Journal of Preventive Medicine and Public Health

Nam Wook Hur

6 Articles

Mathematical Modeling of the Novel Influenza A (H1N1) Virus and Evaluation of the Epidemic Response Strategies in the Republic of Korea.: Mina Suh, Jeehyun Lee, Hye Jin Chi, Young Keun Kim, Dae Yong Kang, Nam Wook Hur, Kyung Hwa Ha, Dong Han Lee, Chang Soo Kim; J Prev Med Public Health. 2010;43(2):109-116.; DOI: https://doi.org/10.3961/jpmph.2010.43.2.109

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OBJECTIVES
The pandemic of novel influenza A (H1N1) virus has required decision-makers to act in the face of the substantial uncertainties. In this study, we evaluated the potential impact of the pandemic response strategies in the Republic of Korea using a mathematical model. METHODS: We developed a deterministic model of a pandemic (H1N1) 2009 in a structured population using the demographic data from the Korean population and the epidemiological feature of the pandemic (H1N1) 2009. To estimate the parameter values for the deterministic model, we used the available data from the previous studies on pandemic influenza. The pandemic response strategies of the Republic of Korea for novel influenza A (H1N1) virus such as school closure, mass vaccination (70% of population in 30 days), and a policy for anti-viral drug (treatment or prophylaxis) were applied to the deterministic model. RESULTS: The effect of two-week school closure on the attack rate was low regardless of the timing of the intervention. The earlier vaccination showed the effect of greater delays in reaching the peak of outbreaks. When it was no vaccination, vaccination at initiation of outbreak, vaccination 90 days after the initiation of outbreak and vaccination at the epidemic peak point, the total number of clinical cases for 400 days were 20.8 million, 4.4 million, 4.7 million and 12.6 million, respectively. The pandemic response strategies of the Republic of Korea delayed the peak of outbreaks (about 40 days) and decreased the number of cumulative clinical cases (8 million). CONCLUSIONS: Rapid vaccination was the most important factor to control the spread of pandemic influenza, and the response strategies of the Republic of Korea were shown to delay the spread of pandemic influenza in this deterministic model.

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Estimation of optimal antiviral stockpile for a novel influenza pandemic
Soyoung Kim, Yu Bin Seo, Jacob Lee, Yang Soo Kim, Eunok Jung
Journal of Infection and Public Health.2022; 15(7): 720. CrossRef
Projections for novel coronavirus (COVID-19) and evaluation of epidemic response strategies for India
Seema Patrikar, Deepti Poojary, D.R. Basannar, D.S. Faujdar, Renuka Kunte
Medical Journal Armed Forces India.2020; 76(3): 268. CrossRef
Prediction of the Transition From Subexponential to the Exponential Transmission of SARS-CoV-2 in Chennai, India: Epidemic Nowcasting
Kamalanand Krishnamurthy, Bakiya Ambikapathy, Ashwani Kumar, Lourduraj De Britto
JMIR Public Health and Surveillance.2020; 6(3): e21152. CrossRef
Mathematical model of transmission dynamics and optimal control strategies for 2009 A/H1N1 influenza in the Republic of Korea
Soyoung Kim, Jonggul Lee, Eunok Jung
Journal of Theoretical Biology.2017; 412: 74. CrossRef
A real option analysis for stochastic disease control and vaccine stockpile policy: An application to H1N1 in Korea
Hojeong Park
Economic Modelling.2016; 53: 187. CrossRef
Stochastic methods for epidemic models: An application to the 2009 H1N1 influenza outbreak in Korea
Hyojung Lee, Sunmi Lee, Chang Hyeong Lee
Applied Mathematics and Computation.2016; 286: 232. CrossRef
Schools’ Response to MERS(MERS-CoV) Outbreak: Schools’ Discretionary Response in Absence of Control Tower
In Sook Lee, Jae Hee Yoon, Eun Joo Hong, Chae Yoon Kim
Journal of the Korean Society of School Health.2015; 28(3): 188. CrossRef
The Effects of School Closures on Influenza Outbreaks and Pandemics: Systematic Review of Simulation Studies
Charlotte Jackson, Punam Mangtani, Jeremy Hawker, Babatunde Olowokure, Emilia Vynnycky, Gerardo Chowell
PLoS ONE.2014; 9(5): e97297. CrossRef
Uncertainty Quantification in Simulations of Epidemics Using Polynomial Chaos
F. Santonja, B. Chen-Charpentier
Computational and Mathematical Methods in Medicine.2012; 2012: 1. CrossRef
Characteristics of Outpatients with Pandemic H1N1/09 Influenza in a Tertiary Care University Hospital in Korea
Kyung Sun Park, Tae Sung Park, Jin Tae Suh, You Sun Nam, Mi Suk Lee, Hee Joo Lee
Yonsei Medical Journal.2012; 53(1): 213. CrossRef
Epidemiological Characteristics of Imported Influenza A (H1N1) Cases during the 2009 Pandemic in Korea
Jun Kil Choi, Sang Won Lee, Bo Youl Choi
Epidemiology and Health.2012; 34: e2012009. CrossRef

