Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Duk Hee Lee 24 Articles
Association Between Gamma-Glutamyltransferase and Hypertension Incidence in Rural Prehypertensive Adults.
Jun Hyun Hwang, Ji Yeon Shin, Byung yeol Chun, Duk Hee Lee, Keon Yeop Kim, Wee hyun Park, Shung chull Chae
J Prev Med Public Health. 2010;43(1):18-25.
DOI: https://doi.org/10.3961/jpmph.2010.43.1.18
  • 4,694 View
  • 52 Download
  • 4 Crossref
AbstractAbstract PDF
OBJECTIVES
Prehypertension is associated with a higher risk of developing hypertension compared with normotension. Yet, factors predicting the development of hypertension among prehypertensive people are ill-understood. This prospective cohort study was performed to examine if serum gamma-glutamyltrasferase (GGT) within a normal range can predict the future risk of hypertension among prehypertensive adults. METHODS: Study subjects were 293 prehypertensive persons >30-years-of-age who participated in a community-based health survey in 2003 and who were followed up in 2008. Sex-specific quartiles of baseline serum GGT were used to examine association with 5-year hypertension incidence. RESULTS: Baseline serum GGT within normal range predicted the risk of developing hypertension for 5 years only in prehypertensive women. Adjusted relative risks were 1.0, 3.7, 3.6, and 6.0 according to quartiles of baseline serum GGT (P for trend <0.01). This pattern was similarly observed in non-drinkers. However, serum GGT was not associated with incident hypertension in men. Different from serum GGT, baseline serum alanine aminotransferase, another well-known liver enzyme, did not predict the risk of incident hypertension in both genders. CONCLUSIONS: Even though baseline serum GGT within normal range strongly predicted the future risk of hypertension, it was observed only in women, Although underlying mechanisms of this association are currently unclear, serum GGT can be used to select a high risk group of hypertension in prehypertensive women.
Summary

Citations

Citations to this article as recorded by  
  • Gamma-glutamyltransferase and risk of hypertension
    Setor K. Kunutsor, Tanefa A. Apekey, Bernard M.Y. Cheung
    Journal of Hypertension.2015; 33(12): 2373.     CrossRef
  • Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
    Jean-Claude, Lapraz, Kamyar M. Hedayat
    Global Advances in Health and Medicine.2013; 2(1): 64.     CrossRef
  • Gamma-Glutamyltransferase Level and Risk of Hypertension: A Systematic Review and Meta-Analysis
    Cun-Fei Liu, Yu-Ting Gu, Hai-Ya Wang, Ning-Yuan Fang, Antony Bayer
    PLoS ONE.2012; 7(11): e48878.     CrossRef
  • Association between γ-glutamyltransferase and prehypertension
    XUZHEN QIN, GUODONG TANG, LING QIU, TAO XU, XINQI CHENG, SHAOMEI HAN, GUANGJIN ZHU, YAJUN LIU
    Molecular Medicine Reports.2012; 5(4): 1092.     CrossRef
Relationship Between Serum Concentrations of Organochlorine Pesticides and Metabolic Syndrome Among Non-Diabetic Adults.
Sun Kyun Park, Hyo Kyung Son, Sung Kook Lee, Jung Ho Kang, Yoon Seok Chang, David R Jacobs, Duk Hee Lee
J Prev Med Public Health. 2010;43(1):1-8.
DOI: https://doi.org/10.3961/jpmph.2010.43.1.1
  • 5,795 View
  • 133 Download
  • 42 Crossref
AbstractAbstract PDF
OBJECTIVES
This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes. METHODS: Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected. RESULTS: After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane (beta-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of beta-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose (> or =100 mg/dL)) were separately analyzed, all components were positively, but not significantly, associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01). CONCLUSIONS: Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.
Summary

Citations

Citations to this article as recorded by  
  • Exposure to Endocrine-Disrupting Chemicals and Type 2 Diabetes Mellitus in Later Life
    Jian-Yan Lin, Rui-Xing Yin
    Exposure and Health.2023; 15(1): 199.     CrossRef
  • Cross-sectional associations of persistent organic pollutants measured in adipose tissue and metabolic syndrome in clinically diagnosed middle-aged adults
    Iris Reina-Pérez, Francisco Artacho-Cordón, Vicente Mustieles, Daniel Castellano-Castillo, Fernando Cardona, Inmaculada Jiménez-Díaz, Jose A. López-Medina, Juan Alcaide, Luis Ocaña-Wilhelmi, Luz M. Iribarne-Durán, Juan P. Arrebola, Nicolás Olea, Francisco
    Environmental Research.2023; 222: 115350.     CrossRef
  • Effect of persistent organic pollutants in patients with ischemic stroke and all stroke: A systematic review and meta-analysis
    Priya Dev, Kamalesh Chakravarty, Manoj Pandey, Rakesh Ranjan, Mareena Cyriac, Vijaya Nath Mishra, Abhishek Pathak
    Toxicology.2023; 494: 153567.     CrossRef
  • Pesticides and insulin resistance-related metabolic diseases: Evidences and mechanisms
    Ali Arab, Sara Mostafalou
    Pesticide Biochemistry and Physiology.2023; 195: 105521.     CrossRef
  • Health risk assessment of exposure to organochlorine pesticides in the general population in Seoul, Korea over 12 years: A cross-sectional epidemiological study
    Sung-Hee Seo, Sung-Deuk Choi, Stuart Batterman, Yoon-Seok Chang
    Journal of Hazardous Materials.2022; 424: 127381.     CrossRef
  • Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)
    Inmaculada Salcedo-Bellido, Esperanza Amaya, Celia Pérez-Díaz, Anabel Soler, Fernando Vela-Soria, Pilar Requena, Rocío Barrios-Rodríguez, Ruth Echeverría, Francisco M. Pérez-Carrascosa, Raquel Quesada-Jiménez, Piedad Martín-Olmedo, Juan Pedro Arrebola
    International Journal of Environmental Research and Public Health.2022; 19(6): 3344.     CrossRef
  • Association of Organochlorine Pesticides With Genetic Markers of Endoplasmic Reticulum Stress in Type 2 Diabetes Mellitus: A Case–Control Study Among the North-Indian Population
    Neha Tawar, Basu Dev Banerjee, Sri Venkata Madhu, Vivek Agrawal, Sanjay Gupta
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
    Rulaiha E. Taylor, Anisha Bhattacharya, Grace L. Guo
    Drug Metabolism and Disposition.2022; 50(4): 456.     CrossRef
  • Metabolic syndrome and pesticides: A systematic review and meta-analysis
    Hugo Lamat, Marie-Pierre Sauvant-Rochat, Igor Tauveron, Reza Bagheri, Ukadike C. Ugbolue, Salwan Maqdasi, Valentin Navel, Frédéric Dutheil
    Environmental Pollution.2022; 305: 119288.     CrossRef
  • Impact of Chemical Endocrine Disruptors and Hormone Modulators on the Endocrine System
    Valentina Guarnotta, Roberta Amodei, Francesco Frasca, Antonio Aversa, Carla Giordano
    International Journal of Molecular Sciences.2022; 23(10): 5710.     CrossRef
  • Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
    Kévin Bernal, Charbel Touma, Chedi Erradhouani, Talía Boronat‐Belda, Lucas Gaillard, Sara Al Kassir, Hélène Le Mentec, Corinne Martin‐Chouly, Normand Podechard, Dominique Lagadic‐Gossmann, Sophie Langouet, François Brion, Anja Knoll‐Gellida, Patrick J. Ba
