Journal of Preventive Medicine and Public Health

Original Articles

The Association Between Oxidative Stress and Depressive Symptom Scores in Elderly Population: A Repeated Panel Study: Changwoo Han, Youn-Hee Lim, Yun-Chul Hong; J Prev Med Public Health. 2016;49(5):260-274. Published online August 23, 2016; DOI: https://doi.org/10.3961/jpmph.16.029

9,348 View
213 Download
13 Crossref

Objectives
Previous epidemiological studies about oxidative stress and depression are limited by hospital-based case-control design, single-time measurements of oxidative stress biomarkers, and the small number of study participants. Therefore, in this study, we analyzed the association between biomarker of oxidative stress and depressive symptom scores using repeatedly measured panel data from a community-dwelling elderly population.
Methods
From 2008 to 2010, a total of 478 elderly participants residing in Seoul, Korea, were evaluated three times. Participants underwent the Korean version of the Short Form Generic Depression Scale (SGDS-K) test for screening depression, and urinary malondialdehyde (MDA) levels were measured as an oxidative stress biomarker. We used a generalized estimating equation with a compound symmetry covariance structure to estimate the effects of oxidative stress on depressive symptom scores.
Results
A two-fold increase in urinary MDA concentration was significantly associated with a 33.88% (95% confidence interval [CI], 21.59% to 47.42%) increase in total SGDS-K scores. In subgroup analyses by gender, a two-fold increase in urinary MDA concentration was significantly associated with increased SGDS-K scores in both men and women (men: 30.88%; 95% CI, 10.24% to 55.37%; women: 34.77%; 95% CI, 20.09% to 51.25%). In bivariate analysis after an SGDS-K score ≥8 was defined as depression, the third and the fourth urinary MDA quartiles showed a significantly increased odds ratio(OR) of depression compared to the lowest urinary MDA quartile (third quartile OR, 6.51; 95% CI, 1.77 to 24.00; fourth quartile OR, 7.11; 95% CI, 1.99 to 25.42).
Conclusions
Our study suggests a significant association between oxidative stress and depressive symptoms in the elderly population.

