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Sung Hi Kim 2 Articles
The Association of Central Obesity with Type 2 Diabetes among Koreans according to the Serum Gamma-Glutamyltransferase Level: Korean Genome and Epidemiology Study.
Ji Yeon Shin, Jun Hyun Hwang, Jin Young Jeong, Sung Hi Kim, Jai Dong Moon, Sang Chul Roh, Young Wook Kim, Yangho Kim, Jong Han Leem, Young Su Ju, Young Seoub Hong, Eun Hee Ha, Yong Hwan Lee, Duk Hee Lee, Dong Hyun Kim
J Prev Med Public Health. 2009;42(6):386-391.
DOI: https://doi.org/10.3961/jpmph.2009.42.6.386
  • 5,456 View
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  • 3 Crossref
AbstractAbstract PDF
OBJECTIVES
This cross-sectional study was performed to examine if the serum gamma-glutamyltransferase (GGT) level that is within its normal range is associated with the risk of type 2 diabetes and if the association between the waist hip ratio (WHR) and type 2 diabetes is different depending on the serum GGT levels. METHODS: The study subjects were 23,436 persons aged 40 years or older and who participated in regular health check-ups at 11 hospitals (males: 5,821, females: 17,615). The gender-specific quintiles of the serum GGT and WHR were used to examine the associations with type 2 diabetes. RESULTS: The serum GGT levels within their normal range were positively associated with type 2 diabetes only in women. The adjusted odds ratios (ORs) were 1.0, 1.0, 1.4, 2.1, and 2.5 according to the quintiles of the serum GGT (p(trend)<0.01). The WHR was more strongly associated with the prevalence of diabetes among the women with a high-normal serum GGT level as compared with those with a low-normal serum GGT level (p for interaction=0.02). For example, the adjusted ORs for women with a low normal serum GGT level were 1.0, 1.2, 1.5, 2.2, and 2.4 according to the quintiles of the WHR, while those figures were 1.0, 2.4, 3.6, 5.0, and 8.3 among the women with a high normal serum GGT level. However, in men, the serum GGT was very weakly associated with type 2 diabetes and the association between the WHR and type 2 diabetes was not different depending on the serum GGT level. CONCLUSIONS: Serum GGT within its normal range was positively associated with type 2 diabetes, and central obesity was more strongly associated with the prevalence of type 2 diabetes when the serum GGT level was high-normal. However, these associations were observed only in women, which is different from the previous findings. The stronger relation between central obesity and type 2 diabetes among women with a high-normal serum GGT level can be useful for selecting a group that is at high risk for type 2 diabetes irregardless of whatever the underlying mechanism is.
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  • Serum gamma-glutamyl transferase and risk of type 2 diabetes in the general Korean population: a Mendelian randomization study
    Youn Sue Lee, Yoonsu Cho, Stephen Burgess, George Davey Smith, Caroline L. Relton, So-Youn Shin, Min-Jeong Shin
    Human Molecular Genetics.2016; 25(17): 3877.     CrossRef
  • Different associations between obesity and impaired fasting glucose depending on serum gamma-glutamyltransferase levels within normal range: a cross-sectional study
    Nam Soo Hong, Jeong-Gook Kim, Yu-Mi Lee, Hyun-Woo Kim, Sin Kam, Keon-Yeop Kim, Ki-Su Kim, Duk-Hee Lee
    BMC Endocrine Disorders.2014;[Epub]     CrossRef
  • Endobiogeny: A Global Approach to Systems Biology (Part 1 of 2)
    Jean-Claude, Lapraz, Kamyar M. Hedayat
    Global Advances in Health and Medicine.2013; 2(1): 64.     CrossRef
Associations of Non Alcoholic Fatty Liver with the Metabolic Syndrome and Serum Carotenoids.
Sun kyun Park, Hyun Jung Lee, Duk Hee Lee, Sung Kook Lee, Byung Yeol Chun, Sung Ae Kim, Hye Sung Lee, Hyo Kyung Son, Sung Hi Kim
J Prev Med Public Health. 2008;41(1):39-44.
