KSPM
Search
- Page Path
- HOME > Search
Original Article
- Association Between Parental BMI and Offspring’s Blood Pressure by Mediation Analysis: A Study Using Data From the Korean National Health and Nutrition Examination Survey
- Hyowon Choi, Hunju Lee, Yeon-Soon Ahn
- J Prev Med Public Health. 2023;56(6):533-541. Published online October 30, 2023
- DOI: https://doi.org/10.3961/jpmph.23.289
- 1,424 View
- 72 Download
-
Abstract
Summary
PDF
Supplementary Material - Objectives
This study analyzed the relationship between parental body mass index (BMI; BMI_p) and hypertension in their adolescent offspring (HTN_a), focusing on the mediating effect of adolescents’ BMI (BMI_a).
Methods
Utilizing data from the Korea National Health and Nutrition Examination Survey, including participants aged 12-18, we conducted a mediation analysis while controlling for confounding factors such as age, sex, physical activity, dietary habits, household income quartile, and parents’ alcohol and smoking habits.
Results
The study included a total of 5731 participants, of whom 3381 and 5455 participants had data on fathers’ and mothers’ BMI, respectively. For adolescent systolic blood pressure (SBP_a), the father’s BMI (BMI_f) had a significant total effect (β, 0.23; 95% confidence interval [CI], 0.12 to 0.34) and average controlled mediated effect (ACME) (β, 0.27; 95% CI, 0.23 to 0.32), but the average direct effect (ADE) was not significant. The mother’s BMI (BMI_m) had a significant total effect (β, 0.17; 95% CI, 0.09 to 0.25), ACME (β, 0.25; 95% CI, 0.22 to 0.28) and ADE (β, -0.08; 95% CI, -0.16 to 0.00). For adolescent diastolic blood pressure, both BMI_f and BMI_m had significant ACMEs (β, 0.10; 95% CI, 0.08 to 0.12 and β, 0.09; 95% CI, 0.07 to 0.12, respectively), BMI_m had a significant ADE (β, -0.09; 95% CI, -0.16 to -0.02) but BMI_f had an insignificant ADE and total effect.
Conclusions
The study found that parental BMI had a significant effect on SBP_a, mediated through BMI_a. Therefore, a high BMI in parents could be a risk factor, mediated through BMI_a, for systolic hypertension in adolescents, necessitating appropriate management. -
SummaryKorean summary
본 연구를 통해 부모의 BMI가 청소년기의 BMI를 매개하여 청소년의 수축기 혈압에 영향을 미침을 확인할 수 있었습니다. 그러나 본 연구는 단면적인 데이터를 활용하였으며, 후향적 연구로 이에 대한 한계를 가지고 있으며, 이후 이에 대한 추가 연구가 필요합니다.Key Message
This study was able to confirm that parents' BMI mediated their BMI during adolescence and affected systolic blood pressure in adolescents. However, this study utilized cross-sectional data, and has limitations on this as a retrospective study, so further studies are needed.
Special Articles
- An Introduction to Causal Mediation Analysis With a Comparison of 2 R Packages
- Sangmin Byeon, Woojoo Lee
- J Prev Med Public Health. 2023;56(4):303-311. Published online July 31, 2023
- DOI: https://doi.org/10.3961/jpmph.23.189
- 4,317 View
- 275 Download
- 2 Web of Science
- 2 Crossref
-
Abstract
Summary
PDFSupplementary Material
- Traditional mediation analysis, which relies on linear regression models, has faced criticism due to its limited suitability for cases involving different types of variables and complex covariates, such as interactions. This can result in unclear definitions of direct and indirect effects. As an alternative, causal mediation analysis using the counterfactual framework has been introduced to provide clearer definitions of direct and indirect effects while allowing for more flexible modeling methods. However, the conceptual understanding of this approach based on the counterfactual framework remains challenging for applied researchers. To address this issue, the present article was written to highlight and illustrate the definitions of causal estimands, including controlled direct effect, natural direct effect, and natural indirect effect, based on the key concept of nested counterfactuals. Furthermore, we recommend using 2 R packages, ‘medflex’ and ‘mediation’, to perform causal mediation analysis and provide public health examples. The article also offers caveats and guidelines for accurate interpretation of the results.
