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Heidi Taipale 1 Article
Month and Season of Birth as a Risk Factor for Alzheimer’s Disease: A Nationwide Nested Case-control Study
Anna-Maija Tolppanen, Riitta Ahonen, Marjaana Koponen, Piia Lavikainen, Maija Purhonen, Heidi Taipale, Antti Tanskanen, Jari Tiihonen, Miia Tiihonen, Sirpa Hartikainen
J Prev Med Public Health. 2016;49(2):134-138.   Published online March 23, 2016
DOI: https://doi.org/10.3961/jpmph.16.018
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AbstractAbstract PDF
Objectives
Season of birth, an exogenous indicator of early life environment, has been related to higher risk of adverse psychiatric outcomes but the findings for Alzheimer’s disease (AD) have been inconsistent. We investigated whether the month or season of birth are associated with AD.
Methods
A nationwide nested case-control study including all community-dwellers with clinically verified AD diagnosed in 2005 to 2012 (n=70 719) and up to four age- sex- and region of residence-matched controls (n=282 862) residing in Finland. Associations between month and season of birth and AD were studied with conditional logistic regression.
Results
Month of birth was not associated with AD (p=0.09). No strong associations were observed with season (p=0.13), although in comparison to winter births (December-February) summer births (June-August) were associated with higher odds of AD (odds ratio, 1.03; 95% confidence interval, 1.00 to 1.05). However, the absolute difference in prevalence in winter births was only 0.5% (prevalence of those born in winter were 31.7% and 32.2% for cases and controls, respectively).
Conclusions
Although our findings do not support the hypothesis that season of birth is related to AD/dementia risk, they do not invalidate the developmental origins of health and disease hypothesis in late-life cognition. It is possible that season does not adequately capture the early life circumstances, or that other (postnatal) risk factors such as lifestyle or socioeconomic factors overrule the impact of prenatal and perinatal factors.
Summary

Citations

Citations to this article as recorded by  
  • Risk factors for the alzheimer's disease. Systematic review and meta-analysis
    G. R. Khasanova, M. Sh. Muzaffarova
    Fundamental and Clinical Medicine.2024; 8(4): 101.     CrossRef
  • Do prenatal factors shape the risk for dementia?: A systematic review of the epidemiological evidence for the prenatal origins of dementia
    Aline Marileen Wiegersma, Amber Boots, Miranda W. Langendam, Jacqueline Limpens, Susan D. Shenkin, Aniko Korosi, Tessa J. Roseboom, Susanne R. de Rooij
    Social Psychiatry and Psychiatric Epidemiology.2023;[Epub]     CrossRef
  • Season of birth and vulnerability to the pathology of Alzheimer's disease: an in vivo positron emission tomography study
    Fumihiko Yasuno, Hiroyuki Minami
    Psychogeriatrics.2022; 22(4): 445.     CrossRef
  • Season-of-birth phenomenon in health and longevity: epidemiologic evidence and mechanistic considerations
    Alexander Vaiserman
    Journal of Developmental Origins of Health and Disease.2021; 12(6): 849.     CrossRef
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    Daria Peleg-Raibstein
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Season of birth and the risk of dementia in the population‐based Rotterdam Study
    Sanne S. Mooldijk, Silvan Licher, Elisabeth J. Vinke, Meike W. Vernooij, Mohammad Kamran Ikram, Mohammad Arfan Ikram
    European Journal of Epidemiology.2021; 36(5): 497.     CrossRef
  • Month of birth and mental disorders: A population‐based study and validation using global meta‐analysis
    Chih‐Wei Hsu, Ping‐Tao Tseng, Yu‐Kang Tu, Pao‐Yen Lin, Chi‐Fa Hung, Chih‐Sung Liang, Yun‐Yu Hsieh, Yao‐Hsu Yang, Liang‐Jen Wang, Hung‐Yu Kao
    Acta Psychiatrica Scandinavica.2021; 144(2): 153.     CrossRef
  • Association Between Season of Birth and Cognitive Aging in Older Adults: Pan-European Population-Based Study on 70,000 Individuals
    Matej Kucera, Katrin Wolfova, Pavla Cermakova
    Journal of Alzheimer's Disease.2021; 82(4): 1703.     CrossRef
  • Season of birth and dementia: Findings from Chinese elderly based on a nationwide data
    Ruoxi Ding, Ping He, Xinming Song, Xiaoying Zheng
    American Journal of Human Biology.2020;[Epub]     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health