Journal of Preventive Medicine and Public Health

Nam-Kyong Choi

3 Articles

Utilization of Acid Suppressants After Withdrawal of Ranitidine in Korea: An Interrupted Time Series Analysis: Jeong Pil Choi, Sangwan Kim, Jung Su Park, Mi-Sook Kim, Nam-Kyong Choi, Cheol Min Shin, Joongyub Lee; J Prev Med Public Health. 2025;58(1):21-30. Published online December 30, 2024; DOI: https://doi.org/10.3961/jpmph.24.357

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Abstract Summary PDF Supplementary Material: Objectives
This study was performed to evaluate the utilization patterns of acid suppressants following the withdrawal of ranitidine in Korea.
Methods
Health Insurance Review & Assessment Service (HIRA) data from January 2016 to May 2023 were utilized to assess the usage of histamine H2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) for acid-related diseases. Drug utilization was calculated for each agent based on the defined daily dose (DDD). To evaluate changes in utilization following the ranitidine recall, an interrupted time series analysis was conducted using segmented linear regression and an autoregressive integrated moving average model.
Results
Before the withdrawal of ranitidine, the DDD per 100 000 inhabitants per day was increasing by 6.9 (95% confidence interval [CI], 4.7 to 9.0) for H2RAs and by 19.3 (95% CI, 16.9 to 21.8) for PPIs each month. After the recall, H2RA utilization immediately declined by -1041.7 (95% CI, -1115.8 to -967.7), followed by a monthly increase of 6.6 (95% CI, 3.7 to 9.6) above the previous trend. PPI utilization temporarily surged by 235.2 (95% CI, 149.1 to 321.3), then displayed a monthly increase of 4.1 (95% CI, 0.7 to 7.6) on top of the pre-recall trend. Among PPIs, esomeprazole and rabeprazole demonstrated notable increases, representing the most commonly used acid suppressants in 2023.
Conclusions
PPI usage rose prominently following the withdrawal of ranitidine from the market. Considering the potential adverse effects of PPIs, further research is necessary to evaluate the public health implications of shifts in the utilization of acid suppressants.; Summary

Korean summary
- 위산분비억제제의 국내 사용량은 양성자 펌프 억제제를 중심으로 지속적으로 증가하고 있으며, 라니티딘이 시장에서 퇴출된 이후 더욱 급격히 증가하는 양상이 관찰되었다. - 양성자 펌프 억제제 사용 증가와 관련해 장기 복용의 안전성, 처방의 적절성, 잠재적 오남용의 가능성, 비용효과성의 측면에서의 보건학적 의의에 대한 평가가 필요하다.

Key Message
- The use of gastric acid suppressive drugs in Korea has demonstrated a consistent upward trend, with proton pump inhibitors (PPIs) predominating, especially following the withdrawal of ranitidine from the market. - The escalating utilization of PPIs necessitates a comprehensive evaluation of their public health implications, encompassing the long-term safety, appropriateness of prescribing, potential overuse, and cost-effectiveness.

Levothyroxine Dose and Fracture Risk According to the Osteoporosis Status in Elderly Women: Young-Jin Ko, Ji Young Kim, Joongyub Lee, Hong-Ji Song, Ju-Young Kim, Nam-Kyong Choi, Byung-Joo Park; J Prev Med Public Health. 2014;47(1):36-46. Published online January 29, 2014; DOI: https://doi.org/10.3961/jpmph.2014.47.1.36

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29 Crossref

Abstract PDF

Objectives

To evaluate the association between fracture risk and levothyroxine use in elderly women with hypothyroidism, according to previous osteoporosis history.

Methods

We conducted a cohort study from the Korean Health Insurance Review and Assessment Service claims database from January 2005 to June 2006. The study population comprised women aged ≥65 years who had been diagnosed with hypothyroidism and prescribed levothyroxine monotherapy. We excluded patients who met any of the following criteria: previous fracture history, hyperthyroidism, thyroid cancer, or pituitary disorder; low levothyroxine adherence; or a follow-up period <90 days. We categorized the daily levothyroxine doses into 4 groups: ≤50 µg/d, 51 to 100 µg/d, 101 to 150 µg/d, and >150 µg/d. The hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with the Cox proportional hazard model, and subgroup analyses were performed according to the osteoporosis history and osteoporosis-specific drug prescription status.

Results

Among 11 155 cohort participants, 35.6% had previous histories of osteoporosis. The adjusted HR of fracture for the >150 µg/d group, compared with the 51 to 100 µg/d group, was 1.56 (95% CI, 1.03 to 2.37) in osteoporosis subgroup. In the highly probable osteoporosis subgroup, restricted to patients who were concurrently prescribed osteoporosis-specific drugs, the adjusted HR of fracture for the >150 µg/d group, compared with the 51 to 100 µg/d group, was 1.93 (95% CI, 1.14 to 3.26).

Conclusions

While further studies are needed, physicians should be concerned about potential levothyroxine overtreatment in elderly osteoporosis patients.

