- The Effects of Social Activities and Living Arrangements on Cognitive Functions in Middle-aged and Elderly Adults: A Panel Study Using the 2006-2018 Korean Longitudinal Study of Aging
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Yoon-Jung Choi, Yun-Chul Hong, Young-Kyung Do
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J Prev Med Public Health. 2021;54(6):395-403. Published online October 22, 2021
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DOI: https://doi.org/10.3961/jpmph.21.384
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 Abstract
Summary
 PDF Supplementary Material
- Objectives
Previous studies have shown that participation in social activities (SA) can prevent cognitive decline (CD) and that living arrangements (LA) can affect cognitive function. This study aimed to evaluate the effects of SA and LA on CD, as well as their interactions, using longitudinal data.
Methods
Data were used from the 2006-2018 Korean Longitudinal Study for Aging, which followed 10 254 adults older than 45 years over a 12-year period. CD was defined as a ≥4-point score decrease in the Mini-Mental Status Exam over 2 years. We developed an extended Cox proportional hazards model for time-dependent covariates to estimate the hazard ratio (HR) of CD in 4 groups: (1) socially active and living with others, (2) socially active and living alone, (3) socially inactive and living with others (SILO), and (4) socially inactive and living alone (SILA). The model was stratified by gender and adjusted for important confounders.
Results
The HR of CD was significantly higher in the SILO group in men (HR,1.36; 95% confidence interval [CI], 1.08 to 1.78) and in the SILA group in women (HR, 1.72; 95% CI, 1.08 to 2.75). However, the interaction term for gender was not significant.
Conclusions
Among socially inactive elderly adults, the HR of CD was elevated in men who lived with others and in women who lived alone, although the interaction term for gender was not significant. Socially inactive men who live with others and socially inactive women who live alone are particularly encouraged to participate in SA to prevent CD.
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Summary
Korean summary
고령화연구패널조사(KLoSA)(2006-2018)에 참여한 10,254명의 45세 이상 성인을 2년마다 추척하여 생존분석을 이용하여, 사회활동 참여여부와 독거 여부가 인지기능 저하에 미치는 영향을 분석하였다. 인지기능 저하는 2년동안 Mini-Mental Status Exam이 4점 이상 감소한 경우로 정의하였다. 그 결과 사회활동에 참여하지 않으면서 가족과 함께 사는 남성과, 사회활동에 참여하지 않으면서 혼자 사는 여성에서 인지기능 저하의 위험이 증가했다.
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Citations
Citations to this article as recorded by  - Association between home dwelling situations, neighborhood social interactions, and subjective cognitive decline plus among older adults: A cross-sectional study
Jing Liu, Dan Liu, Xin-Yan Xie, Cheng Cai, Jing-Jing Zhang, Gui-Rong Cheng, Fei-Fei Hu, Qian-Qian Nie, Juan Zhou, De-Yang Zeng, Xiao-Chang Liu, Dan Song, Jun-Yi Wang, Shi-Yue Li, Yu-Yang Cui, Chen-Lu Hu, Yi-Di Fu, Wan-Yin Cai, Yi-Qing Li, Chun-Li Li, Meng
Journal of Alzheimer’s Disease.2025;[Epub] CrossRef - Eight‐year trajectories and predictors of cognitive function in community‐dwelling Korean older adults with cardiovascular diseases
Youn‐Jung Son, Da‐Young Kim, Yoon‐Gyeong Choi, Eun Young Kim
Journal of Nursing Scholarship.2024; 56(1): 153. CrossRef - ANÁLISE DO ESTADO COGNITIVO DE PESSOAS IDOSAS HOSPITALIZADAS
Heloysa Waleska Soares Fernandes, Bárbara Maria Lopes da Silva Brandão, Tamires Paula Gomes Medeiros, Eduarda Cordeiro D'Oliveira Alves, Luana Rodrigues de Almeida, Rafaella Queiroga Souto
Revista Enfermagem Atual In Derme.2024; 97(4): e024263. CrossRef - Is Formal Social Participation Associated with Cognitive Function in Middle-Aged and Older Adults? A Systematic Review with Meta-Analysis of Longitudinal Studies
