Journal of Preventive Medicine and Public Health

Original Articles

Association Between Parity and Low Bone Density Among Postmenopausal Korean Women: Eunsun Seo, Yongrong Lee, Hyeon Chang Kim; J Prev Med Public Health. 2021;54(4):284-292. Published online June 24, 2021; DOI: https://doi.org/10.3961/jpmph.21.162

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Abstract Summary PDF Supplementary Material

Objectives
Low bone density (LBD) in the postmenopausal period has long been a pervasive public health concern; however, the association between parity and LBD has yet to be fully elucidated. Thus, we investigated the association between parity and LBD in postmenopausal Korean women.
Methods
This study used baseline data from 1287 Korean postmenopausal women aged 40 years or older enrolled in the Cardiovascular and Metabolic Diseases Etiology Research Center community-based cohort study conducted in Korea from 2013 to 2017. The main exposure was parity (nullipara, 1, 2, 3+). The main outcome was LBD, including osteopenia and osteoporosis, based on bone mineral density measured using quantitative computed tomography of the lumbar spine (L1-2).
Results
The mean age of participants was 57.1 years, and the median parity was 2. Of the 1287 participants, 594 (46.2%) had osteopenia and 147 (11.4%) had osteoporosis. No significant difference in the prevalence of LBD was found between nullipara and parous women, whereas higher parity was associated with a higher risk of LBD among parous women; the adjusted odds ratio (95% confidence interval) for the presence of LBD was 1.40 (0.97 to 2.02) for a parity of 2 and 1.95 (1.23 to 3.09) for a parity of 3 relative to a parity of 1.
Conclusions
Women who have given birth multiple times may be at greater risk of bone loss after menopause; therefore, they should be a major target population for osteoporosis prevention.

Summary

Korean summary
40-64세 폐경 여성 1287명을 대상으로 과거 출산 횟수와 골밀도의 관련성을 평가하였다. 정량적 전산화 단층촬영(QCT)으로 L1-L2의 평균 골무기질밀도(bone mineral density, BMD)를 측정하였으며, 그 값이 120mg/cm3 미만이면 골밀도 감소가 있는 것으로 정의하였다. 나이, 비만도, 폐경후기간, 직업, 소득, 교육, 결혼, 흡연, 음주, 신체활동, 질병력 등을 보정하여도, 출산횟수가 많을수록 평균 골밀도는 낮고 골밀도감소의 빈도는 높은 경향이 관찰되었다.

Citations

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The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Meno
David A. Hart
International Journal of Molecular Sciences.2024; 25(7): 3866. CrossRef
Genetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study
Yuan Li, Jinquan Lai, Wenbo Wu, Shuyi Ling, Yuqing Dai, Zhisheng Zhong, Xiaodong Chen, Yuehui Zheng
Calcified Tissue International.2024; 115(1): 41. CrossRef
La densité minérale osseuse est-elle associée à la reproduction et l’allaitement chez les femmes ménopausées ?
I. Cherif, L. Kharrat, H. Ferjani, D. Ben Nessib, F. Majdoub, D. Kaffel, K. Maatallah, W. Hamdi
Revue du Rhumatisme.2024; 91: A341. CrossRef
Bridging the Gap: Pregnancy—And Lactation—Associated Osteoporosis
Mara Carsote, Maria Roxana Turturea, Ana Valea, Cristian Buescu, Claudiu Nistor, Ionut Florin Turturea
Diagnostics.2023; 13(9): 1615. CrossRef
Associations of breastfeeding duration and the total number of children breastfed with self-reported osteoarthritis in Korea women 50 years and older: a cross-sectional study
Dajeong Ham, Sanghyuk Bae
Epidemiology and Health.2023; 45: e2023044. CrossRef
Association between parity and bone mineral density in postmenopausal women
Yimei Yang, Shanshan Wang, Hui Cong
BMC Women's Health.2022;[Epub] CrossRef