The Association between Obesity Indices in Adolescence and Carotid Intima-media Thickness in Young Adults: Kangwha Study.: Yoo Jung Lee, Chung Mo Nam, Hyeon Chang Kim, Nam Wook Hur, Il Suh; J Prev Med Public Health. 2008;41(2):107-114.; DOI: https://doi.org/10.3961/jpmph.2008.41.2.107

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Abstract PDF

OBJECTIVES
The aim of this study is to investigate the association between obesity indices (body mass index, weight, waist-hip ratio and waist circumference) in adolescents and the carotid intima-media thickness (C-IMT) in early adulthood. We also wanted to identify the best predictor for C-IMT among these obesity indices. METHODS: This study used community-based prospective cohort study, known as the Kangwha Study, and the data we used were from subjects who were 16-years old in 1996 (defined as "adolescencec") and 25 years-old in 2005 (defined as "early adulthoodc"). The 256 subjects (113 men and 143 women) who were used for analysis participated in both follow-ups, and they underwent B-mode ultrasonography of the carotid arteries at the early adulthood follow-up. Obesity indices were defined as the body mass index, weight, waist-hip ratio and waist circumference. The C-IMT was defined as the mean of the maximal IMT of each common carotid artery. The C-IMT and obesity indices associations were evaluated via multivariable regression, logistic regression and the receiver-operator characteristic curve analyses. RESULTS: In men, all the obesity indices in adolescence were showed to have statistically significant positive association with C-IMT in early adulthood. However, no such relationship was showed in women. On multiple regression and logistic regression analysis, the waist-hip ratio showed the biggest relationship with the C-IMT among the 4 obesity indices. However, there were no statistical significant differences and no best predictor was found. For the women, the obesity incidences and C-IMT showed no relationships. CONCLUSIONS: This study suggested that obesity in adolescence was related to an increase C-IMT in healthy young Korean men.

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Application of Standardized Regression Coefficient in Meta-Analysis
Pentti Nieminen
BioMedInformatics.2022; 2(3): 434. CrossRef
Comparison analysis of childhood body mass index cut-offs in predicting adulthood carotid intima media thickness: Tehran lipid and glucose study
Farhad Hosseinpanah, Amirhosein Seyedhoseinpour, Maryam Barzin, Maryam Mahdavi, Erfan Tasdighi, Pooneh Dehghan, Amin Momeni Moghaddam, Fereidoun Azizi, Majid Valizadeh
BMC Pediatrics.2021;[Epub] CrossRef
Asian Cohort Studies on Cardiovascular Risk Factors in Childhood
Sun Jae Jung, Hyeon Chang Kim, Il Suh
Cardiovascular Prevention and Pharmacotherapy.2019; 1(1): 3. CrossRef
Carotid intima media thickness in obese children: is there an association with hyperlipidemia?
Zehra Esra Önal, Levent Soydan, Hatice Eren Öztürk, Çiğdem Sağ, Tamay Gürbüz, Çağatay Nuhoğlu, Mehmet Masum Şimşek
Journal of Pediatric Endocrinology and Metabolism.2016;[Epub] CrossRef
Analysis for the Patterns of Medical Care Utilization during 19 Years (1990-2008) and Its Related Factors in Hypertensive Patients Using National Patient Survey in Korea
Nam Wook Hur, Hyeon Chang Kim
Journal of the Korean Society of Hypertension.2014; 20(1): 8. CrossRef
Overview of Noncommunicable Diseases in Korean Children and Adolescents: Focus on Obesity and Its Effect on Metabolic Syndrome
Hye Ah Lee, Hyesook Park
Journal of Preventive Medicine and Public Health.2013; 46(4): 173. CrossRef
Longitudinal Standards for Height and Height Velocity in Korean Children and Adolescents: the Kangwha Cohort Study
Hyun Wook Chae, Il Suh, Ah Reum Kwon, Ye Jin Kim, Yong Hyuk Kim, Dae Ryong Kang, Ha Yan Kim, Sun Min Oh, Hyeon Chang Kim, Duk Hee Kim, Ho-Seong Kim
Journal of Korean Medical Science.2013; 28(10): 1512. CrossRef
Clinical characteristics of obese boys and girls in a high school: focused on abdominal fat indices, fatty liver and carotid intima-media thickness
Jung Eun Oh, Jiyoung Jung, Hae Soon Kim, Young Mi Hong, Jung Hyun Yoo, Young Whan Song, Jo Won Jung, Nam Su Kim, Chung Il Noh
Korean Journal of Pediatrics.2011; 54(7): 292. CrossRef
Association between Blood Pressure and Carotid Intima-Media Thickness
Sun Min Lim, Hyeon Chang Kim, Hoon Sang Lee, Joo Young Lee, Mina Suh, Song Vogue Ahn
The Journal of Pediatrics.2009; 154(5): 667. CrossRef

