Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Rizwana Parveen 1 Article
Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-analysis
Pinki Mishra, Rizwana Parveen, Ram Bajpai, Nidhi Agarwal
J Prev Med Public Health. 2022;55(4):321-333.   Published online June 13, 2022
DOI: https://doi.org/10.3961/jpmph.21.640
  • 5,473 View
  • 201 Download
  • 6 Web of Science
  • 10 Crossref
AbstractAbstract PDFSupplementary Material
Objectives
Extensive evidence links low vitamin D status and comorbidities with coronavirus disease 2019 (COVID-19) outcomes, but the results of published studies are contradictory. Therefore, we investigated the association of lower levels of vitamin D and comorbidities with the risk of COVID-19 infection.
Methods
We searched MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov for articles published until August 20, 2021. Sixteen eligible studies were identified (386 631 patients, of whom 181 114 were male). We included observational cohort and case-control studies that evaluated serum levels of vitamin D in COVID-19-positive and COVID-19-negative patients. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated.
Results
Significantly lower vitamin D levels were found in COVID-19-positive patients (MD, -1.70; 95% CI, -2.74 to -0.66; p=0.001), but with variation by study design (case-control: -4.04; 95% CI, -5.98 to -2.10; p<0.001; cohort: -0.39; 95% CI, -1.62 to 0.84; p=0.538). This relationship was more prominent in female patients (MD, -2.18; 95% CI, -4.08 to -0.28; p=0.024) than in male patients (MD, -1.74; 95% CI, -3.79 to 0.31; p=0.096). Male patients showed higher odds of having low vitamin D levels (odds ratio [OR], 2.09; 95% CI, 1.38 to 3.17; p<0.001) than female patients (OR, 1.17; 95% CI, 0.74 to 1.86; p=0.477). Comorbidities showed inconsistent, but generally non-significant, associations with COVID-19 infection.
Conclusions
Low serum vitamin-D levels were significantly associated with the risk of COVID-19 infection. This relationship was stronger in female than in male COVID-19 patients. Limited evidence was found for the relationships between comorbidities and COVID-19 infection, warranting large population-based studies to clarify these associations.
Summary

Citations

Citations to this article as recorded by  
  • Effects of vitamin D on the incidence and severity of COVID-19
    V. V. Krivosheev, L. Yu. Nikitina, I. V. Kozlovskiy, A. V. Fedorov
    Sanitarnyj vrač (Sanitary Doctor).2024; (1): 27.     CrossRef
  • Ukrainian Consensus on Diagnosis and Management of Vitamin D Deficiency in Adults
    Nataliia Grygorieva, Mykola Tronko, Volodymir Kovalenko, Serhiy Komisarenko, Tetiana Tatarchuk, Ninel Dedukh, Mykola Veliky, Serhiy Strafun, Yulia Komisarenko, Andrii Kalashnikov, Valeria Orlenko, Volodymyr Pankiv, Oleg Shvets, Inna Gogunska, Svitlana Reg
    Nutrients.2024; 16(2): 270.     CrossRef
  • Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials
    Marharyta Sobczak, Rafał Pawliczak
    Nutrients.2024; 16(10): 1402.     CrossRef
  • Unveiling the Interplay—Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2
    Sunil J. Wimalawansa
    Biology.2024; 13(10): 831.     CrossRef
  • Methodological issues in designing and reporting of systematic reviews in assessing association between vitamin D supplementation and COVID-19 severity
    R Bajpai
    QJM: An International Journal of Medicine.2023; 116(5): 406.     CrossRef
  • Mechanistic Insight into the role of Vitamin D and Zinc in Modulating Immunity Against COVID-19: A View from an Immunological Standpoint
    Nuzhat Ahsan, Mohammad Imran, Yousuf Mohammed, Fatme Al Anouti, Mohammad Idreesh Khan, Tanushree Banerjee, Mohd Adnan, Fauzia Ashfaq, Marek Kieliszek, Syed Amir Ashraf, Afrozul Haq
    Biological Trace Element Research.2023; 201(12): 5546.     CrossRef
  • The Role of Diet and Specific Nutrients during the COVID-19 Pandemic: What Have We Learned over the Last Three Years?
    Petra Rust, Cem Ekmekcioglu
    International Journal of Environmental Research and Public Health.2023; 20(7): 5400.     CrossRef
  • Self-Reported Pre-Pandemic Physical Activity and Likelihood of COVID-19 Infection: Data from the First Wave of the CoCo-Fakt Survey
    Nikola Schmidt, Andreas Gehlhar, Barbara Grüne, Annelene Kossow, Thomas Kraus, Johannes Nießen, Stefanie Wessely, Christine Joisten
    Sports Medicine - Open.2023;[Epub]     CrossRef
  • Diagnosis, prevention and treatment of vitamin D deficiency in adults: Ukrainian experts consensus statement
    N.V. Grygorieva, M.D. Tronko, V.M. Kovalenko, S.V. Komisarenko, T.F. Tatarchuk, N.V. Dedukh, M.M. Veliky, S.S. Strafun, Y.I. Komisarenko, A.V. Kalashnikov, V.L. Orlenko, V.I. Pankiv, O.V. Shvets, I.V. Gogunska, S.I. Regeda
    PAIN, JOINTS, SPINE.2023; 13(2): 60.     CrossRef
  • Vitamin D Deficiency and COVID-19: A Biological Database Study on Pathways and Gene-Disease Associations
    Ángela Alcalá-Santiago, Miguel Rodríguez-Barranco, Marta Rava, María Ángeles Jiménez-Sousa, Ángel Gil, María José Sánchez, Esther Molina-Montes
    International Journal of Molecular Sciences.2022; 23(22): 14256.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health
TOP