Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Articles

Page Path
HOME > J Prev Med Public Health > Volume 54(2); 2021 > Article
Brief Report
Reliability and Validity of a Life Course Passive Smoke Exposure Questionnaire in an Australian Cohort From Childhood to Adulthood
Chigozie Ezegbe1orcid, Costan G. Magnussen1,2,3orcid, Amanda Louise Neil1orcid, Marie-Jeanne Buscot1orcid, Terence Dwyer4orcid, Alison Venn1orcid, Seana Gall1orcid
Journal of Preventive Medicine and Public Health 2021;54(2):153-159.
DOI: https://doi.org/10.3961/jpmph.20.559
Published online: March 10, 2021
  • 3,267 Views
  • 95 Download
  • 1 Web of Science
  • 1 Crossref
  • 1 Scopus

1Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia

2Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

3Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland

4George Institute for Global Health, University of Oxford, Oxford, UK

Corresponding author: Seana Gall Menzies Institute for Medical Research, University of Tasmania, 17 Liverpool Street, Hobart TAS 7000, Australia E-mail: Seana.gall@utas.edu.au
• Received: November 12, 2020   • Accepted: February 21, 2021

Copyright © 2021 The Korean Society for Preventive Medicine

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • Objectives:
    Life course exposure to passive smoke may predict health, but there are few validated measures. We tested the reliability and validity of a retrospective life course passive smoking questionnaire.
  • Methods:
    Participants from the third follow-up of the Childhood Determinants of Adult Health study (2014-2019, ages 36-49 years) retrospectively reported mother/father/other household member smoking when living at home during childhood, including duration (years) and smoking location (never/sometimes/always inside house). The severity of exposure index (SEI; sum of mother/father/other years smoked multiplied by smoking location), cumulative years of exposure (CYE; sum of mother/father/other years), and total household smokers (THS) were derived. The reliability of retrospective passive smoking reports was examined with intraclass correlation coefficients (ICCs) using household smoking reported 34 years earlier in 1985 by participants when aged 7-15 years. Construct validity was examined by correlating retrospective passive smoking with participants’ smoking in adulthood and lung function in childhood and adulthood.
  • Results:
    Among 2082 participants (mean±standard deviation [SD], 45.0±2.5 years; 55.2% females), THS ranged from 0 to 5 (mean± SD, 0.9±1.0), CYE ranged from 0 to 106 (mean±SD, 10.5±13.9), and SEI ranged from 0 to 318 (mean±SD, 24.4±36.0). Retrospective measures showed moderate agreement with total household smokers reported in childhood (ICC, 0.58 to 0.62). The retrospective measures were weakly but significantly (p<0.05) correlated with participants’ smoking (r=0.13 to 0.15) and lung function (r= -0.05 to -0.06).
  • Conclusions:
    The retrospective passive smoking questionnaire showed reasonable reliability and validity. This measure may be useful for epidemiological studies.
Passive smoke exposure increases the risk of various diseases, including lower respiratory infections in infancy, lung and cervical cancer, and stroke [1]. The frequency and duration of exposure to passive smoking influence its adverse effects [2,3]. We have found that prospectively reported childhood measures of passive smoke exposure from parents were associated with greater carotid intima-media thickness [4] and increased risk of carotid atherosclerotic plaque [5]. There is increasing recognition of the importance of exposures across the life course from childhood to adulthood [6], but examining relationships between exposures in childhood and health outcomes in adulthood requires measurements of exposures over time. Existing questionnaires on passive smoking in children and adults measure short-term exposure to passive smoking, ranging from 24 hours to a few weeks [7-10]. Some measures of passive smoking have attempted to retrospectively capture prolonged passive smoke exposure across childhood with demonstrated reliability (mostly intra-rater reliability) using repeated assessments in adulthood. Few researchers have examined the validity of these measures, possibly due to the lack of a gold standard [11].
The Childhood Determinants of Adult Health (CDAH) study is a follow-up of the cardiovascular health of participants in the Australian Schools Health and Fitness Survey (ASHFS), which was a nationally representative cross-sectional study of the health and fitness of Australian schoolchildren in 1985. The aim of this study was to assess the reliability and validity of a retrospective life course passive smoking questionnaire making use of rich data on childhood and adulthood social, demographic, and health-related factors captured across the life course.
Study Participants
The participants were drawn from the CDAH study, a follow-up of the 8498 7-year-old to 15-year-old children who participated in the ASHFS in 1985 after 2-staged random sampling, first of schools and then of children within schools [12]. The response proportion in the ASHFS was 67.5%. After the first follow-up in 2004-2006 (CDAH-1; response proportion, 47.0%), subsequent follow-up was conducted in 2009-2011 (CDAH-2; response proportion, 36.0%) and 2014-2019 (CDAH-3; response proportion, 25.0%).
Study Measures