Summary

Citations

Citations to this article as recorded by

Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
Justyna Kuliczkowska-Płaksej, Aleksandra Zdrojowy-Wełna, Aleksandra Jawiarczyk-Przybyłowska, Łukasz Gojny, Marek Bolanowski
Reviews in Endocrine and Metabolic Disorders.2024; 25(3): 513. CrossRef
Hypopituitarism and bone disease: pathophysiology, diagnosis and treatment outcomes
Amit Akirov, Yaron Rudman, Maria Fleseriu
Pituitary.2024; 27(6): 778. CrossRef
Diversity of the diet is correlated with osteoporosis in post-menopausal women: an Iranian case-control study
Behnood Abbasi, Mohammad Mahdi Hajinasab, Zahra Mohammadi Zadeh, Paniz Ahmadi
Frontiers in Public Health.2024;[Epub] CrossRef
Impact of Patient Age on Management of Hypothyroidism: A Survey of Physicians from Three Developing Regions
Salem A. Beshyah, Mohammed Bashir, Khadija Hafidh, Bachar Afandi, Shehla Shaikh, Sonia Hammami, Ali B. Khalil
Journal of Diabetes and Endocrine Practice.2024; 07(03): 135. CrossRef
Association Between Periodontal Diseases and Hypothyroidism: A Case–Control Study
Fatemah AlAhmari, Hind Albahouth, Hadeel Almalky, Ebtihal Almutairi, Muzun Alatyan, Lama Alotaibi
International Journal of General Medicine.2024; Volume 17: 3613. CrossRef
Refractory hypothyroidism in children: an overview
Kotb Abbass Metwalley, Hekma Saad Farghaly
Journal of Pediatric Endocrinology and Metabolism.2024; 37(10): 841. CrossRef
Evaluation of Bone Health in Postmenopausal Women Using Long-Term Levothyroxine Treatment Due to Post-Procedural Hypothyroidism
Mahmut Apaydin, Ferda Surel, Sinan Kazan
International Journal of General Medicine.2024; Volume 17: 6139. CrossRef
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: A Position Statement of the Korean Thyroid Association
A Ram Hong, Ho-Cheol Kang
Endocrinology and Metabolism.2023; 38(2): 175. CrossRef
Refractory Hypothyroidism: Unraveling the Complexities of Diagnosis and Management
Juan Eduardo Quiroz-Aldave, Marcio José Concepción-Zavaleta, María del Carmen Durand-Vásquez, Luis Alberto Concepción-Urteaga, Elman Rolando Gamarra-Osorio, Jacsel Suárez-Rojas, Luciana del Pilar Rafael-Robles, José Paz-Ibarra, Alejandro Román-González
Endocrine Practice.2023; 29(12): 1007. CrossRef
Assessing the cardiovascular effects of levothyroxine use in an ageing United Kingdom population (ACEL-UK) protocol: a cohort and target trial emulation study
Mia Holley, Salman Razvi, Rosie Dew, Ian Maxwell, Scott Wilkes
Thyroid Research.2023;[Epub] CrossRef
Understanding Worry About Risks Associated With Thyroid Hormone Therapy: A National Survey of Endocrinologists, Family Physicians, and Geriatricians
Kimi Shah, David Reyes-Gastelum, Brittany L. Gay, Maria Papaleontiou
Endocrine Practice.2022; 28(1): 25. CrossRef
Evaluation and Management of Bone Health in Patients with Thyroid Diseases: a Position Statement from the Korean Thyroid Association
A Ram Hong, Hwa Young Ahn, Bu Kyung Kim, Seong Hee Ahn, So Young Park, Min-Hee Kim, Jeongmin Lee, Sun Wook Cho, Ho-Cheol Kang
International Journal of Thyroidology.2022; 15(1): 1. CrossRef
Levothyroxine Therapy in Elderly Patients With Hypothyroidism
Grigoris Effraimidis, Torquil Watt, Ulla Feldt-Rasmussen
Frontiers in Endocrinology.2021;[Epub] CrossRef
Systemic medicines taken by adult special care dental patients and implications for the management of their care
Nicholas Ransford, Ben Marnell, Christine Randall, Clare Yates, Gillian Howie
British Dental Journal.2021; 231(1): 33. CrossRef
The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review
Dragos Apostu, Ondine Lucaciu, Daniel Oltean-Dan, Alexandru-Dorin Mureșan, Cristina Moisescu-Pop, Andrei Maxim, Horea Benea
Diagnostics.2020; 10(3): 149. CrossRef
Comparison of the efficacy between once-monthly oral ibandronate and risedronate among Korean women with osteoporosis: a nationwide population-based study
Dong Ryul Lee, Jungun Lee
Osteoporosis International.2019; 30(3): 659. CrossRef
The effect of thyroid functions on osteopenia of prematurity in preterm infants
Ufuk Çakır, Cuneyt Tayman
Journal of Pediatric Endocrinology and Metabolism.2019; 32(1): 65. CrossRef
Understanding hypothyroidism in Unani medicine
Md. Anzar Alam, Mohd Aleemuddin Quamri, Ghulamuddin Sofi, Barkati Md. Tarique
Journal of Integrative Medicine.2019; 17(6): 387. CrossRef
Team Approach: Multidisciplinary Treatment of Hip Fractures in Elderly Patients
Wender Figved, Marius Myrstad, Ingvild Saltvedt, Merete Finjarn, Liv Marie Flaten Odland, Frede Frihagen
JBJS Reviews.2019; 7(6): e6. CrossRef
Effect of sodium levothyroxine on histomorphometry, histopathology, histochemistry, and immunohistochemistry of articular cartilage in female mice
Simin Fazelipour, Minoo Shafii, Mahsa Hadipour Jahromi, Zahra Tootian, Mohammad Taghi Sheibani, Hassan Morovvati, Marzieh Minaei, Anahita Shahriari, Pooneh Koochaki, Safora Karimi
Comparative Clinical Pathology.2018; 27(1): 45. CrossRef
High Prevalence of Radiological Vertebral Fractures in Women on Thyroid-Stimulating Hormone–Suppressive Therapy for Thyroid Carcinoma
Gherardo Mazziotti, Anna Maria Formenti, Stefano Frara, Roberto Olivetti, Giuseppe Banfi, Maurizio Memo, Roberto Maroldi, Raffaele Giubbini, Andrea Giustina
The Journal of Clinical Endocrinology & Metabolism.2018; 103(3): 956. CrossRef
Subclinical thyrotoxicosis and bone
M. Doga, A.M. Formenti, S. Frara, M. Memo, A. Giustina, G. Mazziotti
Current Opinion in Endocrine and Metabolic Researc.2018;[Epub] CrossRef
Effects of Abnormal Thyroid Function Status to Bone Metabolism
Hwa Young Ahn
International Journal of Thyroidology.2018; 11(1): 21. CrossRef
RETRACTED ARTICLE: The relationship between subclinical thyroid dysfunction and the risk of fracture or low bone mineral density: a systematic review and meta-analysis of cohort studies
Ruifei Yang, Liang Yao, Yuan Fang, Jing Sun, Tiankang Guo, Kehu Yang, Limin Tian
Journal of Bone and Mineral Metabolism.2018; 36(2): 209. CrossRef
MANAGEMENT OF ENDOCRINE DISEASE: l-Thyroxine replacement therapy in the frail elderly: a challenge in clinical practice
R M Ruggeri, F Trimarchi, B Biondi
European Journal of Endocrinology.2017; 177(4): R199. CrossRef
THE IMPACT OF AGE IN THE MANAGEMENT OF HYPOTHYROIDISM: RESULTS OF A NATIONWIDE SURVEY
Maria Papaleontiou, Brittany L. Gay, Nazanene H. Esfandiari, Sarah T. Hawley, Megan R. Haymart
Endocrine Practice.2016; 22(6): 708. CrossRef
TSH Suppression after Differentiated Thyroid Cancer Surgery and Osteoporosis
Kyoung Sik Park
Korean Journal of Endocrine Surgery.2016; 16(1): 1. CrossRef
TSH Suppression after Differentiated Thyroid Cancer Surgery and Osteoporosis
Kyoung Sik Park
Korean Journal of Endocrine Surgery.2016; 16(1): 1. CrossRef
Role of Thyroid Hormones in Skeletal Development and Bone Maintenance
J. H. Duncan Bassett, Graham R. Williams
Endocrine Reviews.2016; 37(2): 135. CrossRef

Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients: Dong-Yoon Kang, Soyoung Park, Chul-Woo Rhee, Ye-Jee Kim, Nam-Kyong Choi, Joongyub Lee, Byung-Joo Park; J Prev Med Public Health. 2012;45(4):219-226. Published online July 31, 2012; DOI: https://doi.org/10.3961/jpmph.2012.45.4.219

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Abstract PDF

Objectives

To evaluate the risk of fractures related with zolpidem in elderly insomnia patients.

Methods

Health claims data on the entire South Korean elderly population from January 2005 to June 2006 were extracted from the Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases were defined as insomnia patients who had a fracture diagnosis. We set the hazard period of 1 day length prior to the fracture date and four control periods of the same length at 5, 10, 15, and 20 weeks prior to the fracture date. Time independent confounding factors such as age, gender, lifestyle, cognitive function level, mobility, socioeconomic status, residential environment, and comorbidity could be controlled using the casecrossover design. Time dependent confounding factors, especially co-medication of patients during the study period, were adjusted by conditional logistic regression analysis. The odds ratios and their 95% confidence intervals (CIs) were estimated for the risk of fracture related to zolpidem.

Results

One thousand five hundred and eight cases of fracture were detected in insomnia patients during the study period. In our data, the use of zolpidem increased the risk of fracture significantly (adjusted odds ratio [aOR], 1.72; 95% CI, 1.37 to 2.16). However, the association between benzodiazepine hypnotics and the risk of fracture was not statistically significant (aOR, 1.00; 95% CI, 0.83 to 1.21). Likewise, the results were not statistically significant in stratified analysis with each benzodiazepine generic subgroup.

Conclusions

Zolpidem could increase the risk of fracture in elderly insomnia patients. Therefore zolpidem should be prescribed carefully and the elderly should be provided with sufficient patient education.

