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Dongkyu Lee 1 Article
The Relationship Between Thiamine Intake and Long Sleep Duration: Results From the Korea National Health and Nutrition Examination Survey
Dongkyu Lee, Kwanghyun Kim, Youngrong Lee, Kyungwon Oh, Sun Jae Jung
J Prev Med Public Health. 2022;55(6):520-528.   Published online October 14, 2022
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AbstractAbstract AbstractSummary PDFSupplementary Material
Thiamine is thought to modify sleeping patterns, while alcohol use diminishes internal thiamine levels. We investigated the association between thiamine intake and sleep duration and explored possible heterogeneity in the effect according to alcohol use.
In total, 15 384 participants aged 19-64 were obtained from the Korea National Health and Nutrition Examination Survey 2012-2016. Nutrient intake, including thiamine, was measured using a food frequency questionnaire. Sleep duration was measured by a self-reported questionnaire. The highest thiamine intake quartile was set as the reference group. Participants were divided into 3 groups, with 7-8 hours of daily sleep as a reference group and those who slept more or less than that as “oversleeping” and “insufficient sleeping,” respectively. Multivariate logistic regression was used, adjusting for socioeconomic, medical, and nutritional factors. Additionally, participants were stratified according to high-risk alcohol use defined by the World Health Organization standards on alcohol use.
Low thiamine intake was associated with oversleeping (Q3: odds ratio [OR], 1.06; 95% confidence interval [CI], 0.86 to 1.32; Q2: OR, 1.24; 95% CI, 0.99 to 1.55; Q1: OR, 1.49; 95% CI, 1.16 to 1.91) and showed a significant trend for higher ORs at lower intake levels (p-trend<0.001). The effect was stronger in the high-risk alcohol use group (Q1: OR, 1.78; 95% CI, 1.28 to 2.49).
Low thiamine intake was associated with oversleeping, and alcohol use intensified that association. These results were found in a context where overt clinical symptoms due to thiamine deficiency are considered rare. More awareness of the potential relationship of thiamine intake with oversleeping and its related risks should be considered.
Korean summary
국민건강영양조사 자료에서 낮은 비타민 B1 섭취가 과도한 수면시간과 연관성이 있으며, 고위험 알코올 섭취군에서 더 큰 상관성을 보였다. 현저한 임상 증상이 나타나지 않는 선에서의 섭취부족도 잠재적으로 과도한 수면시간 및 이와 관련된 건강에 대한 부정적 효과들과 관련이 있을 수 있어 주의가 필요하다.


Citations to this article as recorded by  
  • The Therapeutic Potential of Vitamins B1, B3 and B6 in Charcot–Marie–Tooth Disease with the Compromised Status of Vitamin-Dependent Processes
    Victoria Bunik
    Biology.2023; 12(7): 897.     CrossRef
  • Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin
    Matteo De Simone, Rosario De Feo, Anis Choucha, Elena Ciaglia, Francis Fezeu
    Medical Sciences.2023; 12(1): 2.     CrossRef

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