Non-linear Relationship Between Body Mass Index and Lower Urinary Tract Symptoms in Korean Males

Article information

J Prev Med Public Health. 2019;52(3):147-153

Publication date (electronic) : 2019 March 29

doi : https://doi.org/10.3961/jpmph.18.259

Chang Kyun Choi, Sun A Kim, Ji-An Jeong, Sun-Seog Kweon, Min-Ho Shin

Department of Preventive Medicine, Chonnam National University Medical School, Hwasun, Korea

Corresponding author: Min-Ho Shin, MD, PhD Department of Preventive Medicine, Chonnam National University Medical School, 264 Seoyang-ro, Hwasun 58128, Korea E-mail: mhshinx@paran.com

Received 2018 November 9; Accepted 2019 February 14.

Abstract

INTRODUCTION

Lower urinary tract symptoms (LUTS) refer to a combination of urinary symptoms associated with storage and/or voiding disturbance. Diseases such as spinal cord injury, prostate enlargement, and prostate cancer cause LUTS, and LUTS are also associated with cardiovascular risk factors, such as hypertension, dyslipidemia, and diabetes [1-3]. The prevalence of LUTS in Asian populations aged >60 years is >60% [4], and the incidence of prostate diseases, which are the main cause of LUTS in Korea, is increasing [5]. LUTS increase the public health burden by reducing quality of life (QoL) [6,7] and increasing the risk of falls and fracture [8,9].

Many studies have investigated associations between obesity and LUTS, but the results have been inconsistent. In addition, the relevance of LUTS in underweight subjects has not been fully evaluated. Some previous studies have reported an association between obesity and LUTS [10-12], while others did not [13,14]. Additionally, most studies did not evaluate the relationship between underweight and LUTS. As LUTS and obesity are both strongly affected by lifestyle factors, such as diet, physical activity (PA), alcohol consumption, and smoking [10,12,15], a study with sufficient consideration of potential confounders is needed. The aim of this study was to evaluate the relationship between body mass index (BMI) and LUTS in Korean males aged 50 years or over. Specifically, we aimed to evaluate whether the relationship between BMI and LUTS was linear or non-linear, and to investigate the relationships of BMI categories based on World Health Organization cut-off points with LUTS.

METHODS

RESULTS

The weighted baseline characteristics of the study population according to BMI category are presented in Table 1. Participants with higher BMIs were younger, had lower total IPSS and IPSS subscores, had a higher household income, more frequently resided with a partner, had more education, were less likely to be smokers, were more likely to be drinkers, engaged in more PA, and had higher prevalence rates of hypertension, diabetes, and dyslipidemia.

Table 1.

Weighted baseline characteristics of the study population according to BMI categories¹

Table 2 presents PRRs for severe LUTS according to BMI categories. A U-shaped relationship was detected between BMI and severe LUTS. The BMI category of 23.0-24.9 kg/m² was used as the reference. In model 4, the PRR for a BMI <18.5 kg/m² was 1.65 (95% confidence interval [CI], 1.35 to 2.02), that for a BMI of 18.5-22.9 kg/m² was 1.25 (95% CI, 1.09 to 1.44), that for a BMI of 25.0-27.4 kg/m² was 1.20 (95% CI, 1.00 to 1.45), that for a BMI of 27.5-29.9 kg/m² was 1.11 (95% CI, 0.83 to 1.47), and that for a BMI ≥ 30.0 kg/m² was 1.85 (95% CI, 1.18 to 2.88).

Table 2.

PRRs for LUTS according to BMI categories

Table 3 presents the results of a sensitivity analysis excluding subjects with prostate enlargement. The U-shaped relationship between BMI and severe LUTS was more prominent. In model 4, the PRR for a BMI <18.5 kg/m² was 2.06 (95% CI, 1.57 to 2.70), that for a BMI of 18.5-22.9 kg/m² was 1.42 (95% CI, 1.17 to 1.73), that for a BMI of 25.0-27.4 kg/m² was 1.32 (95% CI, 1.02 to 1.71), that for a BMI of 27.5-29.9 kg/m² was 1.26 (95% CI, 0.85 to 1.88), and that for a BMI ≥30.0 kg/m² was 2.07 (95% CI, 1.14 to 3.73).

Table 3.

PRRs for LUTS according to categorized BMI, excluding participants with prostate enlargement

Figure 1 shows the age-adjusted relationship between BMI and total IPSS. Data points below the 0.5th percentile and above the 99.5th percentile were removed as outliers. A U-shaped relationship was observed between BMI and IPSS (p for non-linearity <0.001). When the BMI was 24.0 kg/m², the mean total IPSS was the lowest, at 4.85. The relationship between BMI and the IPSS subscores was also U-shaped (data not shown).

