Journal of Preventive Medicine and Public Health

Original Articles

Relationship Between Pesticide Exposure Factors and Health Symptoms Among Chili Farmers in Northeast Thailand: Ratchadaporn Pengpan, Kulthida Y. Kopolrat, Sribud Srichaijaroonpong, Nutta Taneepanichskul, Patiwat Yasaka, Ratanee Kammoolkon; J Prev Med Public Health. 2024;57(1):73-82. Published online December 20, 2023; DOI: https://doi.org/10.3961/jpmph.23.353

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Objectives
The unsafe use of pesticides in agriculture represents a major hazard to human health. This study was conducted to investigate the association between pesticide exposure and health symptoms among chili farmers in northeast Thailand.
Methods
This cross-sectional analytic study included 141 chili farmers in Sakon Nakhon Province, in northeast Thailand. Data regarding health symptoms were gathered using a self-report questionnaire. A medical technician tested blood cholinesterase activity using an erythrocyte method, and an occupational medicine specialist at Ramathibodi Hospital in Bangkok, Thailand reviewed the results. Associations between personal characteristics, pesticide exposure factors, and health symptoms were analyzed using multiple logistic regression.
Results
Of the 141 chili farmers studied, 66.7% experienced pesticide poisoning, as indicated by below-normal cholinesterase levels. Fatigue was the most frequently reported symptom associated with pesticide exposure, affecting 37.6% of participants. This was followed by nausea and vomiting (31.9%), dizziness (14.9%), and dry throat (14.9%). Multivariate logistic regression analysis revealed that several factors were significantly associated with adverse symptoms: amount of work experience, volume of pesticides used, use of chemical pesticides, use of leaking containers during spraying, direct pesticide exposure while working, contact with pesticide-soaked clothing, consumption of food and drinks in the fields, and blood cholinesterase level indicating risk.
Conclusions
This study suggests potential health risks for chili farmers stemming from exposure to and contamination by pesticides used in agricultural practices. To mitigate these risks, it is essential to supply personal protective equipment and to implement educational programs aimed at improving protective behaviors among farmers.

Summary

Key Message
This study aimed to demonstrate the impact of pesticide exposure on health symptoms. In a cross-sectional study, the effects of pesticide exposure on acetylcholinesterase erythrocyte activity in blood during agricultural practices were examined as potential health risks for chili farmers. It is crucial to provide personal protective equipment and to implement educational initiatives targeted at encouraging farmers to adopt more protective behaviors to reduce these risks.

Citations

Citations to this article as recorded by

Developmental inequity and the impact of pesticide exposure on gut and brain health in developing nations – a Brazilian perspective
Jessica Gama, Bianca Cruz Neves, Antonio Pereira
Humanities and Social Sciences Communications.2025;[Epub] CrossRef
Emerging diseases: trend research and omics-based analysis reveals mechanisms of endophytes modulate Chilli plant resilience
Wiwiek Harsonowati, Evy Latifah, Arinal Haq Izzawati Nurrahma, Jati Purwani, Rashid Iqbal, Javid Ahmad Parray, Ashish D. Patel
Symbiosis.2024; 93(3): 241. CrossRef
An Analysis of Occupational Hazards Based on the Physical Ergonomics Dimension to Improve the Occupational Health of Agricultural Workers: The Case in Mayo Valley, Mexico
Víctor Manuel Ramos-García, Josué Aarón López-Leyva, Ana Paola Balderrama-Carmona, Iván Ochoa-Vázquez, Juan José García-Ochoa, Manuel de Jesús Espinoza-Espino
Safety.2024; 10(3): 61. CrossRef

Determinants of Adherence to Diabetes Screening in Iranian Adults With a Positive Family History of Diabetes: Narges Malih, Mohammad-Reza Sohrabi, Alireza Abadi, Shahnam Arshi; J Prev Med Public Health. 2021;54(3):190-198. Published online April 7, 2021; DOI: https://doi.org/10.3961/jpmph.20.496

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Abstract PDF Supplementary Material

Objectives
Insufficient evidence exists regarding factors that affect screening adherence among people with a family history of diabetes, who comprise roughly half of all patients with diabetes. Therefore, we aimed to identify the determinants of diabetes screening adherence in adults with a family history of diabetes who had not yet been diagnosed with diabetes.
Methods
This cross-sectional study was conducted at selected urban primary healthcare facilities in Tehran, Iran. The study population was clinically non-diabetic adults above 20 years of age with a family history of diabetes in at least 1 first-degree relative. All eligible people identified on randomly-selected days of the month were invited to join the study.
Results
Among 408 participants, 128 (31.4%) had received a fasting blood glucose check during the last year. Using binary logistic regression, the independent predictors of screening adherence were knowledge of adverse effects of diabetes such as sexual disorders (odds ratio [OR], 3.05) and renal failure (OR, 2.73), the impact of family members’ advice on receiving diabetes screening (OR, 2.03), recommendation from a healthcare provider to have a fasting blood glucose check (OR, 2.61), and intention to have a fasting blood glucose check within the next 6 months (OR, 2.85). Other variables that predicted screening adherence were age (OR, 1.05), job (being a housekeeper; OR, 3.39), and having a college degree (OR, 3.55).
Conclusions
Knowledge of the adverse effects of diabetes, physicians’ and healthcare providers’ advice about the benefits of early disease detection, and family members’ advice were independent predictors of screening adherence.

Summary

Citations

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The association between sociodemographic characteristics, clinical indicators and body mass index in a population at risk of type 2 diabetes: A cross-sectional study in two Colombian cities
Yenifer Diaz Montes, Tania Acosta Vergara, Rafael Tuesca Molina, Gillian Martinez Guerrero, Luis A. Anillo Arrieta, Pablo Aschner, Jorge Acosta-Reyes, Victor Florez-Garcia, Edgar Navarro Lechuga, Noël C. Barengo
Primary Care Diabetes.2024; 18(4): 458. CrossRef
Socio-personal factors affecting adherence to treatment in patients with type 2 diabetes: A systematic review and meta-analysis
Nahid Shahabi, Yadolah Fakhri, Teamur Aghamolaei, Zahra Hosseini, Atefeh Homayuni
Primary Care Diabetes.2023; 17(3): 205. CrossRef
Clinical traits and systemic risks of familial diabetes mellitus according to age of onset and quantity: an analysis of data from the community-based KoGES cohort study
Ju-Yeun Lee, Kyungsik Kim, Sangjun Lee, Woo Ju An, Sue K. Park
Epidemiology and Health.2023; 45: e2023029. CrossRef
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Hatice İkiışık, Sibel Sakarya
Eskişehir Türk Dünyası Uygulama ve Araştırma Merkezi Halk Sağlığı Dergisi.2022; 7(1): 98. CrossRef
Association between a family history of diabetes and carotid artery atherosclerosis in Korean adults
Sun Young Shim, Ga Bin Lee, Jee-Seon Shim, Sun Jae Jung, Hyeon Chang Kim
Epidemiology and Health.2021; 43: e2021049. CrossRef