Relationship Between Non-alcoholic Fatty Liver Disease and Decreased Bone Mineral Density: A Retrospective Cohort Study in Korea: Jisun Sung, Seungho Ryu, Yun-Mi Song, Hae-Kwan Cheong; J Prev Med Public Health. 2020;53(5):342-352. Published online July 17, 2020; DOI: https://doi.org/10.3961/jpmph.20.089

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Abstract PDF

Objectives
The aim of this retrospective cohort study was to investigate whether non-alcoholic fatty liver disease (NAFLD) was associated with incident bone mineral density (BMD) decrease.
Methods
This study included 4536 subjects with normal BMD at baseline. NAFLD was defined as the presence of fatty liver on abdominal ultrasonography without significant alcohol consumption or other causes. Decreased BMD was defined as a diagnosis of osteopenia, osteoporosis, or BMD below the expected range for the patient’s age based on dual-energy X-ray absorptiometry. Cox proportional hazards models were used to estimate the hazard ratio of incident BMD decrease in subjects with or without NAFLD. Subgroup analyses were conducted according to the relevant factors.
Results
Across 13 354 person-years of total follow-up, decreased BMD was observed in 606 subjects, corresponding to an incidence of 45.4 cases per 1000 person-years (median follow-up duration, 2.1 years). In the model adjusted for age and sex, the hazard ratio was 0.65 (95% confidence interval, 0.51 to 0.82), and statistical significance disappeared after adjustment for body mass index (BMI) and cardiometabolic factors. In the subgroup analyses, NAFLD was associated with a lower risk of incident BMD decrease in females even after adjustment for confounders. The direction of the effect of NAFLD on the risk of BMD decrease changed depending on BMI category and body fat percentage, although the impact was statistically insignificant.
Conclusions
NAFLD had a significant protective effect on BMD in females. However, the effects may vary depending on BMI category or body fat percentage.

Summary

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Russian Journal of Evidence-Based Gastroenterology.2024; 13(4): 40. CrossRef
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Hyunjung Yoon, Eunju Sung, Jae-Heon Kang, Cheol-Hwan Kim, Hocheol Shin, Eunsol Yoo, Minyoung Kim, Mi Yeon Lee, Sujeong Shin
Scientific Reports.2023;[Epub] CrossRef
Liver fibrosis is associated with impaired bone mineralization and microstructure in obese individuals with non-alcoholic fatty liver disease
Ilaria Barchetta, Carla Lubrano, Flavia Agata Cimini, Sara Dule, Giulia Passarella, Arianna Dellanno, Alberto Di Biasio, Frida Leonetti, Gianfranco Silecchia, Andrea Lenzi, Maria Gisella Cavallo
Hepatology International.2023; 17(2): 357. CrossRef
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Oxana M. Drapkina, Anastasia Yu. Elkina, Anna F. Sheptulina, Anton R. Kiselev
International Journal of Molecular Sciences.2023; 24(9): 8445. CrossRef
Nonalcoholic Fatty Liver Disease Is Associated With Decreased Bone Mineral Density in Adults: A Systematic Review and Meta‐Analysis
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Journal of Bone and Mineral Research.2023; 38(8): 1092. CrossRef
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Terapevticheskii arkhiv.2022; 94(2): 216. CrossRef
Nonalcoholic fatty liver disease and osteoporosis: A potential association with therapeutic implications
Ilias D. Vachliotis, Athanasios D. Anastasilakis, Antonis Goulas, Dimitrios G. Goulis, Stergios A. Polyzos
Diabetes, Obesity and Metabolism.2022; 24(9): 1702. CrossRef
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Hepatology International.2021; 15(6): 1347. CrossRef
NAFLD Associated Comorbidity
L. B. Lazebnik, S. V. Turkina
Experimental and Clinical Gastroenterology.2021; (10): 5. CrossRef

Physical Activity in Adolescence Has a Positive Effect on Bone Mineral Density in Young Men: Jinhyun Kim, Moonki Jung, Yeon-pyo Hong, Jung-Duck Park, Byung-Sun Choi; J Prev Med Public Health. 2013;46(2):89-95. Published online March 28, 2013; DOI: https://doi.org/10.3961/jpmph.2013.46.2.89

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Abstract PDF

Objectives

Little is yet known about the determinants of bone mineral density (BMD) in young adults. Thus, in this study, we aimed to determine the factors that have an impact on BMD in young men.

