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Original Article
Cigarette Smoking and Serum Bilirubin Subtypes in Healthy Korean Men: The Korea Medical Institute Study
Jaeseong Jo, Heejin Kimm, Ji Eun Yun, Kyu Jang Lee, Sun Ha Jee
J Prev Med Public Health. 2012;45(2):105-112.   Published online March 31, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.2.105
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  • 15 Crossref
AbstractAbstract PDF
Objectives

Cigarette smoking is a modifiable risk factor for cardiovascular disease. Bilirubin is a potent antioxidant and its concentration decreases in smokers. However, studies about the association between cigarette smoking and bilirubin are scarce and most are limited to total bilirubin. Additionally, bilirubin is highly related to hemoglobin. Therefore, this study evaluates the association between bilirubin subtypes and cigarette smoking in healthy Korean men independently of hemoglobin.

Methods

This study included 48 040 Korean men aged 30 to 87 years who visited the Korea Medical Institute for routine health examinations from January to December, 2007. The association of smoking with total, direct, and indirect bilirubin was assessed by logistic regression analysis taking into consideration differences in subjects and smoking characteristics.

Results

Current smokers had lower bilirubin concentrations than never-smokers and ex-smokers. Smoking amount and duration were inversely significantly associated with total, direct, and indirect bilirubin. In a multivariable adjusted model, compared to never-smokers, the odds ratios (ORs) and 95% confidence intervals (CIs) of current smokers with the highest number of pack-years were 1.7 (1.6 to 1.9) for total, 1.5 (1.4 to 1.6) for direct, and 1.7 (1.6 to 1.9) for indirect bilirubin. After further adjustment for hemoglobin, this association became stronger (OR [95% CI], 2.1 [1.9 to 2.2] for total; 1.9 [1.8 to 2.0] for direct; 2.0 [1.9 to 2.2] for indirect bilirubin).

Conclusions

In this study, bilirubin subtypes are inversely associated with smoking status, smoking amount, and smoking duration in healthy Korean men independently of hemoglobin. Further studies are needed to investigate this association in healthy Korean women.

Summary

Citations

Citations to this article as recorded by  
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    Udi Shapira, Rafael Y. Brezinski, Ori Rogowski, David Zeltser, Shlomo Berliner, Itzhak Shapira, Shani Shenhar-Tsarfaty, Elizabeth Fireman
    BMC Pulmonary Medicine.2021;[Epub]     CrossRef
  • ROLE OF BILIRUBIN AS A POTENTIALANTIOXIDANT IN SMOKERS
    Varshini. S, A. Preethi, G. Udayakumari
    INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH.2021; : 43.     CrossRef
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    Xiao-Hong Li, Hai-Yan Lin, Li-Ying Guan, Hui Peng, Meng-Meng Wen, Yong-Qian Cao, Xiu-Yun Jiang, Yi-Bing Wang
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    Hyun Sun Cho, Sung Won Lee, Eun Sook Kim, Juyoung Shin, Sung Dae Moon, Je Ho Han, Bong Yun Cha
    Atherosclerosis.2016; 244: 204.     CrossRef
  • Active and Passive Smoking and Serum Total Bilirubin in a Rural Korean Population
    Na Hyun Kim, Hyeon Chang Kim, Joo Young Lee, Ju-Mi Lee, Il Suh
    Nicotine & Tobacco Research.2016; 18(5): 572.     CrossRef
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    International Journal of Epidemiology.2016; 45(5): 1421.     CrossRef
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  • Serum Bilirubin Levels Predict Future Development of Metabolic Syndrome in Healthy Middle-aged Nonsmoking Men
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    The American Journal of Medicine.2015; 128(10): 1138.e35.     CrossRef
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  • Smoking Cessation Is Followed by Increases in Serum Bilirubin, an Endogenous Antioxidant Associated With Lower Risk of Lung Cancer and Cardiovascular Disease
    Stephanie S. O’Malley, Ran Wu, Susan T. Mayne, Peter I. Jatlow
    Nicotine & Tobacco Research.2014; 16(8): 1145.     CrossRef
  • Combined Effects of Smoking and Bilirubin Levels on the Risk of Lung Cancer in Korea: The Severance Cohort Study
    Jung-eun Lim, Heejin Kimm, Sun Ha Jee, Suminori Akiba
    PLoS ONE.2014; 9(8): e103972.     CrossRef
  • The Relationship between Total Bilirubin Levels and Total Mortality in Older Adults: The United States National Health and Nutrition Examination Survey (NHANES) 1999-2004
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    PLoS ONE.2014; 9(4): e94479.     CrossRef
  • The Association Between Heterozygosity forUGT1A1*6,UGT1A1*28, and Variation in the Serum Total-Bilirubin Level in Healthy Young Japanese Adults
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    Genetic Testing and Molecular Biomarkers.2013; 17(6): 464.     CrossRef
  • Serum bilirubin may serve as a marker for increased heme oxygenase activity and inducibility in tissues – A rationale for the versatile health protection associated with elevated plasma bilirubin
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    Medical Hypotheses.2013; 81(4): 607.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health