    FEBS Letters.2022; 596(24): 3107.     CrossRef
  • Gene expression in rat placenta after exposure to di(2-ethylhexyl) phthalate
    Wan Xu, Hongyan Wu, Lixin Shang
    Human & Experimental Toxicology.2021; 40(3): 504.     CrossRef
  • Umweltgifte und ihre hormonelle Wirkung
    Roxana M. Popovici, Barbara Sonntag
    Der Gynäkologe.2021; 54(4): 246.     CrossRef
  • The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis
    Vânia Mendes, Cláudia Ribeiro, Inês Delgado, Bárbara Peleteiro, Martine Aggerbeck, Emilie Distel, Isabella Annesi-Maesano, Denis Sarigiannis, Elisabete Ramos
    Scientific Reports.2021;[Epub]     CrossRef
  • Metabolic Syndrome and Endocrine Disrupting Chemicals: An Overview of Exposure and Health Effects
    Elsi Haverinen, Mariana F. Fernandez, Vicente Mustieles, Hanna Tolonen
    International Journal of Environmental Research and Public Health.2021; 18(24): 13047.     CrossRef
  • Smokeless tobacco use: its prevalence and relationships with dental symptoms, nutritional status and blood pressure among rural women in Burkina Faso
    Jeoffray Diendéré, Augustin Nawidimbasba Zeba, Léon Nikièma, Ahmed Kaboré, Paul Windinpsidi Savadogo, Somnoma Jean-Baptiste Tougma, Halidou Tinto, Arouna Ouédraogo
    BMC Public Health.2020;[Epub]     CrossRef
  • Persistent Organic Pollutant-Mediated Insulin Resistance
    Yeon A. Kim, Joon Beom Park, Min Seok Woo, Sang Yeob Lee, Hye Young Kim, Young Hyun Yoo
    International Journal of Environmental Research and Public Health.2019; 16(3): 448.     CrossRef
  • Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals
    Magda Gasull, Conxa Castell, Natàlia Pallarès, Carme Miret, José Pumarega, María Téllez-Plaza, Tomàs López, Jordi Salas-Salvadó, Duk-Hee Lee, Albert Goday, Miquel Porta
    American Journal of Epidemiology.2018; 187(3): 494.     CrossRef
  • “Trans-nonachlor increases extracellular free fatty acid accumulation and de novo lipogenesis to produce hepatic steatosis in McArdle-RH7777 cells”
    George Eli Howell, Erin McDevitt, Lucie Henein, Charlee Mulligan, Darian Young
    Toxicology in Vitro.2018; 50: 285.     CrossRef
  • Effects on the reproductive parameters of two generations ofRattus norvegicusoffspring from dams exposed to heptachlor during gestation and lactation
    Alejandra Martínez-Ibarra, Sumiko Morimoto, Marco Cerbón, Guadalupe Prado-Flores
    Environmental Toxicology.2017; 32(3): 856.     CrossRef
  • Exposure to an environmentally relevant mixture of organochlorine compounds and polychlorinated biphenyls Promotes hepatic steatosis in male Ob/Ob mice
    Charlee Mulligan, Sandeep Kondakala, Eun‐Ju Yang, John V. Stokes, James A. Stewart, Barbara L. F. Kaplan, George E. Howell
    Environmental Toxicology.2017; 32(4): 1399.     CrossRef
  • Mixture effects of 30 environmental contaminants on incident metabolic syndrome—A prospective study
    Lars Lind, Samira Salihovic, Erik Lampa, P. Monica Lind
    Environment International.2017; 107: 8.     CrossRef
  • Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach
    Vicente Mustieles, Mariana F. Fernández, Piedad Martin-Olmedo, Beatriz González-Alzaga, Andrés Fontalba-Navas, Russ Hauser, Nicolás Olea, Juan P. Arrebola
    Environment International.2017; 104: 48.     CrossRef
  • Metabolic syndrome is associated with exposure to organochlorine pesticides in Anniston, AL, United States
    Paula F. Rosenbaum, Ruth S. Weinstock, Allen E. Silverstone, Andreas Sjödin, Marian Pavuk
    Environment International.2017; 108: 11.     CrossRef
  • Endocrine‐disrupting chemicals, risk of type 2 diabetes, and diabetes‐related metabolic traits: A systematic review and meta‐analysis
    Yan Song, Elizabeth L. Chou, Aileen Baecker, Nai‐Chieh Y. You, Yiqing Song, Qi Sun, Simin Liu
    Journal of Diabetes.2016; 8(4): 516.     CrossRef
  • Article Commentary: Effects of Environmental Pollutants on Cellular Iron Homeostasis and Ultimate Links to Human Disease
    Dina M. Schreinemachers, Andrew J. Ghio
    Environmental Health Insights.2016; 10: EHI.S36225.     CrossRef
  • Persistent organic pollutants and promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene
    Soo Yeun Park, Ki-Su Kim, Yu-Mi Lee, Mi-Jin Kim, David R. Jacobs, Miquel Porta, Dong-Sun Kim, Duk-Hee Lee
    Biomarkers.2015; 20(2): 136.     CrossRef
  • Association of persistent organic pollutants and non-persistent pesticides with diabetes and diabetes-related health outcomes in Asia: A systematic review
    Lindsay M. Jaacks, Lisa R. Staimez
    Environment International.2015; 76: 57.     CrossRef
  • Endokrin wirkende Umweltgifte
    Roxana M. Popovici
    Gynäkologische Endokrinologie.2015; 13(3): 168.     CrossRef
  • Di-(2-Ethylhexyl)-Phthalate (DEHP) Causes Impaired Adipocyte Function and Alters Serum Metabolites
    Nora Klöting, Nico Hesselbarth, Martin Gericke, Anne Kunath, Ronald Biemann, Rima Chakaroun, Joanna Kosacka, Peter Kovacs, Matthias Kern, Michael Stumvoll, Bernd Fischer, Ulrike Rolle-Kampczyk, Ralph Feltens, Wolfgang Otto, Dirk K. Wissenbach, Martin von
    PLOS ONE.2015; 10(12): e0143190.     CrossRef
  • Umweltgifte und ihre hormonelle Wirkung
    R.M. Popovici
    Humanmedizin kompakt.2014;[Epub]     CrossRef
  • Prospective associations between persistent organic pollutants and metabolic syndrome: A nested case–control study
    Yu-Mi Lee, Ki-Su Kim, Se-A Kim, Nam-Soo Hong, Su-Jin Lee, Duk-Hee Lee
    Science of The Total Environment.2014; 496: 219.     CrossRef
  • Association of Persistent Organic Pollutants (POPs) with Age and Body Mass Index in Korean Adults
    Ho Jung Moon, Jung-Eun Lim, Sun Ha Jee
    Korean Journal of Environmental Health Sciences.2014; 40(6): 442.     CrossRef
  • Perinatal Exposure to Low-Dose Methoxychlor Impairs Testicular Development in C57BL/6 Mice
    Xiaohong Du, Hua Zhang, Yuanwu Liu, Wanpeng Yu, Chaobin Huang, Xiangdong Li, Stefan Schlatt
    PLoS ONE.2014; 9(7): e103016.     CrossRef
  • TCDD-Elicited Effects on Liver, Serum, and Adipose Lipid Composition in C57BL/6 Mice
    Michelle Manente Angrish, Claudia Yvette Dominici, Timothy Richard Zacharewski
    Toxicological Sciences.2013; 131(1): 108.     CrossRef
  • Developmental origins of obesity and type 2 diabetes: molecular aspects and role of chemicals
    Hidekuni Inadera
    Environmental Health and Preventive Medicine.2013; 18(3): 185.     CrossRef
  • Agricultural Exposures and Stroke Mortality in the Agricultural Health Study
    Jessica L. Rinsky, Jane A. Hoppin, Aaron Blair, Ka He, Laura E. Beane Freeman, Honglei Chen
    Journal of Toxicology and Environmental Health, Part A.2013; 76(13): 798.     CrossRef
  • Umweltgifte und ihre hormonelle Wirkung
    R.M. Popovici
    Gynäkologische Endokrinologie.2013; 11(3): 213.     CrossRef
  • Can persistent organic pollutants and plastic‐associated chemicals cause cardiovascular disease?
