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Jae-Seok Hong 2 Articles
Serum 2,3,7,8-Tetrachlorodibenzo-p-dioxin Levels and Their Association With Age, Body Mass Index, Smoking, Military Record-based Variables, and Estimated Exposure to Agent Orange in Korean Vietnam Veterans
Sang-Wook Yi, Heechoul Ohrr, Jong-Uk Won, Jae-Seok Song, Jae-Seok Hong
J Prev Med Public Health. 2013;46(5):226-236.   Published online September 30, 2013
DOI: https://doi.org/10.3961/jpmph.2013.46.5.226
  • 11,035 View
  • 87 Download
  • 12 Crossref
AbstractAbstract PDF
Objectives

The aim of this study was to examine the levels of serum 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and evaluate their association with age, body mass index, smoking, military record-based variables, and estimated exposure to Agent Orange in Korean Vietnam veterans.

Methods

Serum levels of TCDD were analyzed in 102 Vietnam veterans. Information on age, body mass index, and smoking status were obtained from a self-reported questionnaire. The perceived exposure was assessed by a 6-item questionnaire. Two proximity-based exposures were constructed by division/brigade level and battalion/company level unit information using the Stellman exposure opportunity index model.

Results

The mean and median of serum TCDD levels was 1.2 parts per trillion (ppt) and 0.9 ppt, respectively. Only 2 Vietnam veterans had elevated levels of TCDD (>10 ppt). The levels of TCDD did not tend to increase with the likelihood of exposure to Agent Orange, as estimated from either proximity-based exposure or perceived self-reported exposure. The serum TCDD levels were not significantly different according to military unit, year of first deployment, duration of deployment, military rank, age, body mass index, and smoking status.

Conclusions

The average serum TCDD levels in the Korean Vietnam veterans were lower than those reported for other occupationally or environmentally exposed groups and US Vietnam veterans, and their use as an objective marker of Agent Orange exposure may have some limitations. The unit of deployment, duration of deployment, year of first deployment, military rank, perceived self-reported exposure, and proximity-based exposure to Agent Orange were not associated with TCDD levels in Korean Vietnam veterans. Age, body mass index and smoking also were not associated with TCDD levels.

Summary

Citations

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    S.-W. Yi, S.-Y. Ryu
    International Journal of Epidemiology.2015; 44(1): 359.     CrossRef
  • A critical review of the epidemiology of Agent Orange or 2,3,7,8-tetrachlorodibenzo-p-dioxin and lymphoid malignancies
    Ellen T. Chang, Paolo Boffetta, Hans-Olov Adami, Jack S. Mandel
    Annals of Epidemiology.2015; 25(4): 275.     CrossRef
  • A critical review of the epidemiology of Agent Orange/TCDD and prostate cancer
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    European Journal of Epidemiology.2014; 29(10): 667.     CrossRef
  • Challenges in investigating the association between Agent Orange and cancer: Site‐specific cancer risk and accuracy of exposure assessment
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  • Agent Orange exposure and cancer incidence in Korean Vietnam veterans: A prospective cohort study
    Sang‐Wook Yi, Heechoul Ohrr
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  • Agent Orange exposure and risk of death in Korean Vietnam veterans: Korean Veterans Health Study
    Sang-Wook Yi, So-Yeon Ryu, Heechoul Ohrr, Jae-Seok Hong
    International Journal of Epidemiology.2014; 43(6): 1825.     CrossRef
Agent Orange Exposure and Prevalence of Self-reported Diseases in Korean Vietnam Veterans
Sang-Wook Yi, Heechoul Ohrr, Jae-Seok Hong, Jee-Jeon Yi
J Prev Med Public Health. 2013;46(5):213-225.   Published online September 30, 2013
DOI: https://doi.org/10.3961/jpmph.2013.46.5.213
  • 12,072 View
  • 150 Download
  • 32 Crossref
AbstractAbstract PDF
Objectives

The aim of this study was to evaluate the association between Agent Orange exposure and self-reported diseases in Korean Vietnam veterans.

Methods

A postal survey of 114 562 Vietnam veterans was conducted. The perceived exposure to Agent Orange was assessed by a 6-item questionnaire. Two proximity-based Agent Orange exposure indices were constructed using division/brigade-level and battalion/company-level unit information. Adjusted odds ratios (ORs) for age and other confounders were calculated using a logistic regression model.

Results

The prevalence of all self-reported diseases showed monotonically increasing trends as the levels of perceived self-reported exposure increased. The ORs for colon cancer (OR, 1.13), leukemia (OR, 1.56), hypertension (OR, 1.03), peripheral vasculopathy (OR, 1.07), enterocolitis (OR, 1.07), peripheral neuropathy (OR, 1.07), multiple nerve palsy (OR, 1.14), multiple sclerosis (OR, 1.24), skin diseases (OR, 1.05), psychotic diseases (OR, 1.07) and lipidemia (OR, 1.05) were significantly elevated for the high exposure group in the division/brigade-level proximity-based exposure analysis, compared to the low exposure group. The ORs for cerebral infarction (OR, 1.08), chronic bronchitis (OR, 1.05), multiple nerve palsy (OR, 1.07), multiple sclerosis (OR, 1.16), skin diseases (OR, 1.05), and lipidemia (OR, 1.05) were significantly elevated for the high exposure group in the battalion/company-level analysis.

Conclusions

Korean Vietnam veterans with high exposure to Agent Orange experienced a higher prevalence of several self-reported chronic diseases compared to those with low exposure by proximity-based exposure assessment. The strong positive associations between perceived self-reported exposure and all self-reported diseases should be evaluated with discretion because the likelihood of reporting diseases was directly related to the perceived intensity of Agent Orange exposure.

Summary

Citations

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JPMPH : Journal of Preventive Medicine and Public Health