Blood Pressure and the Risk of Death From Non-cardiovascular Diseases: A Population-based Cohort Study of Korean Adults: Jeoungbin Choi, Jieun Jang, Yoonsuk An, Sue K. Park; J Prev Med Public Health. 2018;51(6):298-309. Published online November 14, 2018; DOI: https://doi.org/10.3961/jpmph.18.212

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Abstract Summary PDF Supplementary Material

Objectives
The objective of this study was to assess the relationship between systolic and diastolic blood pressure (SBP, DBP) and the risk of death from specific causes other than cardiovascular diseases.
Methods
We calculated the risk of specific death by SBP and DBP categories for 506 508 health examinees in 2002-2003 using hazard ratios (HRs) and 95% confidence intervals (CIs) in a Cox proportional hazards model.
Results
Compared to normal levels (SBP <120 or DBP <90 mmHg), stage I systolic and diastolic hypertension (SBP 140-159, DBP 85- 89 mmHg, respectively) were associated with an increased risk of death from diabetes mellitus, alcoholic liver disease, and renal failure (HR, 1.83; 95% CI, 1.51 to 2.22; HR, 1.24; 95% CI, 1.06 to 1.46; HR, 2.30; 95% CI, 1.64 to 3.21; HR, 1.67; 95% CI, 1.27 to 2.20; HR, 1.99; 95% CI, 1.41 to 2.81; HR, 1.31; 95% CI, 0.99 to 1.73, respectively), but a decreased risk of death from intestinal pneumonia (HR, 0.64; 95% CI, 0.42 to 0.98; HR, 0.59; 95% CI, 0.39 to 0.91). Only stage II systolic hypertension (SBP ≥160 mmHg) was associated with an increased risk of death from pneumonia, liver cirrhosis, and intestinal ischemia (HR, 1.54; 95% CI, 1.19 to 1.98; HR, 1.46; 95% CI, 1.00 to 2.15; HR, 3.77; 95% CI, 1.24 to 11.40, respectively), and stage I and II diastolic hypertension (SBP 140-159 and ≥160 mmHg) were associated with an increased risk of death from intestinal ischemia (HR, 3.07; 95% CI, 1.27 to 7.38; HR, 4.39; 95% CI, 1.62 to 11.88, respectively).
Conclusions
An increase in blood pressure levels may alter the risk of death from certain causes other than cardiovascular diseases, a well-known outcome of hypertension, although the mechanism of these associations is not well documented.

Summary

Korean summary
2002년 및 2003년 한국 국민건강보험공단 건강검진 수검자 코호트(NHIS-HEALS) 중 506,508명을 대상으로 2013년 말일까지의 통계청 사망자료 기반 심뇌혈관질환을 제외한 기타 사망원인으로의 사망위험을 콕스회귀모형으로 분석한 결과에서 1단계 수축기 고혈압 군과 1단계 이완기 고혈압 군에서 당뇨, 알코올성 간질환, 콩팥부전 사망의 위험도가 통계적으로 유의하게 증가함을 보인 반면, 간질성 폐렴의 사망위험은 유의하게 감소함을 보였다. 2단계 수축기 고혈압 군에서는 폐렴, 간경화 및 허혈성 장질환의 사망위험이 증가하는 것을 보였다. 혈압의 증가가 기존에 알려진 심뇌혈관 질환 이외의 사망위험도에도 연관된 것으로 보이며, 고혈압의 질병부담 연구 및 보건정책 수립시 이 같은 점에 대한 고려가 필요하다.

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Sex-specific associations of the Dietary Inflammatory Index with cardiovascular and non-cardiovascular mortality in hypertensive adults: a cohort study
Zhang Youqi, Yan Meng, Ji Liu, Yang Dawei, Wu Jianjun, Yang Fan
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Binary cutpoint and the combined effect of systolic and diastolic blood pressure on cardiovascular disease mortality: A community-based cohort study
Ju-Yeun Lee, Ji Hoon Hong, Sangjun Lee, Seokyung An, Aesun Shin, Sue K. Park, Tariq Jamal Siddiqi
PLOS ONE.2022; 17(6): e0270510. CrossRef
Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19
Reinhold Kreutz, Engi Abd El-Hady Algharably, Michel Azizi, Piotr Dobrowolski, Tomasz Guzik, Andrzej Januszewicz, Alexandre Persu, Aleksander Prejbisz, Thomas Günther Riemer, Ji-Guang Wang, Michel Burnier
Cardiovascular Research.2020; 116(10): 1688. CrossRef
Prevalence of hypertension, levels of lipids and blood glucose in patients with acute pancreatitis, chronic pancreatitis and pancreatic cancer
I. N. Grigorieva, O. V. Efimova, T. S. Suvorova, N. L. Tov, T. I. Romanova
Russian Journal of Cardiology.2020; 25(6): 3823. CrossRef

Low Systolic Blood Pressure and Mortality From All Causes and Vascular Diseases Among Older Middle-aged Men: Korean Veterans Health Study: Sang-Wook Yi, Heechoul Ohrr; J Prev Med Public Health. 2015;48(2):105-110. Published online March 11, 2015; DOI: https://doi.org/10.3961/jpmph.15.003

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Abstract PDF

Objectives
Recently, low systolic blood pressure (SBP) was found to be associated with an increased risk of death from vascular diseases in a rural elderly population in Korea. However, evidence on the association between low SBP and vascular diseases is scarce. The aim of this study was to prospectively examine the association between low SBP and mortality from all causes and vascular diseases in older middle-aged Korean men.
Methods
From 2004 to 2010, 94 085 Korean Vietnam War veterans were followed-up for deaths. The adjusted hazard ratios (aHR) were calculated using the Cox proportional hazard model. A stratified analysis was conducted by age at enrollment. SBP was self-reported by a postal survey in 2004.
Results
Among the participants aged 60 and older, the lowest SBP (<90 mmHg) category had an elevated aHR for mortality from all causes (aHR, 1.9; 95% confidence interval [CI], 1.2 to 3.1) and vascular diseases (International Classification of Disease, 10th revision, I00-I99; aHR, 3.2; 95% CI, 1.2 to 8.4) compared to those with an SBP of 100 to 119 mmHg. Those with an SBP below 80 mmHg (aHR, 4.5; 95% CI, 1.1 to 18.8) and those with an SBP of 80 to 89 mmHg (aHR, 3.1; 95% CI, 0.9 to 10.2) also had an increased risk of vascular mortality, compared to those with an SBP of 90 to 119 mmHg. This association was sustained when excluding the first two years of follow-up or preexisting vascular diseases. In men younger than 60 years, the association of low SBP was weaker than that in those aged 60 years or older.
Conclusions
Our findings suggest that low SBP (<90 mmHg) may increase vascular mortality in Korean men aged 60 years or older.

