- The Effect of Prenatal Cadmium Exposure on Attention-deficit/Hyperactivity Disorder in 6-Year-old Children in Korea
-
Woosung Kim, Yoonyoung Jang, Youn-Hee Lim, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim, Yun-Chul Hong
-
J Prev Med Public Health. 2020;53(1):29-36. Published online November 14, 2019
-
DOI: https://doi.org/10.3961/jpmph.19.175
-
-
6,621
View
-
180
Download
-
18
Crossref
-
Abstract
Summary
PDF Supplementary Material
- Objectives
Prenatal cadmium (Cd) exposure may be associated with attention-deficit/hyperactivity disorder (ADHD) in children. Therefore, the objective of this study was to examine the relationship between Cd exposure during gestation and ADHD at 6 years of age.
Methods As part of an ongoing cohort study (the Environment and Development of Children study), 479 mother-child pairs from Seoul, Korea were included for analysis between 2008 and 2011. The whole blood concentration of Cd was analyzed using atomic absorption spectrophotometry. The parents were surveyed about ADHD behaviors in their children at age 6. Multivariable linear regression models were used to investigate the relationship between prenatal exposure to Cd and ADHD at 6 years of age.
Results Increased prenatal Cd concentrations were associated with increased scores for ADHD for girls, but not for boys, at age 6. A 2-fold increase in the prenatal Cd level was significantly associated with a 22.3% (95% confidence interval, 11.6 to 34.1) increase in ADHD in girls at 6 years of age, as indicated by the linear regression model.
Conclusions Our results identified significant associations between prenatal Cd exposure and ADHD scores in 6-year-old girls.
-
Summary
Korean summary
이 연구의 목적은 산모와 아이의 코호트 추적조사 상 임신 중 혈중의 중금속 카드뮴 농도가 6세 아이의 주의력결핍 과잉행동 장애(ADHD)와 연관이 있는지를 확인하는 것이다. 자료원으로는 환경부와 식약처 지원 어린이 코호트인 환경노출과 어린이 성장 코호트 (EDC)를 이용하였다. 총 479쌍의 산모-아이 쌍을 대상으로 다변수 선형 회귀분석을 통해 연관성을 살펴보았다. 연구 결과, 임신 중 산모의 혈중 카드뮴 농도가 2배 증가함에 따라 6세 여아의 한국어판 주의력결핍장애(ADHD) 평점척도 (K-ARS) 점수가 22.3% 증가하는 것으로 나타났다.
-
Citations
Citations to this article as recorded by 
- Effect of short and long-term cadmium exposure on behaviour and cardiac function in Drosophila
Jessica J. Wellings, Jamie M. Thorpe, Karen Yendole, Yutaka Matsubayashi, Paul S. Hartley Environmental Pollution.2025; 366: 125481. CrossRef - Prenatal exposure to heavy metals and childhood atopic disease
Courtney Dow, Manik Kadawathagedara, Manel Ghozal, Marie-Aline Charles, Karine Adel-Patient, Clémentine Dereumeaux, Blandine de Lauzon-Guillain Environmental Research.2025; 270: 121062. CrossRef - Investigating the Association Between Heavy Metals and Attention Deficit Hyperactivity Disorder in Children: An Exploratory Study
Sharanpreet Kaur, Josefa Canals-Sans, Paula Morales-Hidalgo, José A. Alda, Victoria Arija Journal of Attention Disorders.2025; 29(6): 423. CrossRef - Prenatal placental metal accumulation and its association with child attention deficit/hyperactivity disorder and autism spectrum disorder symptom at 3 years of age: The role of psychosocial-environmental support in infancy
Jixing Zhou, Juan Tong, Chunmei Liang, Penggui Wu, Jiajun Ouyang, Wenjin Cai, Jie Sheng, Guopeng Gao, Shuangqin Yan, Fangbiao Tao, Kun Huang Environmental Research.2025; 274: 121294. CrossRef - Toxicity effects of cadmium exposure on early development: a review of current evidence
Nur Batrisyia Azlan, Siti Sarah Mohamad Zaid, Siti Rosmani Md Zin Critical Reviews in Toxicology.2025; : 1. CrossRef - Cadmium Toxicity in Children and Its Detection Using Colorimetric and Fluorimetric Methods