Summary

Citations

Citations to this article as recorded by

Oxidative balance and mental health: Exploring the link between prooxidant-antioxidant balance and depression in hypertensive and normotensive individuals, accounting for sex differences
Farzam Kamrani, Amirhossein Ataei Kachouei, Narges Fereydouni, Davoud Tanbakuchi, Habibollah Esmaily, Mohsen Moohebati, Hanie Mahaki, Ali Rezaee, Susan Darroudi, Majid Ghayour-Mobarhan, Gordon A. Ferns
Journal of Affective Disorders.2024; 367: 391. CrossRef
Curcumin Ameliorates Neurobehavioral Deficits in Ambient Dusty Particulate Matter-Exposure Rats: The Role of Oxidative Stress
Sadegh Moradi Vastegani, Somayeh Hajipour, Alireza Sarkaki, Zahra Basir, Yaghoob Farbood, Kowsar Bavarsad, Seyed Esmaeil Khoshnam
Neurochemical Research.2023; 48(6): 1798. CrossRef
Evaluation of the Physical Health and Dietary Intake of the Low-Income Elderly with Impaired Mobility for the Design of a Health Meals-on-Wheels Intervention Program in Seoul
Hyeja Chang, Junghyun Kim, Chaewon Park
Journal of the Korean Society of Food Science and Nutrition.2023; 52(7): 740. CrossRef
Can tailored home-delivered meal services alleviate self-rated frailty of the low-income older adults in Korea?
Junghyun Kim, Hyeja Chang
Nutrition Research and Practice.2023; 17(5): 1007. CrossRef
Exploring urinary biomarkers to assess oxidative DNA damage resulting from BTEX exposure in street children
Ata Rafiee, Juana Maria Delgado-Saborit, Peter D. Sly, Hoda Amiri, Mohammad Hoseini
Environmental Research.2022; 203: 111725. CrossRef
Association of ambient air pollution with depressive and anxiety symptoms in pregnant women: A prospective cohort study
Dirga Kumar Lamichhane, Dal-Young Jung, Yee-Jin Shin, Kyung-Sook Lee, So-Yeon Lee, Kangmo Ahn, Kyung Won Kim, Youn Ho Shin, Dong In Suh, Soo-Jong Hong, Hwan-Cheol Kim
International Journal of Hygiene and Environmental Health.2021; 237: 113823. CrossRef
Effects of cholecalciferol on behavior and production of reactive oxygen species in female mice subjected to corticosterone-induced model of depression
Suene Vanessa da Silva Souza, Priscila Batista da Rosa, Vivian Binder Neis, Júlia Dubois Moreira, Ana Lúcia S. Rodrigues, Morgana Moretti
Naunyn-Schmiedeberg's Archives of Pharmacology.2020; 393(1): 111. CrossRef
Air pollution is associated with depressive symptoms in elderly women with cognitive impairment
Hicran Altuğ, Kateryna B. Fuks, Anke Hüls, Anne-Kathrin Mayer, Rachel Tham, Jean Krutmann, Tamara Schikowski
Environment International.2020; 136: 105448. CrossRef
Oxidative stress, antioxidant defense and depressive disorders: A systematic review of biochemical and molecular markers
Maiza Lacerda Barbosa, Ag-Anne Pereira Melo de Meneses, Rai Pablo Sousa de Aguiar, João Marcelo de Castro e Sousa, Ana Amélia de Carvalho Melo Cavalcante, Sharbel Weidner Maluf
Neurology, Psychiatry and Brain Research.2020; 36: 65. CrossRef
Changes in the concentrations of inflammatory and oxidative status biomediators (MIP-1 α, PMN elastase, MDA, and IL-12) in depressed patients with and without posttraumatic stress disorder
Ewa A. Ogłodek
Pharmacological Reports.2018; 70(1): 110. CrossRef
Weight Status, Physical Activity, and Depression in Korean Older Adults
Jinkyung Cho, Youngyun Jin, Hyunsik Kang
Journal of Epidemiology.2018; 28(6): 292. CrossRef
Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study
Md Rabiul Islam, Md Reazul Islam, Imtiaz Ahmed, Abdullah Al Moktadir, Zabun Nahar, Mohammad Safiqul Islam, Shelina Fatema Binte Shahid, Sheikh Nazrul Islam, Md Saiful Islam, Abul Hasnat
SAGE Open Medicine.2018; 6: 205031211877395. CrossRef
Conditional Human Immunodeficiency Virus Transactivator of Transcription Protein Expression Induces Depression-like Effects and Oxidative Stress
Jay P. McLaughlin, Jason J. Paris, Dionyssios Mintzopoulos, Kristen A. Hymel, Jae K. Kim, Thomas J. Cirino, Timothy E. Gillis, Shainnel O. Eans, Gordana D. Vitaliano, Jessica M. Medina, Richard C. Krapf, Heather M. Stacy, Marc J. Kaufman
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging.2017; 2(7): 599. CrossRef

Placental Superoxide Dismutase, Genetic Polymorphism, and Neonatal Birth Weight.: Yun Chul Hong, Kwan Hee Lee, Moon Whan Im, Young Ju Kim, Eun Hee Ha; J Prev Med Public Health. 2004;37(4):306-311. Published online November 30, 2004