Summary

Citations

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Relationship between systolic blood pressure and all-cause mortality: a prospective study in a cohort of Chinese adults
Chunsheng Li, Youren Chen, Qiongbing Zheng, Weiqiang Wu, Zhichao Chen, Lu Song, Shasha An, Zhifang Li, Shuohua Chen, S. L. Wu
BMC Public Health.2018;[Epub] CrossRef
Baseline and longitudinal change in blood pressure and mortality in a Chinese cohort
Jian-Bing Wang, Qiu-Chi Huang, Shu-Chang Hu, Pei-Wen Zheng, Peng Shen, Die Li, Huai-Chu Lu, Xiang Gao, Hong-Bo Lin, Kun Chen
Journal of Epidemiology and Community Health.2018; 72(12): 1083. CrossRef
Low Systolic Blood Pressure and Vascular Mortality Among More Than 1 Million Korean Adults
Sang-Wook Yi, Yejin Mok, Heechoul Ohrr, Jee-Jeon Yi, Young Duk Yun, Jihwan Park, Sun Ha Jee
Circulation.2016; 133(24): 2381. CrossRef

Frequency and Related Factors of Masked Hypertension at a Worksite in Korea: Sang-Kyu Kim, Jun-Ho Bae, Dung-Young Nah, Dong-Wook Lee, Tae-Yoon Hwang, Kyeong-Soo Lee; J Prev Med Public Health. 2011;44(3):131-139. Published online May 17, 2010; DOI: https://doi.org/10.3961/jpmph.2011.44.3.131

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Abstract PDF

Objectives

Masked hypertension is associated with metabolic risks and increased risk of cardiovascular disease. The purpose of this study was to identify the frequency of and risk factors of masked hypertension in Korean workers.

Methods

The study was conducted among 121 employees at a hotel in Gyeongju, Korea, from December 2008 to February 2009. We measured blood pressure (BP) both in the clinic and using 24-hour ambulatory BP monitors for all subjects. Hypertension was defined independently by both methods, and subjects were classified into four groups: true normotension, masked hypertension, white coat hypertension, and sustained hypertension.

Results

The frequency of masked hypertension in our study group was 25.6%. Compared with true normotension, the factors related to masked hypertension were male gender (odds ratio [OR], 10.7; 95% confidence interval [CI], 1.41 to 81.09), aging one year (OR, 0.88; 95% CI, 0.78 to 0.99), clinic BP 120-129/80-84 mmHg (OR, 8.42; 95% CI, 1.51 to 46.82), clinic BP 130-139 / 85-89 mmHg (OR, 12.14; 95% CI, 1.80 to 81.85), smoking (OR, 5.51; 95% CI, 1.15 to 26.54), and increase of total cholesterol 1 mg / dL (OR, 1.05; 95% CI, 1.02 to 1.08). In males only, these factors were clinic BP 120-129 / 80-84 mmHg (OR, 15.07; 95% CI, 1.55 to 146.19), clinic BP 130-139 / 85-89 mmHg (OR, 17.16; 95% CI, 1.56 to 189.45), smoking (OR, 11.61; 95% CI, 1.52 to 88.62), and increase of total cholesterol 1 mg/dL (OR, 1.05; 95% CI, 1.01 to 1.09).

Conclusions

The frequency of masked hypertension was high in our study sample. Detection and management of masked hypertension, a known strong predictor of cardiovascular risk, could improve prognosis for at-risk populations.

Summary

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Does This Adult Patient Have Hypertension?
Anthony J. Viera, Yuichiro Yano, Feng-Chang Lin, David L. Simel, Jonathan Yun, Gaurav Dave, Ann Von Holle, Laura A. Viera, Daichi Shimbo, Shakia T. Hardy, Katrina E. Donahue, Alan Hinderliter, Christiane E. Voisin, Daniel E. Jonas
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Bâ Hamadou, Sylvie Ndongo Amougou, Yolande Tchuendem, Chris Nadège Nganou-Gnindjio, Liliane Mfeukeu-Kuate, Audrey Joyce Foka, Aurel T. Tankeu, Ahmadou Musa Jingi, Alain Patrick Menanga, Samuel Kingue
Blood Pressure Monitoring.2020; 25(4): 212. CrossRef
Frequency of masked hypertension and its relation to target organ damage in the heart
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The Egyptian Heart Journal.2016; 68(1): 53. CrossRef
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Nabil Abdulghany Sarhan, Abdulsalam Mahmoud Algamal
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English Abstracts

A Factor of Fasting Blood Glucose and Dietary Patterns in Korean Adults Using Data From the 2007, 2008 and 2009 Korea National Health and Nutrition Examination Survey.: Kyung Won Paek, Ki Hong Chun, Soo Jin Lee; J Prev Med Public Health. 2011;44(2):93-100.; DOI: https://doi.org/10.3961/jpmph.2011.44.2.93

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Abstract PDF

OBJECTIVES
This study was performed to identify the socioeconomic factors, health behavior factors and dietary patterns that have an influence on the fasting blood glucose in adults. METHODS: This study used data collected from the 2007, 2008, 2009 Korea National Health and Nutrition Examination Survey. The final sample included 4163 subjects who were 30-59 years old and who had completed the necessary health examinations, the health behaviors survey and nutrition survey. RESULTS: Eleven dietary patterns emerged from the factor analysis with different factor loading. After controlling for potential confounders, multiple regression analysis of the dietary patterns showed that 'fruits', 'alcohols', and 'starchy foods' affected the fasting blood. Lower consumption of 'fruits' and higher consumption of 'alcohols' and 'starch foods' were significantly associated only with an increased risk of high blood glucose. CONCLUSIONS: In the light of the results of this study, it appears pretty likely that the risk of developing high blood glucose can be reduced by changing a person's dietary patterns.