Summary

Citations

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Nurses' attitudes, beliefs and knowledge of sleep health in residential aged care: An integrative literature review
Christopher J. Gordon, Tracee Fernandez, Emily Chen, Mariam Basheti, Matthew Rahimi, Bandana Saini
Journal of Advanced Nursing.2025; 81(1): 20. CrossRef
Sedative-hypnotics and osteoporotic fractures: A systematic review of observational studies with over six million individuals
Chong Xu, Janice Ching Nam Leung, Jiaying Shi, Dawn Hei Lum, Francisco Tsz Tsun Lai
Sleep Medicine Reviews.2024; 73: 101866. CrossRef
Burden of narcolepsy in Japan: A health claims database study evaluating direct medical costs and comorbidities
Yuta Kamada, Aya Imanishi, Shih-Wei Chiu, Takuhiro Yamaguchi
Sleep Medicine.2024; 114: 119. CrossRef
Analysis of Drugs Prescribed to Elderly Patients in a Tertiary Health Care Center in Raipur, Central India: An Observational Study
Yogendra Keche, Nitin R Gaikwad, Preetam N Wasnik, Keshao Nagpure, Md Sabah Siddiqui, Apoorva Joshi, Suryaprakash Dhaneria, Gevesh Dewangan, Jhasaketan Meher, Pranita Das
Cureus.2024;[Epub] CrossRef
Professionals' treatment goals for long-term benzodiazepine and Z-drugs management: a qualitative study
Pauline Van Ngoc, Melissa Ceuterick, Jean-Luc Belche, Beatrice Scholtes
BJGP Open.2024; 8(1): BJGPO.2023.0034. CrossRef
Reasons and impacts of hypnotic overuse in seniors
Petra Höferová, Eva Aigelová
Psychiatrie pro praxi.2024; 25(3): E1. CrossRef
Drogas Z: zolpidem está associado a maior risco de fraturas na população idosa?
Carlos Augusto Marques Chirieleison, Edla de Andrade Alves da Silva, Rafael Lucas de Albuquerque Pereira, Genildo da Silva Neto, Laércia Karla Diega Paiva Ferreira
Cuadernos de Educación y Desarrollo.2024; 16(12 Edição ): e6564. CrossRef
Comparative risk of fracture in community‐dwelling older adults initiating suvorexant versus Z‐drugs: Results from LIFE study
Motohiko Adomi, Megumi Maeda, Fumiko Murata, Haruhisa Fukuda
Journal of the American Geriatrics Society.2023; 71(1): 109. CrossRef
Analysis of the prescription trends of potentially inappropriate medications in Korean older outpatients by sex: A retrospective study using data from the health insurance review and assessment service
Jae-Yong Dong, Jin-Han Ju, Young-Mo Yang
Medicine.2023; 102(34): e34818. CrossRef
Effectiveness of suvorexant versus benzodiazepine receptor agonist sleep drugs in reducing the risk of hip fracture: Findings from a regional population-based cohort study
Ryozo Yoshioka, Seiichiro Yamamoto, Eiji Nakatani, Norio Yasui-Furukori
PLOS ONE.2023; 18(4): e0284726. CrossRef
The epidemiology of new persistent hypnotic/sedative use after surgical procedures: a retrospective cohort study
D. H. Magnusson, T. I. Albertsson, F. Jonsdottir, M. I. Sigurdsson
Anaesthesia.2023; 78(8): 995. CrossRef
Zolpidem as a high risk factor for elderly suicide in South Korea
Eun Kim, Jae Hee Lee, Duk Hee Lee
Archives of Suicide Research.2022; 26(2): 831. CrossRef
Reducing Sedative-Hypnotics Among Hospitalized Patients: a Multi-centered Study
Christine Soong, Cheryl Ethier, Yuna Lee, Dalia Othman, Lisa Burry, Peter E. Wu, Karen A. Ng, John Matelski, Barbara Liu
Journal of General Internal Medicine.2022; 37(10): 2345. CrossRef
Very long-term outcome of cognitive behavioral therapy for insomnia: one- and ten-year follow-up of a randomized controlled trial
Susanna Jernelöv, Kerstin Blom, Nils Hentati Isacsson, Pontus Bjurner, Ann Rosén, Martin Kraepelien, Erik Forsell, Viktor Kaldo
Cognitive Behaviour Therapy.2022; 51(1): 72. CrossRef
Efficacy and safety of Z-substances in the management of insomnia in older adults: a systematic review for the development of recommendations to reduce potentially inappropriate prescribing
Vincenz Scharner, Lukas Hasieber, Andreas Sönnichsen, Eva Mann
BMC Geriatrics.2022;[Epub] CrossRef
Insomnia Diagnosis, Prescribed Hypnotic Medication Use, and Risk for Serious Fall Injuries in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study