Methods

Questionnaires were sent out to 111 male medical students. Information on age, socio-economic status, medical history, lifestyle, physical activity during adolescence, school club participation, current physical activity, and dietary intake were collected by the survey. Height, weight, percent body fat and muscle mass were estimated by bioelectrical impedance, and BMD was obtained using calcaneal quantitative ultrasound. Using the Poisson regression model, prevalence ratios (PRs) were used to estimate the degree of association between risk factors and osteopenia.

Results

The height and current physical activity showed a correlation to the Osteoporosis Index. Among the categorized variables, past physical activity during adolescence (p=0.002) showed a positive effect on the bone mineral content. In the multivariate model, past physical activity (≥1 time/wk) had a protective effect on osteopenia (PR, 0.37; 95% confidence interval [CI], 0.18 to 0.75) and present physical activity (1000 metabolic equivalent of task-min/wk) decreased the risk of osteopenia (PR, 0.64; 95% CI, 0.44 to 0.91).

Conclusions

Past physical activity during adolescence is as important as physical activity in the present for BMD in young men.

Summary

Citations

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Chang-Sook Han, Hyo-Kyung Kim, Suhee Kim
International Journal of Environmental Research and Public Health.2021; 18(11): 6170. CrossRef
A Review of Knowledge, Belief and Practice Regarding Osteoporosis among Adolescents and Young Adults
Chin Yi Chan, Norazlina Mohamed, Soelaiman Ima-Nirwana, Kok-Yong Chin
International Journal of Environmental Research and Public Health.2018; 15(8): 1727. CrossRef
Relationship between total and segmental bone mineral density and different domains of physical activity among children and adolescents: cross-sectional study
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Sao Paulo Medical Journal.2017; 135(5): 444. CrossRef
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Journal of Urology.2014; 191(4): 1072. CrossRef
Comparison of Musculoskeletal Characteristics and Bone Mineral Density Related Factors between Male and Female University Students
Seung-Hye Choi, Haeyoung Lee, MiJeong Park, Seungmi Park
Journal of muscle and joint health.2013; 20(3): 161. CrossRef

Zolpidem Use and Risk of Fracture in Elderly Insomnia Patients: Dong-Yoon Kang, Soyoung Park, Chul-Woo Rhee, Ye-Jee Kim, Nam-Kyong Choi, Joongyub Lee, Byung-Joo Park; J Prev Med Public Health. 2012;45(4):219-226. Published online July 31, 2012; DOI: https://doi.org/10.3961/jpmph.2012.45.4.219

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Abstract PDF

Objectives

To evaluate the risk of fractures related with zolpidem in elderly insomnia patients.

Methods

Health claims data on the entire South Korean elderly population from January 2005 to June 2006 were extracted from the Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases were defined as insomnia patients who had a fracture diagnosis. We set the hazard period of 1 day length prior to the fracture date and four control periods of the same length at 5, 10, 15, and 20 weeks prior to the fracture date. Time independent confounding factors such as age, gender, lifestyle, cognitive function level, mobility, socioeconomic status, residential environment, and comorbidity could be controlled using the casecrossover design. Time dependent confounding factors, especially co-medication of patients during the study period, were adjusted by conditional logistic regression analysis. The odds ratios and their 95% confidence intervals (CIs) were estimated for the risk of fracture related to zolpidem.