Summary

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Clinical Study on the Effects of AmorePacific Green Tea Extract (AP GTE) on Postprandial Blood Glucose and Insulin after a High-Fat/High-Carbohydrate Meal
Jae-Heon Kang, Hyun-Jin Nam, Kyoungmi Jung, Gyeyoung Choi, Ji-Hae Lee, Hyun Woo Jeong, Jonghwa Roh, Wangi Kim
Food Supplements and Biomaterials for Health.2021;[Epub] CrossRef
Intake of Fruits for Diabetics: Why and How Much?
Eun Young Lee
The Journal of Korean Diabetes.2019; 20(2): 106. CrossRef
Relationship between fruit and fish intakes and cardiovascular disease risk factors in Korean women with type 2 diabetes mellitus: Based on the 4th and 5th Korea National Health and Nutrition Examination Surveys
Ji Soo Oh, Hyesook Kim, Ki Nam Kim, Namsoo Chang
Journal of Nutrition and Health.2016; 49(5): 304. CrossRef
Association between flavonoid intake and diabetes risk among the Koreans
Jee-Young Yeon, Yun Jung Bae, Eun-Young Kim, Eun-Ju Lee
Clinica Chimica Acta.2015; 439: 225. CrossRef
Association of dietary pattern with biochemical blood profiles and bodyweight among adults with Type 2 diabetes mellitus in Tehran, Iran
Nasrin Darani Zad, Rokiah Mohd Yusof, Haleh Esmaili, Rosita Jamaluddin, Fariba Mohseni
Journal of Diabetes & Metabolic Disorders.2015;[Epub] CrossRef
A factor of periodontal disease and dietary patterns in Korean adults using data from Korea National Health and Nutrition Examination Survey V
Kyung Won Paek, Soojin Lee, Joung Hwan Back
Journal of Korean Academy of Oral Health.2015; 39(4): 280. CrossRef
Less Healthy Dietary Pattern is Associated with Smoking in Korean Men According to Nationally Representative Data
Sang-Yeon Suh, Ju Hyun Lee, Sang Shin Park, Ah-Ram Seo, Hong-Yup Ahn, Woo Kyung Bae, Yong Joo Lee, Eunji Yim
Journal of Korean Medical Science.2013; 28(6): 869. CrossRef
Prevalence of Diabetes and Impaired fasting glucose according to Food frequency Similarity in Korea
So-Hye Jeon, Nam-Hyun Kim
Journal of the Korea Academia-Industrial cooperation Society.2013; 14(2): 751. CrossRef
Diabetes Risk Analysis Model with Personalized Food Intake Preference
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The Prevalence of High Myopia in 19 Year-Old Men in Busan, Ulsan and Gyeongsangnam-Do.: Sang Joon Lee, Sang Hwa Urm, Byeng Chul Yu, Hae Sook Sohn, Young Seoub Hong, Maeng Seok Noh, Yong Hwan Lee; J Prev Med Public Health. 2011;44(1):56-64.; DOI: https://doi.org/10.3961/jpmph.2011.44.1.56

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Abstract PDF

OBJECTIVES
The purpose of this study was to estimate the prevalence and correlated factors of high myopia in 19 year-old men in Southeast Korea. METHODS: This retrospective study was based on the medical checkup data of conscription during 2005. The study subjects were 19 years old men in Busan, Ulsan and Gyeongsangnam-do. The health checkup data of the conscripts consisted of noncycloplegic autorefraction test, the biometric data and social factors. To analyze the social and biometric effects, we classified the biometric factors into 4 or 5 groups and the social factors into 3 groups. High myopia was defined as a spherical equivalent of under -6.0 diopter. Data analysis was performed using the chi square test for trends and multiple logistic regression analysis. The SAS(version 9.1) program was used for all the analyses. RESULTS: The prevalence of high myopia was 12.39% (6256 / 50 508). The factors correlated with high myopia were the residence area (OR, 2.07; 95% CI, 1.77 to 2.4 for small city; OR, 2.01; 95% CI, 1.72 to 2.34 for metropolis; the reference group was rural area), academic achievement (OR, 1.43; 95% CI, 1.34 to 1.53 for students of 4-and 6-year-course university; the reference group was high school graduates & under) and blood pressure (OR, 1.54; 95% CI, 1.10 to 2.16 for hypertension; OR, 1.09; 95% CI, 1.02 to 1.17 for prehypertension; OR, 1.10; 95% CI, 1.01 to 1.20 for hypotension; the reference group was normal blood pressure). CONCLUSIONS: More than one tenth of the young men were high myopia as one of the risk factor for visual loss. Further studies on high myopia and its complications are needed to improve eye health in Southeast Korea.

Summary

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Research Support, Non-U.S. Gov't

Blood Mercury Concentration and Related Factors in an Urban Coastal Area in Korea.: Eun Mi Jo, Byoung Gwon Kim, Yu Mi Kim, Seung Do Yu, Chang Hun You, Joon Youn Kim, Young Seoub Hong; J Prev Med Public Health. 2010;43(5):377-386.; DOI: https://doi.org/10.3961/jpmph.2010.43.5.377

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OBJECTIVES
This study was carried out for the purpose of evaluating the blood mercury concentration of the residents of Busan, Korea, as well as the relationship between the mercury concentration and the pattern of fish consumption along with other epidemiological factors. METHODS: Two hundred ninety-three subjects (147 men and 146 women), who were aged 40 years or more, were recruited into this study between June and October 2009. The mean age of the subjects was 54.3 years (with a range of 40-70 years). Mercury concentrations in blood samples were measured using a gold-amalgam collection method. RESULTS: The geometric mean concentration of mercury in the total subjects was 8.63 microgram/L [range: 1.48~45.71 microgram/L]. The blood mercury concentration of the men (9.55 microgram/L) was significantly higher than that of the women (7.76 microgram/L). The blood mercury concentration of those who eat fish more than 4 times per week was higher than others, and was statistically significant (male p = 0.0019, female p = 0.0002). According to the multiple analysis, the blood mercury concentration was significantly affected by the consumed fish but other epidemiological factors were not related. CONCLUSIONS: It was found that the subjects who have consumed a large amount of fish may have high blood mercury concentration. It appears that fish consumption can influence blood mercury concentration. Therefore, guidelines for fish consumption that will decrease blood mercury concentration might be necessary in Korea.

