Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Search

Page Path
HOME > Search
2 "Albumin"
Filter
Filter
Article category
Keywords
Publication year
Authors
Funded articles
Original Articles
Differential Association of Vitamin D Deficiency With Albuminuria by Sex in the Korean General Population: A Cross-sectional Study of the Korea National Health and Nutrition Examination Survey 2011-2012
Yongwoo Jeon, Jaeyong Shin, Jong Hyun Jhee, Youngdae Cho, Eun-Cheol Park
J Prev Med Public Health. 2018;51(2):92-99.   Published online February 6, 2018
DOI: https://doi.org/10.3961/jpmph.17.005
  • 7,217 View
  • 186 Download
  • 2 Crossref
AbstractAbstract PDFSupplementary Material
Objectives
Albuminuria has emerged as a biomarker for several medical conditions, and vitamin D has received attention due to its associations with various disorders. We evaluated the association between low serum vitamin D levels and prevalent albuminuria by sex in the Korean general population. Methods: We analyzed 9823 participants (4401 males, 5422 females) from the Korea National Health and Nutrition Examination Survey 2011-2012 (KNHANES V-2), and categorized them as having a normal range of vitamin D levels, vitamin D insufficiency, or vitamin D deficiency. A multivariable logistic regression model was used to compare the risk of albuminuria across these groups. Stratified analyses were conducted by smoking status, obesity, and renal function. Results: Albuminuria was found in 325 of the 4401 male participants (7.4%) and in 455 of the 5422 female participants (8.4%). Among the males, vitamin D deficiency was associated with an odds ratio (OR) for albuminuria of 1.78 (95% confidence interval [CI], 1.07 to 2.97, p<0.05). However, such an association was not found in females. The association was stronger in male current smokers (OR, 3.54; 95% CI, 1.47 to 8.50; p=0.005). Conclusions: The findings of this study suggest that sex differences exist in the association between serum vitamin D deficiency and albuminuria. Additionally, we observed that the association was stronger in current smokers than in the overall male population, but was not seen in non-smokers. Therefore, different approaches by sex and smoking status might be needed when considering using vitamin D as a biomarker for renal function.
Summary

Citations

Citations to this article as recorded by  
  • Association between environmental chemical exposure and albumin-to-creatinine ratio is modified by hypertension status in women of reproductive age
    Gowoon Lee, Sunmi Kim, Inae Lee, Habyeong Kang, Jung Pyo Lee, Jeonghwan Lee, Young Wook Choi, Jeongim Park, Gyuyeon Choi, Kyungho Choi
    Environmental Research.2023; 231: 116234.     CrossRef
  • Long-term vitamin D deficiency promotes renal fibrosis and functional impairment in middle-aged male mice
    Zhi-Hui Zhang, Biao Luo, Shen Xu, Zhi-Cheng Zhang, Wei-Yang Xing, Yuan-Hua Chen, Cheng Zhang, Hua Wang, Dong-Dong Xie, De-Xiang Xu
    British Journal of Nutrition.2021; 125(8): 841.     CrossRef
The Association Between Serum Albumin Levels and Metabolic Syndrome in a Rural Population of Korea
Hye Min Cho, Hyeon Chang Kim, Ju-Mi Lee, Sun Min Oh, Dong Phil Choi, Il Suh
J Prev Med Public Health. 2012;45(2):98-104.   Published online March 31, 2012
DOI: https://doi.org/10.3961/jpmph.2012.45.2.98
  • 11,602 View
  • 107 Download
  • 22 Crossref
AbstractAbstract PDF
Objectives

A positive association between serum albumin levels and metabolic syndrome has been reported in observation studies, but it has not been established in the Korean population. The purpose of this study was to evaluate the association between serum albumin levels and the presence of metabolic syndrome among a sample of apparently healthy Korean adults.

Methods

This cross-sectional study analyzed data of 3189 community-dwelling people (1189 men and 2000 women) who were aged 40 to 87 years and were living in a rural area in Korea. Serum albumin levels were classified into quartile groups for each sex. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III guidelines with an adjusted waist circumference cut-off value (≥90 cm for men and ≥85 cm for women). An independent association between serum albumin levels and metabolic syndrome was assessed by multiple logistic regression analysis.

