- Apolipoprotein E Polymorphism and Cognitive Function Change of the Elderly in a Rural Area, Korea.
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Sang Kyu Kim, Tae Yoon Hwang, Kyeong Soo Lee, Pock Soo Kang, Hee Soon Cho, Young Kyung Bae
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J Prev Med Public Health. 2009;42(4):261-266.
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DOI: https://doi.org/10.3961/jpmph.2009.42.4.261
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- OBJECTIVES
The aim of this study is to examine the cognitive function change related to aging, the incidence of cognitive impairment, and the association between apolipoprotein E polymorphism and cognitive impairment through a follow-up of the elderly with normal cognitive ability at baseline. METHODS: Two hundred and fifteen subjects aged 65 and over were surveyed in February, 1998 (baseline survey), and their cognitive function was assessed again in 2003 (1st follow-up) and the once again in 2006 (2nd follow-up). Ninety one subjects completed all surveys up through the 2nd follow-up and their cognitive function scores using MMSE-K (Korean Version of the Mini-Mental State Examination) and the distribution of apolipoprotein E allele were analyzed. RESULTS: The cognitive function scores decreased with aging and the difference between baseline and the 2nd follow-up scores of the study increased with the age group. The incidence rate of cognitive impairment through an 8-year follow-up was 38.5% and higher in older age groups. Age was the only significant factor for incidence of cognitive impairment, but there was no significant association between apolipoprotein E genotype and incidence of cognitive impairment. CONCLUSIONS: The cognition of the elderly decreased with aging and the association of apolipoprotein E genotype with incidence of cognitive impairment was not significant in this study. To confirm the association between apolipoprotein E polymorphism and incidence of cognitive impairment further studies will be needed.
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Citations
Citations to this article as recorded by  - ApoE Type 4 Allele Affects Cognitive Function of Aged Population in Tianjin City, China
Shoudan Sun, Jingming Fu, Jun Chen, Wei Pang, Ruomei Hu, Haiqiang Li, Long Tan, Yugang Jiang
American Journal of Alzheimer's Disease & Other Dementiasr.2015; 30(5): 503. CrossRef
- Change of Cognitive Function and Associated Factors among the Rural Elderly: A 5-Year Follow-up Study.
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Sang Kyu Kim, Pock Soo Kang, Tae Yoon Hwang, Joon Sakong, Kyeong Soo Lee
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J Prev Med Public Health. 2007;40(2):162-168.
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DOI: https://doi.org/10.3961/jpmph.2007.40.2.162
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4,598
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This prospective population-based cohort study was conducted to evaluate the risk factors of cognitive impairment and the degree of cognitive function change through a 5-year follow-up. METHODS: The baseline and follow-up surveys were conducted in 1998 and 2003, respectively. Among 176 subjects who had normal cognitive function in the baseline study, 136 were followed up for 5 years. The cognitive function was investigated using the Korean version of the Mini-Mental State Examination (MMSE-K). The collected data were analyzed using SPSS and Stata. RESULTS: Of the 136 subjects analyzed, 25 (18.4%) were cognitively impaired. Old age and low social support in the baseline survey were risk factors for cognitive impairment after 5 years. In the generalized estimating equation for 128 subjects except severe cognitive impairment about the contributing factors of cognitive function change, the interval of 5 years decreased MMSE-K score by 1.02 and the cognitive function was adversely affected with increasing age, decreasing education and decreasing social support. CONCLUSIONS: Although the study population was small, it was considered that the study results can be used to develop a community-based prevention system for cognitive impairment.
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Citations
Citations to this article as recorded by - Status of Physical and Mental Function and, Its Related Factors Among the Elderly People Using from Long-Term Care Insurance Service
Nam-Kyou Bae, Young-Soo Song, Eun-Sook Shin, Young-Chae Cho
Journal of the Korea Academia-Industrial cooperation Society.2012; 13(12): 5976. CrossRef - Toxicities and functional consequences of systemic chemotherapy in elderly Korean patients with cancer: A prospective cohort study using Comprehensive Geriatric Assessment
Dong-Yeop Shin, Jeong-Ok Lee, Yu Jung Kim, Myung-Sook Park, Keun-Wook Lee, Kwang-Il Kim, Soo-Mee Bang, Jong Seok Lee, Cheol-Ho Kim, Jee Hyun Kim
Journal of Geriatric Oncology.2012; 3(4): 359. CrossRef - Apolipoprotein E Polymorphism and Cognitive Function Change of the Elderly in a Rural Area, Korea
Sang-Kyu Kim, Tae-Yoon Hwang, Kyeong-Soo Lee, Pock-Soo Kang, Hee-Soon Cho, Young-Kyung Bae
Journal of Preventive Medicine and Public Health.2009; 42(4): 261. CrossRef
- Community-based Helicobacter pylori Screening and its Effects on Eradication in Patients with Dyspepsia.