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Assessment of Lead and Mercury Exposure Levels in the General Population of Korea Using Integrated National Biomonitoring Data
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International Journal of Environmental Research and Public Health.2021; 18(13): 6932. CrossRef
Association of Blood Mercury Level with the Risk of Depression According to Fish Intake Level in the General Korean Population: Findings from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2013
Kyung Won Kim, Sundara Raj Sreeja, Minji Kwon, Ye Lee Yu, Mi Kyung Kim
Nutrients.2020; 12(1): 189. CrossRef
Determination of Mercury Daily Intake and Hair-to-Blood Mercury Concentration Ratio in People Resident of the Coast of the Persian Gulf, Iran
Narjes Okati, Abbas Esmaili-sari
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Is mercury exposure causing diabetes, metabolic syndrome and insulin resistance? A systematic review of the literature
Cynthia Roy, Pierre-Yves Tremblay, Pierre Ayotte
Environmental Research.2017; 156: 747. CrossRef
Biomonitoring in California Firefighters
Dina Dobraca, Leslie Israel, Sandra McNeel, Robert Voss, Miaomiao Wang, Ryszard Gajek, June-Soo Park, Suhash Harwani, Frank Barley, Jianwen She, Rupali Das
Journal of Occupational & Environmental Medicine.2015; 57(1): 88. CrossRef
A Study on Mercury Exposure Levels among Schoolchildren and Related Factors in High Mercury Exposure Areas in Korea
Dae Seon Kim, Young Min Kwon, Hee-Ung Chung, Sang Hoon Nam, Seung Do Yu
Korean Journal of Environmental Health Sciences.2015; 41(4): 231. CrossRef
Mercury Exposure Factors among Residents in the Highly Mercury Exposed Area, Seoksan-ri, Korea
Dae Seon KIM, Young Min Kwon, Hee-Ung Chung, Kyunghee CHOI
Korean Journal of Environmental Health Sciences.2015; 41(5): 349. CrossRef
Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review
Mary C Sheehan, Thomas A Burke, Ana Navas-Acien, Patrick N Breysse, John McGready, Mary A Fox
Bulletin of the World Health Organization.2014; 92(4): 254. CrossRef
Population correlates of circulating mercury levels in Korean adults: the Korea National Health and Nutrition Examination Survey IV
Seongbeom Cho, David R Jacobs, Kyong Park
BMC Public Health.2014;[Epub] CrossRef
Bone mineral density and blood metals in premenopausal women
A.Z. Pollack, S.L. Mumford, J. Wactawski-Wende, E. Yeung, P. Mendola, D.R. Mattison, E.F. Schisterman
Environmental Research.2013; 120: 76. CrossRef
Correlation between Hair Mercury Concentration and Blood Total Mercury in Several Area Residents
Gyeong-Yeon Kim, Jeong-Wook Seo, Byoung-Gwon Kim, Yu-Mi Kim, Rock-Bum Kim, Dae-Seon Kim, Jung-Man Kim, Choon-Jin Kim, Young-Seoub Hong
Korean Journal of Environmental Health Sciences.2013; 39(2): 117. CrossRef
Dietary Nutrient and Food Intake and Their Relations with Serum Heavy Metals in Osteopenic and Osteoporotic Patients
Myung-Hwa Kang, Seung-Mi Park, Doo-Nam Oh, Mi-Hyun Kim, Mi-Kyeong Choi
Clinical Nutrition Research.2013; 2(1): 26. CrossRef
Measures for a closer-to-real estimate of dietary exposure to total mercury and lead in total diet study for Koreans
Eunmi Koh, Hyehyung Shin, Miyong Yon, Ji Woon Nam, Yoonna Lee, Dohee Kim, Jeeyeon Lee, Meehye Kim, Sung-Kug Park, Hoon Choi, Cho-il Kim
Nutrition Research and Practice.2012; 6(5): 436. CrossRef
The Relationship between Fish Consumption and Blood Mercury Levels in Residents of Busan Metropolitan City and Gyeongnam Province
Chan Woo Kim, Young Wook Kim, Chang Ho Chae, Jun Seok Son, Ja Hyeon Kim, Hyoung Ouk Park, Yune-Sik Kang, Jang-Rak Kim, Young Seoub Hong, Dae-Seon Kim, Baek Geun Jeong
Journal of agricultural medicine and community health.2012; 37(4): 223. CrossRef
Analysis of Methylmercury Concentration in the Blood of Koreans by Using Cold Vapor Atomic Fluorescence Spectrophotometry
Byoung-Gwon Kim, Eun-Mi Jo, Gyeong-Yeon Kim, Dae-Seon Kim, Yu-Mi Kim, Rock-Bum Kim, Byung-Seong Suh, Young-Seoub Hong
Annals of Laboratory Medicine.2012; 32(1): 31. CrossRef
Blood Heavy Metal Concentrations of Korean Adults by Seafood Consumption Frequency: Using the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV), 2008
Young A Kim, Young-Nam Kim, Kyung-Dong Cho, Mi Young Kim, Eun Jin Kim, Ok-Hee Baek, Bog-Hieu Lee
The Korean Journal of Nutrition.2011; 44(6): 518. CrossRef
Relationship Between Blood Mercury Concentration and Waist-to-Hip Ratio in Elderly Korean Individuals Living in Coastal Areas
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Journal of Preventive Medicine and Public Health.2011; 44(5): 218. CrossRef

English Abstract

The Association of Central Obesity with Type 2 Diabetes among Koreans according to the Serum Gamma-Glutamyltransferase Level: Korean Genome and Epidemiology Study.: Ji Yeon Shin, Jun Hyun Hwang, Jin Young Jeong, Sung Hi Kim, Jai Dong Moon, Sang Chul Roh, Young Wook Kim, Yangho Kim, Jong Han Leem, Young Su Ju, Young Seoub Hong, Eun Hee Ha, Yong Hwan Lee, Duk Hee Lee, Dong Hyun Kim; J Prev Med Public Health. 2009;42(6):386-391.; DOI: https://doi.org/10.3961/jpmph.2009.42.6.386

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OBJECTIVES
This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR) and type 2 diabetes is different depending on the serum GGT levels. METHODS: The study subjects were 23,436 persons aged 40 years or older and who participated in regular health check-ups at 11 hospitals (males: 5,821, females: 17,615). The gender-specific quintiles of the serum GGT and WHR were used to examine the associations with type 2 diabetes. RESULTS: The serum GGT levels within their normal range were positively associated with type 2 diabetes only in women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4, 2.1, and 2.5 according to the quintiles of the serum GGT (p(trend)<0.01). The WHR was more strongly associated with the prevalence of diabetes among the women with a high-normal serum GGT level as compared with those with a low-normal serum GGT level (p for interaction=0.02). For example, the adjusted ORs for women with a low normal serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according to the quintiles of the WHR, while those figures were 1.0, 2.4, 3.6, 5.0, and 8.3 among the women with a high normal serum GGT level. However, in men, the serum GGT was very weakly associated with type 2 diabetes and the association between the WHR and type 2 diabetes was not different depending on the serum GGT level. CONCLUSIONS: Serum GGT within its normal range was positively associated with type 2 diabetes, and central obesity was more strongly associated with the prevalence of type 2 diabetes when the serum GGT level was high-normal. However, these associations were observed only in women, which is different from the previous findings. The stronger relation between central obesity and type 2 diabetes among women with a high-normal serum GGT level can be useful for selecting a group that is at high risk for type 2 diabetes irregardless of whatever the underlying mechanism is.