    L. Lind, P. M. Lind
    Journal of Internal Medicine.2012; 271(6): 537.     CrossRef
  • Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels
    Chirag J Patel, Mark R Cullen, John PA Ioannidis, Atul J Butte
    International Journal of Epidemiology.2012; 41(3): 828.     CrossRef
  • Endocrine Disruptors: From Endocrine to Metabolic Disruption
    Cristina Casals-Casas, Béatrice Desvergne
    Annual Review of Physiology.2011; 73(1): 135.     CrossRef
  • Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat
    Yi Lin, Jie Wei, Yuanyuan Li, Jun Chen, Zhao Zhou, Liqiong Song, Zhengzheng Wei, Ziquan Lv, Xi Chen, Wei Xia, Shunqing Xu
    American Journal of Physiology-Endocrinology and Metabolism.2011; 301(3): E527.     CrossRef
The Association of Central Obesity with Type 2 Diabetes among Koreans according to the Serum Gamma-Glutamyltransferase Level: Korean Genome and Epidemiology Study.
Ji Yeon Shin, Jun Hyun Hwang, Jin Young Jeong, Sung Hi Kim, Jai Dong Moon, Sang Chul Roh, Young Wook Kim, Yangho Kim, Jong Han Leem, Young Su Ju, Young Seoub Hong, Eun Hee Ha, Yong Hwan Lee, Duk Hee Lee, Dong Hyun Kim
J Prev Med Public Health. 2009;42(6):386-391.
DOI: https://doi.org/10.3961/jpmph.2009.42.6.386
  • 5,436 View
  • 64 Download
  • 3 Crossref
AbstractAbstract PDF
OBJECTIVES
This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR) and type 2 diabetes is different depending on the serum GGT levels. METHODS: The study subjects were 23,436 persons aged 40 years or older and who participated in regular health check-ups at 11 hospitals (males: 5,821, females: 17,615). The gender-specific quintiles of the serum GGT and WHR were used to examine the associations with type 2 diabetes. RESULTS: The serum GGT levels within their normal range were positively associated with type 2 diabetes only in women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4, 2.1, and 2.5 according to the quintiles of the serum GGT (p(trend)<0.01). The WHR was more strongly associated with the prevalence of diabetes among the women with a high-normal serum GGT level as compared with those with a low-normal serum GGT level (p for interaction=0.02). For example, the adjusted ORs for women with a low normal serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according to the quintiles of the WHR, while those figures were 1.0, 2.4, 3.6, 5.0, and 8.3 among the women with a high normal serum GGT level. However, in men, the serum GGT was very weakly associated with type 2 diabetes and the association between the WHR and type 2 diabetes was not different depending on the serum GGT level. CONCLUSIONS: Serum GGT within its normal range was positively associated with type 2 diabetes, and central obesity was more strongly associated with the prevalence of type 2 diabetes when the serum GGT level was high-normal. However, these associations were observed only in women, which is different from the previous findings. The stronger relation between central obesity and type 2 diabetes among women with a high-normal serum GGT level can be useful for selecting a group that is at high risk for type 2 diabetes irregardless of whatever the underlying mechanism is.
Summary

Citations

Citations to this article as recorded by  
  • Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study
    Youn Sue Lee, Yoonsu Cho, Stephen Burgess, George Davey Smith, Caroline L. Relton, So-Youn Shin, Min-Jeong Shin
    Human Molecular Genetics.2016; 25(17): 3877.     CrossRef
  • Different associations between obesity and impaired fasting glucose depending on serum gamma-glutamyltransferase levels within normal range: a cross-sectional study
    Nam Soo Hong, Jeong-Gook Kim, Yu-Mi Lee, Hyun-Woo Kim, Sin Kam, Keon-Yeop Kim, Ki-Su Kim, Duk-Hee Lee
    BMC Endocrine Disorders.2014;[Epub]     CrossRef
  • Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
    Jean-Claude, Lapraz, Kamyar M. Hedayat
    Global Advances in Health and Medicine.2013; 2(1): 64.     CrossRef
Associations of Non Alcoholic Fatty Liver with the Metabolic Syndrome and Serum Carotenoids.
Sun kyun Park, Hyun Jung Lee, Duk Hee Lee, Sung Kook Lee, Byung Yeol Chun, Sung Ae Kim, Hye Sung Lee, Hyo Kyung Son, Sung Hi Kim
J Prev Med Public Health. 2008;41(1):39-44.
DOI: https://doi.org/10.3961/jpmph.2008.41.1.39
  • 5,615 View
  • 67 Download
  • 9 Crossref
AbstractAbstract PDF
OBJECTIVES
This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. METHODS: This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males: 180, females: 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). RESULTS: After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum beta-carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum alpha-carotene, lycopene, bata-cryptoxanthin and lutein were not decreased. CONCLSIONS: This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum beta-carotene level.
