KSPM
Search
- Page Path
- HOME > Search
Original Article
- Associations of Serum Ferritin and Transferrin % Saturation With All-cause, Cancer, and Cardiovascular Disease Mortality: Third National Health and Nutrition Examination Survey Follow-up Study
- Ki-Su Kim, Hye-Gyeong Son, Nam-Soo Hong, Duk-Hee Lee
- J Prev Med Public Health. 2012;45(3):196-203. Published online May 31, 2012
- DOI: https://doi.org/10.3961/jpmph.2012.45.3.196
- 13,380 View
- 95 Download
- 32 Crossref
-
Abstract
PDF Objectives Even though experimental studies have suggested that iron can be involved in generating oxidative stress, epidemiologic studies on the association of markers of body iron stores with cardiovascular disease or cancer remain controversial. This study was performed to examine the association of serum ferritin and transferrin saturation (%TS) with all-cause, cancer, and cardiovascular mortality.
Methods The study subjects were men aged 50 years or older and postmenopausal women of the Third National Health and Nutrition Examination Survey 1988-1994. Participants were followed-up for mortality through December 31, 2006.
Results Serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality for either men or postmenopausal women. However, all-cause, cancer, and cardiovascular mortality were inversely associated with %TS in men. Compared with men in the lowest quintile, adjusted hazard ratios for all-cause, cancer, and cardiovascular mortality were 0.85, 0.86, 0.76, and 0.74 (
p for trend < 0.01), 0.82, 0.73, 0.75, and 0.63 (p for trend < 0.01), and 0.86, 0.81, 0.72, and 0.76 (p for trend < 0.01), respectively. For postmenopausal women, inverse associations were also observed for all-cause and cardiovascular mortality, but cancer mortality showed the significantly lower mortality only in the 2nd quintile of %TS compared with that of the 1st quintile.Conclusions Unlike speculation on the role of iron from experimental studies, %TS was inversely associated with all-cause, cancer and cardiovascular mortality in men and postmenopausal women. On the other hand, serum ferritin was not associated with all-cause, cancer, or cardiovascular mortality.
-
Summary
Citations
Citations to this article as recorded by
- Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population ― NIPPON DATA90 ―
Megumi Kawashima, Takashi Hisamatsu, Akiko Harada, Aya Kadota, Keiko Kondo, Yukiko Okami, Takehito Hayakawa, Yoshikuni Kita, Akira Okayama, Hirotsugu Ueshima, Tomonori Okamura, Katsuyuki Miura
Circulation Journal.2024; 88(5): 742. CrossRef - Iron Metabolic Biomarkers and the Mortality Risk in the General Population: A Nationwide Population-Based Cohort Study
Yuanyuan Sun, Wenyao Peng, Siqi Lin, Jingjing Cui, Jiapeng Lu
Journal of the Endocrine Society.2024;[Epub] CrossRef - Advancing Patient Blood Management: Evaluation of Ferric Derisomaltose in a Tertiary Hospital
Mohd Muhaimin Kambali, Engku Hamidah Engku Muhammad Azmi
Global Journal of Transfusion Medicine.2024; 9(1): 65. CrossRef - Investigating the potential association between micronutrient levels and non-dipper hypertension patterns in the elderly population: A retrospective analysis
Ayşenur Uçar, Aynur Doğrusöz
Medicine.2024; 103(36): e38741. CrossRef - Iron metabolism and atherosclerosis
Qian Guo, Christopher Qian, Zhong-Ming Qian
Trends in Endocrinology & Metabolism.2023; 34(7): 404. CrossRef - Transferrin predicts trimethylamine-N-oxide levels and is a potential biomarker of cardiovascular disease
Lamuel D. Bean, Jeffrey J. Wing, Randall E. Harris, Suzanne M. Smart, Subha V. Raman, M. Wesley Milks
BMC Cardiovascular Disorders.2022;[Epub] CrossRef - Iron overload, oxidative stress and vascular dysfunction: Evidences from clinical studies and animal models
Leonardo dos Santos, Sabrina Rodrigues Bertoli, Renata Andrade Ávila, Vinícius Bermond Marques
