Nie, Howard Hu, Jennifer Weuve
Environmental Health Perspectives.2014; 122(10): 1066. CrossRef

Associations of Serum Ferritin and Transferrin % Saturation With All-cause, Cancer, and Cardiovascular Disease Mortality: Third National Health and Nutrition Examination Survey Follow-up Study: Ki-Su Kim, Hye-Gyeong Son, Nam-Soo Hong, Duk-Hee Lee; J Prev Med Public Health. 2012;45(3):196-203. Published online May 31, 2012; DOI: https://doi.org/10.3961/jpmph.2012.45.3.196

12,252 View
93 Download
31 Crossref

Abstract PDF

Objectives

Even though experimental studies have suggested that iron can be involved in generating oxidative stress, epidemiologic studies on the association of markers of body iron stores with cardiovascular disease or cancer remain controversial. This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality.

Methods

The study subjects were men aged 50 years or older and postmenopausal women of the Third National Health and Nutrition Examination Survey 1988-1994. Participants were followed-up for mortality through December 31, 2006.

Results

Serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality for either men or postmenopausal women. However, all-cause, cancer, and cardiovascular mortality were inversely associated with %TS in men. Compared with men in the lowest quintile, adjusted hazard ratios for all-cause, cancer, and cardiovascular mortality were 0.85, 0.86, 0.76, and 0.74 (p for trend < 0.01), 0.82, 0.73, 0.75, and 0.63 (p for trend < 0.01), and 0.86, 0.81, 0.72, and 0.76 (p for trend < 0.01), respectively. For postmenopausal women, inverse associations were also observed for all-cause and cardiovascular mortality, but cancer mortality showed the significantly lower mortality only in the 2nd quintile of %TS compared with that of the 1st quintile.

Conclusions

Unlike speculation on the role of iron from experimental studies, %TS was inversely associated with all-cause, cancer and cardiovascular mortality in men and postmenopausal women. On the other hand, serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality.