Self-reported exposure to passive smoking

In CDAH-3, participants completed face-to-face assessments, along with questionnaires on health and lifestyle, diet, and physical activity when they were aged 36-49 years. Data on exposure to passive smoke during childhood were collected with a questionnaire (Supplemental Material 1) including the number of household members who smoked (mother, father, and other), environments where the exposure occurred (car and house), and the duration of the exposure for each household member (years). Responses were truncated to the period when the person lived at home with their parents.
The questionnaires were used to derive 3 retrospective passive smoke exposure variables described below, based on an approach reported for adults in the literature [13]:
Total household smokers: This represents the sum of the total number of household members who were regular smokers, lived with the participant, and smoked inside the house. Parental smoking in CDAH-3 was categorized as “none,” “either parent smoked,” and “both parents smoked.”
Cumulative years of exposure: This was derived from summing the total number of years that participants were exposed to passive smoke from each household member with whom he or she lived. Cumulative years of exposure was also categorized by tertiles (no exposure, 1-20 years, and 21 years and above).
Severity of exposure index: The frequency of exposure inside the house from each household member was scored as “never” (=1), “sometimes” (=2), and “always” (=3). An index of severity of exposure was calculated by multiplying the years of exposure from each household member by the frequency of the exposure, summed over all household members for each participant [13]. The severity of exposure index was also categorized into quartiles: no exposure, 1-30, 31-60, and >60.
Other measurements
A range of measurements in the same participants taken in childhood during the ASHFS and at adult follow-ups (CDAH-1 and CDAH-3) were used to explore the reliability and validity of the retrospective passive smoke exposure questionnaire administered as part of CDAH-3.

Baseline: Australian Schools Health and Fitness Survey in 1985

The measures included gender, age group (7-9, 10-12, and 13-15 years), area-level socioeconomic status according to the postcode of residence (quartiles of a continuous measure: high, medium-high, medium-low, and low); smoking experimentation in childhood (one, a few puffs, yes, <10 in my life, yes, >10 in my life); total household smokers; parental smoking categorized as “none,” “either parent smoked,” and “both parents smoked”; and lung function using a Vitalograph single-breath wedge spirometer to estimate the forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) [14].

Childhood Determinants of Adult Health-1 in 2004-2006

Lung function was measured using a portable electronic spirometer and included FEV1 and FVC [14]. The mean values of lung function measures were used as cut points for descriptive analyses.

Childhood Determinants of Adult Health-3 in 2014-2019

The measures taken included physical activity level (low, moderate, and high) from the total minutes of physical activity per week using the International Physical Activity Questionnaire [15], employment status (not working, studying, or working) and own smoking status (never, former smoker, or current smoker) in adulthood. The main occupation of participants was categorized into occupation types: A (e.g., managers, administrators, or professionals); B (e.g., tradespersons, clerical or service workers); and C (e.g., production or transport workers, labourers, unemployed).
Statistical Analysis
We explored the descriptive summary statistics of the 3 derived passive smoking exposure measures according to their range, mean, and standard deviation (SD).

