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Journal of Preventive Medicine and Public Health 2006;39(6): 505-510.
The Relationship between ACE I/D Polymorphism and HDL Cholesterol.
Chang Hun You, Young Seoub Hong, Jong Young Kwak, Na Young Kim, Mee Sook Roh, Kap Yeol Jung, Yong Hwan Lee, Jung Man Kim, Joon Youn Kim
1Department of Preventive Medicine and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University, Korea. yshong@dau.ac.kr
2Medical Research Center for Cancer Molecular Therapy and Department of Biochemistry, College of Medicine , Dong-A University, Korea.
3Department of Pathology and Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong-A University, Korea.
4Department of Occupational Medicine, Dong-A University Medical Center, Korea.
5Department of Preventive Medicine, Medical College, Kosin University, Korea.
OBJECTIVES: The purpose of this study is to evaluate the association of the angiotensin converting enzyme (ACE) insertion/deletion (I/D) polymorphism with cardiovascular disease risk factors. METHODS: Out of a total of 608 middle-aged adults who visited local health centers, 424 subjects (104 male, 320 female) who had not been diagnosed with hypertension, diabetes mellitus, or hyperlipidemia were included in this study. ACE genotypes were determined in all subjects by polymerase chain reaction methods. RESULTS: Statistical differences in high-density lipoprotein (HDL) cholesterol levels according to ACE genotype were observed using ANOVA (p<0.05), but no differences were found in other cardiovascular risk factors. Specifically, men with the DD and DI genotypes had significantly lower HDL cholesterol levels than those with the II genotype based on the LSD multi-comparison test (p<0.05). CONCLUSIONS: In men, the D-allele of the ACE I/D polymorphism was significantly associated with reduced HDL cholesterol levels. In the future, larger studies are needed to confirm this relationship between ACE I/D polymorphism and HDL cholesterol.
Key words: Angiotensin converting enzyme 2; Highdensity lipoprotein; Polymorphism
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