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HOME > Korean J Prev Med > Volume 12(1); 1979 > Article
Original Article A Study on the Urinary Lead Excretion after Oral D-penicillamine Administration.
Soo Il Lee
Journal of Preventive Medicine and Public Health 1979;12(1):43-48
DOI: https://doi.org/
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For the purpose of further health control, D-penicillamine was orally administered to 8 persons who were employed in lead industry and suspected lead intoxication routine industrial health examination. The dose of D-penicillamine was 600 mg per day and was administered orally in every other 5 days. For the laboratory analyses 24 hours urine and 10 gm of whole blood were collected every day. The results were as follows ; 1. It was found that mean urinary lead excretion per day was 446.5 g/l and 394.98 g/l, respectively during the first 5-day and the second 5-day administration with D-penicillamine. 2. Mean lead excretion per day was 130.56 +/- 66.42 g/l after first 5-day administration and 159.28 +/- 104.44 g/l after second 5-day administration with D-penicillamine. 3. The level of urinary lead excretion after administration increased 3 to 4 times than that before administration with D-penicillamine. 4. Blood and urinary lead level investigate after 6 months were 44.4 +/- 10.2 g/100g and 72.7 +/- 29.7 g/l for the eight persons.

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