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- Effects of the Exposure to Polycyclic Aromatic Hydrocarbons or Toluene on Thiobarbituric Acid Reactive Substance Level in Elementary School Children and the Elderly in a Rural Area.
- Dae Seon Kim, Chul Ho Lee, Sang Yong Eom, Tackshin Kang, Yong Dae Kim, Heon Kim
- J Prev Med Public Health. 2008;41(1):61-67.
- DOI: https://doi.org/10.3961/jpmph.2008.41.1.61
- 4,909 View
- 45 Download
- 6 Crossref
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Abstract
PDF - OBJECTIVES
Polycyclic aromatic hydrocarbons (PAH) and toluene have been reported to induce reactive oxygen species and oxidative stress. This study was performed to investigate the effects of low level exposure to PAHs or toluene on the lipid peroxidation level in elementary school children and the elderly in a rural area. METHODS: Forty seven elementary school children and 40 elderly people who were living in a rural area and not occupationally exposed to PAH or toluene were the subjects of this study. Information about active or passive smoking and diet was obtained using a self-administered questionnaire. The urinary 1-hydroxypyrene (1-OHP), 2-naphthol, hippuric acid and thiobarbituric acid reactive substance (TBARS) concentrations were measured, and these values were corrected with the urinary creatinine concentration. RESULTS: In school children, the geometric means of the urinary 1-OHP, 2-naphthol, hippuric acid and TBARS levels were 0.02 ymol/mol creatinine, 0.47 micron mol/mol creatinine, 0.14 g/g creatinine and 0.95 micron mol/g creatinine, respectively. Those values for the elderly were 0.07 micron mol/mol creatinine, 1.87 micron mol/mol creatinine, 0.11 g/g creatinine and 1.18 micron mol/g creatinine, respectively. The mean levels of urinary 1-OHP, 2-naphthol and TBARS were significantly higher in the elderly subjects than in the children. The urinary TBARS level was not correlated with the urinary 1-OHP, 2-naphthol and hippuric acid, but they were correlated with the age of the subjects. CONCLSIONS: These results suggest that low level inhalation exposure to PAH or toluene does not markedly increase lipid peroxidation, and age is a significant determinant of lipid peroxidation. -
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- Association between oil spill clean-up work and thyroid cancer: Nine years of follow-up after the Hebei Spirit oil spill accident
Yun-Hee Choi, Lita Kim, Da-An Huh, Kyong Whan Moon, Min-Sung Kang, Yong-Jin Lee
Marine Pollution Bulletin.2024; 199: 116041. CrossRef - Sex-Specific Effects of Combined Heavy Metal Exposure on Blood Pressure: A Bayesian Kernel Machine Regression Analysis
In-Gwon Kim, Seonmi Hong, Sojeong Yim, Jang-Hun Jeong, Kyunghi Choi, Ju-Hee Lee, Young-Seoub Hong, Sang-Yong Eom, Heon Kim, Yong-Dae Kim
Atmosphere.2024; 15(10): 1157. CrossRef - Urinary oxidative stress biomarkers among local residents measured 6 years after the Hebei Spirit oil spill
Jung-Ah Kim, Su Ryeon Noh, Hae-Kwan Cheong, Mina Ha, Sang-Yong Eom, Heon Kim, Myung-Sook Park, Yeonhee Chu, Seung-Hwa Lee, Kyungho Choi
Science of The Total Environment.2017; 580: 946. CrossRef - Concentration of volatile organic compounds(VOCs) in ambient air and level of residents in industrial area
Kyungsook Woo, Heejin Park, Tackshin Kang, Geunbae Kim, Junmin Jeon, Bongki Jang, Jongwha Lee, Busoon Son
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(1): 104. CrossRef - Health Effects of Exposure to Oil-contaminated Water Using Biological Markers: Focusing on G Village near the Area of Daecheon Beach
Doo-Nam Oh, Kyung-Choon Lim, Seungmi Park
Journal of Korean Biological Nursing Science.2013; 15(2): 74. CrossRef - Urinary metabolites before and after cleanup and subjective symptoms in volunteer participants in cleanup of the Hebei Spirit oil spill
Mina Ha, Hojang Kwon, Hae-Kwan Cheong, Sinye Lim, Seung Jin Yoo, Eun-Jung Kim, Seok Gun Park, Jeongae Lee, Bong Chul Chung
Science of The Total Environment.2012; 429: 167. CrossRef
Original Article- Urinary 1-Hydroxypyrene and 2-Naphthol as a Biological Exposure Markers of Total Suspended Particulate in the General Population .
- Jong Won Kang, Soo Hun Cho, Heon Kim, Daehee Kang, Chul Ho Lee
- Korean J Prev Med. 2000;33(3):306-312.
- 2,658 View
- 63 Download
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Abstract
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- BACKGROUND
Polycyclic aromatic hydrocarbons (PAH) are well known environmental pollutants. The measurement of PAH in ambient air is not commonly used, because it is quite difficult to perform and is unreliable. Using biomarkers of PAH can be an alternative approach to this problem. The PAH in ambient air is absorbed in particulate matter. Total suspended particulate(TSP) or particulate matter of less than 10 micrometer in diameter (PM10) can be easily measured. Therefore, TSP or PM10 can be used as a surrogate measurements of ambient air PAH. CONCLUSIONS: We investigated whether the urinary concentration of two biomarkers of PAH, 1-hydroxypyrene (1-OHP) and 2-naphthol, could reflect the total suspended particulate in the general population. METHODS: In order to exclude the effects of occupational exposure and smoking, first grade middle school students were included in this study. Four middle schools within a one kilometer boundary of ambient air monitoring stations were selected. Total suspended particulate was regarded as the marker of airborne PAH. Diet and smoking data were collected by self administered questionnaires, and spot urine samples were collected. Urinary 1-OHP and 2-naphthol were analyzed by high performance liquid chromatography. RESULTS: The correlation between urinary 1-OHP, 2-naphthol and passive smoking was not statistically significant. The correlation between urinary 1-OHP and TSP indices was not statistically significant. The correlations between urinary 2-naphthol and TSP of two lag days, one lag day, and zero lag days were statistically significant. The statistical significance of two lag days was the strongest (p=0.001), one lag day was the next (p=0.0275), and zero lag days was the weakest (p=0.0349). CONCLUSION: Our results imply that the urinary concentration of 2-naphthol can be applied as a PAH exposure marker for the general population with low PAH exposure. -
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