Biochimica et Biophysica Acta (BBA) - General Subjects.2022; 1866(9): 130172. CrossRef - Association of ferritin and transferrin saturation with all-cause mortality, and the effect of concurrent inflammation: a danish cohort study
Nikki H. Mitchell, Henrik L. Jørgensen, Fie J. Vojdeman, Henriette P. Sennels, Christen L. Andersen, Margit Kriegbaum, Mia K. Grand, Christine W. Bang, Bent S. Lind
Scandinavian Journal of Clinical and Laboratory Investigation.2022; 82(7-8): 525. CrossRef - Iron Restriction Alleviates Atherosclerosis in ApoE KO Mice: An iTRAQ Proteomic Analysis
Gang Luo, Lu Xiang, Lin Xiao
International Journal of Molecular Sciences.2022; 23(24): 15915. CrossRef - Nano‐sensing and nano‐therapy targeting central players in iron homeostasis
Linyuan Wu, Yan Li, Ning Gu
WIREs Nanomedicine and Nanobiotechnology.2021;[Epub] CrossRef - Dietary iron overload mitigates atherosclerosis in high-fat diet-fed apolipoprotein E knockout mice: Role of dysregulated hepatic fatty acid metabolism
Lin Xiao, Gang Luo, Hongxia Li, Ping Yao, Yuhan Tang
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(10): 159004. CrossRef - The role of hepcidin and iron homeostasis in atherosclerosis
Florian Wunderer, Lisa Traeger, Haakon H. Sigurslid, Patrick Meybohm, Donald B. Bloch, Rajeev Malhotra
Pharmacological Research.2020; 153: 104664. CrossRef - Iron loading, alcohol and mortality: A prospective study
Rudolph Schutte, Hugo Huisman, Catharina M.C. Mels, Shani Botha, Ruan Kruger, Wayne Smith, Iolanthé M. Kruger, Michelle Hawkins, Lee Smith, Yolandi Breet, Aletta E. Schutte
Clinical Nutrition.2019; 38(3): 1262. CrossRef - Prognostic implications of low transferrin saturation in patients with primary myelofibrosis
Marko Lucijanic, Zeljko Prka, Vlatko Pejsa, Tajana Stoos-Veic, Jelena Lucijanic, Rajko Kusec
Leukemia Research.2018; 66: 89. CrossRef - Iron status in relation to cancer risk and mortality: Findings from a population‐based prospective study
Daniel A. Quintana Pacheco, Disorn Sookthai, Mirja E. Graf, Ruth Schübel, Theron Johnson, Verena A. Katzke, Rudolf Kaaks, Tilman Kühn
International Journal of Cancer.2018; 143(3): 561. CrossRef - Targeting iron metabolism in drug discovery and delivery
Bart J. Crielaard, Twan Lammers, Stefano Rivella
Nature Reviews Drug Discovery.2017; 16(6): 400. CrossRef - The association of ferritin with cardiovascular and all-cause mortality in community-dwellers: The English longitudinal study of ageing
Nikolaos P. E. Kadoglou, Jane P. Biddulph, Snorri B. Rafnsson, Marialena Trivella, Petros Nihoyannopoulos, Panayotes Demakakos, Abelardo I Aguilera
PLOS ONE.2017; 12(6): e0178994. CrossRef - Management of iron overload in hemoglobinopathies: what is the appropriate target iron level?
Thomas D. Coates, Susan Carson, John C. Wood, Vasilios Berdoukas
Annals of the New York Academy of Sciences.2016; 1368(1): 95. CrossRef - Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status
Stephen T. McSorley, Iain Jones, Donald C. McMillan, Dinesh Talwar
Translational Research.2016; 176: 119. CrossRef - High serum levels of ferritin at baseline are not associated with an increased risk of mortality in oldest old community‐dwelling adults: The OCTABAIX study
Francesc Formiga, Assumpta Ferrer, Gloria Padros, Carme Gimenez‐Argente, Rosa López Pisa, Xavier Corbella
Geriatrics & Gerontology International.2016; 16(2): 284. CrossRef - Iron toxicity and its possible association with treatment of Cancer: Lessons from hemoglobinopathies and rare, transfusion-dependent anemias
Mammen Puliyel, Arch G Mainous, Vasilios Berdoukas, Thomas D Coates
Free Radical Biology and Medicine.2015; 79: 343. CrossRef - Parameters influencing in-hospital mortality in patients hospitalized in intensive cardiac care unit: is there an influence of anemia and iron deficiency?