Alaa Shafie, Amal Adnan Ashour Journal of Fluorescence.2025;[Epub] CrossRef - Associations of gestational and childhood exposure to lead, cadmium, and fluoride with cognitive abilities, behavior, and social communication at 4 years of age: NICE birth cohort study
Mariza Kampouri, Eric Zander, Klara Gustin, Anna Sandin, Malin Barman, Ann-Sofie Sandberg, Agnes E. Wold, Sven Bölte, Maria Kippler, Marie Vahter Environmental Research.2024; 263: 120123. CrossRef - Organic food consumption during pregnancy and symptoms of neurodevelopmental disorders at 8 years of age in the offspring: the Norwegian Mother, Father and Child Cohort Study (MoBa)
Johanne T. Instanes, Berit S. Solberg, Liv G. Kvalvik, Kari Klungsøyr, Maj-Britt R. Posserud, Catharina A. Hartman, Jan Haavik BMC Medicine.2024;[Epub] CrossRef - Co-exposure to toxic metals and phthalates in pregnant women and their children’s mental health problems aged four years — Taiwan Maternal and Infant Cohort Study (TMICS)
Tsung-Lin Tsai, Chia-Jung Hsieh, Ming-Tsang Wu, Mei-Lien Chen, Po-Hsiu Kuo, Shu-Li Wang Environment International.2023; 173: 107804. CrossRef - Effects of cadmium on children and adolescents development (systematic review)
Natalia D. Bobrisheva-Pushkina, Lubov Yu. Kuznetsova, Maksim Yu. Mozganov, Azaliya N. Araslanova, Aleksandra A. Kordina, Gennadij G. Onishchenko Hygiene and sanitation.2023; 102(9): 947. CrossRef - Quality and risk assessment of lead and cadmium in drinking water for child development centres use in Phatthalung province, Thailand
Somsiri Decharat, Piriyalux Phethuayluk Environmental Analysis Health and Toxicology.2023; 38(4): e2023020. CrossRef - Developmental exposure to environmental levels of cadmium induces neurotoxicity and activates microglia in zebrafish larvae: From the perspectives of neurobehavior and neuroimaging
Yanyi Xu, Haiyu Zhao, Zuo Wang, Hao Gao, Junru Liu, Kemin Li, Zan Song, Cong Yuan, Xianyong Lan, Chuanying Pan, Shengxiang Zhang Chemosphere.2022; 291: 132802. CrossRef - The Association between ADHD and Environmental Chemicals—A Scoping Review
Sonja Moore, Laura Paalanen, Lisa Melymuk, Andromachi Katsonouri, Marike Kolossa-Gehring, Hanna Tolonen International Journal of Environmental Research and Public Health.2022; 19(5): 2849. CrossRef - Elemental composition of the hair and milk of black-spotted cows and its relationship with intestinal microbiome reorganization
Elena Sizova, Elena Yausheva, Olga Marshinskaia, Tatiana Kazakova, Yuriy Khlopko, Svyatoslav Lebedev Veterinary World.2022; : 2565. CrossRef - Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea
Yoonyoung Jang, Yoon-Jung Choi, Youn-Hee Lim, Kyung-Shin Lee, Bung-Nyun Kim, Choong Ho Shin, Young Ah Lee, Johanna Inhyang Kim, Yun-Chul Hong Journal of Preventive Medicine and Public Health.2021; 54(1): 37. CrossRef - ADHD: Reviewing the Causes and Evaluating Solutions
Luis Núñez-Jaramillo, Andrea Herrera-Solís, Wendy Herrera-Morales Journal of Personalized Medicine.2021; 11(3): 166. CrossRef - Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit/hyperactivity disorder in children
Thea S. Skogheim, Kjell Vegard F. Weyde, Stephanie M. Engel, Heidi Aase, Pål Surén, Merete G. Øie, Guido Biele, Ted Reichborn-Kjennerud, Ida H. Caspersen, Mady Hornig, Line S. Haug, Gro D. Villanger Environment International.2021; 152: 106468. CrossRef - Effect of Cadmium on Children's Health in Prenatal and Postnatal Periods of Development
S. S. Ostrovska, Yu. P. Myasoid, R. V. Kovtunenko, V. A. Myakushko, G. P. Chernenko, I. Y. Pismenetska, V. V. Baklunov Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2021; 6(5): 414. CrossRef
|