S Justin Thomas, Swati Sakhuja, Lisandro D Colantonio, Mei Li, Paul Muntner, Kristi Reynolds, C Barrett Bowling
Sleep.2022;[Epub] CrossRef
Potentially Inappropriate Medication Use in Patients with Dementia
Kyungwon Yoon, Jung-Tae Kim, Won-Gun Kwack, Donghyun Kim, Kyung-Tae Lee, Seungwon Yang, Sangmin Lee, Yeo-Jin Choi, Eun-Kyoung Chung
International Journal of Environmental Research and Public Health.2022; 19(18): 11426. CrossRef
Z-drugs and falls in nursing home patients: data from the INCUR study
Sarah Damanti, Moreno Tresoldi, Philipe de Souto Barreto, Yves Rolland, Matteo Cesari
Aging Clinical and Experimental Research.2022; 34(12): 3145. CrossRef
Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial
Ingo Fietze, Claudio L. A. Bassetti, David W. Mayleben, Scott Pain, Dalma Seboek Kinter, William V. McCall
Drugs & Aging.2022; 39(10): 795. CrossRef
Reacciones adversas medicamentosas de los hipnóticos más utilizados en España
A.J. Pardo-Cabello, V. Manzano-Gamero, J.D. Luna-del Castillo
Revista Clínica Española.2021; 221(2): 128. CrossRef
Adverse drug reactions among the most used hypnotic drugs in Spain
A.J. Pardo-Cabello, V. Manzano-Gamero, J.D. Luna-Del Castillo
Revista Clínica Española (English Edition).2021; 221(2): 128. CrossRef
Non-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies
Kathryn Richardson, George M Savva, Penelope J Boyd, Clare Aldus, Ian Maidment, Eduwin Pakpahan, Yoon K Loke, Antony Arthur, Nicholas Steel, Clive Ballard, Robert Howard, Chris Fox
Health Technology Assessment.2021; 25(1): 1. CrossRef
Sleep Disturbance, Sleep Disorders and Co-Morbidities in the Care of the Older Person
Christine E. Mc Carthy
Medical Sciences.2021; 9(2): 31. CrossRef
Effectiveness of App-Based Yoga of Immortals (YOI) Intervention for Insomnia in Asian Population during Pandemic Restrictions
Renuka Tunuguntla, Hari Siva Gurunadha Rao Tunuguntla, Himanshu Kathuria, Sadhna Verma
International Journal of Environmental Research and Public Health.2021; 18(11): 5706. CrossRef
Effects of anticholinergic and sedative medication use on fractures: A self‐controlled design study
Shahar Shmuel, Virginia Pate, Marc J. Pepin, Janine C. Bailey, Yvonne M. Golightly, Laura C. Hanson, Til Stürmer, Rebecca B. Naumann, Danijela Gnjidic, Jennifer L. Lund
Journal of the American Geriatrics Society.2021; 69(11): 3212. CrossRef
Effect of Multimorbidity on Fragility Fractures in Community-Dwelling Older Adults: Shimane CoHRE Study
Garu A, Shozo Yano, Abdullah Md Sheik, Aorigele Yu, Kenta Okuyama, Miwako Takeda, Kunie Kohno, Masayuki Yamasaki, Minoru Isomura, Toru Nabika, Atsushi Nagai
Journal of Clinical Medicine.2021; 10(15): 3225. CrossRef
Clinical consequences of abuse and misuse of hypnotics and analgesics in geriatric population
Paulina Trawka, Jakub Husejko, Kornelia Kędziora-Kornatowska
BÓL.2021; 22(2): 1. CrossRef
Exploring the Mechanisms Underlying Drug-Induced Fractures Using the Japanese Adverse Drug Event Reporting Database
Shinya Toriumi, Akinobu Kobayashi, Hitoshi Sueki, Munehiro Yamamoto, Yoshihiro Uesawa
Pharmaceuticals.2021; 14(12): 1299. CrossRef
Efficacy and safety of non-benzodiazepine and non-Z-drug hypnotic medication for insomnia in older people: a systematic literature review
Judith Sys, Simon Van Cleynenbreugel, Mieke Deschodt, Lorenz Van der Linden, Jos Tournoy
European Journal of Clinical Pharmacology.2020; 76(3): 363. CrossRef
Association between benzodiazepines use and risk of hip fracture in the elderly people: A meta-analysis of observational studies
Tahmina Nasrin Poly, Md. Mohaimenul Islam, Hsuan-Chia Yang, Yu-Chuan (Jack) Li
Joint Bone Spine.2020; 87(3): 241. CrossRef
Association entre prise de benzodiazépines et risque de fracture de la hanche chez la personne âgée : méta-analyse d’études observationnelles
Tahmina Nasrin Poly, Md. Mohaimenul Islam, Hsuan-Chia Yang, Yu-Chuan (Jack) Li
Revue du Rhumatisme.2020; 87(3): 210. CrossRef
