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Potential Increasing Trend in Schizophrenia Relapse Prevention in the Past 40 Years: A Bibliometric Analysis
Isymiarni Syarif, Hasnawati Amqam, Saidah Syamsuddin, Veni Hadju, Syamsiar Russeng, Yusran Amir
J Prev Med Public Health. 2024;57(5):421-434.   Published online August 26, 2024
DOI: https://doi.org/10.3961/jpmph.24.201
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  • 334 Download
  • 1 Web of Science
  • 1 Crossref
AbstractAbstract AbstractSummary PDF
Objectives
Schizophrenia is an organic disease and a severe mental disorder with a relatively high risk of relapse. The rising rate of schizophrenia relapse has motivated researchers and academics to innovate and develop interventions aimed at relapse prevention. This bibliometric study sought to examine the publication trends in schizophrenia relapse prevention from 1973 to 2023, assess the contribution of international collaborations across various journals, identify the most influential authors and articles, and forecast future developments in this field.
Methods
The study included 683 articles obtained from the Scopus database, analyzed using VOSviewer software, and visualized with Tableau.
Results
Reports of schizophrenia relapse prevention strategies have increased significantly over the last 3 decades. However, fluctuations persist, as evidenced by the annual number of publications ranging from 25 to 40 within the past 5 years. Nevertheless, this increasing trend underscores the sustained interest in this area of research. Regarding contribution size, the United States produced the largest volume of publications on this subject. John M. Kane authored the most articles, while Stefan Leucht exhibited the highest h-index. Frequently used keywords in this field include “relapse AND schizophrenia” AND “prevention.”
Conclusions
These results represent an important reference for determining the current state of research on schizophrenia relapse prevention and future research directions.
Summary
Key Message
- Significant Growth in Schizophrenia Relapse Research: The study revealed a notable increase in research on schizophrenia relapse prevention over the past 40 years.
- Key Contributions: The United States is identified as the largest contributor to this body of research, with John M. Kane being the most prolific author.
- Effective Prevention Strategies: Family interventions, the use of digital technology, and antipsychotic treatments are highlighted as the primary strategies to prevent relapse.
- Bibliometric Approach: A bibliometric analysis of 683 articles provides insights into key trends, collaborations, and research directions for future studies on schizophrenia relapse prevention.

Citations

Citations to this article as recorded by  
  • Knowledge mapping of telemedicine in urology in the past 20 years: A bibliometric analysis (2004–2024)
    Na Zeng, Mei-Cheng Liu, Xing-Yu Zhong, Shao-Gang Wang, Qi-Dong Xia
    DIGITAL HEALTH.2024;[Epub]     CrossRef
Original Article
Relationship of Hair Copper and Mercury Contents to Personality in Chronic Schizophrenia.
Doohie Kim, Young Woo Kang, Soon Woo Park, Kuen Hoo Lee, Young Sook Lee
Korean J Prev Med. 1990;23(3):296-308.
  • 2,204 View
  • 27 Download
AbstractAbstract PDF
The relationship between copper and mercury contents in the scalp hair and chronic schizaphrenia was investigated. The samples of scalp hair were collected from 80 male chronic schizophrenic patients at the age from 20 to 20, who were hospitalized in the National Psychiatric Hospital in Seoul. As the napes and the Minnesota Multiple Personality Inventory (MMPI) was performed also. The copper and mercury contents were determined by an atomic absorption spectrophotometer. Significantly higher T-score of MMPI was seen in patients group for Hypochondriasis Scale (Hs), Depression Scale (D), Psychopathic Deviate Scale (Pd), Paranoia Scale (Pa), Psychasthenia Scale (Pt), Schizophrenia Scale (Sc) subscales than control group, and the frequency distribution by T-score was also significantly different between the patient and the control group for above scales. The content of copper in the hair of patient group was significantly higher than control group. In the case of mercury, the mean value of patient group was significantly higher than control group. Between the value of copper and mercury, statistically significant negative correlation (r=-0.25) was found. When grouped by the T-score of MMPI, there was no difference of copper contents between T-score subgroup at all MMPI scale. But the mercury contents showed significant difference between T-score subgroup at Pt, Sc scale. When compared between the group of above 70 T-score and the group of less than 70, the mercury contents of Pa, Pt, Sc scale of above 70 T-score group were significantly higher than the group of less than 70. In other scales, the mercury content of the above 70 group were higher than the group of less than 70 except Mf scale, although there were no statistically significances. In D, Pa, Sc scales, as the T-score of MMPI increased, the contents of mercury also increased. When divided into the patient group and the control group, the copper contents of the patient groups were significantly lower than the control group at each T-score scale in most MMPI scales. In the case of mercury, the value of patient group were significantly lower than the control group in the less than 44 scale of D, in the 60~69 scale of Pd, in the 45~59 scale of Mf, in the 60~69 scale of Ma, in the less than 44 of Si. These results suggest that the effects of the deficiency of copper or high intake of mercury on schizophrenia and personality may be of possible value. Thus further studies are necessary to determine whether schizophrenia and personality formation would be attributed to copper deficiency or mercury intake.
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