Summary

Citations

Citations to this article as recorded by  
  • Therapeutic potential of bioactive phytoconstituents found in fruits in the treatment of non-alcoholic fatty liver disease: A comprehensive review
    Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Pompy Patowary, Pronobesh Chattopadhyay, Aparoop Das
    Heliyon.2023; 9(4): e15347.     CrossRef
  • The Protection Conferred by HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis and Fibrosis May Be Limited to Selected Subgroups of Patients With NAFLD
    Eduardo Vilar-Gomez, Carlos J. Pirola, Silvia Sookoian, Laura A. Wilson, Tiebing Liang, Naga Chalasani
    Clinical and Translational Gastroenterology.2021; 12(9): e00400.     CrossRef
  • Trends and Patterns of Burden of Disease and Injuries in Korea Using Disability-Adjusted Life Years
    Young-Eun Kim, Hyesook Park, Min-Woo Jo, In-Hwan Oh, Dun-Sol Go, Jaehun Jung, Seok-Jun Yoon
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among US Adults, NHANES 2003–2014
    Krista Christensen, Thomas Lawler, Julie Mares
    Nutrients.2019; 11(5): 1101.     CrossRef
  • Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index
    Qing Pang
    World Journal of Gastroenterology.2015; 21(5): 1650.     CrossRef
  • Association Between Liver Vitamin A Reserves and Severity of Nonalcoholic Fatty Liver Disease in the Class III Obese Following Bariatric Surgery
    Gabriela Villaça Chaves, Sílvia Elaine Pereira, Carlos José Saboya, Daiane Spitz, Camila Santos Rodrigues, Andréa Ramalho
    Obesity Surgery.2014; 24(2): 219.     CrossRef
  • Association of oral health behaviors and status with depression: results from the Korean National Health and Nutrition Examination Survey, 2010
    Se Jin Park, Ki Dong Ko, Seung-Il Shin, Yu Jeong Ha, Gy Young Kim, Hyoung Ah Kim
    Journal of Public Health Dentistry.2014; 74(2): 127.     CrossRef
  • Measuring the burden of chronic diseases in Korea in 2007
    E.-J. Kim, S.-J. Yoon, M.-W. Jo, H.-J. Kim
    Public Health.2013; 127(9): 806.     CrossRef
  • The Association of Cardiovascular Risk Factors with Nonalcoholic Fatty Liver Disease in Health Checkup Examinees
    Jae-Hee Yu, Kang-Sook Lee, Seon-Young Lee, A-Rum Hong, Yong-Sang Park
    Journal of Preventive Medicine and Public Health.2008; 41(6): 407.     CrossRef
Factors Affecting Re-smoking in Male Workers.
Jin Hoon Yang, Hee Sook Ha, Sin Kam, Ji Seun Lim, Yune Sik Kang, Duk Hee Lee, Byung Yeol Chun
J Prev Med Public Health. 2005;38(2):208-214.
  • 2,396 View
  • 49 Download
AbstractAbstract PDF
OBJECTIVES
This study was performed to examine the factors affecting re-smoking in male workers. METHODS: A self-administrated questionnaire survey was conducted during April 2003 to examine the smoking state of 1, 154 employees of a company that launched a smoking cessation campaign in1998. Five hundred and eighty seven persons, who had stopped smoking for at least one week, were selected as the final study subjects. This study collected data on smoking cessation success or failure for 6 months, and looked at the factors having an effect on resmoking within this period. This study employed the Health Belief Model as its theoretical basis. RESULTS: The re-smoking rate of the 587 study subjects who had stopped smoking for at least one week was 44.8% within the 6 month period. In a simple analysis, the resmoking rates were higher in workers with a low age, on day and night shifts, blue collar, of a low rank, where this was their second attempt at smoking cessation and for those with a shorter job duration (p< 0.05). Of the cues to action variables in the Heath Belief Model, re-smoking was significantly related with the perceived susceptibility factor, economic advantages of smoking cessation among the perceived benefits factor, the degree of cessation trial's barrier of the perceived barriers factor, smoking symptom experience, recognition of the degree of harmfulness of environmental tobacco smoke and the existence of chronic disease due to smoking (p< 0.05). In the multiple logistic regression analysis for re-smoking, the significant variables were age, perceived susceptibility for disease, economic advantages due to smoking cessation, the perceived barrier for smoking cessation, recognition on the degree of harmfulness of environmental tobacco smoke, the existence of chronic disease due to smoking and the number of attempts at smoking cessation (p< 0.05). CONCLUSION: From the result of this study, for an effective smoking ban policy within the work place, health education that improves the knowledge of the adverse health effects of smoking and the harmfulness of environmental tobacco smoke will be required, as well as counter plans to reduce the barriers for smoking cessation.
Summary
The Association between Serum GGT Level within Normal Range and Risk Factors of Cardiovascular Diseases.
Ji Seun Lim, Yu Jin Kim, Byung Yeol Chun, Jin Hoon Yang, Duk Hee Lee, Sin Kam
J Prev Med Public Health. 2005;38(1):101-106.
  • 2,565 View
  • 57 Download
AbstractAbstract PDF
OBJECTIVES
We conducted this study to examine the association between serum GGT levels within the normal range and the risk factors of cardiovascular diseases METHODS: We examined the cross-sectional association between serum GGT and the systolic and diastolic blood pressure, fasting blood glucose, total cholesterol, triglyceride, high density lipoprotein cholesterol (HDL-cholesterol), and uric acid among 975 subjects that participated in the health examination of a university hospital located in Daegu city. All the patients' GGT levels were within the normal range. RESULTS: After adjustment were made for age, body mass index (BMI), smoking status, drinking frequency, exercise frequency and coffee intake, the serum GGT level was positively associated with fasting blood glucose (p< 0.01), total cholesterol (p< 0.01), and triglyceride (p< 0.01) in men, and it was positively associated with fasting blood glucose (p< 0.01), total cholesterol (p< 0.05), triglyceride (p< 0.01), and uric acid (p< 0.01) in women. The associations were not significantly different depending on the status of alcohol drinking or obesity, except for the associations of serum GGT with diastolic blood pressure (P for interaction=0.04) and uric acid (P for interaction=0.04) between the lean and obese subjects. CONCLUSIONS: Serum GGT levels within the normal range were positively associated with fasting blood glucose, triglyceride and uric acid in most subgroups irrespective of the drinking or obesity status. These results suggest that GGT has important clinical implications as being more than just a marker of alcohol consumption and hepatobiliary disease.
Summary
A seroepidemiological Study of Hepatitis B and C Virus (HBV and HCV) Infections in the Young Population in parts of Busan, Korea.
Young Hee Ju, Hai Rim Shin, Jin Kyoung Oh, Dong IL Kim, Duk Hee Lee, Byeong Kweon Kim, Jung Il Kim, Kap Yeol Jung
J Prev Med Public Health. 2004;37(3):253-259.
