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6 "Helicobacter pylori"
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Review
Helicobacter pylori Infection and Risk of Gastric Cancer in Korea: A Quantitative Systematic Review
Jong-Myon Bae, Eun Hee Kim
J Prev Med Public Health. 2016;49(4):197-204.   Published online July 7, 2016
DOI: https://doi.org/10.3961/jpmph.16.024
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  • 19 Crossref
AbstractAbstract PDF
Objectives
In the context of the global decrease in mortality due to gastric cancer, previous studies have reported that the effect of chronic Helicobacter pylori (H. pylori) infection on the incidence of gastric cancer varies among regions. This systematic review was conducted to investigate H. pylori as a risk factor for gastric cancer in Korea, where the incidence of gastric cancer is among the highest in the world.
Methods
A search strategy was established to identify articles published in Korean as well as in English. Ultimately, we included observational studies conducted among Korean patients that designed with an age-matched and sex-matched control group that reported the odds ratio associated with H. pylori. Gastric cancer cases were subdivided into overall (OGC), cardia (CGC), non-cardia (NGC), early (EGC), advanced, intestinal (IGC), and diffuse forms of gastric cancer. Summary odds ratios (SORs) with 95% confidence intervals (CIs) were calculated in the meta-analysis using a random-effect model.
Results
Eleven case-control studies were ultimately selected. H. pylori was associated with an SOR of 1.81 (95% CI, 1.29 to 2.54) for OGC. Additionally, statistically significant risks were observed for CGC, NGC, EGC, and IGC.
Conclusions
Chronic H. pylori infection was found to raise the risk of gastric cancer among Koreans, with the highest risk observed for CGC and EGC (SOR=2.88 for both). Follow-up clinical epidemiologic studies are needed to assess the effects of current treatments aimed at eradicating H. pylori infections.
Summary

Citations

Citations to this article as recorded by  
  • The Utility of Gastrointestinal Endoscopic Examination Versus Positron Emission Tomography–Computed Tomography in the Detection of Second Primary Lesions in Korean Patients With Head and Neck Cancer
    Min-Su Kim, In Sik Song, Kyoung Ho Oh, Jae-Gu Cho, Seung-Kuk Baek, Jeong-Soo Woo, Kwang-Yoon Jung, Soon Young Kwon
    Ear, Nose & Throat Journal.2022; 101(2): NP50.     CrossRef
  • Effect of Helicobacter pylori Eradication on Gastric Cancer Prevention: Updated Report From a Randomized Controlled Trial With 26.5 Years of Follow-up
    Lingjun Yan, Ying Chen, Fa Chen, Tao Tao, Zhijian Hu, Junzhuo Wang, Jianwang You, Benjamin C.Y. Wong, Jianshun Chen, Weimin Ye
    Gastroenterology.2022; 163(1): 154.     CrossRef
  • Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta‐Analysis
    Seung Joo Kang, Cheol Min Shin, Joohon Sung, Nayoung Kim
    Alcoholism: Clinical and Experimental Research.2021; 45(1): 6.     CrossRef
  • Antioxidant-Rich Diet, GSTP1 rs1871042 Polymorphism, and Gastric Cancer Risk in a Hospital-Based Case-Control Study
    Jimi Kim, Hyejin Kim, Jeonghee Lee, Il Ju Choi, Young-Il Kim, Jeongseon Kim
    Frontiers in Oncology.2021;[Epub]     CrossRef
  • Disaggregated mortality from gastrointestinal cancers in Asian Americans: Analysis of United States death records
    Robert J. Huang, Nora Sharp, Ruth Talamoa, Kristopher Kapphahn, Vedant Sathye, Bryant Lin, Malathi Srinivasan, Latha P. Palaniappan
    International Journal of Cancer.2021; 148(12): 2954.     CrossRef
  • Asian gastric cardia adenocarcinoma: A distinct and understudied cancer with etiologic similarities to both esophageal squamous cell carcinoma and noncardia gastric adenocarcinoma
    Christian C. Abnet
    Journal of the National Cancer Center.2021; 1(2): 44.     CrossRef