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Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study
Youn Sue Lee, Yoonsu Cho, Stephen Burgess, George Davey Smith, Caroline L. Relton, So-Youn Shin, Min-Jeong Shin
Human Molecular Genetics.2016; 25(17): 3877. CrossRef
Different associations between obesity and impaired fasting glucose depending on serum gamma-glutamyltransferase levels within normal range: a cross-sectional study
Nam Soo Hong, Jeong-Gook Kim, Yu-Mi Lee, Hyun-Woo Kim, Sin Kam, Keon-Yeop Kim, Ki-Su Kim, Duk-Hee Lee
BMC Endocrine Disorders.2014;[Epub] CrossRef
Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
Jean-Claude, Lapraz, Kamyar M. Hedayat
Global Advances in Health and Medicine.2013; 2(1): 64. CrossRef

Research Support, Non-U.S. Gov't

The Association Between Circulating Inflammatory Markers and Metabolic Syndrome in Korean Rural Adults.: So Yeon Ryu, Ki Soon Kim, Jong Park, Myeng Guen Kang, Mi Ah Han; J Prev Med Public Health. 2008;41(6):413-418.; DOI: https://doi.org/10.3961/jpmph.2008.41.6.413

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OBJECTIVES
This study was performed to investigate the associations between the metabolic syndrome (MetS) and inflammatory markers. METHODS: This cross-sectional analysis was performed using data from 1578 Koreans aged 40-69 years residing in a rural area. We investigated associations between MetS and circulating high sensitivity C-reactive protein (hs-CRP), white blood cells (WBC) and adiponectin. MetS was defined using the criteria proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III). RESULTS: Increased WBC counts and hs-CRP levels and decreased adiponectin levels were observed in subjects with MetS. WBC, hs-CRP and adiponectin levels linearly deteriorated with an increase in the number of MetS components (all ptrend <0.005). Finally, adjusted odds ratios (ORs) for the risk of MetS by increase/decrease in 3 inflammatory markers were calculated by multivariate logistic regression analyses. In terms of changes in inflammation markers, in men, the adjusted ORs (95% confidence interval) were 1.15 (1.01-1.31) for WBC, 1.64 (1.02-2.64) for hs-CRP, and 0.19 (0.08-0.45) for adiponectin, whereas corresponding adjusted ORs (95% CIs) in women were 1.27 (1.15-1.40), 0.98 (0.67-1.42), 0.09 (0.04-0.18), respectively. CONCLUSIONS: Serum adiponectin levels and WBC counts were found to be strongly associated with MetS in both sexes. However, hs-CRP lost its significance after adjusting for BMI and other inflammatory markers in women. This study shows that inflammatory response is associated with MetS in the Korean population. Further prospective studies are necessary to confirm the contribution made by inflammatory markers to the development of MetS.

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Associations of Insulin Resistance and High-Sensitivity C-Reactive Protein with Metabolic Abnormalities in Korean Patients with Type 2 Diabetes Mellitus: A Preliminary Study
Yuchul Jeong, Beom Jun Lee, Wonjai Hur, Minjoon Lee, Se-Hyeon Han
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Isabela Peixoto Rabelo, Vanessa Barroco de Paula, Caio Carvalho Bustamante, André Marcos Santana, Daniela Gomes da Silva, Amanda Cristina Baldassi, Paulo Aléscio Canola, Carlos Augusto Araújo Valadão
Frontiers in Veterinary Science.2023;[Epub] CrossRef
Inflammatory Markers and Atherogenic Coefficient: Early Markers of Metabolic Syndrome
Marjan Mahdavi-Roshan, Nargeskhatoon Shoaibinobarian, Morvarid Noormohammadi, Aboozar Fakhr Mousavi, Amir Savar Rakhsh, Arsalan Salari, Zeinab Ghorbani
International Journal of Endocrinology and Metabolism.2022;[Epub] CrossRef
Association between C-Reactive Protein and Metabolic Syndrome in Korean Adults
Youhyun Song, Soo Kyung Yang, Jungeun Kim, Duk-Chul Lee
Korean Journal of Family Medicine.2019; 40(2): 116. CrossRef
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N. J. Menzies‐Gow, P. A. Harris, J. Elliott
Equine Veterinary Journal.2017; 49(3): 300. CrossRef
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Eun Jung Lee, Hye Jin Hwang, Chan Min Jung, Min Ki Kim, Min Seok Kang, Kyung-Su Kim
American Journal of Rhinology & Allergy.2017; 31(4): 222. CrossRef
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Harry Robberecht, Nina Hermans
Metabolic Syndrome and Related Disorders.2016; 14(2): 47. CrossRef
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English Abstracts

The Effect of Smoking Status upon Occurrence of Impaired Fasting Glucose or Type 2 Diabetes in Korean Men.: Chang Hae Park, Hyuk Ga, Jong Han Leem, Seung Min Kwak, Hwan Cheol Kim, Ji Ho Choi; J Prev Med Public Health. 2008;41(4):249-254.; DOI: https://doi.org/10.3961/jpmph.2008.41.4.249

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OBJECTIVES
To investigate whether smoking and the smoking status are predictors of the incident impaired fasting glucose (IFG) or type 2 diabetes in Korean men. METHODS: A cohort of 1,717 Korean men without IFG or diabetes, who underwent annual periodic health examinations for 4 years (2002-2006), were retrospectively investigated. IFG and diabetes were defined as a serum fasting glucose concentration of 100-125 mg/dL and more than 126 mg/dL, respectively. Cox's proportional hazards model was used to evaluate the association between smoking and development of IFG or type 2 diabetes. RESULTS: A total of 558 cases (32.5%) of incident IFG and 50 cases (2.9%) of diabetes occurred. After controlling for the potential predictors of diabetes, the relative risk for IFG, compared with the never smokers, was 1.02 (95% CI=0.88 to 1.19) for the ever-smokers, 0.96 (95% CI=0.79-1.16) for those who smoked 1-9 cigarettes/d, 1.15 (95% CI=1.01 to 1.30) for those who smoked 10-19 cigarettes/d, and 1.31 (95% CI=1.10 to 1.57) for those who smoked 20 or more cigarettes/d (the P value for the current smokers was only p<0.002). The respective multivariate adjusted relative risks for type 2 diabetes, compared with the neversmokers, were 1.07 (95% CI=0.64 to 1.92), 1.47 (95% CI=0.71 to 3.04), 1.84 (95% CI=0.92-3.04), and 1.87 (95% CI=1.13-3.67), respectively (the P value for the current smokers was only p=0.004). CONCLUSIONS: The smoking status and the number of cigarettes smoked daily are associated with an increased risk for developing IFG or type 2 diabetes in Korean men.

