Journal of Preventive Medicine and Public Health

Neurobehavioral Changes according to Cumulative Exposure of Complex Organic Solvents.: Duk Hee Lee, In Geun Park, Jin Ha Kim, Young Hawn Lee, Sung Gye Kang, Doo Hie Kim; Korean J Prev Med. 1995;28(2):386-397.

Abstract PDF: A cross sectional study was performed to evaluate the neurobehavioral effects of chronic exposure of complex organic solvents, using NCTB(Neurobehavioral Core Test Battery) recommended by WHO(World Health organization). Forty female shoe factory workers and twenty-two controls matched with age were participated. The tests were performed in the morning before start of work, to exclude the effects of acute exposure. Workers were exposed mainly to toluene, methyl ethyl ketone, n-hexane, cyclo-hexane, dichloroethylene, trichloroethylene, benzene, xylenes etc. The ranges of present solvent exposure of hygienic effect were 0.46~0.71 in the process using adhesives indirectly, and 1.83-2.39 in the process using it directly. We reclassified the subjects, according to cumulative exposure. It showed significantly poorer performances in high exposed group on Santa Ana Dexterity and Benton visual Retention, compared with control group. After controlling confounder, the significances were still remained. But, further cohort studies, having the information of personal exposure dose from entering a factory, are required to clarify the effects of chronic exposure of complex organic solvents in relation to dose and duration of exposure.; Summary

Neurobehavioral Change on the Lead Exposure Workersq.: In Geun Park, Duk Hee Lee, Yong Hwan Lee, Jin Ha Kim, She Han Jang; Korean J Prev Med. 1995;28(1):175-186.

A study to the workers exposed to organic solvents by neurobehavioral tests.: Seong Kyu Kang, Ho Keun Chung, Jeong Pyo Hong, Ki Woong Kim, Young Sook Cho; Korean J Prev Med. 1993;26(2):210-221.

Abstract PDF: In order to evaluate the confounding factors of neurobehavioral tests and the neurobehavioral effects in the workers exposed to organic solvents, NCTB was carried out on 100 workers. 46 workers had never been exposed to neurotoxic substances, and the others were being exposed to the solvents, mainly toluene. Simple reaction time, digit symbol, Santa Ana dexterity test and persuit aiming were different with age in non exposure group. Simple reaction time was carried out well in males, and digit symbol and persuit aiming were in females. There was no difference at educational level when the subject was educated over 12 years. Santa Ana dexterity and Benton visual test differed according to exposure level to toluene, however simple reaction time didn't. The acute neurotoxic effect was not excluded in this study. But, NCTB could be used to evaluate and prevent neurobehavioral changes in workers exposed to neurotoxic solvents in Korea.; Summary

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