Results

One thousand five hundred and eight cases of fracture were detected in insomnia patients during the study period. In our data, the use of zolpidem increased the risk of fracture significantly (adjusted odds ratio [aOR], 1.72; 95% CI, 1.37 to 2.16). However, the association between benzodiazepine hypnotics and the risk of fracture was not statistically significant (aOR, 1.00; 95% CI, 0.83 to 1.21). Likewise, the results were not statistically significant in stratified analysis with each benzodiazepine generic subgroup.

Conclusions

Zolpidem could increase the risk of fracture in elderly insomnia patients. Therefore zolpidem should be prescribed carefully and the elderly should be provided with sufficient patient education.

Summary

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Journal of Advanced Nursing.2025; 81(1): 20. CrossRef
Sedative-hypnotics and osteoporotic fractures: A systematic review of observational studies with over six million individuals
Chong Xu, Janice Ching Nam Leung, Jiaying Shi, Dawn Hei Lum, Francisco Tsz Tsun Lai
Sleep Medicine Reviews.2024; 73: 101866. CrossRef
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Yuta Kamada, Aya Imanishi, Shih-Wei Chiu, Takuhiro Yamaguchi
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Yogendra Keche, Nitin R Gaikwad, Preetam N Wasnik, Keshao Nagpure, Md Sabah Siddiqui, Apoorva Joshi, Suryaprakash Dhaneria, Gevesh Dewangan, Jhasaketan Meher, Pranita Das
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Professionals' treatment goals for long-term benzodiazepine and Z-drugs management: a qualitative study
Pauline Van Ngoc, Melissa Ceuterick, Jean-Luc Belche, Beatrice Scholtes
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Comparative risk of fracture in community‐dwelling older adults initiating suvorexant versus Z‐drugs: Results from LIFE study
Motohiko Adomi, Megumi Maeda, Fumiko Murata, Haruhisa Fukuda
Journal of the American Geriatrics Society.2023; 71(1): 109. CrossRef
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Jae-Yong Dong, Jin-Han Ju, Young-Mo Yang
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Ryozo Yoshioka, Seiichiro Yamamoto, Eiji Nakatani, Norio Yasui-Furukori
PLOS ONE.2023; 18(4): e0284726. CrossRef
The epidemiology of new persistent hypnotic/sedative use after surgical procedures: a retrospective cohort study
D. H. Magnusson, T. I. Albertsson, F. Jonsdottir, M. I. Sigurdsson
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Journal of General Internal Medicine.2022; 37(10): 2345. CrossRef
Very long-term outcome of cognitive behavioral therapy for insomnia: one- and ten-year follow-up of a randomized controlled trial
Susanna Jernelöv, Kerstin Blom, Nils Hentati Isacsson, Pontus Bjurner, Ann Rosén, Martin Kraepelien, Erik Forsell, Viktor Kaldo
Cognitive Behaviour Therapy.2022; 51(1): 72. CrossRef
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S Justin Thomas, Swati Sakhuja, Lisandro D Colantonio, Mei Li, Paul Muntner, Kristi Reynolds, C Barrett Bowling
Sleep.2022;[Epub] CrossRef
Potentially Inappropriate Medication Use in Patients with Dementia
Kyungwon Yoon, Jung-Tae Kim, Won-Gun Kwack, Donghyun Kim, Kyung-Tae Lee, Seungwon Yang, Sangmin Lee, Yeo-Jin Choi, Eun-Kyoung Chung
International Journal of Environmental Research and Public Health.2022; 19(18): 11426. CrossRef
Z-drugs and falls in nursing home patients: data from the INCUR study
Sarah Damanti, Moreno Tresoldi, Philipe de Souto Barreto, Yves Rolland, Matteo Cesari
Aging Clinical and Experimental Research.2022; 34(12): 3145. CrossRef
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Ingo Fietze, Claudio L. A. Bassetti, David W. Mayleben, Scott Pain, Dalma Seboek Kinter, William V. McCall
Drugs & Aging.2022; 39(10): 795. CrossRef
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A.J. Pardo-Cabello, V. Manzano-Gamero, J.D. Luna-del Castillo