  • Population Attributable Fraction of Helicobacter pylori Infection–Related Gastric Cancer in Korea: A Meta-Analysis
    Yoon Park, Moran Ki
    Cancer Research and Treatment.2021; 53(3): 744.     CrossRef
  • Helicobacter pylori Is Associated With Precancerous and Cancerous Lesions of the Gastric Cardia Mucosa: Results of a Large Population-Based Study in China
    Shuanghua Xie, Shaoming Wang, Liyan Xue, Daniel R. S. Middleton, Chentao Guan, Changqing Hao, Jinwu Wang, Bianyun Li, Ru Chen, Xinqing Li, Wenqiang Wei
    Frontiers in Oncology.2020;[Epub]     CrossRef
  • Vitamin D Status and Gastric Cancer: A Cross-Sectional Study in Koreans
    Jung Hyun Kwak, Jean Kyung Paik
    Nutrients.2020; 12(7): 2004.     CrossRef
  • Impact of previous metronidazole exposure on metronidazole-based second-line quadruple therapy for Helicobacter pylori infection
    Gil Ho Lee, Kee Myung Lee, Sung Jae Shin, Joon Koo Kang, Choong-Kyun Noh, Jin Hong Kim, Sun Gyo Lim
    The Korean Journal of Internal Medicine.2020; 35(5): 1094.     CrossRef
  • Unraveling the identity of gastric cardiac cancer
    Qin Huang, Matthew Read, Jason S. Gold, Xiao Ping Zou
    Journal of Digestive Diseases.2020; 21(12): 674.     CrossRef
  • Smoking status and subsequent gastric cancer risk in men compared with women: a meta-analysis of prospective observational studies
    Wen-Ya Li, Yunan Han, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao
    BMC Cancer.2019;[Epub]     CrossRef
  • Risk of malignancy in patients with psoriasis: a 15‐year nationwide population‐based prospective cohort study in Korea
    J.W. Lee, K.J. Jung, T.G. Kim, M. Lee, J. Oh, S.H. Jee, M.G. Lee
    Journal of the European Academy of Dermatology and Venereology.2019; 33(12): 2296.     CrossRef
  • Epidemiology of gastric cancer in Korea
    Kwang-Pil Ko
    Journal of the Korean Medical Association.2019; 62(8): 398.     CrossRef
  • Cathepsin S as a target in gastric cancer (Review)
    Adriano Da Costa, Fernando Santa‑Cruz, Luiz Mattos, Maria Aquino, Camila Martins, �lvaro Ferraz, Jos� Figueiredo
    Molecular and Clinical Oncology.2019;[Epub]     CrossRef
  • Environmental contributions to gastrointestinal and liver cancer in the Asia–Pacific region
    Kwang‐Pil Ko, Aesun Shin, Sooyoung Cho, Sue K Park, Keun‐Young Yoo
    Journal of Gastroenterology and Hepatology.2018; 33(1): 111.     CrossRef
  • Comparative analysis of the Hom family of outer membrane proteins in isolates from two geographically distinct regions: The United States and South Korea
    Stephanie L. Servetas, Aeryun Kim, Hanfu Su, Jeong‐Heon Cha, D. Scott Merrell
    Helicobacter.2018;[Epub]     CrossRef
  • Family history of gastric cancer is associated with the risk of colorectal neoplasia in Korean population
    Yoon Suk Jung, Nam Hee Kim, Hyo-Joon Yang, Soo-Kyung Park, Jung Ho Park, Dong Il Park, Chong Il Sohn
    Digestive and Liver Disease.2017; 49(10): 1155.     CrossRef
  • Association between alcohol consumption and the risk of gastric cancer: a meta-analysis of prospective cohort studies
    Zheng He, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Zhong-Ran Ni, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao
    Oncotarget.2017; 8(48): 84459.     CrossRef
Original Article
Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China
Xiang-Quan Xie, Kui-Cheng Zheng, Bing-Shan Wu, Tie-Hui Chen, Shan-Rong Lai, Zai-Sheng Lin, Kazuo Aoki
J Prev Med Public Health. 2014;47(5):281-287.   Published online September 12, 2014
DOI: https://doi.org/10.3961/jpmph.14.018
  • 10,762 View
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  • 3 Crossref
AbstractAbstract PDF
Objectives
In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increased risk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogen I:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthy dietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developing gastric cancer than those in Nanjing do.
