Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health


Author index

Page Path
HOME > Browse Articles > Author index
Da-Hye Jeon 1 Article
Are Serum Vitamin D Levels Associated With Dry Eye Disease? Results From the Study Group for Environmental Eye Disease
Da-Hye Jeon, Hyungseon Yeom, Jaewon Yang, Jong Suk Song, Hyung Keun Lee, Hyeon Chang Kim
J Prev Med Public Health. 2017;50(6):369-376.   Published online November 2, 2017
  • 6,189 View
  • 179 Download
  • 14 Crossref
AbstractAbstract PDF
Dry eye disease (DED) is an increasingly important public health problem in Korea. Previous studies conducted in Korea have reported inconsistent results regarding the protective effects of vitamin D on DED, and these discrepancies may be related to the relatively simple questionnaire that has been used. Thus, we evaluated the association of serum vitamin D levels with DED using the ocular surface disease index (OSDI).
The present study evaluated data from participants in the Study Group for Environmental Eye Disease (2014-2015). This group included data from 752 participants, and data from 740 participants (253 men and 487 women) were analyzed in the present study. DED severity was evaluated using the OSDI.
Higher serum vitamin D levels were associated with a non-significantly reduced risk of DED in the crude analysis (odds ratio [OR], 0.991; 95% confidence interval [CI], 0.971 to 1.011) and in the adjusted analysis (OR, 0.988; 95% CI, 0.966 to 1.010). In the crude analysis of no/mild DED vs. moderate/severe DED, men exhibited a decreased risk with increasing serum vitamin D levels (OR, 0.999; 95% CI, 0.950 to 1.051), while women exhibited an increased risk (OR, 1.003; 95% CI, 0.979 to 1.027). In these analyses, we found no significant associations.
The findings of the present study support previous reports that serum vitamin D levels are not associated with DED.


Citations to this article as recorded by  
  • Dry Eye Disease: What Is the Role of Vitamin D?
    Maurizio Rolando, Stefano Barabino
    International Journal of Molecular Sciences.2023; 24(2): 1458.     CrossRef
  • Association of serum 25-hydroxyvitamin D concentrations with Schirmer tear test 1 and tear film breakup time in dogs
    Youngsam Kim, Seonmi Kang, Kangmoon Seo
    Journal of Veterinary Science.2023;[Epub]     CrossRef
  • Vitamin D and eye: Current evidence and practice guidelines
    Bhavya Gorimanipalli, Rohit Shetty, Swaminathan Sethu, Pooja Khamar
    Indian Journal of Ophthalmology.2023; 71(4): 1127.     CrossRef
  • Serum Vitamin D Levels and Dry Eye Disease in Postmenopausal Women: A Case–Control Study at a Tertiary Care Center in Rural Haryana
    Diksha Malik, Renu Garg, Sumita Sethi, Rajiv Mahendru, Sanjeet Singh
    International Journal of Applied & Basic Medical Research.2023; 13(2): 83.     CrossRef
  • Vitamin D and Ocular Diseases: A Systematic Review
    Hei-Nga Chan, Xiu-Juan Zhang, Xiang-Tian Ling, Christine Huyen-Trang Bui, Yu-Meng Wang, Patrick Ip, Wai-Kit Chu, Li-Jia Chen, Clement C. Tham, Jason C. Yam, Chi-Pui Pang
    International Journal of Molecular Sciences.2022; 23(8): 4226.     CrossRef
  • Oral vitamin D3 supplementation for femtosecond LASIK-associated dry eye vitamin D for LASIK dry eye syndrome
    Ying Lin, Huanjun Su, Jianbin Wu, Muzhi Yuan, Yong Zhang
    International Ophthalmology.2022; 42(10): 3145.     CrossRef
  • Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases
    Miłosz Caban, Urszula Lewandowska
    Nutrients.2022; 14(11): 2353.     CrossRef
  • Serum Vitamin D Levels and Status in Thai Optic Neuritis Subjects: A Case-Control Study
    Busayanut Puangsricharoen, Kavin Vanikieti, Panitha Jindahra, Tanyatuth Padungkiatsagul
    Clinical Ophthalmology.2022; Volume 16: 3381.     CrossRef
  • Research on mechanism of vitamin A combined with regenerated oxidation-reducing nanomedicine in treating rats with dry eye
    Lei Shi, Ting-Yu Li, Liang-Yu Li, Bao-Ke Hou
    Materials Express.2022; 12(7): 886.     CrossRef
  • Genistein‐Calcitriol Mitigates Hyperosmotic Stress‐Induced TonEBP, CFTR Dysfunction, VDR Degradation and Inflammation in Dry Eye Disease
    Trailokyanath Panigrahi, Sharon D’Souza, Rohit Shetty, Archana Padmanabhan Nair, Anuprita Ghosh, Everette Jacob Remington Nelson, Arkasubhra Ghosh, Swaminathan Sethu
    Clinical and Translational Science.2021; 14(1): 288.     CrossRef
  • Association Between Dyslipidemia and Dry Eye Syndrome Among the Korean Middle-Aged Population
    Hye Rin Choi, Jung Hyun Lee, Hyung Keun Lee, Jong Suk Song, Hyeon Chang Kim
    Cornea.2020; 39(2): 161.     CrossRef
  • Association between vitamin D and dry eye disease: A systematic review and meta-analysis of observational studies
    Gholamreza Askari, Nahid Rafie, Maryam Miraghajani, Zahra Heidari, Arman Arab
    Contact Lens and Anterior Eye.2020; 43(5): 418.     CrossRef
  • Vitamin D deficiency is associated with dry eye syndrome: a systematic review and meta‐analysis
    Jing Liu, Yi Dong, Yan Wang
    Acta Ophthalmologica.2020; 98(8): 749.     CrossRef
  • Nutrition and dry eye: a systematic review
    Isabel Signes-Soler, Jaime Javaloy Estañ
    Expert Review of Ophthalmology.2019; 14(3): 133.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health