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Shung chull Chae 2 Articles
Association Between Gamma-Glutamyltransferase and Hypertension Incidence in Rural Prehypertensive Adults.
Jun Hyun Hwang, Ji Yeon Shin, Byung yeol Chun, Duk Hee Lee, Keon Yeop Kim, Wee hyun Park, Shung chull Chae
J Prev Med Public Health. 2010;43(1):18-25.
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  • 4 Crossref
AbstractAbstract PDF
Prehypertension is associated with a higher risk of developing hypertension compared with normotension. Yet, factors predicting the development of hypertension among prehypertensive people are ill-understood. This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults. METHODS: Study subjects were 293 prehypertensive persons >30-years-of-age who participated in a community-based health survey in 2003 and who were followed up in 2008. Sex-specific quartiles of baseline serum GGT were used to examine association with 5-year hypertension incidence. RESULTS: Baseline serum GGT within normal range predicted the risk of developing hypertension for 5 years only in prehypertensive women. Adjusted relative risks were 1.0, 3.7, 3.6, and 6.0 according to quartiles of baseline serum GGT (P for trend <0.01). This pattern was similarly observed in non-drinkers. However, serum GGT was not associated with incident hypertension in men. Different from serum GGT, baseline serum alanine aminotransferase, another well-known liver enzyme, did not predict the risk of incident hypertension in both genders. CONCLUSIONS: Even though baseline serum GGT within normal range strongly predicted the future risk of hypertension, it was observed only in women, Although underlying mechanisms of this association are currently unclear, serum GGT can be used to select a high risk group of hypertension in prehypertensive women.


Citations to this article as recorded by  
  • Gamma-glutamyltransferase and risk of hypertension
    Setor K. Kunutsor, Tanefa A. Apekey, Bernard M.Y. Cheung
    Journal of Hypertension.2015; 33(12): 2373.     CrossRef
  • Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
    Jean-Claude, Lapraz, Kamyar M. Hedayat
    Global Advances in Health and Medicine.2013; 2(1): 64.     CrossRef
  • Gamma-Glutamyltransferase Level and Risk of Hypertension: A Systematic Review and Meta-Analysis
    Cun-Fei Liu, Yu-Ting Gu, Hai-Ya Wang, Ning-Yuan Fang, Antony Bayer
    PLoS ONE.2012; 7(11): e48878.     CrossRef
  • Association between γ-glutamyltransferase and prehypertension
    Molecular Medicine Reports.2012; 5(4): 1092.     CrossRef
Development of Measurement Scale for the Quality of Life in Hypertensive Patients.
Keon Yeop Kim, Byung Yeol Chun, Sin Kam, Sang Won Lee, Ki Soo Park, Shung Chull Chae
J Prev Med Public Health. 2005;38(1):61-70.
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AbstractAbstract PDF
To develop a tool for multidimensional measurement of the quality of life, which was psychometrically sound, short, and easy to administer for patients with hypertension. METHODS: A sample of 1, 115 hypertensive patients aged 20 or above in Cheong-Song County was studied from June 1997 to October 1998. In the development of the instrumental stage, the authors first conceptualized the quality of life. Item generation, item reduction, and questionnaire formatting were followed. Item-level (item descriptive, missing%, item internal consistency, item discriminant validity) analysis, scale-level (scale descriptive, floor and ceiling effect) analysis, and other tests (Cronbach's alpha, inter-dimension correlations, factor analysis, clinical validity) were performed to evaluate the validity and reliability of the new measurement scale. After 1 year, responsiveness and confirmatory factor analysis were performed. RESULTS: The results of both item-level and scale-level analyses were acceptable. An acceptable degree of internal consistency was observed for each of the dimensions (Cronbach's alpha was 0.60 or higher). Inter-dimension correlations were below 0.50 and the factor analysis result was the same as the intended dimension structure. Correlation coefficients between perceived health status, stress and dimensions were proven to be acceptable. The result of comparing dimensional score means among ADL and MMSE-K groups above 60 years was statistically significant (p< 0.05). The result of confirmatory factor analysis concluded that the dimensional structure model was well fitted. However, the result of responsiveness test using sensitivity and specificity was unsatisfactory. CONCLUSIONS: The newly developed measurement scale is psychometrically reliable and valid instrument for measuring quality of life in hypertensive patients.

JPMPH : Journal of Preventive Medicine and Public Health