Department of Preventive Medicine, Jeju National University School of Medicine, Jeju, Korea
Copyright © 2016 The Korean Society for Preventive Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
CONFLICT OF INTEREST
The authors have no conflicts of interest associated with the material presented in this paper.
Conditions | No. of articles [datasets] | Reference | I-squared (%) | SOR [95% CI] | p-value of bias (Egger’s test) |
---|---|---|---|---|---|
All | 39 | [38], [40-77] | 65.3 | 10.10 [5.89, 17.29] | 0.003 |
Area | |||||
Far East Asia | 20 | [40], [42], [43], [46], [47], [50-52], [54], [56], [58-60], [63], [65-67], [69], [73], [75] | 63.5 | 14.28 [6.58, 30.98] | 0.03 |
Middle East Asia | 4 | [38], [44], [57], [64] | 84.2 | 8.31 [1.35, 51.12] | 0.52 |
Europe | 6 | [41], [48], [49], [55], [61], [71] | 73.8 | 6.09 [0.66, 56.58] | 0.004 |
The Americas | 9 | [45], [53], [62], [68], [70], [72], [74], [76], [77] | 39.8 | 7.04 [3.05, 16.21] | 0.04 |
Year of publication | |||||
-1999 | 18 | [40], [41], [45-60] | 76.3 | 10.36 [3.43, 31.31] | 0.002 |
2000- | 21 | [38], [42-44], [60-77] | 40.4 | 9.42 [5.67, 15.66] | 0.02 |
Methods | [47] | 70.3 | 8.62 [5.12, 14.49] | <0.001 | |
ISH | [31] | [40-43], [45], [47-50], [52-56], [59-62], [64-66], [68-73], [76] | 72.4 | 10.69 [5.00, 22.87] | <0.001 |
PCR | [16] | [38], [44], [46], [51], [57], [58], [63], [66], [67], [74], [75], [77] | 66.6 | 6.22 [3.06, 12.62] | 0.19 |
Control | |||||
ANT | [33] | [38], [40-43], [45-50], [52-55], [58-62], [64-74], [77] | 65.0 | 14.03 [6.85, 28.74] | 0.007 |
NT | [14] | [44], [51], [52], [56-58], [63], [66], [67], [74], [75], [77] | 65.5 | 3.41 [1.78, 6.51] | 0.19 |
Method & control | |||||
ISH & ANT | [26] | [40-43], [45], [47-50], [52-55], [59-62], [64-66], [68-73] | 64.7 | 13.22 [5.62, 30.04] | 0.03 |
ISH & NT | [5] | [52], [56], [60], [64], [76] | 34.1 | 2.56 [0.79, 8.33] | 0.04 |
PCR & ANT | [7] | [38], [46], [58], [66], [67], [74], [77] | 70.2 | 17.77 [3.58, 88.26] | 0.14 |
PCR & NT | [9] | [44], [51], [57], [58], [63], [67], [74], [75], [77] | 58.6 | 3.72 [1.85, 7.48] | 0.97 |
nat, global region (1=Far East Asia, 2=Middle East Asia, 3= Europe, 4=the Americas); py, year of publication (1≤1999, 2≥2000); mt, methods of test (1=in situ hybridization, 2=polymerase chain reaction); co, types of control tissue (1=adjacent normal tissue away from tumor; 2=normal tissue from healthy control).