Ewa Uscinska, Bozena Sobkowicz, Robert Sawicki, Izabela Kiluk, Malgorzata Baranicz, Tomasz Stepek, Milena Dabrowska, Maciej Szmitkowski, Wlodzimierz J. Musial, Agnieszka M. Tycinska
Internal and Emergency Medicine.2015; 10(3): 337. CrossRef - Low transferrin saturation is associated with impaired fasting glucose and insulin resistance in the South Korean adults: the 2010 Korean National Health and Nutrition Examination Survey
R. J. Park, J. D. Moon
Diabetic Medicine.2015; 32(5): 673. CrossRef - Helicobacter pylori Seropositivity’s Association with Markers of Iron, 1-Carbon Metabolism, and Antioxidant Status among US Adults: A Structural Equations Modeling Approach
May A. Beydoun, Greg A. Dore, Jose A. Canas, Hind A. Beydoun, Alan B. Zonderman, Bradford D. Gessner
PLOS ONE.2015; 10(3): e0121390. CrossRef - Transferrin Saturation Ratio: A Method to Estimate Risk of Cardiovascular Mortality in the General Population?
Austin G Stack, Waleed Mohamed, Mohamed Elsayed
Biomarkers in Medicine.2014; 8(7): 913. CrossRef - Prediabetes, elevated iron and all-cause mortality: a cohort study
Arch G Mainous, Rebecca J Tanner, Thomas D Coates, Richard Baker
BMJ Open.2014; 4(12): e006491. CrossRef - Dietary Iron Intake and Body Iron Stores Are Associated with Risk of Coronary Heart Disease in a Meta-Analysis of Prospective Cohort Studies
Jacob Hunnicutt, Ka He, Pengcheng Xun
The Journal of Nutrition.2014; 144(3): 359. CrossRef - Iron: Protector or Risk Factor for Cardiovascular Disease? Still Controversial
Carlos Muñoz-Bravo, Mario Gutiérrez-Bedmar, Jorge Gómez-Aracena, Antonio García-Rodríguez, Joaquín Navajas
Nutrients.2013; 5(7): 2384. CrossRef - Non-Hfe Iron Overload: Is Phlebotomy the Answer?
Simon Hazeldine, Debbie Trinder, John K. Olynyk
Current Hepatitis Reports.2013; 12(1): 20. CrossRef - Iron Deficiency and Cardiovascular Disease: An Updated Review of the Evidence
Emanuela Lapice, Maria Masulli, Olga Vaccaro
Current Atherosclerosis Reports.2013;[Epub] CrossRef - Iron Status and Survival in Diabetic Patients With Coronary Artery Disease
Beata Ponikowska, Tomasz Suchocki, Bartłomiej Paleczny, Martyna Olesinska, Slawomir Powierza, Ludmila Borodulin-Nadzieja, Krzysztof Reczuch, Stephan von Haehling, Wolfram Doehner, Stefan D. Anker, John G.F. Cleland, Ewa A. Jankowska
Diabetes Care.2013; 36(12): 4147. CrossRef - Presence in the Pre-Surgical Fine-Needle Aspiration of Potential Thyroid Biomarkers Previously Identified in the Post-Surgical One
Federica Ciregia, Laura Giusti, Angelo Molinaro, Filippo Niccolai, Patrizia Agretti, Teresa Rago, Giancarlo Di Coscio, Paolo Vitti, Fulvio Basolo, Pietro Iacconi, Massimo Tonacchera, Antonio Lucacchini, Alfredo Fusco
PLoS ONE.2013; 8(9): e72911. CrossRef
English Abstract- Serum Ferritin and Risk of the Metabolic Syndrome in Some Korean Rural Residents.
- So Yeon Ryu, Ki Soon Kim, Jong Park, Myeng Guen Kang, Mi Ah Han
- J Prev Med Public Health. 2008;41(2):115-120.
