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Kyung-Shin Lee 1 Article
Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea
Yoonyoung Jang, Yoon-Jung Choi, Youn-Hee Lim, Kyung-Shin Lee, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim, Yun-Chul Hong
J Prev Med Public Health. 2021;54(1):37-45.   Published online November 23, 2020
DOI: https://doi.org/10.3961/jpmph.20.310
  • 7,144 View
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  • 9 Web of Science
  • 11 Crossref
AbstractAbstract AbstractSummary PDFSupplementary Material
Objectives
Bisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children.
Methods
Prenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations.
Results
The associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only.
Conclusions
Our findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.
Summary
Korean summary
비스페놀 A의 건강위해성에 대한 역학적 근거들이 축적되어 비스페놀 A 대신 BPF와 BPS와 같은 대체물질이 사용되고 있다. 본 논문에서는 어머니의 산전 비스페놀 A 노출과 6세 어린이의 비스페놀 A, 비스페놀 F, 비스페놀 S 노출 정도에 따라 어린이의 갑상선호르몬 농도에 어떠한 영향을 미치는가 보고자 하였다. 어머니의 산전 비스페놀 A 노출은 어린이의 total T3 농도에 유의하게 영향을 미쳤으며, 특히 여자아이에게서 비스페놀 F 노출이 한 단위 증가할수록 free T4 농도가 유의하게 감소하는 것을 관찰하였다. 본 논문의 의의는 비스페놀 F, S가 어린이의 갑상선기능에 어떠한 영향을 미치는지 역학적 근거를 제시하였다는 점이나, 인과적 연관성을 위해서는 시간적 선후관계를 고려한 더 많은 연구가 필요하다.

Citations

Citations to this article as recorded by  
  • Relationship between bisphenol A and autoimmune thyroid disease in women of childbearing age
    Ning Yuan, Jianbin Sun, Xin Zhao, Wei Li
    Frontiers in Endocrinology.2024;[Epub]     CrossRef
  • The effect of bisphenols on sex and thyroid hormone concentrations in cord blood among newborns
    Francis Manyori Bigambo, Zhaofang Chen, Wentao Yang, Qian Huang, Xu Wang
    Food and Chemical Toxicology.2024; 189: 114750.     CrossRef
  • Temporal trends in risk of bisphenol A, benzophenone-3 and triclosan exposure among U.S. children and adolescents aged 6–19 years: Findings from the National Health and Nutrition Examination Survey 2005–2016
    Ruiqiang Li, Wenqiang Zhan, Jingyi Ren, Fan Zhang, Xin Huang, Yuxia Ma
    Environmental Research.2023; 216: 114474.     CrossRef
  • A case-control study of urinary concentrations of bisphenol A, bisphenol F, and bisphenol S and the risk of papillary thyroid cancer
    Lei Zhang, Jiahuai Zhang, Sai Fan, Yuxin Zhong, Jingguang Li, Yunfeng Zhao, Song Ni, Jiaying Liu, Yongning Wu
    Chemosphere.2023; 312: 137162.     CrossRef
  • Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice
    Pieter Vancamp, Lucile Butruille, Anni Herranen, Anita Boelen, Jean-Baptiste Fini, Barbara A. Demeneix, Sylvie Remaud
    Environment International.2023; 172: 107770.     CrossRef
  • Risk Assessment of Bisphenol A in the Korean General Population
    Myungsil Hwang, Seon-Joo Park, Hae-Jeung Lee
    Applied Sciences.2023; 13(6): 3587.     CrossRef
  • The Joint Effects of Bisphenols and Iodine Exposure on Thyroid during Pregnancy
    Wei Lu, Zhuo Sun, Zhengyuan Wang, Mengying Qu, Zehuan Shi, Qi Song, Liping Shen, Shupeng Mai, Yuan Wang, Xinyu Hong, Jiajie Zang
    Nutrients.2023; 15(15): 3422.     CrossRef
  • Associations of exposure to bisphenol A and its substitutes with neurodevelopmental outcomes among infants at 12 months of age: A cross-sectional study
    Zhuanning Xia, Cheng Lv, Yan Zhang, Rong Shi, Qi Lu, Ying Tian, Xiaoning Lei, Yu Gao
    Chemosphere.2023; 341: 139973.     CrossRef
  • Association of urinary bisphenols with thyroid function in the general population: a cross-sectional study of an industrial park in China
    Yang Hu, Shiming Lai, Ying Li, Xiaodong Wu, Mingluan Xing, Xueqing Li, Dandan Xu, Yuan Chen, Jie Xiang, Ping Cheng, Xiaofeng Wang, Zhijian Chen, Hao Ding, Peiwei Xu, Xiaoming Lou
    Environmental Science and Pollution Research.2023; 30(49): 107517.     CrossRef
  • Associations of Urinary Bisphenol a, Bisphenol F, and Bisphenol S with the Risk of Papillary Thyroid Cancer: A Case-Control Study
    Lei Zhang, Jiahuai Zhang, Sai Fan, Yuxin Zhong, Jingguang Li, Yunfeng Zhao, Song Ni, Jiaying Liu, Yong-Ning Wu
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • The Impact of Bisphenol A on Thyroid Function in Neonates and Children: A Systematic Review of the Literature
    Diamanto Koutaki, George Paltoglou, Aikaterini Vourdoumpa, Evangelia Charmandari
    Nutrients.2021; 14(1): 168.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health