Reliability

We assessed internal reliability or consistency using Cronbach’s alpha [16]. Consistency between each of the 3 derived exposure variables with their component items (e.g., individual exposure from mother, father, and other household smokers) was tested using Cronbach’s alpha, and a score of 0.7 was deemed acceptable [16].
We used the intraclass correlation coefficient (ICC) to examine agreement in passive smoking exposures from childhood to adulthood [17]. We used one-way random-effects ICCs to examine absolute agreement between the 3 retrospective derived measures of passive smoking and parental smoking from CDAH-3 with the childhood (ASHFS) assessment of parental smoking and total number of smokers in the home. An ICC of <0.5 is accepted as indicating poor agreement, 0.50 to 0.75 as moderate agreement; 0.75 to 0.90 as good agreement and >0.90 as excellent agreement [17].

Validity

As there is no gold standard for validating prolonged passive smoking questionnaires, we used a range of variables from ASHFS, CDAH-1, and CDAH-3 to examine aspects of construct validity of the retrospective passive smoke exposure questionnaire. Tests included the t-test and one-way analysis of variance to examine how passive smoke exposure varied by different childhood (e.g., socioeconomic status and smoking experimentation) and adulthood (e.g., employment and smoking status) characteristics, addressing aspects of convergent validity.
We also examined the convergent validity of the 3 derived passive exposure variables and parental smoking in CDAH-3 with participants’ own smoking status at CDAH-3 and lung function tests (FEV1 and FVC) from CDAH-1 and ASHFS using Spearman’s or Pearson’s correlation coefficients, as appropriate based on the distribution of variables [18]. Similarly, an analysis was performed with total household smokers and parental smoking in ASHFS in place of the 3 derived passive exposure variables and parental smoking in CDAH-3. All analyses were conducted with Stata version 16 (StataCorp., College Station, TX, USA).
Ethics Statement
Institutional ethics approval was obtained from the Tasmania Health and Medical Human Research Ethics Committee and participants provided written informed consent.
There were 2082 participants in CDAH-3 (Supplemental Material 2). The number of household smokers ranged from 0 to 5 (mean±SD, 0.9±1.0); cumulative years of exposure range from 0 to 106 (mean±SD, 10.5±13.9) and severity of exposure ranged from 0 to 318 (mean±SD, 24.4±36.0).
Reliability
The Cronbach’s alpha values illustrated good internal consistency for the severity of exposure index (Cronbach’s α=0.70), cumulative years of exposure (Cronbach’s α=0.70) and total household smokers (Cronbach’s α=0.75).
ICCs demonstrated mostly moderate agreement between the derived measures of passive smoking in CDAH-3 and parental smoking and total household smokers in ASHFS (Table 1). For example, the highest agreement was between retrospectively reported parental smoking in CDAH-3 and parental smoking in ASHFS (ICC, 0.65; 95% confidence interval [CI], 0.62 to 0.68). There was lower agreement with less similar items, such as for total household smokers assessed retrospectively with parental smoking in ASHFS (ICC, 0.47; 95% CI, 0.43 to 0.51).
Construct Validity
As shown by the mean of the 3 derived measures of exposure according to childhood and adulthood factors (Supplemental Material 3), demographic factors varied by exposure to passive smoking. Analyses repeated using non-parametric tests confirmed these results (data not shown).
There was a weak but statistically significant positive correlation of retrospective passive smoking measures with participants’ own smoking (CDAH-3) and a significant, negative association with lung function in adulthood (Table 2). Similar results were also obtained between the ASHFS measures of passive smoking and participants’ own smoking and lung function in adulthood. Significant positive correlations were found between retrospective passive smoking measures (CDAH-3) and lung function in childhood, but this was found to be influenced by age (Supplemental Material 4). For total retrospective household smokers, correlations were positive in younger children but negative in older children. Parental smoking in ASHFS was also negatively correlated with lung function in childhood, although this correlation was not statistically significant.
