Abstract

For the purpose of further health control, D-penicillamine was orally administered to 8 persons who were employed in lead industry and suspected lead intoxication routine industrial health examination. The dose of D-penicillamine was 600 mg per day and was administered orally in every other 5 days. For the laboratory analyses 24 hours urine and 10 gm of whole blood were collected every day. The results were as follows ; 1. It was found that mean urinary lead excretion per day was 446.5 g/l and 394.98 g/l, respectively during the first 5-day and the second 5-day administration with D-penicillamine. 2. Mean lead excretion per day was 130.56 +/- 66.42 g/l after first 5-day administration and 159.28 +/- 104.44 g/l after second 5-day administration with D-penicillamine. 3. The level of urinary lead excretion after administration increased 3 to 4 times than that before administration with D-penicillamine. 4. Blood and urinary lead level investigate after 6 months were 44.4 +/- 10.2 g/100g and 72.7 +/- 29.7 g/l for the eight persons.