Summary

Citations

Citations to this article as recorded by

Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population　― NIPPON DATA90 ―
Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura
Circulation Journal.2024; 88(5): 742. CrossRef
Iron Metabolic Biomarkers and the Mortality Risk in the General Population: A Nationwide Population-Based Cohort Study
Yuanyuan Sun, Wenyao Peng, Siqi Lin, Jingjing Cui, Jiapeng Lu
Journal of the Endocrine Society.2024;[Epub] CrossRef
Advancing Patient Blood Management: Evaluation of Ferric Derisomaltose in a Tertiary Hospital
Mohd Muhaimin Kambali, Engku Hamidah Engku Muhammad Azmi
Global Journal of Transfusion Medicine.2024; 9(1): 65. CrossRef
Iron metabolism and atherosclerosis
Qian Guo, Christopher Qian, Zhong-Ming Qian
Trends in Endocrinology & Metabolism.2023; 34(7): 404. CrossRef
Transferrin predicts trimethylamine-N-oxide levels and is a potential biomarker of cardiovascular disease
Lamuel D. Bean, Jeffrey J. Wing, Randall E. Harris, Suzanne M. Smart, Subha V. Raman, M. Wesley Milks
BMC Cardiovascular Disorders.2022;[Epub] CrossRef
Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models
Leonardo dos Santos, Sabrina Rodrigues Bertoli, Renata Andrade Ávila, Vinícius Bermond Marques
Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(9): 130172. CrossRef
Association of ferritin and transferrin saturation with all-cause mortality, and the effect of concurrent inflammation: a danish cohort study
Nikki H. Mitchell, Henrik L. Jørgensen, Fie J. Vojdeman, Henriette P. Sennels, Christen L. Andersen, Margit Kriegbaum, Mia K. Grand, Christine W. Bang, Bent S. Lind
Scandinavian Journal of Clinical and Laboratory Investigation.2022; 82(7-8): 525. CrossRef
Iron Restriction Alleviates Atherosclerosis in ApoE KO Mice: An iTRAQ Proteomic Analysis
Gang Luo, Lu Xiang, Lin Xiao
International Journal of Molecular Sciences.2022; 23(24): 15915. CrossRef
Nano‐sensing and nano‐therapy targeting central players in iron homeostasis
Linyuan Wu, Yan Li, Ning Gu
WIREs Nanomedicine and Nanobiotechnology.2021;[Epub] CrossRef
Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism
Lin Xiao, Gang Luo, Hongxia Li, Ping Yao, Yuhan Tang
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(10): 159004. CrossRef
The role of hepcidin and iron homeostasis in atherosclerosis
Florian Wunderer, Lisa Traeger, Haakon H. Sigurslid, Patrick Meybohm, Donald B. Bloch, Rajeev Malhotra
Pharmacological Research.2020; 153: 104664. CrossRef
Iron loading, alcohol and mortality: A prospective study
Rudolph Schutte, Hugo Huisman, Catharina M.C. Mels, Shani Botha, Ruan Kruger, Wayne Smith, Iolanthé M. Kruger, Michelle Hawkins, Lee Smith, Yolandi Breet, Aletta E. Schutte
Clinical Nutrition.2019; 38(3): 1262. CrossRef
Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
Marko Lucijanic, Zeljko Prka, Vlatko Pejsa, Tajana Stoos-Veic, Jelena Lucijanic, Rajko Kusec
Leukemia Research.2018; 66: 89. CrossRef
Iron status in relation to cancer risk and mortality: Findings from a population‐based prospective study
Daniel A. Quintana Pacheco, Disorn Sookthai, Mirja E. Graf, Ruth Schübel, Theron Johnson, Verena A. Katzke, Rudolf Kaaks, Tilman Kühn
International Journal of Cancer.2018; 143(3): 561. CrossRef
Targeting iron metabolism in drug discovery and delivery
Bart J. Crielaard, Twan Lammers, Stefano Rivella
Nature Reviews Drug Discovery.2017; 16(6): 400. CrossRef
The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing
Nikolaos P. E. Kadoglou, Jane P. Biddulph, Snorri B. Rafnsson, Marialena Trivella, Petros Nihoyannopoulos, Panayotes Demakakos, Abelardo I Aguilera
PLOS ONE.2017; 12(6): e0178994. CrossRef
Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?
Thomas D. Coates, Susan Carson, John C. Wood, Vasilios Berdoukas
Annals of the New York Academy of Sciences.2016; 1368(1): 95. CrossRef
Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status
Stephen T. McSorley, Iain Jones, Donald C. McMillan, Dinesh Talwar
Translational Research.2016; 176: 119. CrossRef
High serum levels of ferritin at baseline are not associated with an increased risk of mortality in oldest old community‐dwelling adults: The OCTABAIX study
Francesc Formiga, Assumpta Ferrer, Gloria Padros, Carme Gimenez‐Argente, Rosa López Pisa, Xavier Corbella
Geriatrics & Gerontology International.2016; 16(2): 284. CrossRef
Iron toxicity and its possible association with treatment of Cancer: Lessons from hemoglobinopathies and rare, transfusion-dependent anemias
Mammen Puliyel, Arch G Mainous, Vasilios Berdoukas, Thomas D Coates
Free Radical Biology and Medicine.2015; 79: 343. CrossRef
Parameters influencing in-hospital mortality in patients hospitalized in intensive cardiac care unit: is there an influence of anemia and iron deficiency?
Ewa Uscinska, Bozena Sobkowicz, Robert Sawicki, Izabela Kiluk, Malgorzata Baranicz, Tomasz Stepek, Milena Dabrowska, Maciej Szmitkowski, Wlodzimierz J. Musial, Agnieszka M. Tycinska
Internal and Emergency Medicine.2015; 10(3): 337. CrossRef
Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey
R. J. Park, J. D. Moon
Diabetic Medicine.2015; 32(5): 673. CrossRef
Helicobacter pylori Seropositivity’s Association with Markers of Iron, 1-Carbon Metabolism, and Antioxidant Status among US Adults: A Structural Equations Modeling Approach
May A. Beydoun, Greg A. Dore, Jose A. Canas, Hind A. Beydoun, Alan B. Zonderman, Bradford D. Gessner
PLOS ONE.2015; 10(3): e0121390. CrossRef
Transferrin Saturation Ratio: A Method to Estimate Risk of Cardiovascular Mortality in the General Population?
Austin G Stack, Waleed Mohamed, Mohamed Elsayed
Biomarkers in Medicine.2014; 8(7): 913. CrossRef
Prediabetes, elevated iron and all-cause mortality: a cohort study
Arch G Mainous, Rebecca J Tanner, Thomas D Coates, Richard Baker
BMJ Open.2014; 4(12): e006491. CrossRef
Dietary Iron Intake and Body Iron Stores Are Associated with Risk of Coronary Heart Disease in a Meta-Analysis of Prospective Cohort Studies
Jacob Hunnicutt, Ka He, Pengcheng Xun
The Journal of Nutrition.2014; 144(3): 359. CrossRef
Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial
Carlos Muñoz-Bravo, Mario Gutiérrez-Bedmar, Jorge Gómez-Aracena, Antonio García-Rodríguez, Joaquín Navajas
Nutrients.2013; 5(7): 2384. CrossRef
Non-Hfe Iron Overload: Is Phlebotomy the Answer?
Simon Hazeldine, Debbie Trinder, John K. Olynyk
Current Hepatitis Reports.2013; 12(1): 20. CrossRef
Iron Deficiency and Cardiovascular Disease: An Updated Review of the Evidence
Emanuela Lapice, Maria Masulli, Olga Vaccaro
Current Atherosclerosis Reports.2013;[Epub] CrossRef
Iron Status and Survival in Diabetic Patients With Coronary Artery Disease
Beata Ponikowska, Tomasz Suchocki, Bartłomiej Paleczny, Martyna Olesinska, Slawomir Powierza, Ludmila Borodulin-Nadzieja, Krzysztof Reczuch, Stephan von Haehling, Wolfram Doehner, Stefan D. Anker, John G.F. Cleland, Ewa A. Jankowska
Diabetes Care.2013; 36(12): 4147. CrossRef
Presence in the Pre-Surgical Fine-Needle Aspiration of Potential Thyroid Biomarkers Previously Identified in the Post-Surgical One
Federica Ciregia, Laura Giusti, Angelo Molinaro, Filippo Niccolai, Patrizia Agretti, Teresa Rago, Giancarlo Di Coscio, Paolo Vitti, Fulvio Basolo, Pietro Iacconi, Massimo Tonacchera, Antonio Lucacchini, Alfredo Fusco
PLoS ONE.2013; 8(9): e72911. CrossRef