This study aimed to establish the reliability and validity of a retrospective questionnaire on prolonged passive smoking exposure in childhood. The 3 derived measures showed good internal consistency and moderate agreement with similar measures reported prospectively in childhood. The 3 retrospective measures in adulthood were weakly but significantly correlated in the expected direction with a number of variables, suggesting that the instrument is valid. Similar results were also observed with childhood exposure measures. The passive smoke exposure questionnaire was therefore found to be reliable and valid in the measurement of prolonged passive smoke exposure.
The retrospective passive smoking measure was found to be reliable. The ICCs are broadly supported by findings in another study with a reference standard using answers from surrogates for the number of years exposed (ICC, 0.89), number of smokers at home (ICC, 0.79) and childhood exposure severity index (ICC, 0.74) [13]. While our ICCs were of smaller magnitude, this could reflect the difficulties in measuring prolonged exposure with reference standards measured more than 30 years ago. Further, the prospective questions were referenced to the current behaviour within the household, whereas the retrospective questions encompassed the entirety of childhood. Therefore, complete agreement would be unlikely given the dynamic nature of smoking behaviour over time.
The retrospective passive smoking measures were found to have reasonable validity. Some other investigators validated their self-reported questionnaires on passive smoking with airborne nicotine concentrations [9] and cotinine levels in urine [8]. However, our measures were validated more indirectly with participants’ own demographic and health-related factors, which included lung function and participants’ own smoking. There were some unexpected positive correlations between passive smoke exposure from retrospective and prospective reports with childhood lung function. This may reflect the proximity of these measures to the single measure of lung function and the need for exposure to accumulate before there are effects on lung health, as well as uncontrolled confounding. We sought to validate prolonged passive smoke exposure instead of recent exposure, and this cannot be done with cotinine and nicotine concentration measurements. There is no gold standard for measuring prolonged passive smoke exposure, as seen in the use of cotinine measurements to validate questionnaires on recent exposure to passive smoking [8]. Our reference standards for convergent validity were selected because they have been associated with sustained or prolonged passive smoking exposure (e.g., decrease in lung function) [19]. Furthermore, exposure to parental smoking in childhood increased the risk of being a current smoker in adulthood [20].
Evidence was found for the reliability and validity of the passive smoking instrument, suggesting that it can be used to measure prolonged passive smoking. Our finding supports the use of exposure from different close contacts, years of exposure, and the intensity of exposure to represent passive smoke exposure across childhood. These holistic data on this exposure will be useful to understand the frequency, determinants, and outcomes of passive smoking exposure.
The limitations of this study are that there is no gold standard measure of prolonged passive smoke exposure that we could use to validate the instrument. Questions on passive smoking were asked differently for the 2 periods. In ASHFS participants were asked, “Does your mother/father smoke at home?” while in CDAH-3 they were asked, “Was your mother/father ever a regular smoker?” Although subtle, these differences in the questions may have affected recall of smoking status and therefore the assessments of reliability.
In conclusion, our sample was relatively large and contained a range of factors with which to validate the prolonged passive smoking exposure questionnaire. The cohort showed heterogeneity in passive smoke exposure and the variables used to examine validity.
Supplemental materials are available at https://doi.org/10.3961/jpmph.20.559.
Supplemental Material 1
jpmph-20-559-suppl1.pdf
Supplemental Material 2
jpmph-20-559-suppl2.pdf
Supplemental Material 3
jpmph-20-559-suppl3.pdf
Supplemental Material 4
jpmph-20-559-suppl4.pdf

