- Association Between Parity and Low Bone Density Among Postmenopausal Korean Women
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Eunsun Seo, Yongrong Lee, Hyeon Chang Kim
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J Prev Med Public Health. 2021;54(4):284-292. Published online June 24, 2021
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DOI: https://doi.org/10.3961/jpmph.21.162
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 Abstract
Summary
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- Objectives
Low bone density (LBD) in the postmenopausal period has long been a pervasive public health concern; however, the association between parity and LBD has yet to be fully elucidated. Thus, we investigated the association between parity and LBD in postmenopausal Korean women.
Methods
This study used baseline data from 1287 Korean postmenopausal women aged 40 years or older enrolled in the Cardiovascular and Metabolic Diseases Etiology Research Center community-based cohort study conducted in Korea from 2013 to 2017. The main exposure was parity (nullipara, 1, 2, 3+). The main outcome was LBD, including osteopenia and osteoporosis, based on bone mineral density measured using quantitative computed tomography of the lumbar spine (L1-2).
Results
The mean age of participants was 57.1 years, and the median parity was 2. Of the 1287 participants, 594 (46.2%) had osteopenia and 147 (11.4%) had osteoporosis. No significant difference in the prevalence of LBD was found between nullipara and parous women, whereas higher parity was associated with a higher risk of LBD among parous women; the adjusted odds ratio (95% confidence interval) for the presence of LBD was 1.40 (0.97 to 2.02) for a parity of 2 and 1.95 (1.23 to 3.09) for a parity of 3 relative to a parity of 1.
Conclusions
Women who have given birth multiple times may be at greater risk of bone loss after menopause; therefore, they should be a major target population for osteoporosis prevention.
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Summary
Korean summary
40-64세 폐경 여성 1287명을 대상으로 과거 출산 횟수와 골밀도의 관련성을 평가하였다. 정량적 전산화 단층촬영(QCT)으로 L1-L2의 평균 골무기질밀도(bone mineral density, BMD)를 측정하였으며, 그 값이 120mg/cm3 미만이면 골밀도 감소가 있는 것으로 정의하였다. 나이, 비만도, 폐경후기간, 직업, 소득, 교육, 결혼, 흡연, 음주, 신체활동, 질병력 등을 보정하여도, 출산횟수가 많을수록 평균 골밀도는 낮고 골밀도감소의 빈도는 높은 경향이 관찰되었다.
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Citations
Citations to this article as recorded by  - The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Meno
David A. Hart
International Journal of Molecular Sciences.2024; 25(7): 3866. CrossRef - Genetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study
Yuan Li, Jinquan Lai, Wenbo Wu, Shuyi Ling, Yuqing Dai, Zhisheng Zhong, Xiaodong Chen, Yuehui Zheng
Calcified Tissue International.2024; 115(1): 41. CrossRef - Bridging the Gap: Pregnancy—And Lactation—Associated Osteoporosis
Mara Carsote, Maria Roxana Turturea, Ana Valea, Cristian Buescu, Claudiu Nistor, Ionut Florin Turturea
Diagnostics.2023; 13(9): 1615. CrossRef - Associations of breastfeeding duration and the total number of children breastfed with self-reported osteoarthritis in Korea women 50 years and older: a cross-sectional study
Dajeong Ham, Sanghyuk Bae
Epidemiology and Health.2023; 45: e2023044. CrossRef - Association between parity and bone mineral density in postmenopausal women
Yimei Yang, Shanshan Wang, Hui Cong
BMC Women's Health.2022;[Epub] CrossRef
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