Results

Higher serum albumin levels were associated with increased prevalence of metabolic syndrome. The odds ratio (95% confidence interval) of the prevalence of metabolic syndrome for the highest versus the lowest serum albumin quartiles was 2.81 (1.91 to 4.14) in men and 1.96 (1.52 to 2.52) in women, after adjusting for age, smoking status, alcohol consumption, and physical activity. When each metabolic abnormality was analyzed separately, higher serum albumin levels were significantly associated with hypertriglyceridemia and hyperglycemia in both sexes, and with abdominal obesity in men.

Conclusions

These results suggest that higher serum albumin levels are positively associated with an increased risk of metabolic syndrome in Korean adults.

Summary

Citations

Citations to this article as recorded by  
  • Prevalence of Non-alcoholic Fatty Liver Disease Detected by Computed Tomography in the General Population Compared with Ultrasonography
    Yuki Ito, Kentaro Yoshioka, Kazuhiko Hayashi, Yuko Shimizu, Ryo Fujimoto, Ryosuke Yamane, Michiyo Yoshizaki, Go Kajikawa, Taro Mizutani, Hidemi Goto
    Internal Medicine.2024; 63(2): 159.     CrossRef
  • Joint modeling of association networks and longitudinal biomarkers: An application to childhood obesity
    Andrea Cremaschi, Maria De Iorio, Narasimhan Kothandaraman, Fabian Yap, Mya Thway Tint, Johan Eriksson
    Statistics in Medicine.2024; 43(6): 1135.     CrossRef
  • Serum Albumin as Prognostic Marker for Older Adults in Hospital and Community Settings
    Nur Riviati, Legiran, Taufik Indrajaya, Irsan Saleh, Zulkhair Ali, Irfannuddin, Probosuseno, Bima Indra
    Gerontology and Geriatric Medicine.2024;[Epub]     CrossRef
  • C-reactive protein to albumin ratio and risk of incident metabolic syndrome in community-dwelling adults: longitudinal findings over a 12-year follow-up period
    Taekyeong Lim, Yong-Jae Lee
    Endocrine.2024; 86(1): 156.     CrossRef
  • Assessment of Subnutritional Indices and Associated Risk Factors of Malnutrition Among Older Adults
    Idongesit KokoAbasi Isong, Kingsley John Emmanuel, Glory Okoi Abam, Iya Eze Bassey, Mercy Etim Jackson, Unwana Paul Obadare, Ifure Uwem KokoAbasi
    Gerontology and Geriatric Medicine.2024;[Epub]     CrossRef
  • Metabolic syndrome: comparison of three diet-induced experimental models
    Alexandra Petrova, Rumyana Simeonova, Christina Voycheva, Yonko Savov, Lyubomir Marinov, Vessela Balabanova, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova
    Pharmacia.2023; 70(4): 1539.     CrossRef
  • The clinical role of serum albumin in Organophospate poisoning
    Eul Noh, Jeong Mi Moon, Byeong Jo Chun, Yong Soo Cho, SeokJin Ryu, Dongki Kim
    Basic & Clinical Pharmacology & Toxicology.2021; 128(4): 605.     CrossRef
  • Anthropometry and Liver Function Parameters in Individuals with Metabolic Syndrome
    Adebowale Emmanuel Aladejana, Elizabeth Bosede Aladejana
    Journal of Pharmacy and Nutrition Sciences .2021; 11: 151.     CrossRef
  • U-shaped association between serum albumin and development of chronic kidney disease in general hypertensive patients
    Chongfei Jiang, Binyan Wang, Youbao Li, Liling Xie, Xianglin Zhang, Jiancheng Wang, Yaren Yu, Yun Song, Min Liang, Guobao Wang, Jianping Li, Yan Zhang, Lishun Liu, Chengzhang Liu, Genfu Tang, Yong Huo, Xiping Xu, Xianhui Qin
    Clinical Nutrition.2020; 39(1): 258.     CrossRef
  • Serum albumin, cardiometabolic and other adverse outcomes: systematic review and meta-analyses of 48 published observational cohort studies involving 1,492,237 participants
    Samuel Seidu, Setor K. Kunutsor, Kamlesh Khunti
    Scandinavian Cardiovascular Journal.2020; 54(5): 280.     CrossRef
  • Impact of Social Jetlag and Circadian Patterns on Patients with Metabolic and Nocturnal Eating Syndromes