  • 2,384 View
  • 39 Download
AbstractAbstract PDF
OBJECTIVES
To investigate the prevalence of hepatitis B and C virus infections and determine the associated risk factors among young adults in Busan, Korea, which is known to have a high incidence of liver cancer. METHODS: The study population consisted of volunteer participants in a health survey during 2002, which included 1, 350 students (515 males and 835 females) aged between 16 and 24 years, from three different schools in Busan. The participating students were asked to fill in a selfadministered questionnaire which included lifestyle habits and risk factors of hepatitis. Sera obtained from the participants were studied for HBsAg, anti-HBs, and Anti- HCV by enzyme immunoassay (EIA) method and for liver function tests. RESULTS: Among the study subjects (N=1, 350), the seropositivities of HBsAg 7.9% (95% CI=7.8-8.0), 7.6% (95% CI=7.6-7.7) in male and 8.1% (95% CI=8.0-8.2) in female. And the seropositivity of Anti-HBs was 69.7% (95% CI=69.0- 70.4), 70.5% (95% CI=69.8-71.2) in male and 69.2% (95% CI=68.5-69.9) in female. The seropositivity of Anti-HCV was 0.4%, 0.2% in male and 0.5% in female. The seropositivity for HBsAg in the subjects not having a hepatitis B vaccination history was twice (95% CI=1.0-4.4) that of those that did. Also, the seropositivity for HBsAg in subjects having experienced sexual intercourse was 1.7 times (95% CI=0.9-3.0) that of the subjects who had not. CONCLUSIONS: The present study confirmed the high prevalence of HBsAg seropositivity and sexual transmission of HBV among adolescents and young adults may occur. Further studies to evaluate the relationship between HBV vaccination and sexual transmission are required for the young population in Korea.
Summary
Factors Associated with Cervical Cancer Screening in Busan, Korea.
Kui Son Choi, Duk Hee Lee, Kap Yeol Jung, Jieun Son, Tae Won Jang, Yoon Kyu Kim, Hai Rim Shin
J Prev Med Public Health. 2004;37(2):166-173.
  • 2,568 View
  • 69 Download
AbstractAbstract PDF
OBJECTIONS: Cervical cancer is the second most frequent cancer among women in Busan. The Pap smear test could have a significant effect on detecting cervical cancer, and enhancing their rate of use is an important strategy for reducing the incidence and mortality of cervical cancer. This study aimed to evaluate the factors associated with the past use of the Pap smear test in Korean women. METHODS: A population-based survey was carried out in Busan between November 1999 and March 2000. 1, 673 participants were randomly selected from 2, 684 women in Busan, using a 2-stage cluster sampling method, and interviewed in their homes. Their socio-demographic characteristics, smoking, drinking, familial cancer history, Pap smear screening history, reproductive and menstrual factors, sexual habits and use of contraceptive methods data were collected by a trained interviewer using a questionnaire. The use of the screening test was defined by a self-report from the participants on how many times they had had a Pap smear test in their lifetime, and when they had received their latest examination. RESULTS: Of the 1, 673 respondents (62.3% response rate), 57.6% had had a Pap smear test during her life (mean number, 2.3). Among the health examination participants (1, 064), 961 (90.3%) reported having sexual experience and 70.9% of these had had a Pap smear test. In a multiple logistic regression analysis, statistically significant relationships were observed for age groups and the Pap smear test rate (odds ratio, OR for 35-44 years=2.45; OR for 45-54 years=3.41; OR for 55 years=2.60; reference, under 34 years). The married or cohabiting women were more likely to have used the Pap smear test than those separated or widowed (OR=1.73). Among the reproductive behavioral measures, the number of births (OR for 3 births=4.22; OR for 2 births=3.95; OR for 1 births=3.38; reference, 0 births) and husband's extra-marital affairs (OR=1.50) were associated with the rates of use of Pap smear tests. CONCLUSION: It appears that the most important contributing factors to cervical cancer screening were age, marital status and number of births. A positive association was also observed for the husband's extra-marital affairs. This study enabled us to systematically assess the relationship between Pap smear rates and risk factors for cervical cancer. It is hoped that this study will make a significant contribution to the accumulating scientific evidence on the identification of factors associated with cervical cancer screening in Korea.
Summary
Risk Factors for Cerebrovascular Disorders in Koreans.
Jong Ku Park, Ki Soon Kim, Chun Bae Kim, Tae Yong Lee, Duk Hee Lee, Kwang Wook Koh, Kang Sook Lee, Sun Ha Jee, Il Suh, So Yeon Ryu, Kee Ho Park
Korean J Prev Med. 2001;34(2):157-165.
  • 2,193 View
  • 24 Download
AbstractAbstract PDF
OBJECTIVES
To identify the risk factors of cerebrovascular disorders(CVD) in Koreans using a nested case-control study. METHODS: The cohort consisted of beneficiaries who had taken health examinations of the Korea Medical Insurance Corporation (KMIC cohort: 115,600 persons) in 1990 and 1992 consecutively. Four hundred and twenty five (425) cases were selected following the validation of diagnosis among 2,026 reported CVD (I60-I68) inpatients during the year from 1993 to 1997. Controls were matched (1:1) with age and gender of the cases among inpatients without CVD during the same period. The source of data in this study were the files of the 1990 health examinations and the 1992 health questionnaires, as well as an additional telephone survey undertaken from March to November 1999. RESULTS: In a bivariate analysis and multiple logistic regression analysis, risk factors for total CVD were hyperglycemia and hypertension. Unrespectively, the odds ratio of ex-smoker was significantly lower than that of those who had never smoked. The risk factors for ischemic CVD also were hyperglycemia and hypertension. However, only blood pressure was found to be a risk factor for hemorrhagic CVD. Hypercholesterolemia was not a risk factor for total CVD, ischemic CVD, and hemorrhagic CVD. CONCLUSION: We concluded that the most important risk factor for CVD (including subtype) in Koreans was hypertension.
Summary
A Nested Case Control Study on Risk Factors for Coronary Heart Disease in Korean.
Ki Soon Kim, So Yeon Ryu, Jong Park, Jong Ku Park, Chun Bae Kim, Byung Yeol Chun, Tae Yong Lee, Kang Sook Lee, Duk Hee Lee, Kwang Wook Koh, Sun Ha Jee, Il Suh
Korean J Prev Med. 2001;34(2):149-156.