Summary

Citations

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  • Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China
    Zhao Zhai, Zi-Yu Zhu, Xi-Liang Cong, Bang-Ling Han, Jia-Liang Gao, Xin Yin, Yu Zhang, Sheng-Han Lou, Tian-Yi Fang, Yi-Min Wang, Chun-Feng Li, Xue-Feng Yu, Yan Ma, Ying-Wei Xue
    World Journal of Gastrointestinal Oncology.2020; 12(10): 1119.     CrossRef
  • Poor expression of microRNA‐135b results in the inhibition of cisplatin resistance and proliferation and induces the apoptosis of gastric cancer cells through MST1‐mediated MAPK signaling pathway
    Jie Zhou, Qing Chen
    The FASEB Journal.2019; 33(3): 3420.     CrossRef
  • HLA‐DQB1*03 genotype and perioperative blood transfusion are not conducive to the prognosis of patients with gastric cancer
    Shen‐Kang Zhou, Lei‐Lei Yang, Rui Chen, Yong Lu, Yong‐Hua Zheng
    Journal of Clinical Laboratory Analysis.2018;[Epub]     CrossRef
English Abstract
The Prevalence of Atrophic Gastritis and Intestinal Metaplasia according to Gender, Age and Helicobacter Pylori Infection in a Rural Population.
Hyun Ja Kim, Bo Youl Choi, Tae Joon Byun, Chang Soo Eun, Kyu Sang Song, Yong Sung Kim, Dong Soo Han
J Prev Med Public Health. 2008;41(6):373-379.
DOI: https://doi.org/10.3961/jpmph.2008.41.6.373
  • 6,033 View
  • 168 Download
  • 24 Crossref
AbstractAbstract PDF
OBJECTIVES
The objective of this study was to evaluate the prevalence of atrophic gastritis and intestinal metaplasia according to gender, age and Helicobacter pylori infection in a rural population in Korea. METHODS: Between April 2003 and January 2007, 713 subjects (298 men and 415 women, age range: 18-85) among the 2,161 adults who participated in a populationbased survey received gastrointestinal endoscopy. All the subjects provided informed consent. Multiple biopsy specimens were evaluated for the presence of atrophic gastritis and intestinal metaplasia. The presence of Helicobacter pylori was determined using CLO and histology testing. RESULTS: The age-adjusted prevalence of atrophic gastritis was 42.7% for men and 38.1% for women and the prevalence of intestinal metaplasia was 42.5% for men and 32.7% for women. The prevalence of atrophic gastritis and intestinal metaplasia increased significantly with age for both men and women (p for trend<0.001). The ageadjusted prevalence of Helicobacter pylori was similar for men (59.0%) and women (56.7%). The subjects with Helicobacter pylori infection showed a significantly higher prevalence of intestinal metaplasia (44.3%) compared with that (26.8%) of the noninfected subjects (p<0.001). However, the prevalence of atrophic gastritis was not statistically different between the Helicobacter pyloriinfected subjects and the noninfected individuals. CONCLUSIONS: Our findings suggest that the prevalence of atrophic gastritis and intestinal metaplasia is higher for a Korean rural population than that for a Western population; this may be related to the high incidence of gastric cancer in Koreans. Especially, the prevalence of intestinal metaplasia was high for the subjects with Helicobacter pylori infection. The multistep process of gastric carcinogenesis and the various factors contributing to each step of this process need to be determined by conducting future follow-up studies.
Summary

Citations

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    Mingee Choi, Woo-Ri Lee, Kyu-Tae Han, Woorim Kim
    Cancer Causes & Control.2024; 35(4): 705.     CrossRef
  • Clinical Practice Guideline for Gastritis in Korea
    Seung Joo Kang, Jae Gyu Kim, Hee Seok Moon, Myeong-Cherl Kook, Jong Yeul Lee, Chang Seok Bang, Chung Hyun Tae, Eun Jeong Gong, Su Youn Nam, Hyun Jung Kim
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2024; 24(2): 143.     CrossRef
  • Validation of a Novel Endoscopic Feature that Predicts Helicobacter pylori-negative Status: Does the Scratch Sign Reflect H. pylori Non-infection?