2,035 View
36 Download

Abstract PDF: BACKGROUND
The roles of antioxidants in the placenta and genetic susceptibility to oxidant chemicals in relation to neonatal birth weight have not been elucidated. We determined whether the level of placental manganese superoxide dismutase (MnSOD) and its genetic polymorphism plays any role in oxidative stress and neonatal birth weight. METHODS: We measured placental MnSOD and determined MnSOD genetic polymorphism among 108 pregnant women who were hospitalized for delivery and their singleton live births in Korea. Main outcome measurements are maternal urinary malondialdehyde (MDA) and birth weight. RESULTS: Maternal urinary concentrations of MDA were significantly associated with neonatal birth weight (P=0.04). The enzyme level of placental MnSOD was also significantly associated with MDA concentration (P=0.04) and neonatal birth weight (P< 0.01). We observed dose-response relationships between placental MnSOD and maternal urinary MDA, and neonatal birth weight after adjusting for maternal weight, height, age, and neonatal sex. After controlling for covariates, MnSOD variant genotype increased maternal urinary MDA concentrations (P< 0.01) and reduced birth weight by 149 gm (P=0.08). CONCLUSIONS: This study demonstrates that the placental level of MnSOD during pregnancy significantly affects fetal growth by reducing oxidative stress, and that genetic polymorphism of MnSOD probably modulate the effects of oxidants on fetal growth.; Summary

Review

Gene-Diet Interaction on Cancer Risk in Epidemiological Studies.: Sang Ah Lee; J Prev Med Public Health. 2009;42(6):360-370.; DOI: https://doi.org/10.3961/jpmph.2009.42.6.360

6,298 View
173 Download
15 Crossref

Abstract PDF

Genetic factors clearly play a role in carcinogenesis, but migrant studies provide unequivocal evidence that environmental factors are critical in defining cancer risk. Therefore, one may expect that the lower availability of substrate for biochemical reactions leads to more genetic changes in enzyme function; for example, most studies have indicated the variant MTHFR genotype 677TT is related to biomarkers, such as homocysteine concentrations or global DNA methylation particularly in a low folate diet. The modification of a phenotype related to a genotype, particularly by dietary habits, could support the notion that some of inconsistencies in findings from molecular epidemiologic studies could be due to differences in the populations studied and unaccounted underlying characteristics mediating the relationship between genetic polymorphisms and the actual phenotypes. Given the evidence that diet can modify cancer risk, gene-diet interactions in cancer etiology would be anticipated. However, much of the evidence in this area comes from observational epidemiology, which limits the causal inference. Thus, the investigation of these interactions is essential to gain a full understanding of the impact of genetic variation on health outcomes. This report reviews current approaches to gene-diet interactions in epidemiological studies. Characteristics of gene and dietary factors are divided into four categories: one carbon metabolism-related gene polymorphisms and dietary factors including folate, vitamin B group and methionines; oxidative stress-related gene polymorphisms and antioxidant nutrients including vegetable and fruit intake; carcinogen-metabolizing gene polymorphisms and meat intake including heterocyclic amins and polycyclic aromatic hydrocarbon; and other gene-diet interactive effect on cancer.