  • 2,824 View
  • 136 Download
AbstractAbstract PDF
OBJECTIVE
To elucidate risk factors for coronary heart diseases among Korean males. METHODS: A nested case control study was conducted among a Korea Medical Insurance Cooperation(KMIC) cohort composed of 108,802 males. The cases included 246 male patients who were admitted to hospital due to coronary heart diseases from 1993 to 1997 (I20-25 by ICD) and whose diagnosis was confirmed by the protocol by WHO MONICA Project(1994). The control group was composed of 483 patients selected by frequency matching considering age and resident area from an inpatient care group without coronary heart disease during the same period. For study cases and the controls, the results of a health check-up in 1990 and a questionnaire on life style in 1992 were received through the KMIC. Some additional information was collected by telephone interviews during October 1999. RESULTS: Multiple logistic regression analysis showed that the odds ratio(OR) of coronary heart diseases among past smokers and current smokers as compared to non-smokers were 1.94(95% CI : 1.14-3.31) and 2.20(95% CI : 1.35-3.59), respectively. The OR among persons who drank 4 cups or more of caffeinated beverages such as coffee or tea daily as compared to persons who drank one cup for 2-3 days was 2.56(95% CI : 1.07-6.12). The OR among persons with high normal BP and stage 3 hypertension against normotension were 2.51(95% CI : 1.44-4.37) and 5.08(95% CI : 2.38-10.84). The OR among persons whose blood cholesterol were 240 mg/dL or more against lower than 200mg/dL was 2.24(95% CI : 1.43-3.49). CONCLUSION: Smoking, drinking of excessive caffeinated beverages, hypertension and high blood cholesterol were proven to be significant risk factors for coronary heart diseases among Korean males.
Summary
Seasonal Variation of Pre-term Births in Korea.
Duk Hee Lee, Sang Hyeok Ma, Hai Rim Shin
Korean J Prev Med. 2000;33(4):402-408.
  • 1,835 View
  • 19 Download
AbstractAbstract PDF
OBJECTIVES
To investigate possible seasonal patterns of pre-term birth in Korea. METHODS: A total number of 2,669,357 single live births reported to the National Statistical Office from 1995 to 1998 were analyzed. Composite monthly cohorts of ongoing pregnancies were constructed for each month of the year and the probability of pre-term birth was estimated. RESULTS: Increases in the probability of a pre-term birth occurred during winter for the birth of first child and during summer for the birth of second or later child. This seasonal variation was similar among groups divided by sex, residency, age of mother, and education of mother. CONCLUSIONS: These findings suggests that some environmental factors related to season may partially explain the incidence of premature births.
Summary
The Cancer-preventive Potential of Panax ginseng: A Review of Human and Experimental Evidence.
Hai Rim Shin, Joon Youn Kim, Duk Hee Lee, Taik Koo Yun, Gareth Morgan, Harri Vainio
Korean J Prev Med. 2000;33(4):383-392.
  • 2,145 View
  • 40 Download
AbstractAbstract PDF
OBJECTIVE
We have reviewed the potential cancer preventive and other relevant properties of Panax ginseng C. A. Meyer, which has been traditionally used as a natural tonic in oriental countries. DATA IDENTIFICATION AND STUDY SELECTION: Publications on Panax ginseng and its relation to cancer were obtained from the Medline database (1983-2000) and by checking reference lists to find earlier reports. The reports cover experimental models and human studies on cancer-preventive activity, carcinogenicity and other beneficial or adverse effects. In addition, possible mechanisms of chemoprevention by ginseng were also considered. RESULTS: Published results from a cohort and two case-control studies in Korea suggest that the intake of ginseng may reduce the risk of several types of cancer. When ginseng was tested in animal models, a reduction in cancer incidence and multiplicity at various sites was noted. Panax ginseng and its chemical constituents have been tested for their inhibiting effect on putative carcinogenesis mechanisms (e.g., cell proliferation and apoptosis, immunosurveillance, angiogenesis); in most experiments inhibitory effects were found. CONCLUSION: While Panax ginseng C. A. Meyer has shown cancer preventive effects both in experimental models and in epidemiological studies, the evidence is currently not conclusive as to its cancer-preventive activity in humans. The available evidence warrants further research into the possible role of ginseng in the prevention of human cancer and carcinogenesis.
Summary
The Accuracy of ICD codes for Cerebrovascular Diseases in Medical Insurance Claims.
Jong Ku Park, Ki Soon Kim, Chun Bae Kim, Tae Yong Lee, Kang Sook Lee, Duk Hee Lee, Sunhee Lee, Sun Ha Jee, Il Suh, Kwang Wook Koh, So Yeon Ryu, Kee Ho Park, Woonje Park, Seungjun Wang, Hwasoon Lee, Yoomi Chae, Hyensook Hong, Jin Sook Suh
Korean J Prev Med. 2000;33(1):76-82.
  • 3,236 View
  • 148 Download
AbstractAbstract PDF
OBJECTIVES
We attempted to assess the accuracy of ICD codes for cerebrovascular diseases in medical insurance claims (ICMIC) and to investigate the reasons for error. This study was designed as a preliminary study to establish a nationwide surveillance system. METHODS: A total of 626 patients with medical insurance claims who indicated a diagnosis of cerebrovascular diseases during the period from 1993 to 1997 was selected from the Korea Medical Insurance Corporation cohort (KMIC cohort: 115,600 persons). The KMIC cohort was 10% of those insured who had taken health examinations in 1990 and 1992 consecutively. The registered medical record administrators were trained in the survey technique and gathered data from March to May 1999. The definition of cerebrovascular diseases in this study included cases which met one of two criteria (Minnesota, WHO) or 'definite stroke' in CT/MRI finding. We questioned the medical record administrators to explain the error if the final diagnoses were not coded as stroke. RESULTS: The accuracy rate of the ICMIC was 83.0% (425 cases). Medical records were not available for 8.2% (51 cases) due to the closing of hospitals, the absence of a computer system or omission of medical record, etc. Sixty-three cases (10.0%) were classified as impossible to interpret due to insufficient records in 'major clinical symptoms' or 'neurological deficits'. The most common reason was 'to meet review criteria of medical insurance benefits (52.9%)'. The department where errors in the ICMIC occurred most frequently was the department for medical insurance claims in the hospital. CONCLUSION: The accuracy rate of the ICMIC was 83.0%.
Summary
Effects of Change in Obestiy and Life Style Factors on Blood Pressure and Serum Cholesterol - 3-year Follow-up among Workers in a Steel Manufacturing Industry -.
Myung Hwa Ha, Duk Hee Lee, Song Kwon Lee
Korean J Prev Med. 1999;32(3):415-420.
  • 1,885 View
  • 19 Download
AbstractAbstract PDF
OBJECTIVES
We investigated the effects of changes in obesity and life style factors, such as cigarette smoking, alcohol drinking, and exercise, on the changes in blood pressure and serum cholesterol among Korean men. METHODS: This study included 7,205 healthy male employees in the steel manufacturing industry. Each subject underwent health examination in 1994 and was re-examined in 1997. The study subjects were classified into four categories, according to changes in body mass index (BMI) (loss; stable; mild gain; severe gain), cigarette smoking (quitter; non-smoker; smoker continued; smoker started), alcohol drinking (quitter; non-drinker; drinker continued; drinker started) and exercise (more exercise; continuous regular exercise; continuous irregular or no exercise; less exercise), respectively. We evaluated the relationship between the categories of change in those independent variables and the changes in blood pressure and serum cholesterol, adjusted for BMI in 1994 and age by analysis of variance. RESULTS: The change in systolic blood pressure was positively associated with the changes in BMI (p<0.001) and drinking (p=0.001), but negatively with smoking (p=0.004), compared to the first category of each independent variables. The systolic blood pressure was significantly less increased in the continuous smoking group than quitter or non-smoker. The changes in diastolic blood pressure and serum cholesterol appeared to have statistically significant linear relationships only with the change in BMI. The change in exercise showed a marginal significance with diastolic blood pressure (p=0.088). CONCLUSIONS: These prospective data emphasize the importance of obesity as a determinant of the changes in blood pressure and serum cholesterol. In addition, the changes in smoking and drinking habits can affect systolic blood pressure.