    Jun-young Seo, Hyo-Jin Cho, Sang Jong Park, Ah Young Lee, Sang-Jung Kim, Ji Yong Ahn
    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2023; 23(3): 197.     CrossRef
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    Seung Joo Kang, Jae Gyu Kim, Hee Seok Moon, Myeong-Cherl Kook, Jong Yeul Lee, Chang Seok Bang, Chung Hyun Tae, Eun Jeong Gong, Su Youn Nam, Hyun Jung Kim
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Prevalencia y localización gástrica del Helicobacter pylori en pacientes con atrofia y metaplasia intestinal en una institución de alta complejidad en Colombia
    Claudia Corso, Diego Mauricio Aponte, Javier Preciado, Jorge Medina-Parra, Luis Carlos Sabbagh Sanvicente
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    Journal of Drug Assessment.2021; 10(1): 57.     CrossRef
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    JGH Open.2020; 4(4): 569.     CrossRef
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    World Journal of Gastroenterology.2019; 25(26): 3344.     CrossRef
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    The Korean Journal of Helicobacter and Upper Gastrointestinal Research.2018; 18(1): 13.     CrossRef
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    Yo Han Park, Nayoung Kim
    Journal of Cancer Prevention.2015; 20(1): 25.     CrossRef
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    Ho Suk Kang, Jeong Hwan Kim
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    Joon Sung Kim, Byung-Wook Kim
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Original Article
Community-based Helicobacter pylori Screening and its Effects on Eradication in Patients with Dyspepsia.
Seong Ho Kim, Dae Yong Hong, Pock Soo Kang, Seok Beom Kim, Kyeong Soo Lee, Sang Kyu Kim, Jeong Ill Suh, Mee Kyung Kim
Korean J Prev Med. 2000;33(3):285-298.
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AbstractAbstract PDF
CONCLUSIONS: To investigate the positive rate of Helicobacter pylori in patients with dyspepsia; medical compliance and related factors; the eradication rate a year after screening and related factors; the relationship between the eradication of Helicobacter pylori and the improvement of symptoms; and the estimated cost of three alternative approaches to treat Helicobacter pylori in the community. METHODS: A total of 510 subjects with dyspeptic symptoms were selected and given the serological test in March 1998. The subjects were all adults over 30 years of age residing in Kyongju city. RESULTS: Of the 510 selected subjects, 375 (73.5%) subjects proved positive for Helicobacter pylori on serological testing. Of these 304 (81.1%) who consented to an endoscopic examination, underwent a Campylobacter-like organism (CLO) test. Of these 304 subjects, 204 (67.1%), who had positive CLO test results, were given the triple therapy - tripotassium dicitrato bismuthate, amoxicillin, and metronidazole. To determine the eradication rate of Helicobacter pylori, 181 (88.7%) out of the 204 subjects who were given the triple therapy completed a follow-up urea breath test one year later. Of these, the Helicobacter pylori of 87(48.1%) subjects was eradicated. Among the 122 subjects who were medication compliant, the Helicobacter pylori eradication rate was 57.4% (70 subjects), while the eradication rates was only 28.8% (17subjects) in the non-compliant group. The Helicobacter pylori eradication was significantly related to compliance (p<0.01), but not to other characteristics and habits. The symptom improvement rate tended to be higher 62.1%), in the Helicobacter pylori eradicated group than in the non-eradicated group (59.6%). CONCLUSIONS: When the advantages and disadvantages of each alternative treatment were considered in the light of cost, antibiotic tolerance and the number of patients to be treated, alternative II was favorable in terms of cost. Alternative III was favorable in terms of the number of patients to be treated, antibiotic tolerance and early detection of gastric cancer. Further long-term research analyzing the cost-benefit and cost-effectiveness of each treatment will be needed as supporting material in creating new policies.