Summary

Citations

Citations to this article as recorded by

Exploring the Interplay Between Vitamin B12-related Biomarkers, DNA Methylation, and Gene-Nutrition Interaction in Esophageal Precancerous Lesions
Da Pan, Ming Su, Dengfeng Xu, Yuanyuan Wang, Han Gao, James Daniel Smith, Jihan Sun, Xin Wang, Qingyang Yan, Guang Song, Yifei Lu, Wuqiong Feng, Shaokang Wang, Guiju Sun
Archives of Medical Research.2023; 54(7): 102889. CrossRef
Genetic Variants in Folate and Cobalamin Metabolism-Related Genes in Pregnant Women of a Homogeneous Spanish Population: The Need for Revisiting the Current Vitamin Supplementation Strategies
Gemma Rodriguez-Carnero, Paula M. Lorenzo, Ana Canton-Blanco, Leire Mendizabal, Maddi Arregi, Mirella Zulueta, Laureano Simon, Manuel Macia-Cortiñas, Felipe F. Casanueva, Ana B. Crujeiras
Nutrients.2022; 14(13): 2702. CrossRef
Genetic Variants Shaping Inter-individual Differences in Response to Dietary Intakes—A Narrative Review of the Case of Vitamins
Aikaterini Niforou, Valentini Konstantinidou, Androniki Naska
Frontiers in Nutrition.2020;[Epub] CrossRef
Bioactive Nutrients and Nutrigenomics in Age-Related Diseases
Tania Rescigno, Luigina Micolucci, Mario Tecce, Anna Capasso
Molecules.2017; 22(1): 105. CrossRef
Genetic polymorphisms and folate status
Mami Hiraoka, Yasuo Kagawa
Congenital Anomalies.2017; 57(5): 142. CrossRef
Methionine-supplemented diet affects the expression of cardiovascular disease-related genes and increases inflammatory cytokines in mice heart and liver
Alexandre Ferro Aissa, Catia Lira do Amaral, Vinicius Paula Venancio, Carla da Silva Machado, Lívia Cristina Hernandes, Patrick Wellington da Silva Santos, Rui Curi, Maria de Lourdes Pires Bianchi, Lusânia Maria Greggi Antunes
Journal of Toxicology and Environmental Health, Part A.2017; 80(19-21): 1116. CrossRef
Nutrigenetics—Personalized Nutrition in the Genetic Age
Emma L. Beckett, Patrice R. Jones, Martin Veysey, Mark Lucock
Exploratory Research and Hypothesis in Medicine.2017; 2(4): 1. CrossRef
Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet
Maurizio Dattilo, D’Amato Giuseppe, Caroppo Ettore, Yves Ménézo
Journal of Assisted Reproduction and Genetics.2016; 33(12): 1633. CrossRef
The protective effect of methylenetetrahydrofolate reductase C677T polymorphism against prostate cancer risk: Evidence from 23 case–control studies
Shanqi Guo, Xingkang Jiang, Xiaobo Chen, Liang Chen, Xiaojiang Li, Yingjie Jia
Gene.2015; 565(1): 90. CrossRef
Cancer biomarkers
Omer Kucuk
Molecular Aspects of Medicine.2015; 45: 1. CrossRef
Cytoplasmic and nuclear toxicity of 3,5-dimethylaminophenol and potential protection by selenocompounds
Pinar Erkekoglu, Ming-Wei Chao, Wenjie Ye, Jing Ge, Laura J. Trudel, Paul L. Skipper, Belma Kocer-Gumusel, Bevin P. Engelward, Gerald N. Wogan, Steven R. Tannenbaum
Food and Chemical Toxicology.2014; 72: 98. CrossRef
Potentially estrogenic polychlorinated biphenyls congeners serum levels and its relation with lung cancer
Rogelio Recio‐Vega, Alejandra Mendez‐Henandez, Antonio Padua y Gabriel, Antonio Jacobo‐Avila, Arnulfo Portales‐Castanedo, Sandra Hernandez‐Gonzalez, Martha Patricia Gallegos‐Arreola, Guadalupe Ocampo‐Gomez
Journal of Applied Toxicology.2013; 33(9): 906. CrossRef
Comprehensive Evaluation of One-Carbon Metabolism Pathway Gene Variants and Renal Cell Cancer Risk
Todd M. Gibson, Paul Brennan, Summer Han, Sara Karami, David Zaridze, Vladimir Janout, Helen Kollarova, Vladimir Bencko, Marie Navratilova, Neonila Szeszenia-Dabrowska, Dana Mates, Alena Slamova, Ruth M. Pfeiffer, Rachael Z. Stolzenberg-Solomon, Susan T.
PLoS ONE.2011; 6(10): e26165. CrossRef
The Role of Gene-environment Interaction in Environmental Carcinogenesis
So-Hee Han, Kyoung-Mu Lee
Korean Journal of Environmental Health Sciences.2010; 36(1): 1. CrossRef
Gene-Environment Interaction: A Genetic-Epidemiological Approach
Tatjana Pekmezović
Journal of Medical Biochemistry.2010; 29(3): 131. CrossRef

Evaluation Studies

Stability and Intra-Individual Variation of Urinary Malondialdehyde and 2-Naphthol.: Kyoung Ho Lee, Daehee Kang; J Prev Med Public Health. 2008;41(3):195-199.; DOI: https://doi.org/10.3961/jpmph.2008.41.3.195

