Skip Navigation
Skip to contents

JPMPH : Journal of Preventive Medicine and Public Health

OPEN ACCESS
SEARCH
Search

Author index

Page Path
HOME > Browse Articles > Author index
Search
Yong Pil Lee 1 Article
Assessment of Di (2-ethylhexyl) Phthalate Exposure by Urinary Metabolites as a Function of Sampling Time.
Moon Seo Park, Yun Jung Yang, Yeon Pyo Hong, Sang Yon Kim, Yong Pil Lee
J Prev Med Public Health. 2010;43(4):301-308.
DOI: https://doi.org/10.3961/jpmph.2010.43.4.301
  • 5,345 View
  • 97 Download
  • 12 Crossref
AbstractAbstract PDF
OBJECTIVES
In most DEHP exposure assessment studies, single spot urine sample was used. It could not compare the exposure level among studies. Therefore, we are going to represent the necessity of selection of proper sampling time of spot urine for assessing the environmental DEHP exposure, and the association urinary DEHP metabolites with steroid hormones. METHODS: We collected urine and plasma from 25 men. The urine sampling times were at the end of the shift (post-shift) and the next morning before the beginning of the shift (pre-shift). Three metabolites of DEHP {mono(2-ethylhexyl) phthalate [MEHP], mono-(2-ethyl-5-hydroxyhexyl)phthalate [MEHHP], and mono(2-ethyl-5-oxohexyl)phthalate [MEOHP]} in urine were analyzed by HPLC/MS/MS. Plasma luteinzing hormone, follicle stimulating hormone, testosterone, and 17beta-estradiol were measured at pre-shift using a ELISA kit. A log-transformed creatinine-adjusted urinary MEHP, MEHHP, and MEOHP concentration were compared between the post- and pre-shift. The Pearson's correlation was calculated to assess the relationships between log-transformed urinary MEHP concentrations in pre-shift urine and hormone levels. RESULTS: The three urinary metabolite concentrations at post-shift were significantly higher than the concentrations in the pre-shift (p<0.0001). The plasma hormones were not significantly correlated with log-transformed creatinine - adjusted DEHP metabolites. CONCLUSIONS: To assess the environmental DEHP exposure, it is necessary to select the urine sampling time according to the study object. There were no correlation between the concentration of urinary DEHP metabolites and serum hormone levels.
Summary

Citations

Citations to this article as recorded by  
  • A Study of the Relationship between Phthalate Exposure and the Occurrence of Adult Asthma in Taiwan
    Tsai-Hui Duh, Chih-Jen Yang, Chien-Hung Lee, Ying-Chin Ko
    Molecules.2023; 28(13): 5230.     CrossRef
  • Effect of the phthalates exposure on sex steroid hormones in the US population
    Yuan-duo Zhu, Xu Han, Xin-qi Wang, Tan-xi Ge, Hang Liu, Lin Fan, Li Li, Li-qin Su, Xian-liang Wang
    Ecotoxicology and Environmental Safety.2022; 231: 113203.     CrossRef
  • The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats
    Sang-Yon Kim, Yeon-Pyo Hong, Yun-Jung Yang
    Development & Reproduction.2021; 25(4): 293.     CrossRef
  • Biomonitoring of occupational exposure to phthalates: A systematic review
    Nadine Fréry, Tiina Santonen, Simo P. Porras, Aleksandra Fucic, Veruscka Leso, Radia Bousoumah, Radu Corneliu Duca, Mounia El Yamani, Marike Kolossa-Gehring, Sophie Ndaw, Susana Viegas, Ivo Iavicoli
    International Journal of Hygiene and Environmental Health.2020; 229: 113548.     CrossRef
  • Phthalate exposure and male reproductive outcomes: A systematic review of the human epidemiological evidence
    Elizabeth G. Radke, Joseph M. Braun, John D. Meeker, Glinda S. Cooper
    Environment International.2018; 121: 764.     CrossRef
  • Impact of Di-2-Ethylhexyl Phthalate Metabolites on Male Reproductive Function: a Systematic Review of Human Evidence
    Birgit Bjerre Høyer, Virissa Lenters, Aleksander Giwercman, Bo A.G. Jönsson, Gunnar Toft, Karin S. Hougaard, Jens Peter E. Bonde, Ina Olmer Specht
    Current Environmental Health Reports.2018; 5(1): 20.     CrossRef
  • Feminization of the fat distribution pattern of children and adolescents in a recent German population
    Christiane Scheffler, Melanie Dammhahn
    American Journal of Human Biology.2017;[Epub]     CrossRef
  • Serum Phthalate Levels and Time to Pregnancy in Couples from Greenland, Poland and Ukraine
    Ina Olmer Specht, Jens Peter Bonde, Gunnar Toft, Christian H. Lindh, Bo A. G. Jönsson, Kristian T. Jørgensen, Jodi Pawluski
    PLOS ONE.2015; 10(3): e0120070.     CrossRef
  • Associations between serum phthalates and biomarkers of reproductive function in 589 adult men
    Ina Olmer Specht, Gunnar Toft, Karin S. Hougaard, Christian H. Lindh, Virissa Lenters, Bo A.G. Jönsson, Dick Heederik, Aleksander Giwercman, Jens Peter E. Bonde
    Environment International.2014; 66: 146.     CrossRef
  • Di(2‐ethylhexyl) phthalate metabolites as markers for blood transfusion in doping control: Intra‐individual variability of urinary concentrations
    E. Solymos, S. Guddat, H. Geyer, A. Thomas, M. Thevis, W. Schänzer
    Drug Testing and Analysis.2011; 3(11-12): 892.     CrossRef
  • Rapid determination of urinary di(2-ethylhexyl) phthalate metabolites based on liquid chromatography/tandem mass spectrometry as a marker for blood transfusion in sports drug testing
    E. Solymos, S. Guddat, H. Geyer, U. Flenker, A. Thomas, J. Segura, R. Ventura, P. Platen, M. Schulte-Mattler, M. Thevis, W. Schänzer
    Analytical and Bioanalytical Chemistry.2011; 401(2): 517.     CrossRef
  • An estimate of phthalate exposure among term pregnant women living in Bucheon: The pilot study
    Tae-Hee Kim, Yeon-pyo Hong, Hae-Hyeog Lee, Soo-Ho Chung, Yun-jung Yang, Sang-yon Kim, Young Lim Kho, Jun-Mo Kim
    Korean Journal of Obstetrics.2011; 54(3): 140.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health