-
SummaryKorean summary
전통적 매개분석은 여러 유형의 변수 혹은 복잡한 상호작용을 포함할 경우, 직접 및 간접효과의 정의가 불분명하다는 비판에 직면해왔다. 이에 대한 대안으로서 인과매개분석은 반사실적 개념에 기반하여 직접 및 간접효과를 명료하게 정의하며 유연한 모델링을 가능하게 한다. 다만 이 새로운 접근의 주요 개념을 응용 연구자들이 이해하는 데에는 다소 어려운 측면이 있다. 이러한 점에서 이 논문에서는 중첩된 반사실적 변수에 기반한 인과적 모수의 정의를 상술하고 인과매개분석을 위한 대표적인 R 패키지인 medflex 및 mediation을 활용하여 공공 보건 사례에 대한 분석 실례 및 유의사항을 제공하였다. -
Citations
Citations to this article as recorded by
- Social class and moral judgment: a process dissociation perspective
Andreas Tutic, Friederike Haiser, Ivar Krumpal
Frontiers in Sociology.2024;[Epub] CrossRef - Mortality Benefits of Cardiac Rehabilitation in Coronary Artery Disease Are Mediated by Comprehensive Risk Factor Modification: A Retrospective Cohort Study
Codie R. Rouleau, Daniele Chirico, Stephen B. Wilton, Matthew K. MacDonald, Tianqi Tao, Ross Arena, Tavis Campbell, Sandeep Aggarwal
Journal of the American Heart Association.2024;[Epub] CrossRef
- Social class and moral judgment: a process dissociation perspective
- Introduction to Mediation Analysis and Examples of Its Application to Real-world Data
- Sun Jae Jung
- J Prev Med Public Health. 2021;54(3):166-172. Published online May 7, 2021
- DOI: https://doi.org/10.3961/jpmph.21.069
- 8,832 View
- 417 Download
- 14 Web of Science
- 17 Crossref
-
Abstract
Summary
PDF
- Traditional epidemiological assessments, which mainly focused on evaluating the statistical association between two major components-the exposure and outcome-have recently evolved to ascertain the in-between process, which can explain the underlying causal pathway. Mediation analysis has emerged as a compelling method to disentangle the complex nature of these pathways. The statistical method of mediation analysis has evolved from simple regression analysis to causal mediation analysis, and each amendment refined the underlying mathematical theory and required assumptions. This short guide will introduce the basic statistical framework and assumptions of both traditional and modern mediation analyses, providing examples conducted with real-world data.
-
SummaryKorean summary
본 리뷰에서는 전통적으로 쓰여왔던 회귀분석 기반 매개요인분석방법과 인과적 매개요인분석방법에 대하여 간략히 소개하며, 또한 예시를 들어 설명하고 있다. 매개요인 분석 전에는 필요한 가정들이 맞는 지를 확인하는 것이 중요하다. 또한 분석결과를 올바르게 해석하는 것 또한 요구된다. 이러한 방법은 그동안의 노출-결과만을 다루는 단순 역학연구을 뛰어넘어, 인구집단연구에서 매커니즘을 밝히는 도구로서 유용하게 쓰일 것이다. -
Citations
Citations to this article as recorded by- Residential greenspace and blood lipids in an essential hypertension population: Mediation through PM2.5 and chemical constituents
Ruoyi Lei, Ling Zhang, Xin Liu, Ce Liu, Ya Xiao, Baode Xue, Zengwu Wang, Jihong Hu, Zhoupeng Ren, Bin Luo
Environmental Research.2024; 240: 117418. CrossRef - The mediation roles of intermuscular fat and inflammation in muscle mitochondrial associations with cognition and mobility
Qu Tian, Philip R. Lee, Qi Yang, Anne Z. Moore, Bennett A. Landman, Susan M. Resnick, Luigi Ferrucci
Journal of Cachexia, Sarcopenia and Muscle.2024; 15(1): 138. CrossRef - Mediators of the Association Between Socioeconomic Status and Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review
Nicholas Grubic, Braeden Hill, Katherine S. Allan, Katerina Maximova, Hailey R. Banack, Marina del Rios, Amer M. Johri
Canadian Journal of Cardiology.2024; 40(6): 1088. CrossRef - Airway inflammation accelerates pulmonary exacerbations in cystic fibrosis
Theodore G. Liou, Natalia Argel, Fadi Asfour, Perry S. Brown, Barbara A. Chatfield, David R. Cox, Cori L. Daines, Dixie Durham, Jessica A. Francis, Barbara Glover, My Helms, Theresa Heynekamp, John R. Hoidal, Judy L. Jensen, Christiana Kartsonaki, Ruth Ke
iScience.2024; 27(3): 108835. CrossRef - Association Between Improved Serum Fatty Acid Profiles and Cognitive Function During a Dietary Intervention Trial in Relapsing-Remitting Multiple Sclerosis