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Health effects associated with smoking: a Burden of Proof study
Xiaochen Dai, Gabriela F. Gil, Marissa B. Reitsma, Noah S. Ahmad, Jason A. Anderson, Catherine Bisignano, Sinclair Carr, Rachel Feldman, Simon I. Hay, Jiawei He, Vincent Iannucci, Hilary R. Lawlor, Matthew J. Malloy, Laurie B. Marczak, Susan A. McLaughlin
Nature Medicine.2022; 28(10): 2045. CrossRef
Systematic review with meta-analysis of the epidemiological evidence relating smoking to type 2 diabetes
Peter N Lee, Katharine J Coombs
World Journal of Meta-Analysis.2020; 8(2): 119. CrossRef
The 2016 global and national burden of diabetes mellitus attributable to PM 2·5 air pollution
Benjamin Bowe, Yan Xie, Tingting Li, Yan Yan, Hong Xian, Ziyad Al-Aly
The Lancet Planetary Health.2018; 2(7): e301. CrossRef
The impact of smoking on the development of diabetes and its complications
Mariola Śliwińska-Mossoń, Halina Milnerowicz
Diabetes and Vascular Disease Research.2017; 14(4): 265. CrossRef
Effects of Nutrition Education on Improvement of Blood Glucose in Type 2 Diabetic Patients with Low Income
Eun-Jin Lim, Mi Jeong Kim, Ji-Sook Han
Journal of the Korean Society of Food Science and Nutrition.2014; 43(1): 141. CrossRef
Associated Factors of Impaired Fasting Glucose in Some Korean Rural Adults
Hye Eun Yun, Mi-ah Han, Ki Soon Kim, Jong Park, Myeng Guen Kang, So Yeon Ryu
Journal of Preventive Medicine and Public Health.2010; 43(4): 309. CrossRef
Association of passive and active smoking with incident type 2 diabetes mellitus in the elderly population: the KORA S4/F4 cohort study
Bernd Kowall, Wolfgang Rathmann, Klaus Strassburger, Margit Heier, Rolf Holle, Barbara Thorand, Guido Giani, Annette Peters, Christine Meisinger
European Journal of Epidemiology.2010; 25(6): 393. CrossRef
Diabetes and impaired fasting glucose in Mongolian population, Inner Mongolia, China
Shaoyan Zhang, Weijun Tong, Tan Xu, Burenbatu Wu, Yonghong Zhang
Diabetes Research and Clinical Practice.2009; 86(2): 124. CrossRef

Fasting Serum Glucose and Subsequent Liver Cancer Risk in a Korean Prospective Cohort.: Jin Gwack, Seung Sik Hwang, Kwang Pil Ko, Jae Kwan Jun, Sue Kyung Park, Soung Hoon Chang, Hai Rim Shin, Keun Young Yoo; J Prev Med Public Health. 2007;40(1):23-28.; DOI: https://doi.org/10.3961/jpmph.2007.40.1.23

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OBJECTIVES
Chronic infections with hepatitis B or C and alcoholic cirrhosis are three well-known major risk factors for liver cancer. Diabetes has also been suggested as a potential risk factor. However, the findings of previous studies have been controversial in terms of the causal association. Therefore, the aim of this study was to evaluate the association between serum glucose levels and liver cancer development in a Korean cohort. METHODS: Thirty-six liver cancer cases were identified in the Korean Multi-Center Cancer Cohort (KMCC). Baseline information on lifestyle characteristics was obtained via questionnaire. Serum glucose levels were measured at the study's enrollment. Relative risks (RRs) were estimated using a Cox proportional hazard regression model. The adjusting variables included age, gender, smoking history, alcohol consumption, body mass index, and hepatitis B surface antigen (HBsAg) seropositivity. RESULTS: The RRs of serum glucose for liver caner were 1.20 (95% CI=0.48-2.99) for the category of 100 to 125 mg/dL of serum glucose and 2.77 (95% CI=1.24-6.18) for the >126 mg/dL serum glucose category (both compared to the <100 mg/dL category). In a subgroup analysis, the RR of serum glucose among those who were both HBsAg seronegative and non-drinkers was 4.46 (95% CI=1.09-18.28) for those with glucose levels >100 mg/dL. CONCLUSIONS: The results of this study suggest that a high level of serum glucose can increase liver cancer risk independently of hepatitis infection and drinking history in Koreans. This study implies that glucose intolerance may be an independent risk factor for liver cancer.

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Jian Yin, Neal D. Freedman, Yiwei Liu, Sanford M. Dawsey, Huan Yang, Philip R. Taylor, Liangyu Yin, Bin Liu, Jianfeng Cui, Jinhu Fan, Wen Chen, Youlin Qiao, Christian C. Abnet
British Journal of Cancer.2023; 128(2): 275. CrossRef
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Kwang‐Pil Ko, Aesun Shin, Sooyoung Cho, Sue K Park, Keun‐Young Yoo
Journal of Gastroenterology and Hepatology.2018; 33(1): 111. CrossRef
Recognition criteria for occupational cancers in relation to hepatitis B virus and hepatitis C virus in Korea
Hogil Kim, Yun Kyung Chung, Inah Kim
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The association between fasting blood glucose and the risk of primary liver cancer in Chinese males: a population-based prospective study
Xiaoshuang Feng, Gang Wang, Ni Li, Zhangyan Lyu, Shuohua Chen, Luopei Wei, Yuheng Chen, Shuanghua Xie, Wenjing Yang, Jian Yin, Hong Cui, Hongda Chen, Jiansong Ren, Jufang Shi, Shouling Wu, Min Dai, Jie He
British Journal of Cancer.2017; 117(9): 1405. CrossRef
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PLOS ONE.2017; 12(11): e0188465. CrossRef
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Hedong Han, Tianyi Zhang, Zhichao Jin, Honglei Guo, Xin Wei, Yuzhou Liu, Qi Chen, Jia He
Oncotarget.2017; 8(30): 50164. CrossRef
European Code against Cancer 4th Edition: Alcohol drinking and cancer
Chiara Scoccianti, Michele Cecchini, Annie S. Anderson, Franco Berrino, Marie-Christine Boutron-Ruault, Carolina Espina, Timothy J. Key, Michael Leitzmann, Teresa Norat, Hilary Powers, Martin Wiseman, Isabelle Romieu
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European Code against Cancer 4th Edition: Alcohol drinking and cancer
Chiara Scoccianti, Michele Cecchini, Annie S. Anderson, Franco Berrino, Marie-Christine Boutron-Ruault, Carolina Espina, Timothy J. Key, Michael Leitzmann, Teresa Norat, Hilary Powers, Martin Wiseman, Isabelle Romieu
Cancer Epidemiology.2015; 39: S67. CrossRef
Cohort Profile: Community-based prospective cohort from the National Cancer Center, Korea
Jin-Kyoung Oh, Min Kyung Lim, E Hwa Yun, Min-Ho Choi, Sung-Tae Hong, Soung-Hoon Chang, Sue Kyung Park, Sung-Il Cho, Dong-Hyun Kim, Keun-Young Yoo, Hai-Rim Shin
International Journal of Epidemiology.2015; : dyv302. CrossRef
Attributable fraction of alcohol consumption on cancer using population-based nationwide cancer incidence and mortality data in the Republic of Korea
Sohee Park, Hai-Rim Shin, Boram Lee, Aesun Shin, Kyu-Won Jung, Duk-Hee Lee, Sun Ha Jee, Sung-Il Cho, Sue Kyung Park, Mathieu Boniol, Paolo Boffetta, Elisabete Weiderpass
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Yi Huang, Xiaoyan Cai, Miaozhen Qiu, Peisong Chen, Hongfeng Tang, Yunzhao Hu, Yuli Huang
Diabetologia.2014; 57(11): 2261. CrossRef
Serum glucose and risk of cancer: a meta-analysis
Danielle J Crawley, Lars Holmberg, Jennifer C Melvin, Massimo Loda, Simon Chowdhury, Sarah M Rudman, Mieke Van Hemelrijck
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Recent Evidence on Alcohol and Cancer Epidemiology
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Jin-Kyoung Oh, Hai-Rim Shin, Min Kyung Lim, Heeyoun Cho, Dong-Il Kim, Youngmee Jee, Haesun Yun, Keun-Young Yoo
BMC Cancer.2012;[Epub] CrossRef
Coinfection of hepatitis B and C viruses and risk of hepatocellular carcinoma: Systematic review and meta‐analysis
Lisa Y. Cho, Jae Jeong Yang, Kwang‐Pil Ko, Boyoung Park, Aesun Shin, Min Kyung Lim, Jin‐Kyoung Oh, Sohee Park, Yoon Jun Kim, Hai‐Rim Shin, Keun‐Young Yoo, Sue K. Park
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Multicenter Study