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A.J. Pardo-Cabello, V. Manzano-Gamero, J.D. Luna-Del Castillo
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Non-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies
Kathryn Richardson, George M Savva, Penelope J Boyd, Clare Aldus, Ian Maidment, Eduwin Pakpahan, Yoon K Loke, Antony Arthur, Nicholas Steel, Clive Ballard, Robert Howard, Chris Fox
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Christine E. Mc Carthy
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International Journal of Environmental Research and Public Health.2021; 18(11): 5706. CrossRef
Effects of anticholinergic and sedative medication use on fractures: A self‐controlled design study
Shahar Shmuel, Virginia Pate, Marc J. Pepin, Janine C. Bailey, Yvonne M. Golightly, Laura C. Hanson, Til Stürmer, Rebecca B. Naumann, Danijela Gnjidic, Jennifer L. Lund
Journal of the American Geriatrics Society.2021; 69(11): 3212. CrossRef
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Garu A, Shozo Yano, Abdullah Md Sheik, Aorigele Yu, Kenta Okuyama, Miwako Takeda, Kunie Kohno, Masayuki Yamasaki, Minoru Isomura, Toru Nabika, Atsushi Nagai
Journal of Clinical Medicine.2021; 10(15): 3225. CrossRef
Clinical consequences of abuse and misuse of hypnotics and analgesics in geriatric population
Paulina Trawka, Jakub Husejko, Kornelia Kędziora-Kornatowska
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Shinya Toriumi, Akinobu Kobayashi, Hitoshi Sueki, Munehiro Yamamoto, Yoshihiro Uesawa
Pharmaceuticals.2021; 14(12): 1299. CrossRef
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Judith Sys, Simon Van Cleynenbreugel, Mieke Deschodt, Lorenz Van der Linden, Jos Tournoy
European Journal of Clinical Pharmacology.2020; 76(3): 363. CrossRef
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Tahmina Nasrin Poly, Md. Mohaimenul Islam, Hsuan-Chia Yang, Yu-Chuan (Jack) Li
Joint Bone Spine.2020; 87(3): 241. CrossRef
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Tahmina Nasrin Poly, Md. Mohaimenul Islam, Hsuan-Chia Yang, Yu-Chuan (Jack) Li
Revue du Rhumatisme.2020; 87(3): 210. CrossRef
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Thomas C Neylan, Anne Richards, Thomas J Metzler, Leslie M Ruoff, Jonathan Varbel, Aoife O’Donovan, Melinda Sivasubramanian, Terri Motraghi, Jennifer Hlavin, Steven L Batki, Sabra S Inslicht, Kristin Samuelson, Stephen R Morairty, Thomas S Kilduff
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Flávio V. Machado, Luciana L. Louzada, Nathan E. Cross, Einstein F. Camargos, Thien Thanh Dang-Vu, Otávio T. Nóbrega
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Biological and Pharmaceutical Bulletin.2020; 43(6): 925. CrossRef
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Journal of Aging and Health.2019; 31(2): 322. CrossRef
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Journal of Contemporary Pharmacy Practice.2019; 66(3): 23. CrossRef
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Journal of Investigative Medicine.2018; 66(3): 684. CrossRef
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Drugs & Aging.2018; 35(9): 791. CrossRef
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Shanna L. Burke, Tianyan Hu, Christine E. Spadola, Tan Li, Mitra Naseh, Aaron Burgess, Tamara Cadet
Sleep Medicine.2018; 52: 168. CrossRef
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Abdolhamid Parsa, Seyyed Ali Tabaeian, Sadra Einizadeh, Mohammad Babaeian
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Viktória Ferencz, Csaba Horváth, Sándor Huszár, Katalin Bors
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The Association between Bone Density at Os Calcis and Body Composition in Healthy Children Aged 9-12 Years.: Eun Kyung Shin, Ki Suk Kim, Hee Young Kim, In Sook Lee, Hyo Jee Joung, Sung Il Cho; J Prev Med Public Health. 2004;37(1):72-79.