Impact of Multiple Cardiovascular Risk Factors on the Carotid Intima-media Thickness in Young Adults: The Kangwha Study.: Hoo Sun Chang, Hyeon Chang Kim, Song Vogue Ahn, Nam Wook Hur, Il Suh; J Prev Med Public Health. 2007;40(5):411-417.; DOI: https://doi.org/10.3961/jpmph.2007.40.5.411

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OBJECTIVES
Although risk factors for coronary artery disease are also associated with increased carotid intima-media thickness (IMT), there is little information available on the asymptomatic, young adult population. We examined the association between multiple cardiovascular risk factors and the common carotid IMT in 280 young Korean adults. METHODS: The data used for this study was obtained from 280 subjects (130 men and 150 women) aged 25 years who participated in the Kangwha Study follow-up examination in 2005. We measured cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry, carotid ultrasonography, and reviewed questionnaires on health behaviors. Risk factors were defined as values above the sex-specific 75th percentile of systolic blood pressure, body mass index, total cholesterol/high-density lipoprotein cholesterol ratio, fasting blood glucose and smoking status. RESULTS: The mean carotid IMT+/-standard deviation observed was 0.683+/-0.079 mm in men and 0.678+/-0.067 mm in women (p=0.567) and the evidence of plaque was not observed in any individuals. Mean carotid IMT increased with an increasing number of risk factors(p for trend <0.001) and carotid IMT values were 0.665 mm, 0.674 mm, 0.686 mm, 0.702 mm, and 0.748 mm for 0, 1, 2, 3, and 4 to 5 risk factors, respectively. The odds ratio for having the top quartile carotid IMT in men with 3 or more risk factors versus 0-2 risk factors was 5.09 (95% CI, 2.05-12.64). CONCLUSIONS: Current findings indicate the need for prevention and control of cardiovascular risk factors in young adults and more focus on those with multiple cardiovascular risk factors.

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Association Between Risk Factors in Childhood and Sex Differences in Prevalence of Carotid Artery Plaques and Intima‐Media Thickness in Mid‐Adulthood in the Childhood Determinants of Adult Health Study
Mohammad Shah, Marie‐Jeanne Buscot, Jing Tian, Hoang T. Phan, Brooklyn J. Fraser, Thomas H. Marwick, Terence Dwyer, Alison Venn, Seana Gall
Journal of the American Heart Association.2023;[Epub] CrossRef
Association between Fibrinogen and Carotid Atherosclerosis According to Smoking Status in a Korean Male Population
Hye Min Cho, Dae Ryong Kang, Hyeon Chang Kim, Sun Min Oh, Byeong-Keuk Kim, Il Suh
Yonsei Medical Journal.2015; 56(4): 921. CrossRef
Myocardial perfusion and intima-media thickness in patients with subclinical hypothyroidism
M Knapp, A Lisowska, B Sobkowicz, A Tycińska, R Sawicki, WJ Musiał
Advances in Medical Sciences.2013; 58(1): 44. CrossRef
Association between Depressive Symptoms and Bone Stiffness Index in Young Adults: The Kangwha Study
Sun Min Oh, Hyeon Chang Kim, Kyoung Min Kim, Song Vogue Ahn, Dong Phil Choi, Il Suh, Chih-Hsin Tang
PLoS ONE.2013; 8(7): e69929. CrossRef
The importance of intima-media thickness (IMT) measurements in monitoring of atherosclerosis progress after myocardial infarction
A Lisowska, M Knapp, S Bolińska, P Lisowski, A Krajewska, B Sobkowicz, WJ Musiał
Advances in Medical Sciences.2012; 57(1): 112. CrossRef
Association between Blood Pressure and Carotid Intima-Media Thickness
Sun Min Lim, Hyeon Chang Kim, Hoon Sang Lee, Joo Young Lee, Mina Suh, Song Vogue Ahn
The Journal of Pediatrics.2009; 154(5): 667. CrossRef

Relationship between Corrected QT Interval and Cardiovascular Risk Factors in Young Healthy Adults: The Kangwha Study.: Song Vogue Ahn, Hyeon Chang Kim, Nam Wook Hur, Kyoung Soo Ha, Hoo Sun Jang, Jin Bae Kim, Il Suh; J Prev Med Public Health. 2006;39(6):455-461.

