Key Message
This study explored the key factors influencing college students’ intentions to undergo premarital screening. Although 97% expressed willingness, only 43.5% reported a high level of intention, which was significantly associated with limited knowledge, negative attitudes, reduced perceived behavioral control, and enrollment in non-health-related fields. These findings highlight the need for comprehensive premarital health education that enhances knowledge and fosters more favorable attitudes and perceptions, even among highly educated populations.