1Department of Preventive Medicine, Dong-A University College of Medicine, Busan, Korea.
2Medical Research Center for Cancer Molecular Therapy, Dong-A University College of Medicine, Busan, Korea.
3Department of Genetic Epidemiology, SNP Genetics Inc., Seoul, Korea.
4Department of Preventive Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Copyright © 2011 The Korean Society for Preventive Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The authors have no conflicts of interest with the material presented in this paper.
This article is available at http://jpmph.org/.
Variables |
n (%) |
p- value | |||
---|---|---|---|---|---|
Genotypes | Patients (n=406) | Controls (n=428) | OR (95% CI) | ||
Total1 | T allele | 416 (51.2) | 466 (54.4) | 1.00 | <0.36 |
C allele | 396 (48.8) | 390 (45.6) | 1.10 (0.90 - 1.35) | ||
TT | 96 (23.7) | 134 (31.3) | 1.00 | <0.05 | |
TC | 224 (55.2) | 198 (46.3) | 1.54 (1.10 - 2.17) | ||
CC | 86 (21.1) | 96 (22.4) | 1.17 (0.77 - 1.76) | ||
TC/CC | 310 (76.4) | 294 (68.7) | 1.42 (1.03 - 1.96) | 0.05 | |
CC vs TC+TT | 86 (21.2) | 96 (22.4) | 0.08 (0.62 - 1.25) | 0.48 | |
Age (y) | |||||
≥60 | T allele | 336 (51.7) | 311 (53.8) | 1.00 | 0.46 |
C allele | 314 (48.3) | 267 (46.2) | 1.09 (0.87 - 1.36) | ||
TT | 81 (24.9) | 93 (32.2) | 1.00 | <0.05 | |
TC | 174 (53.5) | 125 (43.3) | 1.60 (1.10 - 2.33) | ||
CC | 70 (21.5) | 71 (24.6) | 1.13 (0.73 - 1.77) | ||
TC/CC | 224 (75.1) | 196 (67.8) | 1.43 (1.01 - 2.03) | <0.05 | |
CC vs TC+TT | 70 (21.5) | 71 (24.6) | 0.84 (0.58 - 1.23) | 0.37 | |
<60 | T allele | 80 (49.4) | 155 (55.8) | 1.00 | 0.2 |
C allele | 82 (50.6) | 123 (44.2) | 1.29 (0.88 - 1.90) | ||
TT | 15 (18.5) | 41 (29.5) | 1.00 | 0.2 | |
TC | 50 (61.7) | 73 (52.5) | 1.87 (0.94 - 3.74) | ||
CC | 16 (19.8) | 25 (18.0) | 1.75 (0.74 - 4.14) | ||
TC/CC | 66 (81.5) | 98 (70.5) | 1.84 (0.94 - 3.59) | 0.07 | |
CC vs TC+TT | 16 (19.8) | 25 (18.0) | 1.12 (0.56 - 2.25) | 0.75 | |
Sex | |||||
Male | T allele | 330 (51.1) | 368 (54.8) | 1.00 | 0.18 |
C allele | 316 (48.9) | 304 (45.2) | 1.16 (0.93 - 1.44) | ||
TT | 77 (23.9) | 109 (32.4) | 1.00 | 0.02 | |
TC | 176 (54.5) | 150 (44.6) | 1.66 (1.15 - 2.39) | ||
CC | 70 (21.7) | 77 (22.9) | 1.29 (0.83 - 1.99) | ||
TC/CC | 246 (76.2) | 227 (67.6) | 1.53 (1.09 - 2.16) | <0.01 | |
CC vs TC+TT | 70 (21.7) | 77 (22.9) | 0.93 (0.64 - 1.34) | 0.70 | |
Female | T allele | 86 (51.8) | 98 (53.3) | 1.00 | 0.79 |
C allele | 80 (48.2) | 86 (46.7) | 1.06 (0.70 - 1.61) | ||
TT | 19 (22.9) | 25 (27.2) | 1.00 | 0.73 | |
TC | 48 (57.8) | 48 (52.2) | 1.32 (0.64 - 2.70) | ||
CC | 16 (19.3) | 19 (20.7) | 1.11 (0.45 - 2.71) | ||
TC/CC | 64 (77.1) | 67 (72.8) | 1.26 (0.63 - 2.50) | 0.51 | |
CC vs TC+TT | 16 (19.3) | 19 (20.7) | 0.92 (0.44 - 1.93) | 0.82 | |
Smoking status | |||||
Smokers | T allele | 351 (50.7) | 307 (54.1) | 1.00 | 0.24 |
C allele | 341 (49.3) | 261 (46.0) | 1.14 (0.91 - 1.43) | ||
TT | 80 (23.1) | 88 (31.0) | 1.00 | <0.05 | |
TC | 191 (55.2) | 131 (46.1) | 1.60 (1.10 - 2.33) | ||
CC | 75 (21.7) | 65 (22.9) | 1.27 (0.81 - 1.99) | ||
TC/CC | 266 (76.9) | 196 (69.0) | 1.49 (1.05 - 2.13) | <0.05 | |
CC vs TC+TT | 75 (21.7) | 65 (22.9) | 0.93 (0.64 - 1.36) | 0.72 | |
Non-smokers | T allele | 65 (54.2) | 159 (55.2) | 1.00 | 0.85 |
C allele | 55 (45.8) | 129 (44.8) | 1.04 (0.68 - 1.60) | ||
TT | 16 (26.7) | 46 (31.9) | 1.00 | 0.55 | |
TC | 33 (55.0) | 67 (46.5) | 1.42 (0.70 - 2.87) | ||
CC | 11 (18.3) | 31 (21.5) | 1.02 (0.42 - 2.49) | ||
TC/CC | 44 (73.3) | 98 (68.6) | 1.29 (0.66 - 2.52) | 0.46 | |
CC vs TC+TT | 11 (18.3) | 31 (21.5) | 0.82 (0.38 - 1.76) | 0.61 | |
Family history of cancer | |||||
No | T allele | 327 (50.6) | 344 (55.0) | 1.00 | 0.12 |
C allele | 319 (49.4) | 282 (45.0) | 1.19 (0.95 - 1.48) | ||
TT | 75 (23.2) | 100 (32.0) | 1.00 | 0.03 | |
TC | 177 (54.8) | 144 (46.0) | 1.64 (1.13 - 2.38) | ||
CC | 71 (22.0) | 69 (22.0) | 1.37 (0.88 - 2.14) | ||
TC/CC | 248 (76.8) | 213 (68.1) | 1.55 (1.09 - 2.21) | <0.01 | |
CC vs TC+TT | 71 (220.) | 69 (22.0) | 1.00 (0.68 - 1.45) | 0.98 | |
Yes | T allele | 89 (53.6) | 122 (53.0) | 1.00 | 0.91 |
C allele | 77 (46.4) | 108 (47.0) | 0.98 (0.66 - 1.46) | ||
TT | 21 (25.3) | 34 (29.6) | 1.00 | 0.4 | |
TC | 47 (56.6) | 54 (47.0) | 1.41 (0.72 - 2.75) | ||
CC | 15 (18.1) | 27 (23.5) | 0.90 (0.39 - 2.07) | ||
TC/CC | 61 (74.7) | 81 (70.4) | 1.24 (0.66 - 2.34) | 0.51 | |
CC vs TC+TT | 15 (180.) | 22 (23.5) | 0.72 (0.35 - 1.46) | 0.36 |