Summary
A study on Performing Time of Neurobehavioral Test in Workers exposed to Organic Solvents.
Kang Won Park, In Geun Park, Jin Ha Kim, Kang Woo Bae, Duk Hee Lee, Yong Hawn Lee
Korean J Prev Med. 1997;30(1):171-180.
  • 2,132 View
  • 23 Download
AbstractAbstract PDF
This study was performed to see whether neurobehavioral tests was affected by the exposure-free time in the workers chronically exposed to organic solvents. Thirty-four female workers were participated and four items among neurobehavioral core test battery of World Health Organization, including digit span, Santa Ana Dexterity, digit symbol, Benton Visual Retention, were administered to the workers. Test was conducted three times-preshift on Monday, preshift on Weekday and during shift on Weekday-per person and the interval of tests was 2 weeks. Digit span forward, Santa Ana Dexterity, digit symbol, and Benton Visual Retention showed significant decrements by performing time, especially during shift on Weekday versus preshift on Monday and preshift on Weekday. In addition, the score at preshift on Weekday was significantly lower than preshift on Monday, in preferred Santa Ana Dexterity and digit symbol. Generally, those who were exposed to high concentration, over 50 years and under 6 years of education showed marked decrease of score at during shift. So, it would be desirable that neurobehavioral test is conducted at preshift on Monday and items related to short term memory could be considerable to be done at preshift on Weekday.
Summary
Exposed level of workers in the factory next to a led recycling factory.
Jin Ha Kim, Duk Hee Lee, Yong Hwan Lee
Korean J Prev Med. 1996;29(3):693-700.
  • 1,623 View
  • 20 Download
AbstractAbstract PDF
The purpose of this study was to determine whether workers at a factory next to a lead recycling factory in Pusan, were affected by lead contamination. The mean air lead concentration of lead recycling factory was 0.21mg/m3(TWA=0.05mg/m3). Thirty-nine male workers of Factory A, Cr. plating factory next to the lead recycling factory were exposed group and a comparison group, 62 male workers of Factory B were selected from another Cr. plating factory about 8.5km away from lead recycling factory. Air lead concentration of each workplace was checked for 4 times from August 5 to August 20 in 1995 by low volume air sampler. Each subject was interviewed about age, life-style, smoking, work history, and residence etc, and venous blood was drawn for lead measurement by graphite furnace atomic absorption spectrometry. We have observed that air lead concentration and blood lead concentration of Factory A was higher than Factory B(2.6 +/- 1.6 Vs. 1.2 +/- 0.2 microgram/m3, 14.9 +/- 1.6 Vs. 12.2 +/- 1.6 microgram/dl). We believe that other environmental lead sources such as transportation and residence did not affect air lead and blood lead concentration differences of both factory. We concluded that high air lead and blood lead concentration of Factory A were caused by lead contamination generated by the neighboring lead recycling factory.
Summary
Neurobehavioral Changes according to Cumulative Exposure of Complex Organic Solvents.
Duk Hee Lee, In Geun Park, Jin Ha Kim, Young Hawn Lee, Sung Gye Kang, Doo Hie Kim
Korean J Prev Med. 1995;28(2):386-397.
  • 1,836 View
  • 21 Download
AbstractAbstract PDF
A cross sectional study was performed to evaluate the neurobehavioral effects of chronic exposure of complex organic solvents, using NCTB(Neurobehavioral Core Test Battery) recommended by WHO(World Health organization). Forty female shoe factory workers and twenty-two controls matched with age were participated. The tests were performed in the morning before start of work, to exclude the effects of acute exposure. Workers were exposed mainly to toluene, methyl ethyl ketone, n-hexane, cyclo-hexane, dichloroethylene, trichloroethylene, benzene, xylenes etc. The ranges of present solvent exposure of hygienic effect were 0.46~0.71 in the process using adhesives indirectly, and 1.83-2.39 in the process using it directly. We reclassified the subjects, according to cumulative exposure. It showed significantly poorer performances in high exposed group on Santa Ana Dexterity and Benton visual Retention, compared with control group. After controlling confounder, the significances were still remained. But, further cohort studies, having the information of personal exposure dose from entering a factory, are required to clarify the effects of chronic exposure of complex organic solvents in relation to dose and duration of exposure.
Summary
Blood Lead Level and Intelligence among Children.
Duk Hee Lee, Yong Hwan Lee, Jin Ha Kim, In Geun Park, Tae Young Han, She Han Jang
Korean J Prev Med. 1995;28(2):373-385.
  • 1,924 View
  • 22 Download
AbstractAbstract PDF
The association between blood lead children and Intelligent Quotient(IQ) was investigated in a sample of l00 boys and girls aged 6-8 years from one primary school within an industrial area of Pusan. The trained undergraduates in school of public health administered an I.Q. test one by one. Parents answered a questionnaire on demographic, perinatal and socioeconomic variables. Atomic Absorbtion spectrophotometer was used to determine blood lead levels. The geometric mean of blood lead value was 7.99 microgram/dl. In total children, there was no significant relationship between blood lead level and I.Q. But in the children who were born of gestational age of less than 38 weeks, children with higher levels of blood lead performed more poorly on I.Q. test with correlation coefficient from -0.68 to -0.71. But, the children who were born of gestational age of 38 weeks and more were same as total children. These results suggest that exposure to low levels of lead in the children who were born premature probably may result in impaired intelligent development. But, we think that more profound study should be performed with sufficient numbers of subjects.
Summary
Neurobehavioral Change on the Lead Exposure Workersq.
In Geun Park, Duk Hee Lee, Yong Hwan Lee, Jin Ha Kim, She Han Jang
Korean J Prev Med. 1995;28(1):175-186.
  • 1,821 View
  • 19 Download
AbstractAbstract PDF
No abstract available.
Summary
Interhospital Comparison of Outcome from Intensive Care Unit with APACHE III Scoring System.
Duk Hee Lee, Mee Young No, Byun Sung Kim
Korean J Prev Med. 1994;27(3):437-446.