CONFLICT OF INTEREST

The authors have no conflicts of interest associated with the material presented in this paper.

FUNDING

This baseline study was supported by grants from the Commonwealth Departments of Sport, Recreation and Tourism, and Health; the National Heart Foundation; and the Commonwealth Schools Commission. The follow-up study was funded by grants from the National Health and Medical Research Council (NHMRC), the National Heart Foundation, the Tasmanian Community Fund, and Veolia Environmental Services.

We acknowledge with thanks the contributions of the study participants and the Data Manager of the Childhood Determinants of Adult Health (CDAH-3) study, Marita Dalton. SLG is supported by the National Heart Foundation of Australia Future Leader Fellowship (102061 and 100446). ALN is supported by a Select Foundation Research Fellowship. CGM is supported by a National Heart Foundation of Australia Future Leader Fellowship (100849).
The study sponsors played no role in the study design, the analysis, the interpretation of the results, or submission for publication. None of the authors have any financial relationships relevant to this article to disclose.

AUTHOR CONTRIBUTIONS

Conceptualization: CE, SG. Data curation: CE, CGM, ALN, MJB, TD, AV, SG. Formal analysis: CE, CGM, ALN, MJB, TD, AV, SG. Funding acquisition: CGM, TD, AV, SG. Methodology: CE, CGM, ALN, MJB, TD, AV, SG. Project administration: CE, CGM, ALN, MJB, TD, AV, SG. Visualization: CE, CGM, ALN, MJB, TD, AV, SG. Writing – original draft: CE, SG. Writing – review & editing: CE, CGM, ALN, MJB, TD, AV, SG.

Table 1.
ICCs of the CDAH-3 measures of passive smoking with similar measures of passive smoking in the ASHFS
Variables Prospective passive smoke exposure (ASHFS)
Total household smokers in ASHFS (1985)
Parental smoking in ASHFS (1985)
No. of observations ICC (95% CI) No. of observations ICC (95% CI)
Retrospective passive smoke exposure (CDAH-3)
 Total household smokers 1603 0.58 (0.55, 0.61) 1613 0.47 (0.43, 0.51)
 Cumulative years of exposure 1604 0.62 (0.59, 0.65) 1613 0.64 (0.61, 0.67)
 Severity of exposure index 1604 0.59 (0.56, 0.62) 1613 0.54 (0.50, 0.57)
 Parental smoking 1586 0.55 (0.52, 0.59) 1596 0.65 (0.62, 0.68)

ICC, intraclass correlation coefficients; CDAH, Childhood Determinants of Adult Health; ASHFS, Australian Schools Health and Fitness Survey; CI, confidence interval.

Table 2.
Convergent validity of the measures of passive smoking using CDAH-3 smoking status and CDAH-1 lung function
Variables Adulthood (CDAH-3 and CDAH-1)
Participant smoking status1
FEV12
FVC2
r p-value r p-value r p-value
Retrospective passive smoke exposure (CDAH-3)
 Total household smokers 0.15 <0.001 -0.06 0.032 -0.04 0.110
 Cumulative years of exposure 0.13 <0.001 -0.05 0.054 -0.03 0.237
 Severity of exposure index 0.14 <0.001 -0.06 0.019 -0.04 0.107
 Parental smoking 0.13 <0.001 -0.05 0.064 -0.04 0.185
Passive smoke exposure (ASHFS)
 Total household smokers 0.16 <0.001 -0.05 0.054 -0.03 0.155
 Parental smoking 0.11 <0.001 -0.05 0.021 -0.04 0.087

CDAH, Childhood Determinants of Adult Health; ASHFS, Australian Schools Health and Fitness Survey; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity.