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Abstract PDF: OBJECTIVES
Prolongation of the heart rate-corrected QT (QTc) interval has been reported to be associated with cardiovascular morbidity and mortality. However, few studies have examined the relationship between the QTc interval and cardiovascular risk factors in young healthy people. The aim of this study was to examine the associations between the QTc interval and cardiovascular risk factors in young healthy adults. METHODS: This study was performed as part of the Kangwha study, which started in 1986, and is an on-going follow-up study on blood pressure and related cardiovascular risk factors. In follow-up examinations during 2005, cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry and carotid ultrasonography, were measured, and questionnaires on health behaviors completed by 127 men and 149 women aged 25 years. The QTc interval was measured on the resting 12-lead electrocardiogram using an automatic analysis program. RESULTS: The mean QTc interval was significantly longer in women (419+/-17ms) than in men (405+/-17ms) (p<0.001). A significant positive correlation was found between the QTc interval and waist-hip ratio (p=0.030) in men. Women showed a positive correlation between the QTc interval and systolic blood pressure (p=0.017). On a multiple regression analysis, the QTc interval was positively associated with the waist-hip ratio in men (p=0.012) and with the systolic blood pressure (p=0.020) in women. CONCLUSIONS: In young healthy Korean adults, the QTc interval was independently associated with the waist-hip ratio in men and with the systolic blood pressure in women.; Summary

A Study on Scheduling Periodic Examinations for the Early Detection of Breast Cancer in Korea.: Seong Hwa Jeong, Dae Ryong Kang, Nam Wook Hur, Jinheum Kim, Soon Young Lee, Sang Hyuk Jung, Chung Mo Nam; J Prev Med Public Health. 2006;39(4):346-352.

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Abstract PDF: OBJECTIVES
The purposes of this study were to propose a screening schedule for the early detection of breast cancer among Korean women, as based on the statistical model, and to compare the efficacy of the proposed screening schedule with the current recommendations. METHODS: The development of the screening schedule for breast cancer closely followed the work of Lee and Zelen (1998). We calculated the age-specific breast cancer incidence rate from the Korea Central Cancer Registry (2003), and then we estimated the scheduling of periodic examinations for the early detection of breast cancer, using mammography, and based on the threshold method. The efficacy of the derived screening schedule was evaluated by the schedule sensitivity. RESULTS: For estimating the screening schedule threshold method, we set the threshold value as the probability of being in the preclinical stage at age 35, the sensitivity of mammography as 0.9 and the mean sojourn time in the preclinical stage as 4 years. This method generated 14 examinations within the age interval [40, 69] of 40.0, 41.3, 42.7, 44.1, 45.4, 46.7, 48.0, 49.3, 51.0, 53.2, 55.3, 57.1, 59.0 and 63.6 years, and the schedule sensitivity was 75.4%. The proposed screening schedule detected 85.2% (74.5/87.4) of the cases that could have been detected by annual screening, but it required only about 48.7% (14.0/30.0) of the total number of examinations. We also examined the threshold screening schedules for a range of sensitivities of mammography and the mean sojourn time in the preclinical stage. CONCLUSIONS: The proposed screening schedule for breast cancer with using the threshold method will be helpful to provide guidelines for a public health program for choosing an effective screening schedule for breast cancer among Korean women.; Summary

Kangwha Study Association Analysis of the Essential Hypertension Susceptibility Genes in Adolescents: Kangwha Study.: Il Suh, Chung Mo Nam, Sung Joo Kim, Dong Jik Shin, Nam Wook Hur, Dae Ryong Kang; J Prev Med Public Health. 2006;39(2):177-183.

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Abstract PDF: OBJECTIVES
In this study we examined the association between the genetic markers ACE (A-240T, C-93T, I/D, A2350G), AGT (M235T), AT1R (A1166C), CYP11B2 (T-344C, V386A), REN (G2646A), ADRB2 (G46A, C79G, T-47C, T164I), GNB3 (C825T) and ADD1 (G460W) and the presence of essential hypertension in adolescents. METHODS: The Kangwha Study is an 18-year prospective study that is aimed at elucidating the determinants of the blood pressure level from childhood to early adulthood. For this study, we constructed a case-control dataset of size of 277 and 40 family trios data from the Kangwha Study. For this purpose, we perform a single locus-based case-control association study and a single locus-based TDT (transmission/disequilibrium test) study. RESULTS: In the case-control study, the single locus-based association study indicated that the ADD1 (G460W) (p=0.0403), AGT (M235T) (p=0.0002), and REN (G2646A) (p=0.0101) markers were significantly associated with the risk of hypertension. These results were not confirmed on the TDT study. This study showed that genetic polymorphisms of the ADD1, AGT and REN genes might be related to the hypertension in Korean adolescents. CONCLUSIONS: This study provided useful information on genetics markers related to blood pressure. Further study will be needed to confirm the effect of the alpha adducin gene, the angiotensinogen gene and the renin gene on essential hypertension.; Summary

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