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Seong Ho Kim, Dae Yong Hong, Pock Soo Kang, Seok Beom Kim, Kyeong Soo Lee, Sang Kyu Kim, Jeong Ill Suh, Mee Kyung Kim
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Korean J Prev Med. 2000;33(3):285-298.
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- CONCLUSIONS: To investigate the positive rate of Helicobacter pylori in patients with dyspepsia; medical compliance and related factors; the eradication rate a year after screening and related factors; the relationship between the eradication of Helicobacter pylori and the improvement of symptoms; and the estimated cost of three alternative approaches to treat Helicobacter pylori in the community. METHODS: A total of 510 subjects with dyspeptic symptoms were selected and given the serological test in March 1998. The subjects were all adults over 30 years of age residing in Kyongju city. RESULTS: Of the 510 selected subjects, 375 (73.5%) subjects proved positive for Helicobacter pylori on serological testing. Of these 304 (81.1%) who consented to an endoscopic examination, underwent a Campylobacter-like organism (CLO) test. Of these 304 subjects, 204 (67.1%), who had positive CLO test results, were given the triple therapy - tripotassium dicitrato bismuthate, amoxicillin, and metronidazole. To determine the eradication rate of Helicobacter pylori, 181 (88.7%) out of the 204 subjects who were given the triple therapy completed a follow-up urea breath test one year later. Of these, the Helicobacter pylori of 87(48.1%) subjects was eradicated. Among the 122 subjects who were medication compliant, the Helicobacter pylori eradication rate was 57.4% (70 subjects), while the eradication rates was only 28.8% (17subjects) in the non-compliant group. The Helicobacter pylori eradication was significantly related to compliance (p<0.01), but not to other characteristics and habits. The symptom improvement rate tended to be higher 62.1%), in the Helicobacter pylori eradicated group than in the non-eradicated group (59.6%). CONCLUSIONS: When the advantages and disadvantages of each alternative treatment were considered in the light of cost, antibiotic tolerance and the number of patients to be treated, alternative II was favorable in terms of cost. Alternative III was favorable in terms of the number of patients to be treated, antibiotic tolerance and early detection of gastric cancer. Further long-term research analyzing the cost-benefit and cost-effectiveness of each treatment will be needed as supporting material in creating new policies.
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- Association between Cognitive Impairment and ADL of the Elderly in Rural Area.
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Sang Kyu Kim, Seok Beom Kim, Pock Soo Kang
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Korean J Prev Med. 1999;32(1):65-71.
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The purpose of this investigation was to study the correlation between cognitive impairment and activities of daily living(ADL) in the elderly of rural area. METHODS: The study population consisted of 210 elderly people aged 65 years and older, living in a district of Kyongju City. The cognitive impairment was measured with the Korean version of mini-mental state examination(MMSE-K) and newly constructed the Korean version of mini-mental state examination (K-MMSE). Bristol activities of daily living scale developed specifically to be used with people with dementia was used to measure ADL. RESULTS: The mean scores of both MMSE-K and K-MMSE were significantly different by sex groups and by age groups, respectively(p<0.05). The mean scores of ADL were significantly different by age groups(p<0.01) not by sex groups. Among the 4 components of ADL(instrumental activities of daily living(IADL), self care, orientation, and mobility), the mean score of the orientation was significantly higher in men(p<0.01); and IADL, orientation and mobility components were significantly different by age groups(p<0.01). ADL correlated well with MMSE-K (r=0.54) and K-MMSE(r=0.52) and showed higher correlation in female (r=0.73, 0.71) than male(r=0.27, 0.29). IADL and orientation showed significant correlation with MMSE-K(r=0.52, 0.62) and K-MMSE(r=0.50, 0.63), respectively(p<0.01). CONCLUSIONS: In developing and establishing a care model for people with dementia in the community, both cognitive impairment and the activities of daily living(ADL) need to be considered.
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