1 Spearman’s correlation.

2 Pearson’s or Spearman’s correlation.

  • 1. Cao S, Yang C, Gan Y, Lu Z. The health effects of passive smoking: an overview of systematic reviews based on observational epidemiological evidence. PLoS One 2015;10(10):e0139907.ArticlePubMedPMC
  • 2. Öberg M, Jaakkola MS, Prüss-Üstün A, Schweizer C, Woodward A. Second hand smoke: assessing the burden of disease at national and local levels; 2010 [cited 2020 Nov 11]. Available from: https://www.who.int/quantifying_ehimpacts/publications/ebd18/en/.
  • 3. Centers for Disease Control and Prevention; National Center for Chronic Disease Prevention and Health Promotion; Office on Smoking and Health. How tobacco smoke causes disease: the biology and behavioral basis for smoking-attributable disease. a report of the Surgeon General; 2010 [cited 2020 Nov 11]. Available from: https://www.cdc.gov/tobacco/data_statistics/sgr/2010/index.htm.
  • 4. Gall S, Huynh QL, Magnussen CG, Juonala M, Viikari JS, Kähönen M, et al. Exposure to parental smoking in childhood or adolescence is associated with increased carotid intima-media thickness in young adults: evidence from the Cardiovascular Risk in Young Finns study and the Childhood Determinants of Adult Health Study. Eur Heart J 2014;35(36):2484-2491.ArticlePubMed
  • 5. West HW, Juonala M, Gall SL, Kähönen M, Laitinen T, Taittonen L, et al. Exposure to parental smoking in childhood is associated with increased risk of carotid atherosclerotic plaque in adulthood: the Cardiovascular Risk in Young Finns Study. Circulation 2015;131(14):1239-1246.ArticlePubMed
  • 6. Magnussen CG, Smith KJ, Juonala M. What the long term cohort studies that began in childhood have taught us about the origins of coronary heart disease. Curr Cardiovasc Risk Rep 2014;8: 373.Article
  • 7. Coultas DB, Peake GT, Samet JM. Questionnaire assessment of lifetime and recent exposure to environmental tobacco smoke. Am J Epidemiol 1989;130(2):338-347.ArticlePubMed
  • 8. Prochaska JJ, Grossman W, Young-Wolff KC, Benowitz NL. Validity of self-reported adult secondhand smoke exposure. Tob Control 2015;24(1):48-53.ArticlePubMed
  • 9. Arechavala T, Continente X, Pérez-Ríos M, Fernández E, CortésFrancisco N, Schiaffino A, et al. Validity of self-reported indicators to assess secondhand smoke exposure in the home. Environ Res 2018;164: 340-345.ArticlePubMed
  • 10. Matt GE, Hovell MF, Zakarian JM, Bernert JT, Pirkle JL, Hammond SK. Measuring secondhand smoke exposure in babies: the reliability and validity of mother reports in a sample of low-income families. Health Psychol 2000;19(3):232-241.ArticlePubMed
  • 11. Avila-Tang E, Elf JL, Cummings KM, Fong GT, Hovell MF, Klein JD, et al. Assessing secondhand smoke exposure with reported measures. Tob Control 2013;22(3):156-163.ArticlePubMed
  • 12. Gliksman MD, Dwyer T, Wlodarczyk J. Differences in modifiable cardiovascular disease risk factors in Australian schoolchildren: the results of a nationwide survey. Prev Med 1990;19(3):291-304.ArticlePubMed
  • 13. Cummings KM, Markello SJ, Mahoney MC, Marshall JR. Measurement of lifetime exposure to passive smoke. Am J Epidemiol 1989;130(1):122-132.ArticlePubMed
  • 14. Curry BA, Blizzard CL, Schmidt MD, Walters EH, Dwyer T, Venn AJ. Longitudinal associations of adiposity with adult lung function in the Childhood Determinants of Adult Health (CDAH) study. Obesity (Silver Spring) 2011;19(10):2069-2075.ArticlePubMed
  • 15. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003;35(8):1381-1395.ArticlePubMed
  • 16. Catallo C, Sidani S. The self-assessment for organizational capacity instrument for evidence-informed health policy: preliminary reliability and validity of an instrument. Worldviews Evid Based Nurs 2014;11(1):35-45.ArticlePubMed
  • 17. Koo TK, Li MY. A guideline of selecting and reporting intraclass correlation coefficients for reliability research. J Chiropr Med 2016;15(2):155-163.ArticlePubMedPMC
  • 18. Liu J, Tang W, Chen G, Lu Y, Feng C, Tu XM. Correlation and agreement: overview and clarification of competing concepts and measures. Shanghai Arch Psychiatry 2016;28(2):115-120.PubMedPMC
  • 19. Belgrave DC, Granell R, Turner SW, Curtin JA, Buchan IE, Le Souëf PN, et al. Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies. Lancet Respir Med 2018;6(7):526-534.ArticlePubMed
  • 20. Paul SL, Blizzard L, Patton GC, Dwyer T, Venn A. Parental smoking and smoking experimentation in childhood increase the risk of being a smoker 20 years later: the Childhood Determinants of Adult Health Study. Addiction 2008;103(5):846-853.ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Childhood secondhand smoke exposure and respiratory disease mortality among never-smokers: the Japan collaborative cohort study for evaluation of cancer risk
      Haruna Kawachi, Masayuki Teramoto, Isao Muraki, Kokoro Shirai, Kazumasa Yamagishi, Akiko Tamakoshi, Hiroyasu Iso
      Journal of Public Health.2023; 45(3): 604.     CrossRef


    JPMPH : Journal of Preventive Medicine and Public Health