Interaction Between Persistent Organic Pollutants and C-reactive Protein in Estimating Insulin Resistance Among Non-diabetic Adults: Ki-Su Kim, Nam-Soo Hong, David R Jacobs, Duk-Hee Lee; J Prev Med Public Health. 2012;45(2):62-69. Published online March 31, 2012; DOI: https://doi.org/10.3961/jpmph.2012.45.2.62

10,449 View
82 Download
12 Crossref

Abstract PDF

Objectives

Chronic inflammation is now thought to play a key pathogenetic role in the associations of obesity with insulin resistance and diabetes. Based on our recent findings on persistent organic pollutants (POPs) including the lack of an association between obesity and either insulin resistance or diabetes prevalence among subjects with very low concentrations of POPs, we hypothesized that POP concentrations may be associated with inflammation and modify the associations between inflammation and insulin resistance in non-diabetic subjects.

Methods

Cross-sectional associations among serum POPs, C-reactive protein (CRP), and homeostasis model assessment of insulin resistance (HOMA-IR) were investigated in 748 non-diabetic participants aged ≥20 years. Nineteen types of POPs in 5 subclasses were selected because the POPs were detectable in ≥60% of the participants.

Results

Among the five subclasses of POPs, only organochlorine (OC) pesticides showed positive associations with CRP concentrations, while polychlorinated biphenyls (PCBs) showed inverse associations with CRP concentrations. There were statistically significant interactions between CRP and OC pesticides and between CRP and PCBs, in estimating HOMA-IR (P for interaction <0.01 and <0.01, respectively). CRP was not associated with HOMA-IR among subjects with low concentrations of OC pesticides or PCBs, while CRP was strongly associated with HOMA-IR among subjects with high concentrations of these POPs.

Conclusions

In the current study, OC pesticides were associated with increased levels of CRP, a marker of inflammation, and both OC pesticides and PCBs may also modify the associations between CRP and insulin resistance.

Summary

Citations

Citations to this article as recorded by

Is Physical Activity an Efficient Strategy to Control the Adverse Effects of Persistent Organic Pollutants in the Context of Obesity? A Narrative Review
Quentin A. Serrano, Sébastien Le Garf, Vincent Martin, Serge S. Colson, Nicolas Chevalier
International Journal of Molecular Sciences.2024; 25(2): 883. CrossRef
The associations between endocrine disrupting chemicals and markers of inflammation and immune responses: A systematic review and meta-analysis
Zhiqin Liu, Yao Lu, Kunxia Zhong, Chenchen Wang, Xi Xu
Ecotoxicology and Environmental Safety.2022; 234: 113382. CrossRef
Endocrine Disruptors and the Induction of Insulin Resistance
Rafael Vanni, Renata Maksoud Bussuan, Renato Luiz Rombaldi, Alberto K. Arbex
Current Diabetes Reviews.2021;[Epub] CrossRef
Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies
F.M. Peinado, F. Artacho-Cordón, R. Barrios-Rodríguez, J.P. Arrebola
Environmental Research.2020; 186: 109561. CrossRef
Associations between persistent organic pollutants and metabolic syndrome in morbidly obese individuals
S. Dusanov, J. Ruzzin, H. Kiviranta, T.O. Klemsdal, L. Retterstøl, P. Rantakokko, R. Airaksinen, S. Djurovic, S. Tonstad
Nutrition, Metabolism and Cardiovascular Diseases.2018; 28(7): 735. CrossRef
Health and environmental effects of persistent organic pollutants
Omar M.L. Alharbi, Al Arsh Basheer, Rafat A. Khattab, Imran Ali
Journal of Molecular Liquids.2018; 263: 442. CrossRef
The influence of persistent organic pollutants in the traditional Inuit diet on markers of inflammation
L. K. Schæbel, E. C. Bonefeld-Jørgensen, H. Vestergaard, S. Andersen, Jaymie Meliker
PLOS ONE.2017; 12(5): e0177781. CrossRef
Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study
Martha P. Montgomery, Eric Postel, David M. Umbach, Marie Richards, Mary Watson, Aaron Blair, Honglei Chen, Dale P. Sandler, Silke Schmidt, Freya Kamel
Environmental Health Perspectives.2017;[Epub] CrossRef
Hemostatic, inflammatory, and oxidative markers in pesticide user farmers
Fatima Zohra Madani, Merzouk Hafida, Sid Ahmed Merzouk, Bouchra Loukidi, Katia Taouli, Michel Narce
Biomarkers.2016; 21(2): 138. CrossRef
Persistent organic pollutants and biomarkers of diabetes risk in a cohort of Great Lakes sport caught fish consumers
Mary Turyk, Giamila Fantuzzi, Victoria Persky, Sally Freels, Anissa Lambertino, Maria Pini, Davina H. Rhodes, Henry A. Anderson
Environmental Research.2015; 140: 335. CrossRef
Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland
L. K. Schæbel, E. C. Bonefeld-Jørgensen, P. Laurberg, H. Vestergaard, S. Andersen
Journal of Nutritional Science.2015;[Epub] CrossRef
Persistent Organic Pollutants and Inflammatory Markers in a Cross-Sectional Study of Elderly Swedish People: The PIVUS Cohort
Jitender Kumar, P. Monica Lind, Samira Salihovic, Bert van Bavel, Erik Ingelsson, Lars Lind
Environmental Health Perspectives.2014; 122(9): 977. CrossRef

Author index