- Developmental Toxicity by Exposure to Bisphenol A Diglycidyl Ether during Gestation and Lactation Period in Sprague-dawley Male Rats.
-
Un jun Hyoung, Yun Jung Yang, Su Kyoung Kwon, Jae Hyoung Yoo, Soon Chul Myoung, Sae Chul Kim, Yeon Pyo Hong
-
J Prev Med Public Health. 2007;40(2):155-161.
-
DOI: https://doi.org/10.3961/jpmph.2007.40.2.155
-
-
5,927
View
-
96
Download
-
33
Crossref
-
 Abstract
 PDF
- OBJECTIVES
Bisphenol A diglycidyl ether (BADGE) is the major component in commercial liquid epoxy resins, which are manufactured by co-reacting bisphenol A with epichlorohydrin. This study was performed to show the developmental effects of prenatal and postnatal exposures to BADGE in male rat offspring. METHODS: Mated female rats were divided into four groups, each containing 12 rats. The dosing solutions were prepared by thoroughly mixing BADGE in corn oil at the 0, 375, 1500 and 3000 mg/kg/day concentrations. Mated females were dosed once daily by oral gavage on gestation day (GD) 6 - 20 and postnatal day (PND) 0 - 21. Pregnant female dams were observed general symptoms and body weight. Also, male pups were observed the general symptoms, body weight, developmental parameters (e.g. anogenital distance, pina detachment, incisor eruption, nipple retention, eye opening, testis descent), organ pathologic changes and hormone levels of plasma. RESULTS: Pregnant rats treated with BADGE died at a rate of about 70% in the 1500 mg/kg/day group and all rats treated with 3000 mg/kg/day died. Body weight, for male pups treated with doses of 375 mg/kg/day, was significantly lower than in the control group at PND 42, 56, and 63 (p<0.05). Evaluation of body characteristics including; separation of auricle, eruption of incisor, separation of eyelid, nipple retention, descent of testis, and separation of the prepuce in the BADGE treated group showed no difference in comparisons with the control group. AGD and adjusted AGD (mm/kg) for general developmental items in BADGE 375 mg/kg/day treated pups tended to be longer than in controls, however, these differences were not statistically significant. Relative weights of adrenal gland, lung (p<0.05), brain, epididymis, prostate, and testis (p<0.01) were heavier than in control in measures at PND 9 weeks. There were no significant changes in comparisons of histological findings of these organs. Loss of spermatids was observed in the seminiferous tubule at PND 9 weeks, but no weight changes were observed. The plasma estrogen levels were similar in the control and treatment groups at PND 3, 6 and 9 weeks. The plasma testosterone levels in the control group tended to increase with age. However, in the BADGE 375 mg/kg/day treated male pups it did not tend to increase. CONCLUSIONS: These findings suggest that BADGE is a chemical that has developmental effects consistent with it being an endocrine disruptor.
-
Summary
-
Citations
Citations to this article as recorded by  - Nature-Derived Epoxy Resin Monomers with Reduced Sensitizing Capacity─Isosorbide-Based Bis-Epoxides
Isabella Karlsson, David J. Ponting, Miguel A. Ortega, Ida B. Niklasson, Lorena Ndreu, E. Johanna L. Stéen, Tina Seifert, Kristina Luthman, Ann-Therese Karlberg
Chemical Research in Toxicology.2023; 36(2): 281. CrossRef - Developmental neurotoxic effects of bisphenol A and its derivatives in Drosophila melanogaster
Jie Wang, Chunyan Wu, Xing Zhang, Yuanyuan Song, Binquan Wang, Ke Zhang, Mingkuan Sun
Ecotoxicology and Environmental Safety.2023; 260: 115098. CrossRef - A review of properties, production, human exposure, biomonitoring, toxicity, and regulation of bisphenol A diglycidyl ethers and novolac glycidyl ethers
Jingchuan Xue, Yuxian Liu, Danlin Yang, Yanan Zhao, Yanpeng Cai, Tao Zhang, Kurunthachalam Kannan
Environmental Chemistry and Ecotoxicology.2022; 4: 216. CrossRef - A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE
Dongqi Wang, Haoduo Zhao, Xunchang Fei, Shane Allen Synder, Mingliang Fang, Min Liu
