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JPMPH : Journal of Preventive Medicine and Public Health



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2 "Kui-Cheng Zheng"
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Original Articles
Differences in the Levels of Gastric Cancer Risk Factors Between Nanjing and Minqing Counties, China
Xiang-Quan Xie, Kui-Cheng Zheng, Bing-Shan Wu, Tie-Hui Chen, Shan-Rong Lai, Zai-Sheng Lin, Kazuo Aoki
J Prev Med Public Health. 2014;47(5):281-287.   Published online September 12, 2014
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  • 82 Download
  • 3 Crossref
AbstractAbstract PDF
In Fujian Province, China, gastric cancer is one of the leading causes of mortality among all malignant tumors. Nanjing county and Minqing county are located in inland Fujian and have similar general demographics. However, the adjusted mortality rate of gastric cancer in Minqing was found to be much higher than that in Nanjing. We sought to explore factors associated with this increased risk of gastric cancer between the two counties. Methods: We recruited 231 and 224 residents from Nanjing and Minqing, respectively, and analyzed differences between their dietary habits, Helicobacter pylori infection rates, and concentrations of serum pepsinogen I, pepsinogen II, gastrin-17, and ratio of pepsinogen I:II. Results: Subjects in Minqing had more first-degree relatives who had been diagnosed with upper gastrointestinal tumor, more unhealthy dietary habits, a higher Helicobacter pylori positive rate, and greater proportion of abnormal serum gastrin-17 than those in Nanjing did. Conclusions: The factors that differed between these two counties might indicate that residents in Minqing have a higher risk for developing gastric cancer than those in Nanjing do.


Citations to this article as recorded by  
  • Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China
    Zhao Zhai, Zi-Yu Zhu, Xi-Liang Cong, Bang-Ling Han, Jia-Liang Gao, Xin Yin, Yu Zhang, Sheng-Han Lou, Tian-Yi Fang, Yi-Min Wang, Chun-Feng Li, Xue-Feng Yu, Yan Ma, Ying-Wei Xue
    World Journal of Gastrointestinal Oncology.2020; 12(10): 1119.     CrossRef
  • Poor expression of microRNA‐135b results in the inhibition of cisplatin resistance and proliferation and induces the apoptosis of gastric cancer cells through MST1‐mediated MAPK signaling pathway
    Jie Zhou, Qing Chen
    The FASEB Journal.2019; 33(3): 3420.     CrossRef
  • HLA‐DQB1*03 genotype and perioperative blood transfusion are not conducive to the prognosis of patients with gastric cancer
    Shen‐Kang Zhou, Lei‐Lei Yang, Rui Chen, Yong Lu, Yong‐Hua Zheng
    Journal of Clinical Laboratory Analysis.2018;[Epub]     CrossRef
IL-4 and IL-5 Secretions Predominate in the Airways of Wistar Rats Exposed to Toluene Diisocyanate Vapor
Kouame Kouadio, Kui-Cheng Zheng, Abdoulaye Abba Toure, Mireille Dosso, Hidemi Todoriki
J Prev Med Public Health. 2014;47(1):57-63.   Published online January 29, 2014
  • 8,137 View
  • 95 Download
  • 1 Crossref
AbstractAbstract PDF

We established a Wistar rat model of asthma caused by toluene diisocyanate (TDI) exposure, and investigated the relationship between TDI exposure concentrations and respiratory hypersensitivity, airway inflammation, and cytokine secretions in animals, to better understand the mechanism of TDI induced occupational asthma.


Wistar rats were exposed to two different concentrations of TDI vapor four hours a day for five consecutive days. Bronchoalveolar lavage (BAL) was performed, and differential leucocytes from the BAL fluid were analyzed. Lung histopathological examination was carried out to investigate the inflammatory status in the airways. Production of cytokines interleukin (IL)-4 and IL-5 productions in the BAL fluid in vivo was determined with enzyme-linked immunosorbent assay kits.


The TDI-exposed rats exhibited greater airway hypersensitivity symptoms than the control rats. The BAL differential cell count and lung histopathological examination demonstrated that inflammation reactions were present in both the central and peripheral airways, characterized with marked infiltration of eosinophils in the TDI-exposed rats. The cytokine assay showed that IL-4 and IL-5 were predominantly produced in the BAL fluid in vivo.


These findings imply that TDI exposure concentrations may greatly affect the occurrence and extent of inflammatory events and that Th2 type cytokines may play an important role in the immunopathogenesis of TDI-induced occupational respiratory hypersensitivity.



Citations to this article as recorded by  
  • Evaluation of animal toxicity studies with diisocyanates regarding presence of thresholds for induction and elicitation of respiratory allergy by quantitative weight of evidence
    Wolfgang Dekant, Thomas Colnot
    Toxicology and Industrial Health.2022; 38(9): 578.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health