Acute cognitive effects of the hypocretin receptor antagonist almorexant relative to zolpidem and placebo: a randomized clinical trial
Thomas C Neylan, Anne Richards, Thomas J Metzler, Leslie M Ruoff, Jonathan Varbel, Aoife O’Donovan, Melinda Sivasubramanian, Terri Motraghi, Jennifer Hlavin, Steven L Batki, Sabra S Inslicht, Kristin Samuelson, Stephen R Morairty, Thomas S Kilduff
Sleep.2020;[Epub] CrossRef
More than a quarter century of the most prescribed sleeping pill: Systematic review of zolpidem use by older adults
Flávio V. Machado, Luciana L. Louzada, Nathan E. Cross, Einstein F. Camargos, Thien Thanh Dang-Vu, Otávio T. Nóbrega
Experimental Gerontology.2020; 136: 110962. CrossRef
Association of Hypnotic Drug Use with Fall Incidents in Hospitalized Elderly Patients: A Case-Crossover Study
Haruki Torii, Motozumi Ando, Hideaki Tomita, Tomoko Kobaru, Mahoko Tanaka, Kazuhide Fujimoto, Rumiko Shimizu, Hiroaki Ikesue, Satoshi Okusada, Tohru Hashida, Noriaki Kume
Biological and Pharmaceutical Bulletin.2020; 43(6): 925. CrossRef
Treatment of Sleep Disturbance May Reduce the Risk of Future Probable Alzheimer’s Disease
Shanna L. Burke, Tianyan Hu, Christine E. Spadola, Aaron Burgess, Tan Li, Tamara Cadet
Journal of Aging and Health.2019; 31(2): 322. CrossRef
Twelve-year trend in the use of zolpidem and physicians’ non-compliance with recommended duration: a Korean national health insurance database study
Yunjeung Jang, Inmyung Song, In-Sun Oh, Ju-Young Shin
European Journal of Clinical Pharmacology.2019; 75(1): 109. CrossRef
Association between Elimination Half-life of Benzodiazepines and Falls in the Elderly: A Meta-analysis of Observational Studies
Chikako Masudo, Yukari Ogawa, Naomi Yamashita, Kiyoshi Mihara
YAKUGAKU ZASSHI.2019; 139(1): 113. CrossRef
Effectiveness and safety of fire-needle moxibustion on insomnia
Cuiling Liu, Zhiqiang Chen, Ting Li, Zhihua Yang, Qingsong Zhang, Jianping Yin, Peng Zhou, Wei Fu, BaiShu Chen
Medicine.2019; 98(7): e14509. CrossRef
Treatment of sleep disturbance in older adults
Amy C. Reynolds, Robert J. Adams
Journal of Pharmacy Practice and Research.2019; 49(3): 296. CrossRef
An Implementation Guide to Promote Sleep and Reduce Sedative-Hypnotic Initiation for Noncritically Ill Inpatients
Christine Soong, Lisa Burry, Hyung J. Cho, Evelyn Gathecha, Flora Kisuule, Cara Tannenbaum, Abi Vijenthira, Timothy Morgenthaler
JAMA Internal Medicine.2019; 179(7): 965. CrossRef
Evaluation of Dissolution Profile between Original and Generic Products of Zolpidem Tartrate by Microdialysis-HPLC
Kazunori Inaba, Toshiharu Oie, Hiroko Otake, Takeshi Kotake, Noriaki Nagai
Chemical and Pharmaceutical Bulletin.2019; 67(2): 120. CrossRef
Insomnia, Benzodiazepine Use, and Falls among Residents in Long-term Care Facilities
Yu Jiang, Qinghua Xia, Jie Wang, Peng Zhou, Shuo Jiang, Vinod K. Diwan, Biao Xu
International Journal of Environmental Research and Public Health.2019; 16(23): 4623. CrossRef
Association Between Sleep Medications and Falls and Fall-related Worries in Community-Dwelling Older Adults in the United States
Kathy Nguyen, Jonathan Watanabe
Journal of Contemporary Pharmacy Practice.2019; 66(3): 23. CrossRef
Z-drugs and risk for falls and fractures in older adults—a systematic review and meta-analysis
Nir Treves, Amichai Perlman, Lital Kolenberg Geron, Angham Asaly, Ilan Matok
Age and Ageing.2018; 47(2): 201. CrossRef
Age, Sex, and Dose Effects of Nonbenzodiazepine Hypnotics on Hip Fracture in Nursing Home Residents
David D. Dore, Andrew R. Zullo, Vincent Mor, Yoojin Lee, Sarah D. Berry
Journal of the American Medical Directors Association.2018; 19(4): 328. CrossRef
Cognitive Enhancers Associated with Decreased Risk of Injury in Patients with Dementia: A Nationwide Cohort Study in Taiwan
Pei-Chun Chao, Wu-Chien Chien, Chi-Hsiang Chung, Ching-Wen Chu, Chin-Bin Yeh, San-Yuan Huang, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Nian-Sheng Tzeng
Journal of Investigative Medicine.2018; 66(3): 684. CrossRef
Insomnia in Elderly Patients: Recommendations for Pharmacological Management