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Abstract PDF: OBJECTIVE
This cross-sectional study aimed to quantify the relationship between the bone mineral density at the os calcis and the body mass composition in healthy children. METHODS: The areal bone mineral density was measured at the os calcis with peripheral dual energy X-ray absorptiometry. The fat free mass, fat mass and percentage fat mass were measured using bioelectric impedance, in 237 Korean children, aged 9 to 12 years. The sexual maturity was determined by self assessment, using standardized series of the 5 Tanner stage drawings, accompanied by explanatory text. RESULTS: From multiple linear regression models, adjusted for age, sexual maturity and height, the fat free mass was found to be the best predictor of the calcaneal bone mineral density in both sexes. About 15 and 20% variabilities were found in the calcaneal bone mineral densities of the boys and girls, respectively, which can be explained by the fat free mass. After weight adjustment, the percentage fat mass was negatively associated with the calcaneal bone mineral density in both sexes. CONCLUSIONS: The findings of this study suggest that the fat free mass, among the body compositions, is the major determinant of bone mineral density at the os calcis in Korean children aged 9 to 12 years. Obesity, defined as the percentage fat mass, is assumed to have a negative effect on the calcaneal bone density in children of the same weight.; Summary

Association of Hospital Procedure Volume with Post-Transplant Survival for Allogeneic Bone Marrow Transplantation.: Choon Seon Park, Hee Kyung Moon, Hye Young Kang, Yoo Hong Min, Woo Hyun Cho; J Prev Med Public Health. 2004;37(1):26-36.

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Abstract PDF: OBJECTIVE
To examine the association between hospital procedure volume and treatment outcomes following allogeneic bone marrow transplantation (allo-BMT). METHODS: Out of 1, 050 patients who received allo-BMTs between 1998 and 2000 in 21 Korean hospitals, 752 with first allo-BMT and complete data were included in this study. Study subjects were divided into the following three groups according to cumulative hospital experience of all-BMTs during the study period: low (< 30 cases), medium (30-49) and high (> or =50 cases) volume. Patient outcome was defined as early survival at day 100 and one-year survival. Multiple logistic regression analyses were performed to examine the association between hospital experience and survival at day 100 and one year. RESULTS: When the low volume group was defined as the reference group, the adjusted relative risks (RR) of survival at day 100 for the high volume group were 2.46 (95% CI, 1.13-5.36) for all patients, 2.61 (1.04-6.57) for those with leukemia, and 2.20 (0.47-10.32) for those with aplastic anemia. For one-year survival, adjusted RR for the high volume group were 2.52 (1.40-4.51) for all patients, 1.99 (1.01-3.93) for leukemia, and 6.50 (1.57-26.80) for aplastic anemia. None of the RR for the medium volume group was statistically significant. Patient factors showing significant relationship with survival were donor-recipient relation, human leukocyte antigen matching status, time from diagnosis to transplant, and disease stage. CONCLUSION: The study results suggest that the cumulative experience of hospitals in providing allo-BMT is positively associated with patient survival.; Summary

Association of osteoarthritis and bone mineral density in women: The health and nutritional examination survey in Kuri.: Seung Soo Sheen, Soon Young Lee, Byung Hyun Min, Il Suh; Korean J Prev Med. 1997;30(4):669-685.