- DOI: https://doi.org/10.3961/jpmph.2008.41.2.115
- 5,962 View
- 53 Download
- 11 Crossref
-
Abstract
PDF
- OBJECTIVES
The purpose of this study was to examine the relationship between serum ferritin and the metabolic syndrome (MS). METHODS: We conducted a cross-sectional study of 1,444 adults over age 40 and under age 70 that lived in a rural area and participated in a survey conducted as part of the Korean Rural Genomic Cohort Study (KRGCS). The MS was defined as the presence of at least three of the followings: elevated blood pressure, low high density lipoprotein cholesterol, elevated serum triglycerides, elevated plasma glucose, or abdominal obesity. After adjustment for age, alcohol intake, menopausal status, body mass index (BMI), high sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT), odds ratios (ORs) for the prevalence of the MS by sex were calculated for quartiles of serum ferritin using logistic regression analysis. RESULTS: The MS was more common in those persons with the highest levels of serum ferritin, compared to persons with the lowest levels, in men (37.1% vs. 22.4%, p=0.006) and women (58.8% vs. 34.8, p<0.001). In both sexes, the greater the number of MS components presents, the greater the serum ferritin levels. After adjustment for age, alcohol intake, and menopausal status, the OR for metabolic syndrome, comparing the fourth quartile of ferritin with the first quartile, was 2.21 (95% confidence interval ; CI=1.26-3.87; p-trend=0.024) in men and 2.10 (95% CI=1.40-3.17; p-trend=0.001) in women. However, after further adjustment for BMI, hs-CRP, and ALT, the ORs were statistically attenuated in both sexes. CONCLUSIONS: Moderately elevated serum ferritin levels were not independently associated with the prevalence of the MS after adjusting for other risk factors. Further studies are needed to obtain evidence concerning the association between serum ferritin levels and the MS. -
Summary
Citations
Citations to this article as recorded by- Serum GGT and serum ferritin as early markers for metabolic syndrome
Eli Mohapatra, Ritu Priya, Rachita Nanda, Suprava Patel
Journal of Family Medicine and Primary Care.2020; 9(7): 3458. CrossRef - Association of serum ferritin level and depression with respect to the body mass index in Korean male adults
Hea Shoon Lee, Eunmi Park
Nutrition Research and Practice.2019; 13(3): 263. CrossRef - Ferritin, metabolic syndrome and its components: A systematic review and meta-analysis
Milton Fabian Suárez-Ortegón, Eduardo Ensaldo-Carrasco, Ting Shi, Stela McLachlan, José Manuel Fernández-Real, Sarah H. Wild
Atherosclerosis.2018; 275: 97. CrossRef - Serum ferritin and high sensitivity C-reactive protein are associated with metabolic syndrome in Japanese men and women
Chizumi YAMADA, Noriaki KISHIMOTO, Nobushige YUKUMATSU, Asami TAKEDA, Tamae OGATA, Emiko KIKUCHI, Emiko KURODA, Shigeyuki MOTEGI, Naoaki ISHII, Yasuhiro NISHIZAKI
Health evaluation and promotion.2016; 43(4): 511. CrossRef - The Association of Serum Ferritin and Metabolic Syndrome and Metabolic Syndrome Score in Korean Adults
Hyun Yoon, Jae Seong Go, Kang Uk Kim, Keon Woo Lee
The Korean Journal of Clinical Laboratory Science.2016; 48(4): 287. CrossRef - STUDY OF SERUM FERRITIN IN METABOLIC SYNDROME AND ITS COMPONENTS
Sachin Bongale, Yeshwanth G, Nagaraja V T
Journal of Evidence Based Medicine and Healthcare.2015; 2(32): 4743. CrossRef - Ferritin levels and risk of metabolic syndrome: meta-analysis of observational studies
Victoria Abril-Ulloa, Gemma Flores-Mateo, Rosa Solà-Alberich, Begoña Manuel-y-Keenoy, Victoria Arija
BMC Public Health.2014;[Epub] CrossRef - Serum ferritin level is higher in male adolescents with obesity: results from the Korean National Health and Nutrition Examination Survey 2010
Yeon Jin Jeon, In Ah Jung, Shin Hee Kim, Won-Kyoung Cho, Seung Hee Jeong, Kyoung Soon Cho, So Hyun Park, Min Ho Jung, Byung-Kyu Suh
Annals of Pediatric Endocrinology & Metabolism.2013; 18(3): 141. CrossRef - Prevalence of Metabolic Syndrome and Assessment of Food·Nutrient Intakes among Adult Visitors of a Public Health Center in Korea
Won-Hoon Jeong, Bok-Hee Jin, Eun-Hee Hwang
Journal of the Korean Society of Food Science and Nutrition.2012; 41(2): 205. CrossRef - Serum Ferritin and Metabolic Syndrome in Perimenopausal and Postmenopausal Women
Soo Hyun Cho
The Journal of Korean Society of Menopause.2011; 17(3): 166. CrossRef - The Association Between Circulating Inflammatory Markers and Metabolic Syndrome in Korean Rural Adults
So Yeon Ryu, Ki Soon Kim, Jong Park, Myeng Guen Kang, Mi Ah Han
Journal of Preventive Medicine and Public Health.2008; 41(6): 413. CrossRef
First
Prev