Vivien C. Abad, Christian Guilleminault
Drugs & Aging.2018; 35(9): 791. CrossRef
Mild cognitive impairment: associations with sleep disturbance, apolipoprotein e4, and sleep medications
Shanna L. Burke, Tianyan Hu, Christine E. Spadola, Tan Li, Mitra Naseh, Aaron Burgess, Tamara Cadet
Sleep Medicine.2018; 52: 168. CrossRef
An effectiveness comparison of acupuncture treatments for insomnia disorder
Jing Chen, Liming Lu, Nenggui Xu, Jun Chen, Yupeng Fan, Fen Feng, Xiaolan Qin, Yu Kui
Medicine.2018; 97(35): e12060. CrossRef
Zolpidem-Induced Acute Altered Level of Consciousness: A Report of Two Cases
Abdolhamid Parsa, Seyyed Ali Tabaeian, Sadra Einizadeh, Mohammad Babaeian
Iranian Journal of Psychiatry and Behavioral Sciences.2018;[Epub] CrossRef
Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
Daniel F. Kripke
F1000Research.2018; 5: 918. CrossRef
Effects of Ramelteon and Other Sleep-Promoting Drugs on Serum Low-Density Lipoprotein and Non-high-density Lipoprotein Cholesterol: A Retrospective Comparative Pilot Study
Haruki Torii, Rumiko Shimizu, Yuriko Tanizaki, Yurina Omiya, Miwa Yamamoto, Sayaka Kamiike, Daisuke Yasuda, Yoshinori Hiraoka, Tohru Hashida, Noriaki Kume
Biological and Pharmaceutical Bulletin.2018; 41(12): 1778. CrossRef
Zopiclone Use and Risk of Fractures in Older People: Population-Based Study
Prasad S. Nishtala, Te-yuan Chyou
Journal of the American Medical Directors Association.2017; 18(4): 368.e1. CrossRef
Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
Daniel F. Kripke
F1000Research.2017; 5: 918. CrossRef
Benzodiazepines, Z-drugs and the risk of hip fracture: A systematic review and meta-analysis
Karen Donnelly, Robert Bracchi, Jonathan Hewitt, Philip A. Routledge, Ben Carter, Tuan Van Nguyen
PLOS ONE.2017; 12(4): e0174730. CrossRef
Benzodiazepines and Z-Drugs: An Updated Review of Major Adverse Outcomes Reported on in Epidemiologic Research
Jaden Brandt, Christine Leong
Drugs in R&D.2017; 17(4): 493. CrossRef
Sleep in the Elderly
Steven H. Feinsilver, Adam B. Hernandez
Clinics in Geriatric Medicine.2017; 33(4): 579. CrossRef
A Greater Extent of Insomnia Symptoms and Physician-Recommended Sleep Medication Use Predict Fall Risk in Community-Dwelling Older Adults
Tuo-Yu Chen, Soomi Lee, Orfeu M Buxton
Sleep.2017;[Epub] CrossRef
High Prevalence of Inappropriate Benzodiazepine and Sedative Hypnotic Prescriptions among Hospitalized Older Adults
Elisabeth Anna Pek, Andrew Remfry, Ciara Pendrith, Chris Fan‐Lun, R. Sacha Bhatia, Christine Soong
Journal of Hospital Medicine.2017; 12(5): 310. CrossRef
Zolpidem use and risk of fractures: a systematic review and meta-analysis
S. M. Park, J. Ryu, D. R. Lee, D. Shin, J. M. Yun, J. Lee
Osteoporosis International.2016; 27(10): 2935. CrossRef
Melatonin, hypnotics and their association with fracture: a matched cohort study
Martin Frisher, Nicholas Gibbons, James Bashford, Steve Chapman, Scott Weich
Age and Ageing.2016; 45(6): 801. CrossRef
Characteristics and Trends in Hypnotics Consumption in the Largest Health Care System in Israel
O. Marom, G. Rennert, N. Stein, K. Landsman, G. Pillar
Sleep Disorders.2016; 2016: 1. CrossRef
Screening Tool for Older Persons’ Appropriate Prescriptions for Japanese: Report of the Japan Geriatrics Society Working Group on “Guidelines for medical treatment and its safety in the elderly”
Taro Kojima, Katsuyoshi Mizukami, Naoki Tomita, Hiroyuki Arai, Takashi Ohrui, Masato Eto, Yasushi Takeya, Yoshitaka Isaka, Hiromi Rakugi, Noriko Sudo, Hidenori Arai, Hiroaki Aoki, Shigeo Horie, Shinya Ishii, Koh Iwasaki, Shin Takayama, Yusuke Suzuki, Tosh
Geriatrics & Gerontology International.2016; 16(9): 983. CrossRef
Review of Safety and Efficacy of Sleep Medicines in Older Adults
Jennifer L. Schroeck, James Ford, Erin L. Conway, Kari E. Kurtzhalts, Megan E. Gee, Krista A. Vollmer, Kari A. Mergenhagen
Clinical Therapeutics.2016; 38(11): 2340. CrossRef
Nonbenzodiazepine Sedative Hypnotics and Risk of Fall-Related Injury
