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Yu-Mi Lee 2 Articles
Comparison of Trends in Blood Pressure and the Prevalence of Obesity Among Korean and American Adolescents: A 12-Years Cross-sectional Study
Somi Heo, Seyoung Kwon, Yu-Mi Lee, Ji-Yeon Shin, Duk-Hee Lee
J Prev Med Public Health. 2020;53(1):45-55.   Published online November 20, 2019
  • 4,738 View
  • 197 Download
  • 7 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
This study was conducted to explore recent trends in the prevalence of pediatric elevated blood pressure and hypertension (HTN) in Korea and the United States, applying the new HTN reference values for adolescents.
This study analyzed 17 339 (8755 Korean and 8584 American) adolescents aged 10 to 17 who participated in the Korea National Health and Nutrition Examination Survey and the National Health and Nutrition Examination Survey, respectively, between 2005 and 2016. HTN was defined using percentile-based reference values for non-overweight adolescents from 7 nations, and obesity was defined by body mass index (BMI) based on country-specific growth charts. All analyses were stratified by sex and year-over-year changes were evaluated by calculating the p for trend.
Systolic blood pressure showed a statistically meaningful upward trend in Korean boys and girls, while diastolic blood pressure did not show any significant changes. Both systolic and diastolic blood pressure levels declined among United States boys and girls. The prevalence of elevated blood pressure and HTN remained similar in Korean adolescents, but declined in both sexes among United States adolescents. BMI increased in both sexes among Korean adolescents, although the overweight and obesity rates stayed the same. No significant trends were found in any obesity indices among United States adolescents. The prevalence of elevated blood pressure and HTN by obesity level was higher among Korean adolescents than among their United States peers in both sexes, and the gap became higher at more severe levels of obesity.
Despite the strong correlation between obesity and HTN, recent trends in the prevalence of HTN and obesity among Korean and United States adolescents were strikingly different. Follow-up studies are necessary to determine why the prevalence of HTN was more than twice as high among Korean adolescents than among their United States counterparts.
Korean summary
본 연구에서는 새로운 소아청소년 고혈압 기준을 이용하여, 최근 한국과 미국 소아청소년들의 혈압 및 고혈압 유병률의 변화 추이를 비교하였다. 비만과 고혈압간의 높은 관련성에도 불구하고 한국과 미국 소아청소년의 고혈압 유병률과 비만율은 서로 다른 변화 추이를 나타내었으며, 고혈압 발생에 있어서 한국 소아청소년들이 미국 소아청소년들보다 비만에 더 취약할 가능성을 나타내고 있어 이에 관한 후속연구가 필요하다.


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    Dong Zhao, Jiali Zhou, Danting Su, Yun Li, Weidi Sun, Boren Tan, Shuting Li, Ronghua Zhang, Peige Song
    The Journal of Clinical Hypertension.2023; 25(11): 983.     CrossRef
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    Ateroscleroz.2023; 19(3): 210.     CrossRef
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    Sangjun Lee, Jieun Jang, Sarah Krull Abe, Shafiur Rahman, Eiko Saito, Rashedul Islam, Prakash C Gupta, Norie Sawada, Akiko Tamakoshi, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Jeongseon Kim, Isao Oze, Chisato Nagata, San-Lin You, Myung-He
    International Journal of Epidemiology.2022; 51(4): 1190.     CrossRef
  • Correlates of Undiagnosed Hypertension Among Chinese and Korean American Immigrants
    Brittany N. Morey, Connie Valencia, Sunmin Lee
    Journal of Community Health.2022; 47(3): 425.     CrossRef
  • Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants
    Jieun Jang, Sangjun Lee, Kwang-Pil Ko, Sarah K. Abe, Md. Shafiur Rahman, Eiko Saito, Md. Rashedul Islam, Norie Sawada, Xiao-Ou Shu, Woon-Puay Koh, Atsuko Sadakane, Ichiro Tsuji, Jeongseon Kim, Isao Oze, Chisato Nagata, Shoichiro Tsugane, Hui Cai, Jian-Min
    Cancer Epidemiology, Biomarkers & Prevention.2022; 31(9): 1727.     CrossRef
  • Association Between Obesity and Blood Pressure Among Iranian Children and Adolescents: A Sub-analysis from the SHED LIGHT Study
    Avisa Tabib, Akbar Nikpajouh, Maryam Aryafar, Niloufar Samiei, Yousef Rezaei, Hassan Ziaodini, Azam Goodarzi, Bahareh Kazemborji, Nasim Naderi, Sepideh Taghavi, Hooman Bakhshandeh, Saeid Hosseini
    Pediatric Cardiology.2022;[Epub]     CrossRef
Association of Homocysteine Levels With Blood Lead Levels and Micronutrients in the US General Population
Yu-Mi Lee, Mi-Kyung Lee, Sang-Geun Bae, Seon-Hwa Lee, Sun-Young Kim, Duk-Hee Lee
J Prev Med Public Health. 2012;45(6):387-393.   Published online November 29, 2012
  • 9,363 View
  • 79 Download
  • 18 Crossref
AbstractAbstract PDF

Even though several epidemiological studies have observed positive associations between blood lead levels and homocysteine, no study has examined whether this association differs by the levels of micronutrients, such as folate, vitamin B6, and vitamin B12, which are involved in the metabolism of homocysteine. In this study, we examined the interactions between micronutrients and blood lead on homocysteine levels.


This study was performed with 4089 adults aged ≥20 years old in the US general population using the National Health and Nutrition Examination Survey 2003-2004.


There were significant or marginally significant interactions between micronutrients and blood lead levels on mean homocysteine levels. Positive associations between blood lead and homocysteine were clearly observed among subjects with low levels of folate or low vitamin B6 (p-trend <0.01, respectively). However, in the case of vitamin B12, there was a stronger positive association between blood lead and homocysteine among subjects with high levels of vitamin B12, compared to those with low levels of vitamin B12. In fact, the levels of homocysteine were already high among subjects low in vitamin B12, irrespective of blood lead levels. When we used hyperhomocysteinemia (homocysteine>15 µmol/L) as the outcome, there were similar patterns of interaction, though p-values for each interaction failed to reach statistical significance.


In the current study, the association between blood lead and homocysteine differed based on the levels of folate, vitamin B6, or vitamin B12 present in the blood. It may be important to keep sufficient levels of these micronutrients to prevent the possible harmful effects of lead exposure on homocysteine levels.



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    European Journal of Clinical Nutrition.2022; 76(4): 616.     CrossRef
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    Environmental Research.2022; 212: 113432.     CrossRef
  • Lead (Pb) exposure and heart failure risk
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    Environmental Science and Pollution Research.2021; 28(23): 28833.     CrossRef
  • Plasma Vitamin B12 and Folate Alter the Association of Blood Lead and Cadmium and Total Urinary Arsenic Levels with Chronic Kidney Disease in a Taiwanese Population
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    Nutrients.2021; 13(11): 3841.     CrossRef
  • Modification of vitamin B6 on the associations of blood lead levels and cardiovascular diseases in the US adults
    Jia Wei, John S Ji
    BMJ Nutrition, Prevention & Health.2020; 3(2): 180.     CrossRef
  • Nonlinear association between blood lead and hyperhomocysteinemia among adults in the United States
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    Scientific Reports.2020;[Epub]     CrossRef
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JPMPH : Journal of Preventive Medicine and Public Health