Environment International.2021; 155: 106701. CrossRef - Effects of maternal bisphenol A diglycidyl ether exposure during gestation and lactation on behavior and brain development of the offspring
Ikuko Miyazaki, Ryo Kikuoka, Nami Isooka, Mika Takeshima, Kanau Sonobe, Rei Arai, Hidemaru Funakoshi, Kyle E. Quin, Jonathan Smart, Kazumasa Zensho, Masato Asanuma
Food and Chemical Toxicology.2020; 138: 111235. CrossRef - Exposure to the environmental pollutant bisphenol A diglycidyl ether (BADGE) causes cell over-proliferation in Drosophila
Michael J. Williams, Hao Cao, Therese Lindkvist, Tobias J. Mothes, Helgi B. Schiöth
Environmental Science and Pollution Research.2020; 27(20): 25261. CrossRef - Prenatal BPA and its analogs BPB, BPF, and BPS exposure and reproductive axis function in the male offspring of Sprague Dawley rats
A Ullah, M Pirzada, S Jahan, H Ullah, S Razak, N Rauf, MJ Khan, SZ Mahboob
Human & Experimental Toxicology.2019; 38(12): 1344. CrossRef - Resin-based dental sealants as a source of human exposure to bisphenol analogues, bisphenol A diglycidyl ether, and its derivatives
Jingchuan Xue, Pranav Kannan, Taha A. Kumosani, Abdulrahman L. Al-Malki, Kurunthachalam Kannan
Environmental Research.2018; 162: 35. CrossRef - Association between bisphenol A diglycidyl ether-specific IgG in serum and food sensitization in young children
Mayumi Tsuji, Chihaya Koriyama, Yasuhiro Ishihara, Christoph F. A. Vogel, Toshihiro Kawamoto
European Journal of Medical Research.2018;[Epub] CrossRef - Concentrations of Bisphenols in Canned Foods and Their Risk Assessment in Korea
Su Jeong Choi, Eun Sun Yun, Jae Min Shin, Yeo Sook Kim, Jeong Sook Lee, Jin Hyo Lee, Dong Gu Kim, Young Hee Oh, Kweon Jung, Gun Hee Kim
Journal of Food Protection.2018; 81(6): 903. CrossRef - Bisphenols, Benzophenones, and Bisphenol A Diglycidyl Ethers in Textiles and Infant Clothing
Jingchuan Xue, Wenbin Liu, Kurunthachalam Kannan
Environmental Science & Technology.2017; 51(9): 5279. CrossRef - A simple method for the enrichment of bisphenols using boron nitride
Martin Fischnaller, Rania Bakry, Günther K. Bonn
Food Chemistry.2016; 194: 149. CrossRef - Occurrence of phthalate diesters (phthalates), p-hydroxybenzoic acid esters (parabens), bisphenol A diglycidyl ether (BADGE) and their derivatives in indoor dust from Vietnam: Implications for exposure
Tri Manh Tran, Tu Binh Minh, Taha A. Kumosani, Kurunthachalam Kannan
Chemosphere.2016; 144: 1553. CrossRef - Occurrence of bisphenols, bisphenol A diglycidyl ethers (BADGEs), and novolac glycidyl ethers (NOGEs) in indoor air from Albany, New York, USA, and its implications for inhalation exposure
Jingchuan Xue, Yanjian Wan, Kurunthachalam Kannan
Chemosphere.2016; 151: 1. CrossRef - Developmental toxicity of bisphenol A diglycidyl ether (epoxide resin badge) during the early life cycle of a native amphibian species
Ianina Hutler Wolkowicz, Gabriela V. Svartz, Carolina M. Aronzon, Christina Pérez Coll
Environmental Toxicology and Chemistry.2016; 35(12): 3031. CrossRef - Reduction in semen quality after mixed exposure to bisphenol A and isobutylparaben in utero and during lactation periods
Yun-Jung Yang, Yeon-Pyo Hong, Soo Ahn Chae
Human & Experimental Toxicology.2016; 35(8): 902. CrossRef - Endocrine Disruptors as Pollutants in Marine Ecosystem: A Case Study in Egypt
Maha Ahmed Mohamed Abdallah
The Open Biotechnology Journal.2016; 10(1): 131. CrossRef - Widespread Occurrence and Accumulation of Bisphenol A Diglycidyl Ether (BADGE), Bisphenol F Diglycidyl Ether (BFDGE) and Their Derivatives in Human Blood and Adipose Fat
Lei Wang, Jingchuan Xue, Kurunthachalam Kannan
Environmental Science & Technology.2015; 49(5): 3150. CrossRef - Distribution of serum bisphenol A diglycidyl ether and its metabolite in Korean adult men and its association with reproductive hormone levels
Sang-il Kim, Yun-jung Yang, Yeon-pyo Hong, Soon-Chul Myung, Sae-Chul Kim