    Yasmin Atwa Mohamed Ali, Naglaa Elsayed Abbas, Amany Abdel Hamid Mousa, Azza Abdelbaky, Ahmed Salem Bahammam, Nevin Fayez Wanis Zaki
    Chronobiology in Medicine.2020; 2(4): 175.     CrossRef
  • Age-differential association between serum uric acid and incident hypertension
    Seung Won Lee, Hyeon Chang Kim, Chungmo Nam, Hae-Young Lee, Song Vogue Ahn, Young A Oh, Il Suh
    Hypertension Research.2019; 42(3): 428.     CrossRef
  • Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study
    Sarah J. Schrauben, Christopher Jepson, Jesse Y. Hsu, F. Perry Wilson, Xiaoming Zhang, James P. Lash, Bruce M. Robinson, Raymond R. Townsend, Jing Chen, Leon Fogelfeld, Patricia Kao, J. Richard Landis, Daniel J. Rader, L. Lee Hamm, Amanda H. Anderson, Har
    BMC Nephrology.2019;[Epub]     CrossRef
  • Hookworm infection aggravates metabolic disorder in obesity
    Vivian Jordania da Silva, Sílvia Regina Costa Dias, William Pereira Alves, Luis Fernando Viana Furtado, Luciana Ribeiro Serafim, Thayse Batista Moreira, Pedro Henrique Nascimento de Aguiar, Ana Maria Caetano de Faria, Élida Mara Leite Rabelo
    Molecular and Biochemical Parasitology.2019; 232: 111200.     CrossRef
  • Baseline level and change in serum albumin concentration and the risk of incident type 2 diabetes
    You-Cheol Hwang, Ji Eun Jun, Won-Jung Hong, Sang-Man Jin, Ji Cheol Bae, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
    Journal of Diabetes and its Complications.2018; 32(1): 61.     CrossRef
  • A comparative research on obesity hypertension by the comparisons and associations between waist circumference, body mass index with systolic and diastolic blood pressure, and the clinical laboratory data between four special Chinese adult groups
    Ou Wu, Jian-hang Leng, Fen-fang Yang, Hai-ming Yang, Hu Zhang, Zeng-fang Li, Xing-yu Zhang, Cheng-Da Yuan, Jia-jia Li, Qi Pan, Wei Liu, Yan-jun Ren, Bing Liu, Qing-min Liu, Cheng-jian Cao
    Clinical and Experimental Hypertension.2018; 40(1): 16.     CrossRef
  • The Effect of Nutrition and Sleep Habits on Predisposition for Metabolic Syndrome in Greek Children
    Maria Efthymia Katsa, Anastasios Ioannidis, Sofia Zyga, Maria Tsironi, Paraskevas Koutsovitis, Stylianos Chatzipanagiotou, Demosthenes Panagiotakos, Athanasios Sachlas, Petros Kolovos, Kleopatra Routsi, Anna Maria Pistikou, Dafni Eleni Kougioumtzi Dimolia
    Journal of Pediatric Nursing.2018; 40: e2.     CrossRef
  • Metabolic syndrome and hip fracture: Epidemiology and perioperative outcomes
    Kyle H. Cichos, Jessica L. Churchill, Sierra G. Phillips, Shawna L. Watson, Gerald McGwin, Elie S. Ghanem, Brent A. Ponce
    Injury.2018; 49(11): 2036.     CrossRef
  • Increase in serum albumin concentration is associated with prediabetes development and progression to overt diabetes independently of metabolic syndrome
    Ji Eun Jun, Seung-Eun Lee, You-Bin Lee, Jae Hwan Jee, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim, Vince Grolmusz
    PLOS ONE.2017; 12(4): e0176209.     CrossRef
  • Serum albumin concentration and incident type 2 diabetes risk: new findings from a population-based cohort study
    Setor K. Kunutsor, Hassan Khan, Jari A. Laukkanen
    Diabetologia.2015; 58(5): 961.     CrossRef
  • Association between Serum 25-Hydroxyvitamin D Level and Insulin Resistance in a Rural Population
    Bo Mi Song, Hyeon Chang Kim, Dong Phil Choi, Sun Min Oh, Il Suh
    Yonsei Medical Journal.2014; 55(4): 1036.     CrossRef
  • Serum Albumin Levels: A Simple Answer to a Complex Problem? Are We on the Right Track of Assessing Metabolic Syndrome?
    Sohee Kim, Shinae Kang
    Endocrinology and Metabolism.2013; 28(1): 17.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health
TOP