Assessment of DNA Viability in Long Term-Stored Buffy Coat Species for the Korean Multicenter Cancer Cohort.: Mihi Yang, Jihyun Yoo, Cheong Sik Kim, Aesun Shin, Daehee Kang, Soung Hoon Chang, Sue Kyung Park, Hai Rim Shin, Keun Young Yoo; Korean J Prev Med. 2003;36(4):373-376.

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Abstract PDF: OBJECTIVES
Peripheral blood-buffy coat fractions (N = 14, 956) have been stored at -70degrees C in the headquarter of the Korean Multicenter Cancer Cohort (KMCC), since 1993. To study the future molecular etiology of cancers using specimens of the cohort, properly stored specimens are necessary. Therefore, the DNA-viability of the buffy coat samples was investigated. METHODS: Buffy coat fraction samples were randomly selected from various collection areas and years (N = 100). The DNA viability was evaluate from the UV-absorbent ratios at 260/280nm and the PCR for beta-globin was performed with genomic DNA isolated from the buffy coat. RESULTS: PCR products were obtained from 85 and 98% of the C and H area-samples, respectively, using 50 or 100mul of the buffy coat. There were significant differences in the yields of the PCR-amplifications from the C and H areas (p < 0.05), which was due to differences in the homogenization of the buffy coat fractions available as aliquots. The PCR-products were obtained from all of the samples (N = 7) stored at the C area-local center, but the other aliquots stored at the headquarter were not PCR-amplified. Therefore, the PCR products in almost all the samples, even including the DNA-degraded samples, were obtained. In addition, an improvement in the DNA isolation, i.e. approx. 1.6 fold, was found after using extra RBC lysis buffer. CONCLUSIONS: PCR products for beta-globin were obtained from nearly all of the samples. The regional differences in the PCR amplifications were thought to have originated from the different sample-preparation and homogenization performance. Therefore, the long term-stored buffy coat species at the KMCC can be used for future molecular studies.; Summary

In Vitro

Exposure Assessment of PCDD/Fs and Monitoring of Health Effects on Workers and Residents near the Waste Incinerators in Korea.: Jong Han Leem, Yun Chul Hong, Kwan Hee Lee, Ho Jang Kwon, Jae Yeon Jang; Korean J Prev Med. 2003;36(4):314-322.

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Abstract PDF: OBJECTIVES
In this study, the exposure status of the hazardous substances from incinerators, such as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), were studied, and the relationship between the exposure of these hazardous substances and their heath effects on the workers and residents near municipal solid waste (MSW) incinerators and an industrial incinerator investigated. METHODS: Between July 2001 and June 2002, 13 workers at two MSW incinerators, 16 residents from the area around the two MSW incinerators, 6 residents from the control area, and further 10 residents near an industrial incinerator, estimated to emit higher levels of hazardous substances, were interviewed. Information, including sociodemographic information, personal habits, and work history, detailed gynecologic and other medical history were collected through interviews. Blood samples were also collected from 45 subjects, and analyzed for PCDD/DFs, by high resolution gas chromatography - high resolution mass spectrometry, using the US EPA 1613 method. In addition to the questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. The urinary concentrations of 8-OH-dG were determined by in vitro ELISA, and the MDA by HPLC, using an adduct with thiobarbituric acid. RESULTS: The PCDD/DFs concentrations in the residents near the industrial incinerator were higher than those in the controls, workers and residents near the MSW incinerators. The average TEQ (Toxic Equivalencies) concentrations of the PCDD/DFs in residents near the industrial incinerator were 53.4pg I-TEQs/g lipid. The estimated daily intakes were within the tolerable daily intake range (1-4 pg I-TEQ/Kg bw/day) suggested by WHO (1997) in only 30% to the people near the industrial incinerator. Animal studies have already shown that even a low body burden of PCDD/DFs, such as 10ng TEQ/kg bw, can cause oxidative damage in laboratory animals. Our study also showed that the same body burden of PCDD/DFs can cause oxidative damage to humans. CONCLUSIONS: The exposures to PCDD/DFs and the oxidative stress of residents near the industrial incinerator, were higher than those in the controls, workers and residents near the MSW incinerators. Proper protection strategies against these hazardous chemicals are needed. Because a lower body burden of PCDD/Fs, such as 10ng TEQ/kg bw, can cause oxidative damage, the tolerable daily intake range should be restrictedly limited to 1pg I-TEQ/kg bw/day.; Summary

Original Article

Relationship of Serum Uric Acid to Cardiovascular Risk Factors in Korean Male Workers.: So Yeon Ryu, Jong Gab Oh, Chul Gab Lee, Ki Soon Kim; Korean J Prev Med. 2002;35(3):214-220.

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Abstract PDF: OBJECTIVES
To investigate the relationship of serum uric acid to cardiovascular risk factors in Korean male workers. METHODS: We screened 522 male workers at an electrical manufacturing company by a periodic health examination and a questionnaire survey in 2000. We collected data relating to age, smoking status, alcohol drinking status, body mass index (BMI), blood pressure, serum lipid, fasting blood glucose and serum uric acid. The data were analyzed using a variety of methods, including ANOVA, Pearson's correlation, and multivariate regression analyses, to examine the association between uric acid and cardiovascular risk factors with a cross-sectional study design. RESULTS: The concentration of serum uric acid showed positive associations with BMI, total cholesterol, triglyceride, and LDL-cholesterol; it was also significantly correlated to systolic and diastolic blood pressures. Life-style characteristics, such as smoking and alcohol drinking showed no significant association. From the multivariate regression analyses, BMI, total cholesterol and fasting blood glucose levels were found to be independent positive predictors of uric acid; while age, blood pressure and smoking status give no independent contribution explaining the variability of serum uric acid levels. Conclusions : This study demonstrates that serum uric acid level have a significant association with cardiovascular risk factors, such as BMI, total cholesterol and blood glucose in some Korean male workers.; Summary

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