DOI: https://doi.org/10.3961/jpmph.2008.41.1.39
  • 5,637 View
  • 67 Download
  • 10 Crossref
AbstractAbstract PDF
OBJECTIVES
This study was conducted to investigate the associations of non alcoholic fatty liver with metabolic syndrome and the serum carotenoids. METHODS: This study was conducted in a general hospital in South Korea from November, 2004 to August, 2005. The study subjects were 350 sampled persons who were aged from 40 years and older (males: 180, females: 170). They were grouped into the normal, mild and severe groups according to fat accumulation in their livers, as determined by ultrasonography. We analyzed the association between non alcoholic fatty liver and metabolic syndrome by multiple logistic regression analysis and we analyzed the association between non alcoholic fatty liver and the serum carotenoids by a general linear model(ANCOVA). RESULTS: After adjustment for the effect of potential covariates, the prevalence of metabolic syndrome was associated with fat accumulation in the liver (p trend <0.001). If the odds ratio of normal group is 1.00, then that of the mild group is 2.80 (95% C.I=1.17-6.71) and that of the severe group is 7.29 (95% C.I=2.76-19.30). The prevalence of metabolic alterations fitting the criteria of metabolic syndrome, according to the class of fat accumulation in the liver, was significantly increased, except for criteria of high blood pressure, a large waist circumference and low HDL (high density lipoprotein) cholesterol level (p trend <0.001). The level of serum beta-carotene was decreased according to the class of fat accumulation in the liver (p trend=0.036), but the levels of serum alpha-carotene, lycopene, bata-cryptoxanthin and lutein were not decreased. CONCLSIONS: This study shows that non alcoholic fatty liver was associated with metabolic syndrome and with the serum beta-carotene level.
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  • Estimation of Attributable Risk and Direct Medical and Non-Medical Costs of Major Mental Disorders Associated With Air Pollution Exposures Among Children and Adolescents in the Republic of Korea, 2011–2019
    Yae Won Ha, Tae Hyun Kim, Dae Ryong Kang, Ki-Soo Park, Dong Chun Shin, Jaelim Cho, Changsoo Kim
    Journal of Korean Medical Science.2024;[Epub]     CrossRef
  • Therapeutic potential of bioactive phytoconstituents found in fruits in the treatment of non-alcoholic fatty liver disease: A comprehensive review
    Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Pompy Patowary, Pronobesh Chattopadhyay, Aparoop Das
    Heliyon.2023; 9(4): e15347.     CrossRef
  • The Protection Conferred by HSD17B13 rs72613567 Polymorphism on Risk of Steatohepatitis and Fibrosis May Be Limited to Selected Subgroups of Patients With NAFLD
    Eduardo Vilar-Gomez, Carlos J. Pirola, Silvia Sookoian, Laura A. Wilson, Tiebing Liang, Naga Chalasani
    Clinical and Translational Gastroenterology.2021; 12(9): e00400.     CrossRef
  • Trends and Patterns of Burden of Disease and Injuries in Korea Using Disability-Adjusted Life Years
    Young-Eun Kim, Hyesook Park, Min-Woo Jo, In-Hwan Oh, Dun-Sol Go, Jaehun Jung, Seok-Jun Yoon
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among US Adults, NHANES 2003–2014
    Krista Christensen, Thomas Lawler, Julie Mares
    Nutrients.2019; 11(5): 1101.     CrossRef
  • Central obesity and nonalcoholic fatty liver disease risk after adjusting for body mass index
    Qing Pang
    World Journal of Gastroenterology.2015; 21(5): 1650.     CrossRef
  • Association Between Liver Vitamin A Reserves and Severity of Nonalcoholic Fatty Liver Disease in the Class III Obese Following Bariatric Surgery
    Gabriela Villaça Chaves, Sílvia Elaine Pereira, Carlos José Saboya, Daiane Spitz, Camila Santos Rodrigues, Andréa Ramalho
    Obesity Surgery.2014; 24(2): 219.     CrossRef
  • Association of oral health behaviors and status with depression: results from the Korean National Health and Nutrition Examination Survey, 2010
    Se Jin Park, Ki Dong Ko, Seung-Il Shin, Yu Jeong Ha, Gy Young Kim, Hyoung Ah Kim
    Journal of Public Health Dentistry.2014; 74(2): 127.     CrossRef
  • Measuring the burden of chronic diseases in Korea in 2007
    E.-J. Kim, S.-J. Yoon, M.-W. Jo, H.-J. Kim
    Public Health.2013; 127(9): 806.     CrossRef
  • The Association of Cardiovascular Risk Factors with Nonalcoholic Fatty Liver Disease in Health Checkup Examinees
    Jae-Hee Yu, Kang-Sook Lee, Seon-Young Lee, A-Rum Hong, Yong-Sang Park
    Journal of Preventive Medicine and Public Health.2008; 41(6): 407.     CrossRef

JPMPH : Journal of Preventive Medicine and Public Health