5,382 View
83 Download
10 Crossref

Abstract PDF

OBJECTIVES
Malondialdehyde (MDA), a lipid peroxidation by-product, has been widely used as an indicator of oxidative stress. Urinary 2-naphthol, a urinary PAH metabolite, is used as a marker of ambient particulate exposure and is associated with lung cancer and chronic obstructive pulmonary disease. However, the stability and intra-individual variation associated with urinary MDA and 2-naphthol have not been thoroughly addressed. The objective of this study was to assess the stability and intraindividual variation associated with urinary MDA and 2-naphthol. METHODS: Urine samples were collected from 10 healthy volunteers (mean age 34, range 27~42 years old). Each sample was divided into three aliquots and stored under three different conditions. The levels of urinary MDA and 2-naphthol were analyzed 1) just after sampling, 2) after storage at room temperature (21degrees C) for 16 hours, and 3) after storage in a -20degrees C freezer for 16 hours. In addition, an epidemiological study was conducted in 44 Chinese subjects over a period of 3 weeks. The urinary MDA and 2-naphthol were measured by HPLC three times. RESULTS: There was no difference in the levels of urinary MDA and 2-naphthol between the triplicate measurements (n=10, p=0.84 and p=0.83, respectively). The intra-class correlation coefficients (ICC) for urinary MDA and 2-naphthol were 0.74 and 0.42, respectively. However, the levels of PM2.5 in the air were well correlated with the levels of both MDA and 2-naphthol in the epidemiological study. CONCLUSIONS: These results suggest that urinary MDA and 2-naphthol remain stable under variable storage conditions, even at room temperature for 16 hours, and indicate that these markers can be used in epidemiological studies involving various sample storage conditions. The intra-CC of urinary 2-naphthol and MDA were acceptable for application to epidemiological studies.

Summary

Citations

Citations to this article as recorded by

Methodological confounds of measuring urinary oxidative stress in wild animals
Zoe E. Melvin, Hussein Dhirani, Christopher Mitchell, Tim R. B. Davenport, Jonathan D. Blount, Alexander V. Georgiev
Ecology and Evolution.2022;[Epub] CrossRef
Analysis of urinary metabolites of polycyclic aromatic hydrocarbons and cotinine in pooled urine samples to determine the exposure to PAHs in an Australian population.
Phong K. Thai, Andrew P.W. Banks, Leisa-Maree L. Toms, Phil M. Choi, Xianyu Wang, Peter Hobson, Jochen F. Mueller
Environmental Research.2020; 182: 109048. CrossRef
Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees
Nicole Thompson González, Emily Otali, Zarin Machanda, Martin N. Muller, Richard Wrangham, Melissa Emery Thompson, Emmanuel Serrano
PLOS ONE.2020; 15(9): e0238066. CrossRef
Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases
Yao‐Kuang Wang, Wei‐Chih Chiang, Fu‐Chen Kuo, Meng‐Chieh Wu, Hsiang‐Yao Shih, Sophie S.W. Wang, Chung‐Jung Liu, Yen‐Hsu Chen, Deng‐Chyang Wu, Wei‐Wen Su, Yeou‐Lih Huang
Helicobacter.2018;[Epub] CrossRef
Mechanism of oxidative DNA damage induced by metabolites of carcinogenic naphthalene
Shiho Ohnishi, Yusuke Hiraku, Keishi Hasegawa, Kazutaka Hirakawa, Shinji Oikawa, Mariko Murata, Shosuke Kawanishi
Mutation Research/Genetic Toxicology and Environmental Mutagenesis.2018; 827: 42. CrossRef
Simultaneous pentafluorobenzyl derivatization and GC-ECNICI-MS measurement of nitrite and malondialdehyde in human urine: Close positive correlation between these disparate oxidative stress biomarkers
Erik Hanff, Michele F. Eisenga, Bibiana Beckmann, Stephan J.L. Bakker, Dimitrios Tsikas
Journal of Chromatography B.2017; 1043: 167. CrossRef
A longitudinal study of atrazine and 2,4‐D exposure and oxidative stress markers among iowa corn farmers
Catherine C. Lerro, Laura E. Beane Freeman, Lützen Portengen, Daehee Kang, Kyoungho Lee, Aaron Blair, Charles F. Lynch, Berit Bakke, Anneclaire J. De Roos, Roel C.H. Vermeulen
Environmental and Molecular Mutagenesis.2017; 58(1): 30. CrossRef
Polycyclic aromatic hydrocarbon (1-OHPG and 2-naphthol) and oxidative stress (malondialdehyde) biomarkers in urine among Korean adults and children
Hyung-Suk Yoon, Kyoung-Mu Lee, Kyoung-Ho Lee, Sungkyoon Kim, Kyungho Choi, Daehee Kang
International Journal of Hygiene and Environmental Health.2012; 215(4): 458. CrossRef
Determination of urinary malondialdehyde by isotope dilution LC-MS/MS with automated solid-phase extraction: A cautionary note on derivatization optimization
Jian-Lian Chen, Yu-Jie Huang, Chih-Hong Pan, Chiung-Wen Hu, Mu-Rong Chao
Free Radical Biology and Medicine.2011; 51(9): 1823. CrossRef
Breast Cancer and Urinary Biomarkers of Polycyclic Aromatic Hydrocarbon and Oxidative Stress in the Shanghai Women's Health Study
Kyoung-Ho Lee, Xiao-Ou Shu, Yu-Tang Gao, Bu-Tian Ji, Gong Yang, Aaron Blair, Nathaniel Rothman, Wei Zheng, Wong-Ho Chow, Daehee Kang
Cancer Epidemiology, Biomarkers & Prevention.2010; 19(3): 877. CrossRef