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Abstract PDF: Previous studies, reporting the inverse relationship between osteoarthritis and osteoporosis suggest the existence of possible pathophysiologic mechanisms between them. To examine the hypothessis that "bone mineral densities of women with osteoarthritis are significantly higher than that of women without osteoarthritis in Korea", subjects from the health and nutritional examination survey in Kuri city were sampled. Samples were selected through multi-stage sampling frame using established clusters in Kuri city. From August 18 to September 10, 1997, the survey was conducted. Among the total number of selected sample population(1,656 people), response rate was 52.4 percent(348 men and 519 women). 420 women who took BMD measurement, radiologic exam, and anthropometric exam were selected for the analysis. The analysis results are as follows. 1. General characteristics : Mean BMD was 0.493 g/cm2, mean age was 43.0, mean BMI was 23.9 kg/m(3). The number of women who experienced menopause was 106, hysterectomy was 19. There were 0 case of osteoarthritis of hip, 64 cases of osteoarthritis of knee, and 2 cases of osteoarthritis of hand. 2. Univariate analysis results : Mean BMD of women with the osteoarthritis of knee was significantly lower than that of women without the osteoarthritis of knee(0.4296 vs. 0.5057 g/cm2). But, there were to few cases of osteoarthritis of hip and hand, so comparative studies of BMD in ostearthritis of hip and hand could not be conducted. There were significant differences of BMD among pre-menopause group(0.5204), post-menopause group(0.4206), and hysterectomy group(0.4881). Additionally, there were significant differences of BMD among diabetes group(0.4297), impaired glucose tolerance group(0.4874), and normal group(0.5057). Furthermore, age, parity, BMI, bioimpedance wer significantly related with BMD. 3. Multivariate analysis results : To examine the relationship between osteoarthritis and BMD while controlling the other variables' effects which were significant in the univariate analyses, multiple linear regression analysis was done. But, it was found that osteoarthritis of knee was not a significant variable to BMD anymore. While age and menopause had significant negative relationship with BMD. Diabetes, parity, BMI, and bioimpedance did not have significant relationships with BMD. After stratification of subjects according to menopause, multiple linear regression analyses were done to each strata. Consequently, age in post-menopause group, age and osteoarthritis of knee in hysterectomy group showed significant negative relationship with BMD. The results did not support the many results of other previous studies done with white men and women. Further studies of biological plausibility to Korean women are recommended. Also it is suggested that longitudinal study to verify the relationship between osteoarthritis and BMD will be valuable.; Summary

Contents of Lead, Cadmium and Zinc in Bone, Muscle and Fin of Carassius carassius from Middle Stream of Nakdong River, Korea.: Doohie Kim, Yong Gu Kim, Bong Ki Jang; Korean J Prev Med. 1988;21(2):307-319.

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Abstract PDF: In order to determine the contents of lead, cadmium and zinc, the tissues of the crussian carp, Carassius carassius, collected from the middle streams of the Nakdong river were examined. During the dry season from 8 to 15, March, 1987, six loci were selected to sample the fish and river water; five of them were the midstreams of the Nakdong river i.e., the vicinities of the Andong dam, the Nakdong bridge, the Waegwan bridge, Gangjung and Gaepori, the other one was the Kumho river around the Paldal bridge(see Fig.1). The microanalyses of lead and cadmium contents were undertaken by the atomic absorption spectrophotometer(Model IL-551) connected with CTF-IL 655, while that of zinc by the flame method with IL-551 only. The contents of lead and cadmium in water sampled from Gaepori distant from about 30km downward from the junction with the Kumho river were about 1.5 times higher than those from Gangjung distant about 0.5km upward from the junction, and the content of zinc from Gaepori was slightly higher than that from Gangjung. However, the contents of lead and cadmium in water sampled from Gaepori were three fifth of those from the vicinity of Paldal bridge far about 2km upperward from the junction. In the other words, the contents of lead and cadmium in the samples from the vicinity of the Paldal bridge were about 2.5 to 3 times higher than those from the Gangjung and 5 times higher than those from the Andong dam. The contents of the heavy metals in the tissues of Carassius carassius were relatively consistent to those of the aquatic environments were the fish were collected, with higher contents in the tissues of the crussian carp collected from the vicinity of Gaepori and the Paldal bridge which were so much polluted than in those from other loci in upper stream from the junction. And the contents of lead and cadmium in tissues were positively correlated with the age of the fish, however, that zinc was not. The contents of lead in bone of crussian carp from the vicinity of the Paldal bridge in the group of 0-1 year old fish were similar to those of 4-5 years old fish from Gaepori, and higher than those of 3-4 years old fish collected from the upper stream of the junction. It is likely that fishing from Gaepori and the paldal bridge is not recommended, and all the industrial producers have to pay intensive attention to the water pollution due to the sewage disposal.; Summary

