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Original Articles
- Replication of Early B-cell Factor 1 (EBF1) Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population
- Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min
- J Prev Med Public Health. 2016;49(5):253-259. Published online July 10, 2016
- DOI: https://doi.org/10.3961/jpmph.16.028
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- 2 Crossref
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Abstract
PDF - Objectives
Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity. Although several large-scale genome-wide association studies have reported susceptibility genes for central adiposity, the effects of interactions between genes and psychosocial stress on central adiposity have rarely been examined. A recent study focusing on Caucasians discovered the novel gene
Methods
A total of 1467 Korean adults were included in this study. We selected 22 single-nucleotide polymorphisms (SNPs) in the EBF1 gene and analyzed their interactions with stress on central adiposity using additive, dominant, and recessive genetic modeling.
Results
The four SNPs that had strong linkage disequilibrium relationships (rs10061900, rs10070743, rs4704967, and rs10056564) demonstrated significant interactions with the waist-hip ratio in the dominant model (pint<0.007). In addition, two other SNPs (rs6556377 and rs13180086) were associated with VAT by interactions with stress levels, especially in the recessive genetic model (pint<0.007). As stress levels increased, the mean values of central adiposity traits according to SNP genotypes exhibited gradual but significant changes (p<0.05).
Conclusions
These results suggest that the common genetic variants for EBF1 are associated with central adiposity through interactions with stress levels, emphasizing the importance of managing stress in the prevention of central obesity. -
Summary
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- Analysis of the Change of Health Status Among the Republic of Korea Air Force Soldiers During Military Service
- Seok-Ju Yoo, Won-Ju Park, Kwan Lee, Hyun-Sul Lim, Hyun-Jin Kim, Suk-Ho Lee
- J Prev Med Public Health. 2014;47(4):230-235. Published online July 31, 2014
- DOI: https://doi.org/10.3961/jpmph.2014.47.4.230
- 8,546 View
- 75 Download
- 2 Crossref
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Abstract
PDF
- Objectives
The aim of this study was to investigate whether the health status of Republic of Korea Air Force (ROKAF) soldiers changed after one year of military service. Methods: We selected 483 ROKAF soldiers from the 11 749 recruits who participated in the 2011 physical examination. The selected soldiers underwent another physical examination in 2012 for advancement to senior airman. Data from 2011 and 2012 were merged. To collect data on lifestyle, a questionnaire was sent to all included subjects via the military intranet e-mail service. Results: The percentage of recruits with an abnormal alanine transaminase level (normal range <40 IU/L) decreased from recruitment (13.7%) to the following year (2.7%). Moreover, the percentage of obese soldiers (body mass index ≥25 kg/m2) decreased from recruitment (20.5%) to the following year (10.4%). There was a significant change in mean duration of exercise carried out each day before (0.8±1.3 hours) and after (1.0±0.7 hours) joining the ROKAF service. Conclusions: These ROKAF soldiers were generally in good health before and after joining the armed service. After one year of military service, the health status of most soldiers improved, especially with respect to body mass index and alanine transaminase level. -
Summary
Citations
Citations to this article as recorded by- Behavioral impact of national health campaigns on healthy lifestyle practices among young adults in Singapore: a cross-sectional study
Yong Zhi Khow, Talia Li Yin Lim, Jarret Shoon Phing Ng, Jiaxuan Wu, Chuen Seng Tan, Kee Seng Chia, Nan Luo, Wei Jie Seow
BMC Public Health.2021;[Epub] CrossRef - Strategic Priorities to Improve Effectiveness of Anti-smoking Interventions for the Korean Military: An Application of the Analytic Hierarchy Process
Yun-Kyoung Song, Jae Hyun Kim, Boyoon Choi, Nayoung Han, Myeong Gyu Kim, Jeongsam Lee, Handuk Lee, Jieun Yoon, Beom-Jin Lee, Jung Mi Oh
Military Medicine.2018; 183(7-8): e223. CrossRef
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