English Abstract

Associations of Non Alcoholic Fatty Liver with the Metabolic Syndrome and Serum Carotenoids.: Sun kyun Park, Hyun Jung Lee, Duk Hee Lee, Sung Kook Lee, Byung Yeol Chun, Sung Ae Kim, Hye Sung Lee, Hyo Kyung Son, Sung Hi Kim; J Prev Med Public Health. 2008;41(1):39-44.; DOI: https://doi.org/10.3961/jpmph.2008.41.1.39

5,832 View
69 Download
10 Crossref

Abstract PDF

OBJECTIVES
This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. METHODS: This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males: 180, females: 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). RESULTS: After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum beta-carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum alpha-carotene, lycopene, bata-cryptoxanthin and lutein were not decreased. CONCLSIONS: This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum beta-carotene level.

Summary

Citations

Citations to this article as recorded by

Estimation of Attributable Risk and Direct Medical and Non-Medical Costs of Major Mental Disorders Associated With Air Pollution Exposures Among Children and Adolescents in the Republic of Korea, 2011–2019
Yae Won Ha, Tae Hyun Kim, Dae Ryong Kang, Ki-Soo Park, Dong Chun Shin, Jaelim Cho, Changsoo Kim
Journal of Korean Medical Science.2024;[Epub] CrossRef
Therapeutic potential of bioactive phytoconstituents found in fruits in the treatment of non-alcoholic fatty liver disease: A comprehensive review
Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Pompy Patowary, Pronobesh Chattopadhyay, Aparoop Das
Heliyon.2023; 9(4): e15347. CrossRef
The Protection Conferred by HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis and Fibrosis May Be Limited to Selected Subgroups of Patients With NAFLD
Eduardo Vilar-Gomez, Carlos J. Pirola, Silvia Sookoian, Laura A. Wilson, Tiebing Liang, Naga Chalasani
Clinical and Translational Gastroenterology.2021; 12(9): e00400. CrossRef
Trends and Patterns of Burden of Disease and Injuries in Korea Using Disability-Adjusted Life Years
Young-Eun Kim, Hyesook Park, Min-Woo Jo, In-Hwan Oh, Dun-Sol Go, Jaehun Jung, Seok-Jun Yoon
Journal of Korean Medical Science.2019;[Epub] CrossRef
Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among US Adults, NHANES 2003–2014
Krista Christensen, Thomas Lawler, Julie Mares
Nutrients.2019; 11(5): 1101. CrossRef
Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index
Qing Pang
World Journal of Gastroenterology.2015; 21(5): 1650. CrossRef
Association Between Liver Vitamin A Reserves and Severity of Nonalcoholic Fatty Liver Disease in the Class III Obese Following Bariatric Surgery
Gabriela Villaça Chaves, Sílvia Elaine Pereira, Carlos José Saboya, Daiane Spitz, Camila Santos Rodrigues, Andréa Ramalho
Obesity Surgery.2014; 24(2): 219. CrossRef
Association of oral health behaviors and status with depression: results from the Korean National Health and Nutrition Examination Survey, 2010
Se Jin Park, Ki Dong Ko, Seung-Il Shin, Yu Jeong Ha, Gy Young Kim, Hyoung Ah Kim
Journal of Public Health Dentistry.2014; 74(2): 127. CrossRef
Measuring the burden of chronic diseases in Korea in 2007
E.-J. Kim, S.-J. Yoon, M.-W. Jo, H.-J. Kim
Public Health.2013; 127(9): 806. CrossRef
The Association of Cardiovascular Risk Factors with Nonalcoholic Fatty Liver Disease in Health Checkup Examinees
Jae-Hee Yu, Kang-Sook Lee, Seon-Young Lee, A-Rum Hong, Yong-Sang Park
Journal of Preventive Medicine and Public Health.2008; 41(6): 407. CrossRef