Sarah E. Tom, Emerson M. Wickwire, Yujin Park, Jennifer S. Albrecht
Sleep.2016; 39(5): 1009. CrossRef
Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit
Daniel F. Kripke
F1000Research.2016; 5: 918. CrossRef
Pharmacologic Treatment of Insomnia Disorder: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians
Timothy J. Wilt, Roderick MacDonald, Michelle Brasure, Carin M. Olson, Maureen Carlyle, Erika Fuchs, Imran S. Khawaja, Susan Diem, Erin Koffel, Jeannine Ouellette, Mary Butler, Robert L. Kane
Annals of Internal Medicine.2016; 165(2): 103. CrossRef
Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians
Amir Qaseem, Devan Kansagara, Mary Ann Forciea, Molly Cooke, Thomas D. Denberg
Annals of Internal Medicine.2016; 165(2): 125. CrossRef
Dependence, misuse, and beliefs regarding use of hypnotics by elderly psychiatric patients taking zolpidem, estazolam, or flunitrazepam
Cheng-Fang Yen, Chih-Hung Ko, Yu-Ping Chang, Cheng-Ying Yu, Mei-Feng Huang, Yi-Chun Yeh, Jin-Jia Lin, Cheng-Sheng Chen
Asia-Pacific Psychiatry.2015; 7(3): 298. CrossRef
An Increased Risk of Reversible Dementia May Occur After Zolpidem Derivative Use in the Elderly Population
Hsin-I Shih, Che-Chen Lin, Yi-Fang Tu, Chia-Ming Chang, Hsiang-Chin Hsu, Chih-Hsien Chi, Chia-Hung Kao
Medicine.2015; 94(17): e809. CrossRef
The Use of Hypnotics to Treat Sleep Problems in the Elderly
Catherine McCall, John W. Winkelman
Psychiatric Annals.2015;[Epub] CrossRef
Risk of Type 2 Diabetes in Patients With Nonapnea Sleep Disorders in Using Different Types of Hypnotics
Chia-Ling Lin, Mei-Chang Yeh, Tomor Harnod, Cheng-Li Lin, Chia-Hung Kao
Medicine.2015; 94(38): e1621. CrossRef
Care Needs and Clinical Outcomes of Older People with Dementia: A Population-Based Propensity Score-Matched Cohort Study
Fei-Yuan Hsiao, Li-Ning Peng, Yu-Wen Wen, Chih-Kuang Liang, Pei-Ning Wang, Liang-Kung Chen, Alessandra Marengoni
PLOS ONE.2015; 10(5): e0124973. CrossRef
Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwan
Yih-Jing Tang, Shinn-Ying Ho, Fang-Ying Chu, Hung-An Chen, Yun-Ju Yin, Hua-Chin Lee, William Cheng-Chung Chu, Hui-Wen Yeh, Wei-Shan Chiang, Chia-Lun Yeh, Hui-Ling Huang, Nian-Sheng Tzeng, Uwe Rudolph
PLOS ONE.2015; 10(12): e0146030. CrossRef
Evaluation of risk factors for fractures in postmenopausal women with osteoporosis
Viktória Ferencz, Csaba Horváth, Sándor Huszár, Katalin Bors
Orvosi Hetilap.2015; 156(4): 146. CrossRef
Association between use of benzodiazepines and risk of fractures: a meta-analysis
D. Xing, X. L. Ma, J. X. Ma, J. Wang, Y. Yang, Y. Chen
Osteoporosis International.2014; 25(1): 105. CrossRef
Non-benzodiazepine hypnotics and older adults: what are we learning about zolpidem?
Hedva B Levy
Expert Review of Clinical Pharmacology.2014; 7(1): 5. CrossRef
Long-Term Use of Zolpidem Increases the Risk of Major Injury: A Population-Based Cohort Study
Ming-May Lai, Cheng-Chieh Lin, Che-Chen Lin, Chiu-Shong Liu, Tsai-Chung Li, Chia-Hung Kao
Mayo Clinic Proceedings.2014; 89(5): 589. CrossRef
Risk of hip fracture among older people using anxiolytic and hypnotic drugs: a nationwide prospective cohort study
Marit Stordal Bakken, Anders Engeland, Lars B. Engesæter, Anette Hylen Ranhoff, Steinar Hunskaar, Sabine Ruths
European Journal of Clinical Pharmacology.2014; 70(7): 873. CrossRef
Treatment of Insomnia in Older Adults: Re-Evaluating the Benefits and Risks of Sedative Hypnotic Agents
Nicole J. Brandt, Jennifer M. Piechocki
Journal of Gerontological Nursing.2013; 39(4): 48. CrossRef
In the Zzz Zone: The Effects of Z-Drugs on Human Performance and Driving
Naren Gunja
Journal of Medical Toxicology.2013; 9(2): 163. CrossRef
Ten-year trend in prescriptions of z-hypnotics among the elderly: A nationwide, cross-sectional study in Taiwan
Fei-Yuan Hsiao, Pei-Hua Hsieh, Churn-Shiouh Gau
Journal of Clinical Gerontology and Geriatrics.2013; 4(2): 37. CrossRef
Zolpidem, Is it a Safe Drug for Insomnia Management?
Kyung Hee Park, Jae-Hyun Lee
Korean Journal of Medicine.2013; 84(6): 802. CrossRef

Author index