KSPM
Search
- Page Path
- HOME > Search
Original Article
- Interaction of Vitamin D and Smoking on Inflammatory Markers in the Urban Elderly
- Hyemi Lee, Kyoung-Nam Kim, Youn-Hee Lim, Yun-Chul Hong
- J Prev Med Public Health. 2015;48(5):249-256. Published online September 17, 2015
- DOI: https://doi.org/10.3961/jpmph.15.042
- 9,791 View
- 132 Download
- 12 Crossref
-
Abstract
PDF
Supplementary Material - Objectives
Epidemiological studies have reported that vitamin D deficiency is associated with inflammatory disease. Smoking is a well-known risk factor for inflammation. However, few studies have investigated the interactive effect of vitamin D deficiency and smoking on inflammation. This study aims to investigate the interaction of vitamin D and smoking with inflammatory markers in the urban elderly.
Methods
We used data from the Korean Elderly Environmental Panel Study, which began in August 2008 and ended in August 2010, and included 560 Koreans ≥60 years old living in Seoul. Data was collected via questionnaires that included items about smoking status at the first visit. Vitamin D levels, high-sensitivity C-reactive protein (hs-CRP), and white blood cell (WBC) counts were repeatedly measured up to three times.
Results
The association of vitamin D and hs-CRP was significant after adjusting for known confounders (β=-0.080, p=0.041). After separate analysis by smoking status, the association of vitamin D deficiency and hs-CRP in smokers was stronger than that in nonsmokers (smokers: β=-0.375, p=0.013; non-smokers: β=-0.060, p=0.150). Smoking status was an effect modifier that changed the association between vitamin D deficiency and hs-CRP (interaction estimate: β=-0.254, p=0.032). Vitamin D was not significantly associated with WBC count (β=0.003, p=0.805).
Conclusions
Vitamin D deficiency was associated with hs-CRP in the urban elderly. Smoking status was an effect modifier of this association. Vitamin D deficiency was not significantly associated with WBC count. -
Summary
Citations
Citations to this article as recorded by
- Identification of trans-genus biomarkers for early diagnosis of intestinal schistosomiasis and progression of gut pathology in a mouse model using metabolomics
Peerut Chienwichai, Phornpimon Tipthara, Joel Tarning, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Nuttapohn Kiangkoo, Poom Adisakwattana, Onrapak Reamtong, Gabriel Rinaldi
PLOS Neglected Tropical Diseases.2024; 18(2): e0011966. CrossRef - Vitamin D Status of People 3 to 79 Years of Age from the Canadian Health Measures Survey 2012–2019
Hope A. Weiler, Kurtis Sarafin, Chantal Martineau, Janice L. Daoust, Krista Esslinger, Linda S. Greene-Finestone, Lidia Loukine, Veronique Dorais
The Journal of Nutrition.2023; 153(4): 1150. CrossRef - Analysis of different risk factors of hospitalized COVID-19 patients from North-Eastern Bangladesh
Mohammad Golam Rob Mahmud, Md. Toasin Hossain Aunkor, Fatima Rahman, Darimi Hasin, Jilwatun Noor, Md. Faruque Miah
Journal of Clinical and Experimental Investigations.2023; 14(3): em00818. CrossRef - C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians
Dimitra S. Mouliou
Diseases.2023; 11(4): 132. CrossRef - Adiposity is a confounding factor which largely explains the association of serum vitamin D concentrations with C-reactive protein, leptin and adiponectin
Rachida Rafiq, Hassana El Haddaoui, Renée de Mutsert, Frits R. Rosendaal, Pieter S. Hiemstra, Christa M. Cobbaert, Martin den Heijer, Renate T. de Jongh
Cytokine.2020; 131: 155104. CrossRef - The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk
Amy M Lavery, Bradley N Collins, Amy T Waldman, Chantelle N Hart, Amit Bar-Or, Ruth Ann Marrie, Douglas Arnold, Julia O’Mahony, Brenda Banwell
Multiple Sclerosis Journal.2019; 25(4): 515. CrossRef - A Review of the Potential Benefits of Increasing Vitamin D Status in Mongolian Adults through Food Fortification and Vitamin D Supplementation
William B. Grant, Barbara J. Boucher
Nutrients.2019; 11(10): 2452. CrossRef - Relationship between serum vitamin D levels and inflammatory markers in acute stroke patients
Qiongzhang Wang, Zhuoying Zhu, Yuntao Liu, Xinjie Tu, Jincai He
Brain and Behavior.2018;[Epub] CrossRef - Prevalence of vitamin D deficiency and its associated factors among the urban elderly population in Hyderabad metropolitan city, South India
Palla Suryanarayana, Nimmathota Arlappa, Vadakattu Sai Santhosh, Nagalla Balakrishna, Pondey Lakshmi Rajkumar, Undrajavarapu Prasad, Banavath Bhoja Raju, Kommula Shivakeseva, Kondru Divya Shoshanni, Madabushi Seshacharyulu, Jagjeevan Babu Geddam, Prabhaka
Annals of Human Biology.2018; 45(2): 133. CrossRef - Relationship between vitamin D status and leukocytes in hospitalised cats
Helen F Titmarsh, Jennifer A Cartwright, Scott Kilpatrick, Donna Gaylor, Elspeth M Milne, Jacqueline L Berry, Nicholas X Bommer, Danièlle Gunn-Moore, Nicola Reed, Ian Handel, Richard J Mellanby
Journal of Feline Medicine and Surgery.2017; 19(4): 364. CrossRef - Vitamin D Status and Gestational Diabetes: Effect of Smoking Status during Pregnancy
Linda Dodds, Christy G. Woolcott, Hope Weiler, Anne Spencer, Jean‐Claude Forest, B. Anthony Armson, Yves Giguère
Paediatric and Perinatal Epidemiology.2016; 30(3): 229. CrossRef - Modification of the association between smoking status and severity of coronary stenosis by vitamin D in patients suspected of coronary heart disease
Kuibao Li, Xiyan Yang, Lefeng Wang, Mulei Chen, Wenshu Zhao, Li Xu, Xinchun Yang
Medicine.2016; 95(36): e4817. CrossRef
First
Prev