In Vitro

Exposure Assessment of PCDD/Fs and Monitoring of Health Effects on Workers and Residents near the Waste Incinerators in Korea.: Jong Han Leem, Yun Chul Hong, Kwan Hee Lee, Ho Jang Kwon, Jae Yeon Jang; Korean J Prev Med. 2003;36(4):314-322.

46,859 View
41 Download

Abstract PDF: OBJECTIVES
In this study, the exposure status of the hazardous substances from incinerators, such as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs), were studied, and the relationship between the exposure of these hazardous substances and their heath effects on the workers and residents near municipal solid waste (MSW) incinerators and an industrial incinerator investigated. METHODS: Between July 2001 and June 2002, 13 workers at two MSW incinerators, 16 residents from the area around the two MSW incinerators, 6 residents from the control area, and further 10 residents near an industrial incinerator, estimated to emit higher levels of hazardous substances, were interviewed. Information, including sociodemographic information, personal habits, and work history, detailed gynecologic and other medical history were collected through interviews. Blood samples were also collected from 45 subjects, and analyzed for PCDD/DFs, by high resolution gas chromatography - high resolution mass spectrometry, using the US EPA 1613 method. In addition to the questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. The urinary concentrations of 8-OH-dG were determined by in vitro ELISA, and the MDA by HPLC, using an adduct with thiobarbituric acid. RESULTS: The PCDD/DFs concentrations in the residents near the industrial incinerator were higher than those in the controls, workers and residents near the MSW incinerators. The average TEQ (Toxic Equivalencies) concentrations of the PCDD/DFs in residents near the industrial incinerator were 53.4pg I-TEQs/g lipid. The estimated daily intakes were within the tolerable daily intake range (1-4 pg I-TEQ/Kg bw/day) suggested by WHO (1997) in only 30% to the people near the industrial incinerator. Animal studies have already shown that even a low body burden of PCDD/DFs, such as 10ng TEQ/kg bw, can cause oxidative damage in laboratory animals. Our study also showed that the same body burden of PCDD/DFs can cause oxidative damage to humans. CONCLUSIONS: The exposures to PCDD/DFs and the oxidative stress of residents near the industrial incinerator, were higher than those in the controls, workers and residents near the MSW incinerators. Proper protection strategies against these hazardous chemicals are needed. Because a lower body burden of PCDD/Fs, such as 10ng TEQ/kg bw, can cause oxidative damage, the tolerable daily intake range should be restrictedly limited to 1pg I-TEQ/kg bw/day.; Summary

First
Prev
Page of 1
Next
Last

Search