Summary
Meta-Analysis
Meta Analysis of Symptom Improvement through Eradication of Helicobacter pylori in Patients with Non-ulcer Dyspepsia.
Sung Jun Kim, Sang Hwa Ohm, Ki Won Jeong, Won Chang Shin, Jong Rae Cho, Hye Suk Shon, Ki Taek Pae
Korean J Prev Med. 1999;32(4):427-434.
  • 1,913 View
  • 28 Download
AbstractAbstract PDF
OBJECTIVES
This study was conducted to determine, by reviewing the literature, whether treatment of Helicobacter pylori infection in patients with non-ulcer dyspepsia affects symptoms. METHODS: We retrieved the literature using MEDLINE search, with nonulcer dyspepsia and Hericobacter pylori and treatment as key words, which were reported from 1984 to 1998, and manual literature search. The criteria for inclusion was as follows; 1) The paper should have confirmed nonulcer dyspepsia as case definition. 2) The paper should have performed a randomized, blind trial. 3) Confirmation of Helicobacter pylori eradication should be done 4 weeks after treatment. 4) studies with no information on measurement of symptoms after treatment were not accepted. The percentage of patients with symptom improvement after eradication therapy for Helicobacter pylori infection was calculated. Cumulative odds ratio was compared by fixed effect model and random effect model as sensitivity and funnel plot was used to evaluate publication bias. RESULTS: The overall effect size of symptom improvement was calculated by cumulative odds ratio. Cumulative odds ratio of random effect model was 4.16(95% CI: 1.55-11.19). Before integrating each effect sizes into common effect size, the homogeneity test was conducted and random effect model was selected(Cochran's Q=41.08 (d.f=10, p<0.001)). The heterogeneity across studies was evaluated and the different methodological aspects of studies led to differences between study results. CONCLUSIONS: The results suggest that the eradication of Helicobacter pylori in patients with non-ulcer dyspepsia results more symptom improvement. In studies that shows the opposite results there are methodological aspects explaining the heterogeneity.
Summary
Original Article
The Seroprevalence and Related Factors of Helicobacter pylori Infection.
Yeung Wook Kim, Su Ill Lee, Byung Mann Cho, Young Sil Kim, Su Yong Kang, Oae Ri Cha, Don Kyoun Kim
Korean J Prev Med. 1996;29(3):669-678.
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AbstractAbstract PDF
Helicobacter pylori is now recognized as causative agent of chronic gastritis and peptic ulcer, and strongly associated with development of gastric carcinoma. With development of sensitive and specific serologic tests to identify individuals infected with Helicobacter pylori, the epidemiologic study of this diseases has been investigated. But it's transmission route is not established, yet. The purpose of this study is to measure the prevalence of Helicobacter pylori infection in healthy children and young adults and to evaluate related factors for Helicobacter pylori infection in Korea. The seroprevalence of Ig G antibodies to Helicobacter pylori was determined using a Enzyme Linked Immunosorbent Assay and we obtained the information, such as demographic characteristics, monthly household income, numbers of family members in the house, numbers of persons using same room, type of house, and type of drinking water through the questionnaire survey. The observed overall seropositivity rate was 25.7%. The rate is increased progressively from 5.8% in the age group 1~3 years to 44.4% in the age group 20~29 years(chi-square for trend, p<0.001). Especially, the rate increased steeply from 6.5% in the age group 4~6 years to 20.8% in the age group 7~9 years, and this suggested that elementary school age was the major acquisition time of Helicobacter pylori infection. In multivariate logistic regression model, age, numbers of family members in the house, and type of house was statistically significant variables for Helicobacter pylori infection. Each odds ratio(95% CI) were as follows; base to age group 1~9 years, age group 10~19 years 3.6(2.0~6.4), age group 20~29 years 7.3(4.1~13.1) and base to group of 1~3 family members, groups of 4~5 family members 2.1(1.1~4.0), group of 6 or more family members 2.7(1.3~5.4) and base to apartment, single and multihouse 1.9(1.1~3.5). Sex, monthly household income, numbers of persons using same room, and type of drinking water was not statistically significant for Helicobacter pylori infection.
Summary

JPMPH : Journal of Preventive Medicine and Public Health