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Korean Journal of Preventive Medicine 2000;33(2): 226-230.
Comparison of Methods for the Detection of Anti-HBs for Hepatitis B Vaccination Program in Korea.
Hae Sook Sohn, Jeong Nyeo Lee, Sang Hwa Urm, Jong Tae Lee, Jin Ho Chun
1Department of Preventive Medicine, Inje University.
2Department of Clinical Pathology, Pusan Paik Hosipital, Inje University.
OBJECTIVES: The purpose of this study was to suggest a proper method for the detection of heaptitis B surface antibody(anti-HBs) in a screening program for hepatitis B vaccination. METHODS: Sensivitity, specificity and predictive values were compared between Immunochromatographic assay (ICA) and passive hemagglutination(PHA) in 978 subjects(565 males, 413 females, 19-78 years ranging in age, mean 46.5 years old). EIA was used as a standard method for the detection of HBsAb. RESULTS: Sensitivity in the detection of anti-HBs of PHA and ICA was 88.7% and 94.9%, specificity was 94.3% and 96.6%, negative predictive value was 96.5% and 98.0%, and positive predictive value was 82.3% and 91.3%, respectively. False negative rate(11.3%) of PHA was higher than that(5.1%) of ICA. The higher the titer of anti-HBs in EIA was, the lower the false negative rate was. There was no false negative result in the cases with 101mIU/ml or more in EIA. CONCLUSION: We suggest that ICA should be the choice of screening method in the detection of anti-HBs in Hepatitis B vaccination program.
Key words: Anti-HBs; Immunochromatographic assay(ICA); Passive hemagglutination(PHA)
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