Cláudia Cunha, Gina Voss, Renato Andrade, Alice Delerue-Matos
Behavioral Sciences.2024; 14(4): 262. CrossRef - Longitudinal Relationship Between Baseline Social Frailty and Cognitive Impairment in Older Adults: 14-Year Follow-Up Results From the Korean Longitudinal Study of Ageing
Jae Jun Lee, Min Kyung Park, Namhee Kim, Layoung Kim, Gwang Suk Kim
Journal of the American Medical Directors Association.2024; 25(9): 105124. CrossRef - The Effect of Cognitive Impairment on the Association Between Social Network Properties and Mortality Among Older Korean Adults
Eunji Kim, Kiho Sung, Chang Oh Kim, Yoosik Youm, Hyeon Chang Kim
Journal of Preventive Medicine and Public Health.2023; 56(1): 31. CrossRef - Effects of a ‘social activity program that encourages interaction’ on rural older people's psychosocial health: Mixed‐methods research
Mami Kikuchi, Ryuta Onishi, Risa Takashima, Kazuko Saeki, Michiyo Hirano
International Journal of Older People Nursing.2023;[Epub] CrossRef - Green Space, Air Pollution, Weather, and Cognitive Function in Middle and Old Age in China
Lingling Zhang, Ye Luo, Yao Zhang, Xi Pan, Dandan Zhao, Qing Wang
Frontiers in Public Health.2022;[Epub] CrossRef
- Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea
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Yoonyoung Jang, Yoon-Jung Choi, Youn-Hee Lim, Kyung-Shin Lee, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim, Yun-Chul Hong
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J Prev Med Public Health. 2021;54(1):37-45. Published online November 23, 2020
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DOI: https://doi.org/10.3961/jpmph.20.310
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8,813
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191
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15
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18
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Abstract
Summary
PDFSupplementary Material
- Objectives
Bisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children.
Methods
Prenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations.
Results
The associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only.
Conclusions
Our findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.
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Summary
Korean summary
비스페놀 A의 건강위해성에 대한 역학적 근거들이 축적되어 비스페놀 A 대신 BPF와 BPS와 같은 대체물질이 사용되고 있다. 본 논문에서는 어머니의 산전 비스페놀 A 노출과 6세 어린이의 비스페놀 A, 비스페놀 F, 비스페놀 S 노출 정도에 따라 어린이의 갑상선호르몬 농도에 어떠한 영향을 미치는가 보고자 하였다. 어머니의 산전 비스페놀 A 노출은 어린이의 total T3 농도에 유의하게 영향을 미쳤으며, 특히 여자아이에게서 비스페놀 F 노출이 한 단위 증가할수록 free T4 농도가 유의하게 감소하는 것을 관찰하였다. 본 논문의 의의는 비스페놀 F, S가 어린이의 갑상선기능에 어떠한 영향을 미치는지 역학적 근거를 제시하였다는 점이나, 인과적 연관성을 위해서는 시간적 선후관계를 고려한 더 많은 연구가 필요하다.
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Citations
Citations to this article as recorded by - Temporal and geographic variability of bisphenol levels in humans: A systematic review and meta-analysis of international biomonitoring data
Jonathan M. Acevedo, Linda G. Kahn, Kristyn A. Pierce, Anna Carrasco, Marissa Singer Rosenberg, Leonardo Trasande
Environmental Research.2025; 264: 120341. CrossRef - The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake
Ziwei Pei, Lei Zhang, Yan Bao, Jingguang Li, Qin Zhuo
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Ege Tıp Dergisi.2025; 64(1): 15. CrossRef - Evaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6−14 Years
Pinar Altun Yildirim, Ersin Nazlican, Zeliha Haytoglu, İhsan Turan, Betul Kilincli, Asli Atasoy Aydin, Eda Mengen, Nebile Daglioglu
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