Molecular & Cellular Toxicology.2015; 11(1): 71. CrossRef - Occurrence of Bisphenol A Diglycidyl Ethers (BADGEs) and Novolac Glycidyl Ethers (NOGEs) in Archived Biosolids from the U.S. EPA’s Targeted National Sewage Sludge Survey
Jingchuan Xue, Arjun K. Venkatesan, Qian Wu, Rolf U. Halden, Kurunthachalam Kannan
Environmental Science & Technology.2015; 49(11): 6538. CrossRef - Quick and simple sample treatment for multiresidue analysis of bisphenols, bisphenol diglycidyl ethers and their derivatives in canned food prior to liquid chromatography and fluorescence detection
A. Alabi, N. Caballero-Casero, S. Rubio
Journal of Chromatography A.2014; 1336: 23. CrossRef - Widespread occurrence of bisphenol A diglycidyl ethers, p-hydroxybenzoic acid esters (parabens), benzophenone type-UV filters, triclosan, and triclocarban in human urine from Athens, Greece
Alexandros G. Asimakopoulos, Nikolaos S. Thomaidis, Kurunthachalam Kannan
Science of The Total Environment.2014; 470-471: 1243. CrossRef - Bisphenol A Diglycidyl Ether Induces Adipogenic Differentiation of Multipotent Stromal Stem Cells through a Peroxisome Proliferator–Activated Receptor Gamma-Independent Mechanism
Raquel Chamorro-García, Séverine Kirchner, Xia Li, Amanda Janesick, Stephanie C. Casey, Connie Chow, Bruce Blumberg
Environmental Health Perspectives.2012; 120(7): 984. CrossRef - Bisphenol A and estrone‐induced developmental effects in early chick embryos
Kenichi Saito, Azusa Niijima, Eri Kamite, Mari Watanabe
Environmental Toxicology.2012; 27(1): 58. CrossRef - Occurrence and Human Exposure of p-Hydroxybenzoic Acid Esters (Parabens), Bisphenol A Diglycidyl Ether (BADGE), and Their Hydrolysis Products in Indoor Dust from the United States and Three East Asian Countries
Lei Wang, Chunyang Liao, Fang Liu, Qian Wu, Ying Guo, Hyo-Bang Moon, Haruhiko Nakata, Kurunthachalam Kannan
Environmental Science & Technology.2012; 46(21): 11584. CrossRef - Widespread Occurrence and Distribution of Bisphenol A Diglycidyl Ether (BADGE) and its Derivatives in Human Urine from the United States and China
Lei Wang, Yinghong Wu, Wei Zhang, Kurunthachalam Kannan
Environmental Science & Technology.2012; 46(23): 12968. CrossRef - In vivo alternative assessment of the chemicals that interfere with anterior pituitary POMC expression and interrenal steroidogenesis in POMC: EGFP transgenic zebrafish
Lingli Sun, Wei Xu, Jiangyan He, Zhan Yin
Toxicology and Applied Pharmacology.2010; 248(3): 217. CrossRef - Acute Testis Toxicity of Bisphenol A Diglycidyl Ether in Sprague-Dawley Rats
Yun-jung Yang, Shin-young Lee, Kyung-yong Kim, Yeon-pyo Hong
Journal of Preventive Medicine and Public Health.2010; 43(2): 131. CrossRef - Developmental Toxicity of Bisphenol-A on Post-Implantation Rat Embryos Cultured in Vitro
Dong Li, Hua Fan, Wen-Jing Ye, Hai-Feng Hou
Journal of Health Science.2010; 56(1): 57. CrossRef - Effects of Bisphenol-A and Other Endocrine Disruptors Compared With Abnormalities of Schizophrenia: An Endocrine-Disruption Theory of Schizophrenia
J. S. Brown
Schizophrenia Bulletin.2009; 35(1): 256. CrossRef - Epoxy networks for medicine applications: Mechanical properties and in vitro biological properties
Filiberto González Garcia, Maria Elena Leyva, Alvaro Antonio Alencar de Queiroz, Olga Zazuco Higa
Journal of Applied Polymer Science.2009; 112(3): 1215. CrossRef - Breast-Feeding and Type 2 Diabetes in the Youth of Three Ethnic Groups
Elizabeth J. Mayer-Davis, Dana Dabelea, Archana Pande Lamichhane, Ralph B. D'Agostino, Angela D. Liese, Joan Thomas, Robert E. McKeown, Richard F. Hamman
Diabetes Care.2008; 31(3): 470. CrossRef - Bisphenol A Bis(2,3-dihydroxypropyl) ether (BADGE.2H2O) Induces Orphan Nuclear Receptor Nur77 Gene Expression and Increases Steroidogenesis in Mouse Testicular Leydig Cells
Seung-Won Ahn, Balachandar Nedumaran, Yuanbin Xie, Don-Kyu Kim, Yong Deuk Kim, Hueng-Sik Choi
Molecules and Cells.2008; 26(1): 74. CrossRef
|
KSPM