English Abstracts

Prevalence and Associated Factors of Osteoporosis among Postmenopausal Women in Chuncheon: Hallym Aging Study(HAS).: Soong Nang Jang, Young Ho Choi, Moon Gi Choi, Sung Hyun Kang, Jin Young Jeong, Yong Jun Choi, Dong Hyun Kim; J Prev Med Public Health. 2006;39(5):389-396.

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Abstract PDF: OBJECTIVES
A community-based, cross-sectional survey was conducted to determine theprevalence of osteoporosis and to evaluate the effects of body composition, health behaviors and reproductive history on bone density in postmenopausal women. METHODS: The study subjects were 362 postmenopausal women, aged 45 years old or over, who were invited to the hospital. Information on their socio-demographic characteristics and the potential risk factors such as their past medical history, smoking, alcohol intake, exercise, diet and menstrual/reproductive histories were collected by trained interviewers. Weight, height, the body mass index (kg/m2), and body composition variables were measured. Bone mineral density of the lumbar spine was measured by dual energy X-ray absorptiometry (DXA). RESULTS: The prevalence of osteoporosis was 30.6% in the 45~64 years old women, 52.5% in the elderly women aged 65~74, and 68.7% in the women aged 75 years or over. After adjustment for the effect of potential covariates, those women in the highest 25% (4th quartile) of the lean body mass are less likely to have osteoporosis (aOR=0.31, 95% CI=0.12-0.76), compared with the lowest quartile group. More parity also had significantly detrimental effects on osteoporosis. CONCLUSIONS: These findings suggest that the prevalence of osteoporosis in postmenopausal women increased with age from 46.3% of those aged 45-64 to 68.7% fo those aged 75 and over. Lean body mass and parity appeared significant contributor to bone mineral density in postmenopausal women in this population.; Summary

Distribution of Calcaneal Bone Density According to the Mechanical Strain of Exercise and Calcium Intake in Premenarcheal Girls.: Eun Kyung Shin, Ki Suk Kim, Hee Young Kim, In Sook Lee, Hyo Jee Joung, Sung Il Cho; J Prev Med Public Health. 2005;38(3):291-297.

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Abstract PDF: OBJECTIVE
The effects of exercise on bone density have been found to be inconsistent in previous studies. We conducted a cross-sectional study in premenarcheal girls to test two hypotheses to explain these inconsistencies. Firstly, "the intensity of mechanical strain, in terms of the ground reaction force (GRF), has more important effects on the bone mass at a weight-bearing site", and secondly, "calcium intake modifies the bone response to exercise". METHODS: The areal bone mineral density was measured at the Os calcis, using peripheral dual energy X-ray absorptiometry, in 91 premenarcheal girls aged between 9 and 12 years. The intensity of mechanical strain of exercise was assessed by a self-report questionnaire and scored by the GRF as multiples of body weight, irrespective of the frequency and duration of exercise. The energy and calcium intake were calculated from the 24-hour dietary recall. An analysis of covariance (ANCOVA) was used to determine the interaction and main effects of exercise and calcium on the bone density, after adjusting for age, weight, height and energy intake. RESULTS: The difference in the bone density between moderate and low impact exercise was more pronounced in the high than low calcium intake group. The bone density for moderate impact exercise and high calcium intake was significantly higher than that for low impact exercise (p=0.046) and low calcium intake, after adjusting for age, weight, height and energy intake. CONCLUSIONS: Our study suggests that the bone density at a weight-bearing site is positively related to the intensity of mechanical loading exercise, and the calcium intake may modify the bone response to exercise at the loaded site in premenarcheal girls.; Summary

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