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Hwa Young Lee 2 Articles
Body Weight at Birth and at Age Three and Respiratory Illness in Preschool Children.
Yoolwon Jeong, Kyunghee Jung-Choi, Jin Hwa Lee, Hwa Young Lee, Eun Ae Park, Young Ju Kim, Eunhee Ha, Se Young Oh, Hyesook Park
J Prev Med Public Health. 2010;43(5):369-376.
DOI: https://doi.org/10.3961/jpmph.2010.43.5.369
  • 5,707 View
  • 59 Download
  • 18 Crossref
AbstractAbstract PDF
OBJECTIVES
The purpose of this study was to examine the associations of current body weight and body mass index (BMI) at age three and birth weight in developing chronic respiratory illness in childhood and identify possible interaction underlying its mechanism. METHODS: The study was carried out with 422 children who were enrolled in a hospital-based birth cohort. Birth related anthropometric data were collected at birth. At age 3 years, the presence of respiratory symptoms was evaluated by using the Korean version of core questionnaire for wheezing and asthma from the International Study of Asthma and Allergies in Childhood (ISAAC). Physical examination was carried out to measure the child's weight and height. RESULTS: Children in the lowest birth weight tertile (aOR = 3.97, 95% CI = 0.94-16.68) or highest BMI tertile (aOR = 3.68, 95% CI = 1.24-10.95) at three years of age were at an increased risk of chronic respiratory illness. Children who were initially in the lowest birth weight tertile but now belong in the highest weight tertile had higher risk of chronic respiratory illness compared to those who had remained in the middle tertile (OR=16.35, 95% CI=1.66-160.57). CONCLUSIONS: Children with lower birth weight or higher BMI were at an increased risk of chronic respiratory illness. In addition, children who were initially in the lowest birth weight tertile but are now in the highest weight tertile had higher risk of chronic respiratory illness compared to those who remained in the middle tertile.
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Citations

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    American Journal of Epidemiology.2020; 189(6): 583.     CrossRef
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    Magdalena Muc, Anabela Mota-Pinto, Cristina Padez
    Nutrition Research Reviews.2016; 29(2): 194.     CrossRef
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    Sari Törmänen, Eero Lauhkonen, Antti Saari, Petri Koponen, Matti Korppi, Kirsi Nuolivirta
    Pediatric Pulmonology.2015; 50(5): 424.     CrossRef
  • Birth weight and childhood wheezing disorders: a systematic review and meta-analysis
    Teumzghi F Mebrahtu, Richard G Feltbower, Darren C Greenwood, Roger C Parslow
    Journal of Epidemiology and Community Health.2015; 69(5): 500.     CrossRef
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    Finn Rasmussen, Robert J. Hancox
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    Yueh-Hsiu Mathilda Chiu, Brent A. Coull, Michelle J. Sternthal, Itai Kloog, Joel Schwartz, Sheldon Cohen, Rosalind J. Wright
    Journal of Allergy and Clinical Immunology.2014; 133(3): 713.     CrossRef
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    Gustavo F. Wandalsen, Herberto J. Chong-Neto, Fabíola S. de Souza, Dirceu Solé, Leonard B. Bacharier
    Current Opinion in Allergy & Clinical Immunology.2014; 14(2): 126.     CrossRef
  • Childhood Overweight/Obesity and Asthma: Is There a Link? A Systematic Review of Recent Epidemiologic Evidence
    Constantina Papoutsakis, Kostas N. Priftis, Maria Drakouli, Stamatina Prifti, Eva Konstantaki, Maria Chondronikola, Georgios Antonogeorgos, Vasiliki Matziou
    Journal of the Academy of Nutrition and Dietetics.2013; 113(1): 77.     CrossRef
  • Overview of Noncommunicable Diseases in Korean Children and Adolescents: Focus on Obesity and Its Effect on Metabolic Syndrome
    Hye Ah Lee, Hyesook Park
    Journal of Preventive Medicine and Public Health.2013; 46(4): 173.     CrossRef
  • Fetal growth and risk of childhood asthma and allergic disease
    S. G. Tedner, A. K. Örtqvist, C. Almqvist
    Clinical & Experimental Allergy.2012; 42(10): 1430.     CrossRef
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    Yueh-Hsiu Mathilda Chiu, Brent A. Coull, Sheldon Cohen, Alana Wooley, Rosalind J. Wright
    American Journal of Respiratory and Critical Care Medicine.2012; 186(2): 147.     CrossRef
  • Body Mass Index May Modify Asthma Prevalence Among Low-Birth-Weight Children
    F. L. Lu, C.-J. Hsieh, J. L. Caffrey, M.-H. Lin, Y.-S. Lin, C.-C. Lin, M.-S. Tsai, W.-C. Ho, P.-C. Chen, F.-C. Sung, R.-S. Lin
    American Journal of Epidemiology.2012; 176(1): 32.     CrossRef
  • Joint effects of birth outcomes and childhood body mass index on respiratory symptoms
    Wen-Hua Wang, Pau-Chung Chen, Wu-Shiun Hsieh, Yungling Leo Lee
    European Respiratory Journal.2012; 39(5): 1213.     CrossRef
  • Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone
    Theresa W. Guilbert, David T. Mauger, David B. Allen, Robert S. Zeiger, Robert F. Lemanske, Stanley J. Szefler, Robert C. Strunk, Leonard B. Bacharier, Ronina Covar, Christine A. Sorkness, Lynn M. Taussig, Fernando D. Martinez
    Journal of Allergy and Clinical Immunology.2011; 128(5): 956.     CrossRef
Folate and Homocysteine Levels during Pregnancy affect DNA Methylation in Human Placenta.
Bo hyun Park, Young Ju Kim, Jong soon Park, Hwa young Lee, Eun hee Ha, Jung won Min, Hye sook Park
J Prev Med Public Health. 2005;38(4):437-442.
  • 2,475 View
  • 101 Download
AbstractAbstract PDF
OBJECTIVES
DNA methylation is one of the best characterized epigenetic mechanisms that play a regulatory role in genome programming and imprinting during embryogenesis. In this present study, we investigated the association between DNA methylation in the human placenta and the maternal folate and homocysteine concentrations on the Methylenetetrahydrofolatereductase (MTHFR) genetic polymorphism during pregnancy. METHODS: We investigated 107 pregnant women who visited Ewha Woman's University Hospital for prenatal care during their 24~28 weeks-period of gestation. During the second trimester, we measured the serum homocysteine and folate concentrations. The MTHFR 677 genetic polymorphism was determine by performing PCR-RFLP assay. The expression of DNA methylation in the human placentas was estimated by using immunohistochemistry method. RESULTS: Serum folate was negatively correlated with the serum homocysteine concentration for all the MTHFR genotypes. We found positive correlation between the folate concentrations and the DNA methylation in the human placenta (p< 0.05). An increasing concentration of homocysteine was associated with reduced DNA methylation in the human placenta. The coefficient value was -2.03 (-3.77, -0.29) on the regression model (p< 0.05). CONCLUSION: These findings suggest that the maternal folate and homocysteine levels along with the MTHFR 677 genetic polymorphism during pregnancy affect the DNA methylation in the human placenta.
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