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Original Article
Association of Selected Medical Conditions With Breast Cancer Risk in Korea
Sun Jae Jung, Minkyo Song, Ji-Yeob Choi, Nan Song, Sue Kyung Park, Keun-Young Yoo, Daehee Kang
J Prev Med Public Health. 2013;46(6):346-352.   Published online November 28, 2013
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AbstractAbstract PDF

To estimate the effect of medical conditions in the population of Korea on breast cancer risk in a case-control study.


The cases were 3242 women with incident, histologically confirmed breast cancer in two major hospitals interviewed between 2001 and 2007. The controls were 1818 women each admitted to either of those two hospitals for a variety of non-neoplastic conditions. Information on each disease was obtained from a standardized questionnaire by trained personnel. Odds ratios (ORs) for each disease were derived from multiple logistic regression adjusted for age, age of menarche, pregnancy, age of first pregnancy, and family history of breast cancer.


Among all of the incident breast cancer patients, pre-existing diabetes (OR, 1.33; 95% confidence interval [CI], 0.99 to 1.78), hypertension (OR, 1.46; 95% CI, 1.18 to 1.83), thyroid diseases (OR, 1.26; 95% CI, 1.00 to 1.58), and ovarian diseases (OR, 1.70; 95% CI, 1.23 to 2.35) were associated with an increased risk of breast cancer when other factors were adjusted for. In a stratified analysis by menopausal status, pre-existing hypertension (pre-menopause OR, 0.80; 95% CI, 0.48 to 1.34 vs. post-menopause OR, 1.87; 95% CI, 1.44 to 2.43; p-heterogeneity <0.01) and ovarian disease (pre-menopause OR, 4.20; 95% CI, 1.91 to 9.24 vs. post-menopause OR, 1.39; 95% CI, 1.02 to 1.91; p-heterogeneity 0.01) showed significantly different risks of breast cancer.


Our results suggest the possibility that medical conditions such as hypertension affect breast cancer development, and that this can differ by menopausal status. Our study also indicates a possible correlation between ovarian diseases and breast cancer risk.



Citations to this article as recorded by  
  • Diabetes and incidence of breast cancer and its molecular subtypes: A systematic review and meta‐analysis
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  • Reverse Onco-Cardiology: What Is the Evidence for Breast Cancer? A Systematic Review of the Literature
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  • Association of Hypertension and Organ-Specific Cancer: A Meta-Analysis
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  • Risk of breast cancer among women with benign ovarian tumors: a Danish nationwide cohort study
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  • Hypertension and breast cancer risk: a systematic review and meta-analysis
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  • Cancer du sein et diabète de type 2 : des interactions complexes
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  • Associations between Medical Conditions and Breast Cancer Risk in Asians: A Nationwide Population-Based Study in Taiwan
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JPMPH : Journal of Preventive Medicine and Public Health