Figure. 1.

Mean total International Prostate Symptom Score (IPSS) according to body mass index (BMI) with 3 knots at the 5th, 50th, and 95th percentiles, adjusted for age. Data points below the 0.5th percentile and above the 99.5th percentile were removed as outliers. The gray band represents the 95% confidence interval.

DISCUSSION

In this large-scale cross-sectional study using a nationally representative sample of Korean adults, a U-shaped relationship was detected between BMI and LUTS, and the prevalence was lowest at a BMI of 23.0-24.9 kg/m². The sensitivity analysis revealed that this relationship was more prominent in subjects without prostate enlargement. These results were independent of age, lifestyle, and comorbidities. This is the first study to show a non-linear relationship between BMI and LUTS.

In previous studies on the associations between BMI and LUTS, a U-shaped association was not fully evaluated and the association was inconsistent. Most previous studies evaluated linear associations between BMI and LUTS [10,11,13] or did not evaluate the association between underweight and LUTS [12,14]. Chen et al. [10] reported that a high BMI was associated with a large prostate volume and a high IPSS in the Chinese population. Bhindi et al. [13] reported that BMI was not related to the IPSS, but was related to prostate volume. In the Third National Health and Nutrition Examination Survey, Rohrmann et al. [14] determined that current BMI was not associated with LUTS, but subjects who were obese and overweight at the age of 25 years had a low prevalence of LUTS. Associations between high BMI and LUTS have been reported in prospective studies. In the Boston Area Community Health Survey, Maserejian et al. [11] reported that a high BMI was associated with symptom progression. In the Osteoporotic Fractures in Men Study, Parsons et al. [12] reported a higher incidence of LUTS in subjects with overweight and obesity. In our study, a significant U-shaped relationship was observed between BMI and LUTS. Similar to our results, Smith et al. [21] reported a U-shaped relationship, with a high prevalence of severe LUTS found in individuals with obesity and underweight. However, no statistically significant differences were observed in the prevalence of LUTS between underweight and normal-weight participants because there were few underweight participants. In a study based on the 2012 KCHS, the relationship between BMI and overactive bladder was also U-shaped [22].

The association between obesity and LUTS can be explained by hormonal changes. First, obesity induces insulin resistance, and the increased serum insulin elevates sympathetic nerve tone, leading to overactive bladder and prostate enlargement [23]. In addition, the androgen receptor located in the prostate smooth muscle binds insulin-like growth factor, so insulin can induce smooth muscle contraction [24]. Second, changes in sex hormones can exacerbate LUTS. Increased adipose tissue in obese subjects increases serum estrogen levels [25]. Estrogen is involved in the pathogenesis of prostate cancer, one of the causes of LUTS. In animal studies, estrogen has been found to act on estrogen receptor alpha, leading to prostate cancer [26]. In addition, higher testosterone-to-estrogen enzyme conversion activity resulted in a higher incidence of prostate cancer in a genome-wide association study [27].

The mechanism for the relationship between underweight and LUTS is unclear, but a possible explanation is as follows. First, BMI reflects not only adiposity, but also lean body mass, and underweight is associated with sarcopenia [28]. Degradation of bladder function by sarcopenia or decreased muscle strength may be associated with voiding symptoms. In addition, the percentage of body fat may be high even in a subject with a low BMI because the percentage of muscle decreases with age [29]. LUTS can be induced by increased adipose tissue in both underweight and obesity. Second, the relationship between underweight and LUTS may reflect reverse causation. Poor QoL leads to weight loss [30], and LUTS deteriorates several indicators of QoL, such as sleep quality, depression, mobility, and self-rated health [31].

The limitations of this study are as follows. First, we only used BMI as an index of obesity, but the relationships of underweight and obesity with LUTS have also been explored through other anthropometric methods, such as fat distribution, waist circumference, and the waist-hip ratio index. Second, BMI was calculated from self-reported body weight and height. In a study based on the 2016 KCHS, the correlation between measured BMI and BMI calculated by self-reported body weight and height was 0.86 at ages ≥60 years, which was lower than at other ages [32]. Therefore, further studies using accurately measured data are needed.

In conclusion, a U-shaped relationship was detected between BMI and LUTS in Korean males, and this relationship was significant even after adjusting for lifestyle, socioeconomic status, and comorbidities. These results suggest that both underweight and obesity can contribute to LUTS. It also suggests that healthcare providers caring for LUTS patients need to pay attention to the issues of underweight and obesity. However, the role of underweight is unclear in the etiology of LUTS development. Further studies are needed on the mechanisms underlying this relationship.

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