  • 1,672 View
  • 19 Download
AbstractAbstract PDF
The objective of this study was to evaluate outcome for the patients of the intensive care unit, using APACHE III prognostic system. We prospectively collected the information of 429 patients in intensive care units at 2 tertiary care hospitals and 4 secondary care hospitals in PUSAN who had been admitted from December 1, 1993 to February 28, 1994. The results were as follows. 1. APACHE 111 scores were various from 0 to 173. But the distribution of the scores were similar between tertiary care hospitals and secondary care hospitals. 2. The mortality rate significantly increased as APACHE 111 score rised (P<0.001). Within the interval of same score, generally, the mortality of operative patients was higher in secondary care hospitals but in the case of nonoperative patients higher in tertiary care hospitals. 3. when the tertiary care hospitals compared with secondary for ratio of the predicted mortality rate to the actual mortality rate, there was little difference. 4. when we compared the 6 hospitals, one hospital had significantly better results and another hospital was significantly inferior (P<0.05).
Summary
A Survey on the Prevalence of Musculoskeletal Symptom accord ing to Work Task.
Hae Ju Oh, Duk Hee Lee, In Guen Park, She Han Jang
Korean J Prev Med. 1994;27(2):230-241.
  • 1,893 View
  • 20 Download
AbstractAbstract PDF
Though people occupationally exposed to machineries and automation in the industrialized society desire work involving decreased strength, due to the continuous and repetitive activities, a new industrial stress is present. Studies on prevalence of musculoskeletal disease and their related risk factors have evolved. In this study in relation to work tasks, we investigated the differences in musculoskeletal symptoms occurring in each body region. The results of the survey were as follows. 1. When comparing age, level of education, work duration, job satisfaction and leisure time activities according to work risk, age in control group was 32.83+/-5.5, in comparison to the other 2 groups was smaller(p<0.05), and level of education in control group was higher(p<0.05) Work duration in the cutting department as 8.04+/-4.99 years longer than the other 2 groups(p<0.05), but there was no difference in the job satisfaction and leisure time activities. 2. The mean of symptom scores of each work task was 1.54 in the cutting department, 1.57 in the press department and 1.59 in the control group, and there was no significant difference in the 3 groups. The mean of symptom scores for upper extremities in the control group was low but mo statistically significant difference was shown. 3. When comparing the mean of symptom score according to work task in the each body region, in the shoulder region, the symptom score in the press department which desired strength was higher than the other 2 groups but no significant difference was shown. In the wrist region the cutting department scored 1.01 and in comparison to the other 2 groups was significantly increased(p<0.05). 4. The results of the univariate regression analysis on the major individual risk factors associated with musculoskeletal symptom relating work showed that previous symptom complaints in the same body region was significant risk factor(p<0.001) in the whole body, Besides wrist, hip, and knee, psychological problem was shown to be a significant factor(p<0.05). And the body regions which work task was significant risk factor were wrist and neck region(p<0.05). 5. The results of the multiple regression analysis involving significant factors of each body region from the unfavorite regression analysis showed that previous symptom shoulder, elbow and lumbar region(p<0.001) and psychological problem in the shoulder, elbow and lumbar region(p<0.05) were significant factors, and work task was significant factor in the wrist(p<0.05).
Summary
Relationship between Violent Criminal Behavior and Imbalance of Scalp Hair Minerals in Man.
Doo Hie Kim, Bon Ki Jang, Duk Hee Lee, Sung Chul Hong, Byung Hie Kim
Korean J Prev Med. 1994;27(1):25-43.
  • 2,217 View
  • 21 Download
AbstractAbstract PDF
To estimate the factors to the inclination of the criminal violence, the content of trace minerals and toxic metals in the scalp hair were measured during the period from May 1992 to october 1992. One hundred eleven violent and 89 nonviolent criminal inmates of Taegu correctional Institute were selected. The inmates of violent criminals were imprisoned by murder, robber, rape, injury and violent acts. Those of nonviolent criminals were swindle, larceny, and adultery and had no history of institutional violence. The contents of two toxic metals(cadmium, lead) and five trace minerals(Cu, Fe, Zn, Mg, Na) were determined by an atomic absorption spectrophotometer(lL. 551). The contents of cadmium and lead in hair of violent criminals were significantly higher as 0.56+/-0.14ppm, 11.53+/-3.32ppm, respectively, than 0.42+/-0.20ppm, 9.63+/-4.31ppm of nonviolent group (P<0.01). But the level of copper was significantly lower than nonviolent group (P<0.05). The factors that had a significant correlation with the inclination of violence in multiple logistic regression analysis were cadmium (odds ratio=98.09), unmarried (odds ratio=0.39), many times of criminal history (odds ratio=l.57) and residence of rural area (odds ratio=0.44). The results suggest that the sub-toxic contents of cadmium and lead in the hair may be of potential effect on behavior, and the mineral analysis may be an important adjunctive diagnostic procedure. Further studies into this problem are necessary.
Summary
Illness Associated With Contamination Of Drinking Water Supplies With Phenol.
Doo Hie Kim, Sung Kook Lee, Byung Yeol Chun, Duk Hee Lee, Sung Chul Hong, Bong Ki Jang
Korean J Prev Med. 1993;26(2):202-209.
  • 1,960 View
  • 26 Download
AbstractAbstract PDF
A accidental spills of phenol(100%) to the river Nakdong with subsequent contamination of the tap water for about two million consumers in Taegu city of Korea were occurred in March 1991. A historical cohort study of 6,913 individuals was undertaken to determine the associated with illness. Population subjects were divided into two groups of exposed and unexposed. Exposed subjects were reported to be phenol associated symptoms significantly higher than those in a nearby unexposed area(39.6% vs 9.4%, p<0.01). Especially, in the related symptoms, highly significant differences were noted in the number of subjects reporting gastrointestinal illness such as nausea, vomiting, diarrhea, or abdominal pain. During the accident, study subjects who experienced peculiar taste or odor in the tap water were significantly higher in the exposed areas(92% vs 34.3%). Chlorophenols formed from chlorination of water may have aggravated the problem.
Summary
Relationship of Low Blood Cadmium and Zinc to Blood Pressure.
Duk Hee Lee, Doo Hie Kim
Korean J Prev Med. 1992;25(2):148-156.
  • 1,966 View
  • 31 Download
AbstractAbstract PDF
A case-control study was conducted to investigate the relationship between blood cadmium, blood zinc and cadmium/zinc ratio and hypertension. Eighty-three hypertensive and seventy-seven normotensive study subjects matched for age and sex were selected from the workers who had no history of job-related cadmium exposure, in Ulsan city and it's vincinity, Korea. The blood cadmium in hypertensive group was 2.90 etag/mL, which was significantly higher than that of control group, 1.99 etag/mL(P<0.01). After stratifing for smoking and age variables, the relationship was still remained. The blood cadmium/zinc ratio in hypertensive group was 2.46, which was significantly higher than that of control group, 1.65(P<0.01). After stratifing for smoking and age variables, the relationship was still remained. There was no significant difference in blood zinc between hypertensive and control group. On multiple logistic regression analysis, the blood cadmium/zinc ratio is highly significant than blood cadmium. In conclusion, there is the possible relationship between blood cadmium level which has been known to be within normal limits and hypertension. But, further cohort studies to define the effect of cadmium on human hypertension are required.
Summary

JPMPH : Journal of Preventive Medicine and Public Health