Solange M. Saxby, Carlyn Haas, Farnoosh Shemirani, Tyler J. Titcomb, Patrick Ten Eyck, Linda M. Rubenstein, Karin F. Hoth, Linda G. Snetselaar, Terry L. Wahls
International Journal of MS Care.2024; 26(2): 61. CrossRef - Effects of Covid-19-related anxiety on overeating and weight gain in a diverse college sample
Stephanie Guzman, Robert D. Melara
Journal of American College Health.2024; : 1. CrossRef - Childhood undernutrition mediates the relationship between open defecation with anemia among Ethiopian children: a nationally representative cross-sectional study
Biniyam Sahiledengle, Pammla Petrucka, Fikreab Desta, Yordanos Sintayehu, Telila Mesfin, Lillian Mwanri
BMC Public Health.2024;[Epub] CrossRef - Mixed heavy metals exposure affects the renal function mediated by 8-OHG: A cross-sectional study in rural residents of China
Xiaoyu Tian, Xiaobing Shan, Li Ma, Chenyang Zhang, Mei Wang, Jie Zheng, Ruoyi Lei, Li He, Jun Yan, Xun Li, Yanjun Bai, Keqin Hu, Sheng Li, Jingping Niu, Bin Luo
Environmental Pollution.2023; 317: 120727. CrossRef - Association between the overall burden of comorbidity and Ct values among the older patients with Omicron infection: Mediated by inflammation
Meixia Wang, Hongfei Mi, Na Li, Qingfeng Shi, Wei Sun, Tingjuan He, Jiabing Lin, Wenting Jin, Xiaodong Gao, Bijie Hu, Chenghao Su, Jue Pan
Frontiers in Immunology.2023;[Epub] CrossRef - Preferences of Young Polish Renters: Findings from the Mediation Analysis
Janusz Sobieraj, Marek Bryx, Dominik Metelski
Buildings.2023; 13(4): 920. CrossRef - Association of serum homocysteine, folate, and vitamin B12 and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial
Farnoosh Shemirani, Tyler J. Titcomb, Solange M. Saxby, Patrick Ten Eyck, Linda M. Rubenstein, Karin F. Hoth, Linda G. Snetselaar, Terry L. Wahls
Multiple Sclerosis and Related Disorders.2023; 75: 104743. CrossRef - Mediation Analysis of Maternal Smoking, Gestational Age, and Birth Weight on the Texas–Mexico Border
Chinodebem Ogbutor, Stephanie M. Mishaw, Zuber D. Mulla
Southern Medical Journal.2023; 116(6): 478. CrossRef - Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction
Jiajia Wang, Shen Shen, Bing Yan, Yunsheng He, Guoji Zhang, Chunguang Shan, Qintai Yang, Long Qin, Zhijian Duan, Luyun Jiang, Xin Wang, Xin Wei, Chengshuo Wang, Rui Chen, Luo Zhang
Environment International.2023; 177: 108031. CrossRef - The association between lead exposure and crime: A systematic review
Maria Jose Talayero, C. Rebecca Robbins, Emily R. Smith, Carlos Santos-Burgoa, Naveen Puttaswamy
PLOS Global Public Health.2023; 3(8): e0002177. CrossRef - Mediation analysis of mental health characteristics linking social needs to life satisfaction among immigrants
David Adzrago, Faustine Williams
SSM - Population Health.2023; 24: 101522. CrossRef - Maternal anemia and baby birth size mediate the association between short birth interval and under-five undernutrition in Ethiopia: a generalized structural equation modeling approach
Desalegn Markos Shifti, Catherine Chojenta, Elizabeth G. Holliday, Deborah Loxton
BMC Pediatrics.2022;[Epub] CrossRef - Association of Elevated Maternal Psychological Distress, Altered Fetal Brain, and Offspring Cognitive and Social-Emotional Outcomes at 18 Months
Yao Wu, Kristina M. Espinosa, Scott D. Barnett, Anushree Kapse, Jessica Lynn Quistorff, Catherine Lopez, Nickie Andescavage, Subechhya Pradhan, Yuan-Chiao Lu, Kushal Kapse, Diedtra Henderson, Gilbert Vezina, David Wessel, Adré J. du Plessis, Catherine Lim
JAMA Network Open.2022; 5(4): e229244. CrossRef
- Residential greenspace and blood lipids in an essential hypertension population: Mediation through PM2.5 and chemical constituents
First
Prev
