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1 "Jae-Hong Ryoo"
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Original Article
Serum Uric Acid Level and the Incidence of Metabolic Syndrome in Middle-aged Korean Men: A 5-Year Follow-up Study
Jong-Keun Lee, Jae-Hong Ryoo, Joong-Myung Choi, Sung Keun Park
J Prev Med Public Health. 2014;47(6):317-326.   Published online November 4, 2014
DOI: https://doi.org/10.3961/jpmph.14.028
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  • 5 Crossref
AbstractAbstract PDF
Objectives
Elevated serum uric acid (UA) has been known to be associated with the prevalence of metabolic syndrome (MetS). However, no prospective studies have examined whether serum UA levels are actually associated with the development of MetS. We performed a prospective study to evaluate the longitudinal effects of baseline serum UA levels on the development of MetS.
Methods
A MetS-free cohort of 14 906 healthy Korean men, who participated in a medical check-up program in 2005, was followed until 2010. MetS was defined according to the Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention. Cox proportional hazards models were performed.
Results
During 52 466.1 person-years of follow-up, 2428 incident cases of MetS developed between 2006 and 2010. After adjusting for multiple covariates, the hazard ratios (95% confidence intervals) for incident MetS for the second, the third, and the fourth quartile to the first quartile of serum UA levels were 1.09 (0.92-1.29), 1.22 (1.04-1.44), and 1.48 (1.26-1.73), respectively (p for trend <0.001). These associations were also significant in the clinically relevant subgroup analyses.
Conclusions
Elevated serum UA levels were independently associated with future development of MetS in Korean men during the 5-year follow-up period.
Summary

Citations

Citations to this article as recorded by  
  • Which Clusters of Metabolic Syndrome Are the Most Associated with Serum Uric Acid?
    Jurgita Mikolaitytė, Jolita Badarienė, Roma Puronaitė, Alma Čypienė, Irma Rutkauskienė, Jolanta Dadonienė, Aleksandras Laucevičius
    Medicina.2022; 58(2): 297.     CrossRef
  • Association between serum uric acid and metabolic syndrome: a cross-sectional study in Bangladeshi adults
    Nurshad Ali, Rakib Miah, Mahmudul Hasan, Zitu Barman, Ananya Dutta Mou, Jaasia Momtahena Hafsa, Aporajita Das Trisha, Akibul Hasan, Farjana Islam
    Scientific Reports.2020;[Epub]     CrossRef
  • Association between uric acid and metabolic syndrome in elderly women
    Hui-Juan Wang, Lei-Zhi Shi, Cun-Fei Liu, Shi-Min Liu, Song-Tao Shi
    Open Medicine.2018; 13(1): 172.     CrossRef
  • The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices
    Cuiling Zhu, Ran Cui, Mingming Gao, Sharvan Rampersad, Hui You, Chunjun Sheng, Peng Yang, Hui Sheng, Xiaoyun Cheng, Le Bu, Shen Qu
    International Journal of Endocrinology.2017; 2017: 1.     CrossRef
  • Association between Serum Uric Acid and Mortality among Chinese Patients with Coronary Artery Disease
    Qing Li, Yuan Zhang, Ding Ding, Yunou Yang, Qian Chen, Chaoqun Liu, Xinrui Li, Changjiang Hong, Wenhua Ling
    Cardiology.2016; 134(3): 347.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health